iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000103426.12	ENST00000572467.5	ENSP00000460885.1
ENSG00000103426.12	ENST00000575334.5	ENSP00000458607.1

Annotation

Cancer Mutation
ICGC	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
CircNet	TRANSFAC	TargetScan	SomamiR
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
PhosphositePlus	dbPTM	HPRD	Phospho.ELM
BioGRID
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.60e-36	122.6	635	672
UBD/Beta-Prp	3.00e-40	139.9	542	669

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH+d +++la+ +d   l++ + Dg ++v+++r+g+ +
   Q: 635  GHQDQIFSLAWsPDgQQLATVCKDGRVRVYRPRSGPEP 672
           8***********9999*****************99865 PP

UBD/Beta-Prp

   S: 91   kghedsvlslsfsp.sgdklvsGshdrtirvwdletgqclee......tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrt 174
           + + + v++l+++p + ++l+++++d  ir+w ++ +   e       +l+gh++ ++++++hp + n+l+s+s+D tvr+Wdl+ g    +
   Q: 542  Q-NGAAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAEGLEEVlttpetVLTGHTEKICSLRFHPLAaNVLASSSYDLTVRIWDLQAGADRLK 632
           5.66889*******666*****************99877666789*********************************************** PP
   S: 175  ltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtg 212
           l+g h+d++ sl+++++g++l+++ +dg+v+++  ++g
   Q: 633  LQG-HQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSG 669
           **9.*****************************98765 PP

Organism

Homo sapiens

Functional Description
(View)

F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

Protein Sequence
(Fasta)

MNRFRVSKFR HTEARPPRRE SWISDIRAGT APSCRNHIKS SCSLIAFNSD RPGVLGIVPL 60
QGQGEDKRRV AHLGCHSDLV TDLDFSPFDD FLLATGSADR TVKLWRLPGP GQALPSAPGV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTAAGGAGT GGAGTGGATG ATGGTAATTA CCAAAAGAGA GGACAAAGTC CTTGGGATCT 60
GCCACACAGA AGAAAGAAAA ACATGGGAAA GACTCCCAGC TGAGAGCAGC CTGGGCCTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0333--Golgi apparatus
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027331--CORO7
IPR015505--Coronin
IPR003143--Cyt_cd1_C
IPR015048--DUF1899
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0005802--C:trans-Golgi network
GO:0003779--F:actin binding
GO:0030041--P:actin filament polymerization
GO:0006895--P:Golgi to endosome transport
GO:0015031--P:protein transport

KEGG

hsa:79585

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002235	Ailuropoda melanoleuca	86.35	0.00e+00	1367.00
IUUC-Apl-004126	Anas platyrhynchos	59.27	3.00e-116	412.00
IUUC-Ame-011310	Astyanax mexicanus	66.48	2.00e-73	269.00
IUUC-Bta-012843	Bos taurus	85.39	0.00e+00	1403.00
IUUC-Cel-018204	Caenorhabditis elegans	35.46	2.00e-70	261.00
IUUC-Cja-019024	Callithrix jacchus	91.67	0.00e+00	1449.00
IUUC-Cfa-020626	Canis familiaris	86.90	0.00e+00	1393.00
IUUC-Cpo-022429	Cavia porcellus	86.36	0.00e+00	1479.00
IUUC-Csa-023919	Chlorocebus sabaeus	96.85	0.00e+00	1756.00
IUUC-Dno-029234	Dasypus novemcinctus	74.22	0.00e+00	1174.00
IUUC-Dor-030242	Dipodomys ordii	87.77	0.00e+00	1422.00
IUUC-Dme-032156	Drosophila melanogaster	43.97	1.00e-120	428.00
IUUC-Ete-032862	Echinops telfairi	82.49	0.00e+00	1240.00
IUUC-Eca-033902	Equus caballus	85.53	0.00e+00	1361.00
IUUC-Eeu-034540	Erinaceus europaeus	65.01	0.00e+00	657.00
IUUC-Fca-036335	Felis catus	87.73	0.00e+00	1432.00
IUUC-Fal-037278	Ficedula albicollis	72.19	0.00e+00	681.00
IUUC-Gmo-038846	Gadus morhua	66.67	5.00e-179	621.00
IUUC-Gga-041144	Gallus gallus	60.74	0.00e+00	1030.00
IUUC-Ggo-045469	Gorilla gorilla	90.30	0.00e+00	702.00
IUUC-Itr-048351	Ictidomys tridecemlineatus	88.31	0.00e+00	1449.00
IUUC-Laf-053869	Loxodonta africana	71.76	0.00e+00	968.00
IUUC-Mcc-054896	Macaca mulatta	97.04	0.00e+00	1781.00
IUUC-Meu-056428	Macropus eugenii	74.05	0.00e+00	1282.00
IUUC-Mga-059389	Meleagris gallopavo	64.61	0.00e+00	1104.00
IUUC-Mvi-060231	Microbotryum violaceum	34.90	3.00e-60	227.00
IUUC-Mmr-060935	Microcebus murinus	87.97	0.00e+00	1468.00
IUUC-Mdo-062707	Monodelphis domestica	74.78	0.00e+00	1322.00
IUUC-Mmu-063976	Mus musculus	83.77	0.00e+00	1462.00
IUUC-Mpu-066441	Mustela putorius furo	87.27	0.00e+00	1349.00
IUUC-Mlu-067524	Myotis lucifugus	87.23	0.00e+00	1446.00
IUUC-Opr-071099	Ochotona princeps	84.34	0.00e+00	1266.00
IUUC-Oan-072860	Ornithorhynchus anatinus	69.16	0.00e+00	808.00
IUUC-Ocu-074794	Oryctolagus cuniculus	86.80	0.00e+00	1378.00
IUUC-Oga-088030	Otolemur garnettii	85.28	0.00e+00	1320.00
IUUC-Oar-090379	Ovis aries	72.36	0.00e+00	1159.00
IUUC-Ptr-091006	Pan troglodytes	94.70	0.00e+00	1488.00
IUUC-Pan-092428	Papio anubis	96.65	0.00e+00	1597.00
IUUC-Pfo-096558	Poecilia formosa	55.58	0.00e+00	1011.00
IUUC-Pab-098298	Pongo abelii	86.50	0.00e+00	1318.00
IUUC-Pca-100305	Procavia capensis	77.92	0.00e+00	930.00
IUUC-Pva-102702	Pteropus vampyrus	85.41	0.00e+00	1150.00
IUUC-Rno-105934	Rattus norvegicus	77.62	0.00e+00	1406.00
IUUC-Sar-112987	Sorex araneus	83.77	4.00e-110	392.00
IUUC-Ssc-116071	Sus scrofa	86.80	0.00e+00	1433.00
IUUC-Tgu-116813	Taeniopygia guttata	66.03	9.00e-175	606.00
IUUC-Tru-118359	Takifugu rubripes	54.81	0.00e+00	1006.00
IUUC-Ttr-129020	Tursiops truncatus	84.63	0.00e+00	1439.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence