iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000104228.12	ENST00000305364.8	ENSP00000301924.4
ENSG00000104228.12	ENST00000521283.1	ENSP00000429356.1
ENSG00000104228.12	ENST00000521253.1	ENSP00000428770.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.10e-08	36.7	16	85
E3 activity/RING/RING	1.30e-06	30.5	21	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwlasggk.tcPvtrqplteedlvPnltlrrliqawcee 71
            ee+lC++ ++++rd v+l +G+ + r ++ ++ + + + tcPv++ + ++ dl  n+tl +l+++ + e
   Q: 16   KEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSpTCPVCKDRASPADLRTNHTLNNLVEKLLRE 85
           689******************************97766669**********************9987765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           Ca+C+++f+d  ++l+CgH f++ C+  +w     + + + +CP+C+
   Q: 21   CAVCYDPFRD-AVTLRCGHNFCRGCVsRCW-----EVQVSPTCPVCK 61
           ********99.999************9999.....799999*****6 PP

Organism

Homo sapiens

Functional Description
(View)

Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Involved in the cell death mechanism (By similarity).

Protein Sequence
(Fasta)

MERSPDVSPG PSRSFKEELL CAVCYDPFRD AVTLRCGHNF CRGCVSRCWE VQVSPTCPVC 60
KDRASPADLR TNHTLNNLVE KLLREEAEGA RWTSYRFSRV CRLHRGQLSL FCLEDKELLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACTCGGGTC GCGGGCGTTG GCAGCCGGGC GGGTGGGAGG GGCCGGAGCA AAAGTTCCGG 60
GCGCCCGAGC CGGCTGCTCG TGCCATGGAG CGGAGTCCCG ACGTGTCCCC CGGGCCTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0045087--P:innate immune response
GO:0045930--P:negative regulation of mitotic cell cycle
GO:1902187--P:negative regulation of viral release from host cell
GO:0043065--P:positive regulation of apoptotic process

KEGG

hsa:23087

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001788	Ailuropoda melanoleuca	91.48	0.00e+00	941.00
IUUC-Apl-003958	Anas platyrhynchos	53.54	5.00e-133	468.00
IUUC-Aca-005199	Anolis carolinensis	47.52	3.00e-126	445.00
IUUC-Ame-011964	Astyanax mexicanus	36.33	9.00e-73	267.00
IUUC-Bta-013359	Bos taurus	88.98	0.00e+00	900.00
IUUC-Cja-018900	Callithrix jacchus	82.80	0.00e+00	843.00
IUUC-Cfa-020685	Canis familiaris	91.28	0.00e+00	940.00
IUUC-Cpo-022253	Cavia porcellus	81.54	0.00e+00	806.00
IUUC-Csa-023777	Chlorocebus sabaeus	99.59	0.00e+00	1019.00
IUUC-Dre-027686	Danio rerio	33.84	2.00e-59	223.00
IUUC-Dno-029065	Dasypus novemcinctus	85.74	0.00e+00	893.00
IUUC-Dor-030248	Dipodomys ordii	65.40	1.00e-102	366.00
IUUC-Ete-033183	Echinops telfairi	74.44	0.00e+00	733.00
IUUC-Eca-033263	Equus caballus	90.29	0.00e+00	819.00
IUUC-Eeu-034699	Erinaceus europaeus	80.75	4.00e-116	411.00
IUUC-Fca-036366	Felis catus	89.86	0.00e+00	926.00
IUUC-Fal-037257	Ficedula albicollis	56.58	4.00e-157	547.00
IUUC-Gmo-038512	Gadus morhua	35.37	4.00e-69	255.00
IUUC-Gga-041125	Gallus gallus	54.81	2.00e-106	379.00
IUUC-Gac-042136	Gasterosteus aculeatus	35.31	9.00e-71	260.00
IUUC-Ggo-045233	Gorilla gorilla	100.00	0.00e+00	653.00
IUUC-Itr-048751	Ictidomys tridecemlineatus	91.67	0.00e+00	921.00
IUUC-Lch-049548	Latimeria chalumnae	35.12	1.00e-81	297.00
IUUC-Loc-051729	Lepisosteus oculatus	35.89	2.00e-82	299.00
IUUC-Laf-054322	Loxodonta africana	90.79	0.00e+00	911.00
IUUC-Mcc-055555	Macaca mulatta	97.39	0.00e+00	1000.00
IUUC-Meu-055900	Macropus eugenii	80.46	0.00e+00	804.00
IUUC-Mga-059380	Meleagris gallopavo	56.23	3.00e-105	375.00
IUUC-Mmr-061296	Microcebus murinus	92.09	0.00e+00	935.00
IUUC-Mdo-062811	Monodelphis domestica	80.50	0.00e+00	804.00
IUUC-Mmu-063718	Mus musculus	79.42	0.00e+00	806.00
IUUC-Mpu-066219	Mustela putorius furo	90.44	0.00e+00	909.00
IUUC-Mlu-067033	Myotis lucifugus	85.77	0.00e+00	885.00
IUUC-Nle-069806	Nomascus leucogenys	99.13	0.00e+00	947.00
IUUC-Opr-070248	Ochotona princeps	82.61	0.00e+00	799.00
IUUC-Ont-072083	Oreochromis niloticus	32.79	5.00e-71	261.00
IUUC-Oan-073364	Ornithorhynchus anatinus	71.66	1.00e-99	355.00
IUUC-Ocu-074572	Oryctolagus cuniculus	93.90	0.00e+00	966.00
IUUC-Oga-088378	Otolemur garnettii	89.66	0.00e+00	905.00
IUUC-Oar-089516	Ovis aries	88.12	0.00e+00	886.00
IUUC-Ptr-091313	Pan troglodytes	100.00	0.00e+00	1021.00
IUUC-Pan-092877	Papio anubis	99.80	0.00e+00	1021.00
IUUC-Psi-093928	Pelodiscus sinensis	59.58	7.00e-164	570.00
IUUC-Pfo-096690	Poecilia formosa	34.95	2.00e-69	256.00
IUUC-Pab-098624	Pongo abelii	99.59	0.00e+00	1013.00
IUUC-Pca-100469	Procavia capensis	83.51	0.00e+00	838.00
IUUC-Pva-103227	Pteropus vampyrus	90.67	0.00e+00	934.00
IUUC-Rno-105778	Rattus norvegicus	79.22	0.00e+00	806.00
IUUC-Sha-107392	Sarcophilus harrisii	69.82	0.00e+00	690.00
IUUC-Sar-113297	Sorex araneus	72.09	4.00e-53	201.00
IUUC-Ssc-115739	Sus scrofa	89.81	0.00e+00	902.00
IUUC-Tru-117718	Takifugu rubripes	32.21	1.00e-63	237.00
IUUC-Tbe-127926	Tupaia belangeri	86.43	6.00e-138	484.00
IUUC-Ttr-129293	Tursiops truncatus	90.87	0.00e+00	927.00
IUUC-Vpa-130379	Vicugna pacos	91.28	3.00e-159	554.00
IUUC-Xma-134222	Xiphophorus maculatus	33.12	3.00e-62	233.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence