iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000106100.10	ENST00000222823.8	ENSP00000222823.4
ENSG00000106100.10	ENST00000434755.5	ENSP00000416946.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/CARD	CARD	23300079

Organism

Homo sapiens

Functional Description
(View)

Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.

Protein Sequence
(Fasta)

MEEQGHSEME IIPSESHPHI QLLKSNRELL VTHIRNTQCL VDNLLKNDYF SAEDAEIVCA 60
CPTQPDKVRK ILDLVQSKGE EVSEFFLYLL QQLADAYVDL RPWLLEIGFS PSLLTQSKVV 120

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Nucleotide Sequence
(Fasta)

AGTTCCCGTT CCGGGCCCGC GAGGCAGCCG CCCCGGTCCT GCCCCTCCCT CGCGCTACTG 60
CGGGAGCAGC GTCCTCCCGG GCCACGGCGC TTCCCGGCCC CGGCGTCCCC GGACCATGGC 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR007109--Brix
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase

PROSITE

PS50209--CARD
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0050700--F:CARD domain binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0042802--F:identical protein binding
GO:0042834--F:peptidoglycan binding
GO:0042803--F:protein homodimerization activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0000187--P:activation of MAPK activity
GO:0006915--P:apoptotic process
GO:0071225--P:cellular response to muramyl dipeptide
GO:0006952--P:defense response
GO:0042742--P:defense response to bacterium
GO:0050830--P:defense response to Gram-positive bacterium
GO:0016045--P:detection of bacterium
GO:0009595--P:detection of biotic stimulus
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0042228--P:interleukin-8 biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0007254--P:JNK cascade
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002606--P:positive regulation of dendritic cell antigen processing and presentation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032731--P:positive regulation of interleukin-1 beta production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0051000--P:positive regulation of nitric-oxide synthase activity
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:1904417--P:positive regulation of xenophagy
GO:0016579--P:protein deubiquitination
GO:0051259--P:protein oligomerization
GO:0007165--P:signal transduction

KEGG

hsa:10392

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001299	Ailuropoda melanoleuca	82.79	0.00e+00	1415.00
IUUC-Apl-003908	Anas platyrhynchos	62.37	0.00e+00	1148.00
IUUC-Aca-005144	Anolis carolinensis	60.81	0.00e+00	1125.00
IUUC-Ame-010829	Astyanax mexicanus	51.26	0.00e+00	897.00
IUUC-Bta-013358	Bos taurus	83.23	0.00e+00	1491.00
IUUC-Cja-019392	Callithrix jacchus	94.02	0.00e+00	1702.00
IUUC-Cfa-020776	Canis familiaris	83.84	0.00e+00	1474.00
IUUC-Cpo-021393	Cavia porcellus	79.77	0.00e+00	1464.00
IUUC-Csa-023872	Chlorocebus sabaeus	97.06	0.00e+00	1781.00
IUUC-Cho-024569	Choloepus hoffmanni	74.12	0.00e+00	629.00
IUUC-Dre-027478	Danio rerio	50.85	0.00e+00	874.00
IUUC-Dno-029231	Dasypus novemcinctus	83.84	0.00e+00	1531.00
IUUC-Dor-030251	Dipodomys ordii	57.55	8.00e-156	544.00
IUUC-Ete-032484	Echinops telfairi	73.30	0.00e+00	778.00
IUUC-Eca-033564	Equus caballus	86.33	0.00e+00	1556.00
IUUC-Eeu-034456	Erinaceus europaeus	66.75	3.00e-141	495.00
IUUC-Fca-036372	Felis catus	83.00	0.00e+00	1483.00
IUUC-Fal-037418	Ficedula albicollis	62.53	0.00e+00	1141.00
IUUC-Gmo-038740	Gadus morhua	50.81	0.00e+00	894.00
IUUC-Gga-040775	Gallus gallus	62.53	0.00e+00	1176.00
IUUC-Gac-041612	Gasterosteus aculeatus	49.69	0.00e+00	899.00
IUUC-Ggo-045161	Gorilla gorilla	99.88	0.00e+00	1557.00
IUUC-Itr-048414	Ictidomys tridecemlineatus	85.59	0.00e+00	1630.00
IUUC-Lch-049764	Latimeria chalumnae	58.90	0.00e+00	1016.00
IUUC-Loc-052143	Lepisosteus oculatus	54.30	0.00e+00	1001.00
IUUC-Laf-053503	Loxodonta africana	82.98	0.00e+00	1514.00
IUUC-Mcc-054992	Macaca mulatta	96.43	0.00e+00	1773.00
IUUC-Meu-056406	Macropus eugenii	62.86	0.00e+00	1107.00
IUUC-Mga-059351	Meleagris gallopavo	61.88	0.00e+00	1172.00
IUUC-Mmr-061537	Microcebus murinus	86.15	0.00e+00	1496.00
IUUC-Mdo-061832	Monodelphis domestica	65.08	0.00e+00	1078.00
IUUC-Mmu-064282	Mus musculus	81.63	0.00e+00	1496.00
IUUC-Mpu-066399	Mustela putorius furo	84.05	0.00e+00	1509.00
IUUC-Mlu-067265	Myotis lucifugus	81.62	0.00e+00	1446.00
IUUC-Nle-069078	Nomascus leucogenys	97.17	0.00e+00	1778.00
IUUC-Opr-070946	Ochotona princeps	74.77	0.00e+00	1359.00
IUUC-Ont-071355	Oreochromis niloticus	49.16	0.00e+00	900.00
IUUC-Oan-072937	Ornithorhynchus anatinus	73.78	0.00e+00	1365.00
IUUC-Ocu-073815	Oryctolagus cuniculus	81.74	0.00e+00	1540.00
IUUC-Ola-087381	Oryzias latipes	49.30	0.00e+00	871.00
IUUC-Oga-088725	Otolemur garnettii	85.31	0.00e+00	1572.00
IUUC-Oar-090401	Ovis aries	80.92	0.00e+00	1503.00
IUUC-Ptr-090590	Pan troglodytes	99.58	0.00e+00	1825.00
IUUC-Pan-091765	Papio anubis	96.75	0.00e+00	1778.00
IUUC-Psi-093182	Pelodiscus sinensis	62.11	0.00e+00	1160.00
IUUC-Pfo-097422	Poecilia formosa	48.88	0.00e+00	872.00
IUUC-Pab-098289	Pongo abelii	98.22	0.00e+00	1792.00
IUUC-Pca-100165	Procavia capensis	73.29	0.00e+00	1019.00
IUUC-Pva-102943	Pteropus vampyrus	85.20	0.00e+00	1545.00
IUUC-Rno-104930	Rattus norvegicus	81.53	0.00e+00	1518.00
IUUC-Sha-106800	Sarcophilus harrisii	50.21	0.00e+00	801.00
IUUC-Sar-113205	Sorex araneus	70.92	0.00e+00	982.00
IUUC-Ssc-115910	Sus scrofa	83.43	0.00e+00	1317.00
IUUC-Tgu-117179	Taeniopygia guttata	63.28	0.00e+00	1157.00
IUUC-Tru-118220	Takifugu rubripes	48.23	0.00e+00	850.00
IUUC-Tsy-119418	Tarsius syrichta	84.40	0.00e+00	1258.00
IUUC-Tni-120033	Tetraodon nigroviridis	51.62	4.00e-71	261.00
IUUC-Tbe-127308	Tupaia belangeri	85.83	0.00e+00	628.00
IUUC-Ttr-129233	Tursiops truncatus	83.11	0.00e+00	1501.00
IUUC-Vpa-130620	Vicugna pacos	80.88	1.00e-110	394.00
IUUC-Xtr-132075	Xenopus tropicalis	52.89	0.00e+00	993.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence