iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/GAT	2.00e-47	161.5	190	316

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/GAT

   S: 1    deeksklLerLlkskkPeDLreAnkLikelvkededkaekikkliseleevksnvkllnemlselspegeepednellqelyetckaar 89
           deeksklL+rLlks++PeDL++An+Lik+lvke+++k+ek+++++s++eev+s+v++l emls++++ g++  d+ +lq +ye+c+++r
   Q: 190  DEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSRRVSAVEEVRSHVRVLREMLSMYRRPGHALPDQQALQVVYERCEKLR 278
           79*************************************************************************************** PP
   S: 90   pkllklieeeedndellaellkanDelnqvlnkykqlk 127
           p+l++l+++++d+d++lae+l+anD l+q +  ykq++
   Q: 279  PTLFRLASDTTDDDDALAEILQANDLLTQGVRLYKQVV 316
           ***********************************986 PP

Organism

Mus musculus

Functional Description
(View)

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (By similarity).

Protein Sequence
(Fasta)

MAATAVAAGT GSPAGTESAE GGPGAAAALE LWLNKATDPS MAEQDWSAIQ KFCEQVNTDP 60
SGPTHAPWLL AHKIQSPQEK EALYALTVLE ICMNHCGEKF HSEVAKFRFL NELIKVLSPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTCCAATA GGGCCCGCCC CGTCACGTGC CTCTCAGTGT CTGCCGCGTC GGCAGCTGGA 60
GCGAAGGCTA GGCGGCGGCG GTGGCTGCAG CTTTTGGGCA GGAGTGACTG CGGCCGCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR008152--Clathrin_a/b/g-adaptin_app_Ig
IPR008153--Clathrin_g-adaptin_app
IPR013041--Coatomer/clathrin_app_Ig-like
IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR002014--VHS_dom

PROSITE

PS50180--GAE
PS50909--GAT
PS50179--VHS

Pfam

PF02883--Alpha_adaptinC2
PF03127--GAT
PF00790--VHS

SMART

SM00809--Alpha_adaptinC2
SM00288--VHS

Gene Ontology

GO:0030131--C:clathrin adaptor complex
GO:0030136--C:clathrin-coated vesicle
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0005802--C:trans-Golgi network
GO:0030306--F:ADP-ribosylation factor binding
GO:0006886--P:intracellular protein transport
GO:0016192--P:vesicle-mediated transport

KEGG

mmu:74105

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001341	Ailuropoda melanoleuca	84.56	0.00e+00	932.00
IUUC-Afl-008682	Aspergillus flavus	24.76	6.00e-20	92.80
IUUC-Bta-013492	Bos taurus	84.02	0.00e+00	924.00
IUUC-Cja-018800	Callithrix jacchus	83.56	0.00e+00	860.00
IUUC-Cfa-021014	Canis familiaris	84.73	0.00e+00	933.00
IUUC-Cpo-021561	Cavia porcellus	85.23	0.00e+00	914.00
IUUC-Csa-024178	Chlorocebus sabaeus	85.88	0.00e+00	956.00
IUUC-Cho-024564	Choloepus hoffmanni	84.75	1.00e-108	387.00
IUUC-Dno-029286	Dasypus novemcinctus	82.99	0.00e+00	894.00
IUUC-Dor-030125	Dipodomys ordii	77.53	2.00e-169	589.00
IUUC-Ete-032922	Echinops telfairi	79.27	0.00e+00	793.00
IUUC-Eca-034426	Equus caballus	84.91	0.00e+00	985.00
IUUC-Eeu-034886	Erinaceus europaeus	66.88	7.00e-99	354.00
IUUC-Fca-035516	Felis catus	84.98	0.00e+00	947.00
IUUC-Gga-040548	Gallus gallus	68.17	1.00e-112	400.00
IUUC-Ggo-044638	Gorilla gorilla	78.15	0.00e+00	853.00
IUUC-Hsa-045912	Homo sapiens	84.88	0.00e+00	949.00
IUUC-Itr-048824	Ictidomys tridecemlineatus	88.21	0.00e+00	956.00
IUUC-Lma-053070	Leptosphaeria maculans	24.28	3.00e-19	90.10
IUUC-Laf-054401	Loxodonta africana	85.27	0.00e+00	889.00
IUUC-Mcc-055612	Macaca mulatta	85.30	0.00e+00	947.00
IUUC-Meu-056854	Macropus eugenii	67.18	6.00e-88	318.00
IUUC-Mga-060197	Meleagris gallopavo	67.96	1.00e-103	370.00
IUUC-Mmr-061458	Microcebus murinus	81.69	0.00e+00	855.00
IUUC-Mdo-062796	Monodelphis domestica	63.08	0.00e+00	691.00
IUUC-Mpu-066175	Mustela putorius furo	82.70	0.00e+00	863.00
IUUC-Mlu-068058	Myotis lucifugus	87.34	5.00e-132	464.00
IUUC-Nle-069012	Nomascus leucogenys	83.84	0.00e+00	926.00
IUUC-Opr-070412	Ochotona princeps	74.40	0.00e+00	748.00
IUUC-Oan-073129	Ornithorhynchus anatinus	77.60	1.00e-101	363.00
IUUC-Ocu-073919	Oryctolagus cuniculus	74.81	2.00e-147	516.00
IUUC-Oga-087960	Otolemur garnettii	86.23	0.00e+00	905.00
IUUC-Oar-089238	Ovis aries	84.36	0.00e+00	927.00
IUUC-Ptr-090778	Pan troglodytes	78.90	0.00e+00	862.00
IUUC-Pan-092917	Papio anubis	86.05	0.00e+00	955.00
IUUC-Psi-093912	Pelodiscus sinensis	57.06	2.00e-90	326.00
IUUC-Pab-098685	Pongo abelii	78.26	1.00e-178	619.00
IUUC-Pca-100932	Procavia capensis	88.82	2.00e-132	466.00
IUUC-Pva-102575	Pteropus vampyrus	77.80	0.00e+00	828.00
IUUC-Pte-104353	Pyrenophora teres	25.24	4.00e-19	90.10
IUUC-Pyt-104704	Pyrenophora triticirepentis	24.92	8.00e-19	89.00
IUUC-Rno-105093	Rattus norvegicus	97.03	0.00e+00	1025.00
IUUC-Sha-106784	Sarcophilus harrisii	65.16	0.00e+00	711.00
IUUC-Ssc-115750	Sus scrofa	74.40	2.00e-152	533.00
IUUC-Tgu-116453	Taeniopygia guttata	65.74	2.00e-104	372.00
IUUC-Tsy-119576	Tarsius syrichta	75.93	7.00e-92	331.00
IUUC-Tvi-122537	Trichoderma virens	26.52	3.00e-15	77.00
IUUC-Tme-126920	Tuber melanosporum	25.00	1.00e-19	91.70
IUUC-Tbe-127374	Tupaia belangeri	84.60	4.00e-170	591.00
IUUC-Ttr-128868	Tursiops truncatus	80.27	0.00e+00	869.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence