iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000107872.12	ENST00000457067.1	ENSP00000392215.1
ENSG00000107872.12	ENST00000224862.7	ENSP00000224862.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	21572392

Organism

Homo sapiens

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

Protein Sequence
(Fasta)

MEPPMEPSGG EQEPGAVRFL DLPWEDVLLP HVLNRVPLRQ LLRLQRVSRA FRSLVQLHLA 60
GLRRFDAAQV GPQIPRAALA RLLRDAEGLQ ELALAPCHEW LSDEDLVPVL ARNPQLRSVA 120

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Nucleotide Sequence
(Fasta)

ACACGGTATG GGTGTAGACT GGACCCGCCC CCTAAATCCA GGAGACCATC AACTATGGAA 60
AGGAGATCTA GGGAACACCG TCTTGAACCC GCCAGGGGTT TTGAGTCTCG GACCCAGGAG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

Pfam

PF00646--F-box
PF13516--LRR_6

SMART

SM00367--LRR_CC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030282--P:bone mineralization
GO:0009953--P:dorsal/ventral pattern formation
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

hsa:79176

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002259	Ailuropoda melanoleuca	93.33	9.00e-145	506.00
IUUC-Apl-003471	Anas platyrhynchos	66.21	4.00e-80	290.00
IUUC-Aca-005211	Anolis carolinensis	63.42	7.00e-102	363.00
IUUC-Ame-011477	Astyanax mexicanus	56.90	6.00e-95	340.00
IUUC-Bta-013461	Bos taurus	95.00	9.00e-160	555.00
IUUC-Cja-019278	Callithrix jacchus	97.99	9.00e-148	516.00
IUUC-Cfa-020248	Canis familiaris	96.67	2.00e-152	531.00
IUUC-Cpo-021313	Cavia porcellus	91.67	1.00e-129	455.00
IUUC-Csa-023633	Chlorocebus sabaeus	97.33	7.00e-163	566.00
IUUC-Cin-025760	Ciona intestinalis	30.59	4.00e-36	144.00
IUUC-Csv-025866	Ciona savignyi	31.54	4.00e-39	154.00
IUUC-Dre-027366	Danio rerio	58.42	1.00e-99	355.00
IUUC-Dno-029700	Dasypus novemcinctus	95.67	7.00e-150	523.00
IUUC-Dor-031069	Dipodomys ordii	92.62	5.00e-153	533.00
IUUC-Dme-031701	Drosophila melanogaster	31.52	1.00e-26	113.00
IUUC-Ete-032998	Echinops telfairi	86.29	2.00e-130	458.00
IUUC-Eca-034140	Equus caballus	96.33	2.00e-146	511.00
IUUC-Fca-035431	Felis catus	96.67	1.00e-151	529.00
IUUC-Fal-036960	Ficedula albicollis	65.25	1.00e-101	362.00
IUUC-Gmo-039411	Gadus morhua	57.09	1.00e-94	338.00
IUUC-Gga-040351	Gallus gallus	65.25	6.00e-100	357.00
IUUC-Gac-041972	Gasterosteus aculeatus	58.16	4.00e-87	314.00
IUUC-Ggo-044538	Gorilla gorilla	99.33	2.00e-150	525.00
IUUC-Itr-048011	Ictidomys tridecemlineatus	95.99	9.00e-150	522.00
IUUC-Lch-049710	Latimeria chalumnae	55.63	3.00e-99	354.00
IUUC-Loc-052288	Lepisosteus oculatus	59.04	1.00e-97	349.00
IUUC-Laf-053590	Loxodonta africana	86.73	2.00e-131	461.00
IUUC-Meu-056548	Macropus eugenii	79.50	3.00e-122	431.00
IUUC-Mga-059794	Meleagris gallopavo	64.18	2.00e-98	352.00
IUUC-Mmr-060829	Microcebus murinus	95.67	6.00e-150	523.00
IUUC-Mdo-062207	Monodelphis domestica	80.74	2.00e-133	468.00
IUUC-Mmu-063353	Mus musculus	96.33	1.00e-150	525.00
IUUC-Mpu-065841	Mustela putorius furo	97.00	6.00e-152	530.00
IUUC-Mlu-068035	Myotis lucifugus	93.08	1.00e-139	488.00
IUUC-Nle-069269	Nomascus leucogenys	98.67	2.00e-149	521.00
IUUC-Opr-070289	Ochotona princeps	88.14	1.00e-107	382.00
IUUC-Ont-072581	Oreochromis niloticus	55.52	2.00e-93	335.00
IUUC-Oan-073529	Ornithorhynchus anatinus	67.41	9.00e-79	286.00
IUUC-Ocu-074827	Oryctolagus cuniculus	95.67	5.00e-155	540.00
IUUC-Ola-087306	Oryzias latipes	56.04	8.00e-97	346.00
IUUC-Oga-088596	Otolemur garnettii	94.20	1.00e-133	469.00
IUUC-Oar-089473	Ovis aries	74.18	2.00e-81	294.00
IUUC-Ptr-091197	Pan troglodytes	99.67	6.00e-151	526.00
IUUC-Pan-092908	Papio anubis	98.00	6.00e-159	553.00
IUUC-Psi-093318	Pelodiscus sinensis	60.28	3.00e-68	251.00
IUUC-Pfo-097479	Poecilia formosa	56.76	1.00e-95	343.00
IUUC-Pab-097744	Pongo abelii	97.67	4.00e-148	517.00
IUUC-Pca-100930	Procavia capensis	91.00	3.00e-138	484.00
IUUC-Pva-102763	Pteropus vampyrus	87.14	4.00e-58	218.00
IUUC-Rno-105651	Rattus norvegicus	95.33	2.00e-154	538.00
IUUC-Tgu-117097	Taeniopygia guttata	65.96	1.00e-103	369.00
IUUC-Tru-118057	Takifugu rubripes	56.21	4.00e-94	337.00
IUUC-Tni-120693	Tetraodon nigroviridis	56.90	5.00e-94	337.00
IUUC-Tbe-127992	Tupaia belangeri	96.34	1.00e-101	363.00
IUUC-Xtr-132283	Xenopus tropicalis	56.51	1.00e-99	356.00
IUUC-Xma-134238	Xiphophorus maculatus	57.19	8.00e-95	340.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence