iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	23658844
UBD/Beta-Prp	Beta-Prp	21070969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.0021	19.8	28	71
E3 adaptor/Cullin RING/DCX/DWD	4.50e-17	63.1	201	234
UBD/Beta-Prp	1.50e-39	137.7	272	410

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 103  ldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           l rlpee+l+ i+++ld + l+r+a+vcr +++++s + lw+++
   Q: 28   LWRLPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRI 71
           569********************************999**9986 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H+ +v+c++  ++++vsGs+D t kvW l +g+l
   Q: 201  HEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL 234
           99*******9449***************999875 PP

UBD/Beta-Prp

   S: 161  vrlWdlktgkllrtltgghtdsvyslsfdsng.kelvsgsldgtvklwdlq..tgecvrtlng.htdnvksvrfspnderlvsgs.sDgsir 247
           +r+Wdl++g+l+++l ++  +    l++ +++ + l+s+++d++v++wdl+    +cv+++++ h+++ ++++++  +++l++gs   g++r
   Q: 272  LRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESpFTLLSCGYDTYVRYWDLRtsVRKCVMEWEEpHDSTLYCLQTD-GNHLLATGSsYYGVVR 362
           79*************99999*******9999989*****************88789*****9999**********.999999999789**** PP
   S: 248  iWdlrsgdllktlqlhn.ssvisvavlsfgdnvlvlgsedskvniwklk 295
           +Wd r++ +l+++ l+    +++v +l+++ ++l+++ +  ++++++++
   Q: 363  LWDRRQRACLHAFPLTStPLSSPVYCLRLTTKHLYAALS-YNLHVLDFQ 410
           ***************99667889**********999866.467777665 PP

Organism

Homo sapiens

Functional Description
(View)

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

Protein Sequence
(Fasta)

MAAAAGEEEE EEEAARESAA RPAAGPALWR LPEELLLLIC SYLDMRALGR LAQVCRWLRR 60
FTSCDLLWRR IARASLNSGF TRLGTDLMTS VPVKERVKVS QNWRLGRCRE GILLKWRCSQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGTGTCA GCGCCCCGGC CCCAGCCCGC ACCCCGAAGT GGCTCCAAGG CTGCAGGTGT 60
GAGGGGCGTG CCCAGGGCTC GGCCCGCGCC GCCCCATGTG ACCCGGTCCG ACATGGTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0879--Wnt signaling pathway

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051216--P:cartilage development
GO:0042733--P:embryonic digit morphogenesis
GO:0030326--P:embryonic limb morphogenesis
GO:0002053--P:positive regulation of mesenchymal cell proliferation
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway

KEGG

hsa:6468

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002129	Ailuropoda melanoleuca	97.59	0.00e+00	761.00
IUUC-Apl-003837	Anas platyrhynchos	72.05	9.00e-142	496.00
IUUC-Aca-004776	Anolis carolinensis	67.65	6.00e-140	490.00
IUUC-Ame-010651	Astyanax mexicanus	62.42	3.00e-114	404.00
IUUC-Bta-013495	Bos taurus	96.52	0.00e+00	718.00
IUUC-Cja-018901	Callithrix jacchus	99.73	0.00e+00	733.00
IUUC-Cfa-021251	Canis familiaris	96.52	0.00e+00	753.00
IUUC-Cpo-021750	Cavia porcellus	94.46	0.00e+00	647.00
IUUC-Csa-024026	Chlorocebus sabaeus	98.92	0.00e+00	766.00
IUUC-Cho-024496	Choloepus hoffmanni	75.61	2.00e-158	551.00
IUUC-Cin-025142	Ciona intestinalis	31.50	2.00e-24	106.00
IUUC-Csv-025883	Ciona savignyi	36.87	1.00e-65	243.00
IUUC-Dre-027447	Danio rerio	58.85	2.00e-132	465.00
IUUC-Dno-029572	Dasypus novemcinctus	81.79	6.00e-173	600.00
IUUC-Dor-030982	Dipodomys ordii	89.16	0.00e+00	672.00
IUUC-Dme-031804	Drosophila melanogaster	22.70	2.00e-11	63.50
IUUC-Ete-032917	Echinops telfairi	95.08	0.00e+00	653.00
IUUC-Eca-033969	Equus caballus	98.21	0.00e+00	728.00
IUUC-Eeu-034850	Erinaceus europaeus	85.91	0.00e+00	649.00
IUUC-Fca-036182	Felis catus	92.25	0.00e+00	690.00
IUUC-Fal-037391	Ficedula albicollis	68.53	1.00e-147	516.00
IUUC-Gmo-038632	Gadus morhua	56.51	1.00e-127	449.00
IUUC-Gga-040783	Gallus gallus	73.05	4.00e-160	557.00
IUUC-Gac-042314	Gasterosteus aculeatus	56.07	1.00e-111	396.00
IUUC-Ggo-044739	Gorilla gorilla	99.46	0.00e+00	766.00
IUUC-Itr-048014	Ictidomys tridecemlineatus	98.27	2.00e-172	597.00
IUUC-Loc-052397	Lepisosteus oculatus	65.19	2.00e-139	488.00
IUUC-Laf-054544	Loxodonta africana	94.35	0.00e+00	658.00
IUUC-Meu-056363	Macropus eugenii	59.38	2.00e-102	365.00
IUUC-Mga-059275	Meleagris gallopavo	73.35	2.00e-143	501.00
IUUC-Mmr-060906	Microcebus murinus	98.92	0.00e+00	764.00
IUUC-Mdo-062400	Monodelphis domestica	77.81	2.00e-175	608.00
IUUC-Mmu-063556	Mus musculus	93.22	0.00e+00	719.00
IUUC-Mpu-066500	Mustela putorius furo	97.33	0.00e+00	759.00
IUUC-Mlu-068074	Myotis lucifugus	97.23	0.00e+00	663.00
IUUC-Nle-069601	Nomascus leucogenys	99.73	0.00e+00	768.00
IUUC-Opr-070904	Ochotona princeps	88.65	4.00e-148	517.00
IUUC-Ont-072679	Oreochromis niloticus	55.75	1.00e-121	429.00
IUUC-Oan-073434	Ornithorhynchus anatinus	73.36	1.00e-84	305.00
IUUC-Ocu-074649	Oryctolagus cuniculus	96.48	0.00e+00	734.00
IUUC-Ola-087336	Oryzias latipes	49.22	4.00e-104	371.00
IUUC-Oga-088590	Otolemur garnettii	95.93	0.00e+00	709.00
IUUC-Oar-090178	Ovis aries	93.87	0.00e+00	671.00
IUUC-Pan-092881	Papio anubis	99.19	0.00e+00	765.00
IUUC-Pfo-096176	Poecilia formosa	55.22	1.00e-113	402.00
IUUC-Pab-098285	Pongo abelii	99.73	0.00e+00	769.00
IUUC-Pca-100888	Procavia capensis	91.44	0.00e+00	693.00
IUUC-Pva-102184	Pteropus vampyrus	83.20	2.00e-177	615.00
IUUC-Rno-105668	Rattus norvegicus	93.77	0.00e+00	725.00
IUUC-Sha-106629	Sarcophilus harrisii	77.64	4.00e-154	537.00
IUUC-Ssc-116183	Sus scrofa	98.13	0.00e+00	768.00
IUUC-Tgu-116630	Taeniopygia guttata	71.73	2.00e-167	582.00
IUUC-Tru-118761	Takifugu rubripes	52.11	7.00e-117	413.00
IUUC-Tni-120651	Tetraodon nigroviridis	51.49	5.00e-59	220.00
IUUC-Ttr-128582	Tursiops truncatus	95.72	0.00e+00	710.00
IUUC-Vpa-130431	Vicugna pacos	76.62	1.00e-97	349.00
IUUC-Xtr-132655	Xenopus tropicalis	66.40	4.00e-148	517.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence