iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021606

Ensembl Protein ID

ENSCPOP00000009007.2

UniProt Accession

H0VFZ1; H0VFZ1_CAVPO

Genbank Protein ID

ENSCPOP00000009007

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02026268

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000010034.3	ENSCPOT00000010125.2	ENSCPOP00000009007.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-22	78.4	606	644
UBD/Beta-Prp	2.80e-40	138.3	474	644

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 606  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 644
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 474  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 561
           5666788889998885.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 562  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 644
           88888888999*********************************9.********************************997443 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

PLLTPAPRPP ESTRPAPHQP AQPFFTISES CDRIKEEFQF LQAQYHSLKL ECEKLASEKT 60
EMQRHYVMYY EMSYGLNIEM HKQQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCTGCTGA CACCCGCACC GCGTCCCCCT GAGAGCACGA GGCCTANNNN NNNNNNNNNN 60
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005279	Anolis carolinensis	96.74	0.00e+00	1286.00
IUUC-Bta-012646	Bos taurus	96.87	0.00e+00	1331.00
IUUC-Cel-018361	Caenorhabditis elegans	55.53	1.00e-122	433.00
IUUC-Cja-019079	Callithrix jacchus	96.87	0.00e+00	1357.00
IUUC-Cfa-020987	Canis familiaris	97.20	0.00e+00	1329.00
IUUC-Csa-023445	Chlorocebus sabaeus	97.26	0.00e+00	1331.00
IUUC-Cho-024590	Choloepus hoffmanni	87.20	0.00e+00	1183.00
IUUC-Csv-026174	Ciona savignyi	57.22	1.00e-163	570.00
IUUC-Dno-028979	Dasypus novemcinctus	96.99	0.00e+00	1291.00
IUUC-Dor-030533	Dipodomys ordii	90.87	0.00e+00	1143.00
IUUC-Dme-031576	Drosophila melanogaster	86.03	0.00e+00	665.00
IUUC-Ete-032887	Echinops telfairi	86.58	0.00e+00	1197.00
IUUC-Eca-034397	Equus caballus	97.12	0.00e+00	1253.00
IUUC-Eeu-035237	Erinaceus europaeus	81.40	0.00e+00	1137.00
IUUC-Fca-036030	Felis catus	97.50	0.00e+00	1356.00
IUUC-Fal-037460	Ficedula albicollis	97.11	0.00e+00	1321.00
IUUC-Gga-040416	Gallus gallus	96.87	0.00e+00	1324.00
IUUC-Ggo-045633	Gorilla gorilla	93.69	0.00e+00	1323.00
IUUC-Hsa-046461	Homo sapiens	93.23	0.00e+00	1330.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	97.39	0.00e+00	1337.00
IUUC-Lch-049943	Latimeria chalumnae	93.96	0.00e+00	1222.00
IUUC-Loc-052835	Lepisosteus oculatus	93.88	0.00e+00	1251.00
IUUC-Laf-053425	Loxodonta africana	97.63	0.00e+00	1351.00
IUUC-Mcc-055766	Macaca mulatta	93.36	0.00e+00	1330.00
IUUC-Mmr-061317	Microcebus murinus	93.83	0.00e+00	1331.00
IUUC-Mdo-062956	Monodelphis domestica	96.48	0.00e+00	1323.00
IUUC-Mmu-063576	Mus musculus	97.26	0.00e+00	1321.00
IUUC-Mpu-066410	Mustela putorius furo	97.48	0.00e+00	1259.00
IUUC-Mlu-067456	Myotis lucifugus	96.15	0.00e+00	1276.00
IUUC-Nle-069495	Nomascus leucogenys	97.76	0.00e+00	1325.00
IUUC-Ont-071419	Oreochromis niloticus	84.49	0.00e+00	1155.00
IUUC-Oan-072842	Ornithorhynchus anatinus	93.52	0.00e+00	1305.00
IUUC-Ocu-074453	Oryctolagus cuniculus	95.95	0.00e+00	1307.00
IUUC-Ola-087090	Oryzias latipes	83.83	0.00e+00	1151.00
IUUC-Oga-087939	Otolemur garnettii	97.26	0.00e+00	1336.00
IUUC-Oar-090347	Ovis aries	97.19	0.00e+00	1240.00
IUUC-Ptr-091048	Pan troglodytes	97.26	0.00e+00	1331.00
IUUC-Pan-091973	Papio anubis	92.56	0.00e+00	1280.00
IUUC-Pma-094452	Petromyzon marinus	77.50	0.00e+00	1106.00
IUUC-Pfo-097518	Poecilia formosa	83.44	0.00e+00	1120.00
IUUC-Pab-097539	Pongo abelii	93.56	0.00e+00	1234.00
IUUC-Pca-101137	Procavia capensis	86.33	0.00e+00	1123.00
IUUC-Pva-103037	Pteropus vampyrus	90.72	0.00e+00	1318.00
IUUC-Rno-105314	Rattus norvegicus	97.13	0.00e+00	1251.00
IUUC-Ssc-116408	Sus scrofa	96.88	0.00e+00	1365.00
IUUC-Tgu-117068	Taeniopygia guttata	96.67	0.00e+00	1329.00
IUUC-Tru-118782	Takifugu rubripes	80.76	0.00e+00	1098.00
IUUC-Tsy-118884	Tarsius syrichta	82.61	0.00e+00	1067.00
IUUC-Tni-120404	Tetraodon nigroviridis	82.75	0.00e+00	1153.00
IUUC-Tbe-128013	Tupaia belangeri	89.73	0.00e+00	1249.00
IUUC-Vpa-130577	Vicugna pacos	86.23	0.00e+00	664.00
IUUC-Xtr-132974	Xenopus tropicalis	95.62	0.00e+00	1259.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence