iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
InWeb_IM
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19687296

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.2	10.5	304	341

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPl 44
           C++C+    + +++   g vf+  C+ ++       + ++ CP+
   Q: 304  CPLCRKTRVNDTVLATSGYVFCYRCVFHY------VRSHQACPI 341
           ****9966444888999*********999......899999996 PP

Organism

Homo sapiens

Functional Description
(View)

Required for protein import into peroxisomes.

Protein Sequence
(Fasta)

MAEHGAHFTA ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPT HYGFLWRWFD 60
EIFTLLDLLL QQHYLSRTSA SFSENFYGLK RIVMGDTHKS QRLASAGLPK QQLWKSIMFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGACGTCTGC GCGGTGCCCC AAACAGCTTG TCAAAAAGAC CTCGCAGAGA GAGGTTCAGA 60
GCTGTAGCTT TCCAGCGAGG CTACCATGCA GACCCAGCTA CGAAAAGTAA ACCAAACTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0958--Peroxisome biogenesis disorder
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0861--Zellweger syndrome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR017375--PEX12
IPR006845--Pex_N
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF04757--Pex2_Pex12

Gene Ontology

GO:0005779--C:integral component of peroxisomal membrane
GO:1990429--C:peroxisomal importomer complex
GO:0005778--C:peroxisomal membrane
GO:0005777--C:peroxisome
GO:0008022--F:protein C-terminus binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007031--P:peroxisome organization
GO:0016558--P:protein import into peroxisome matrix
GO:0006513--P:protein monoubiquitination
GO:0006625--P:protein targeting to peroxisome

KEGG

hsa:5193

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001074	Aegilops tauschii	27.58	3.00e-25	109.00
IUUC-Aml-001787	Ailuropoda melanoleuca	93.04	3.00e-166	577.00
IUUC-Atr-002774	Amborella trichopoda	32.38	2.00e-42	166.00
IUUC-Apl-003884	Anas platyrhynchos	70.40	2.00e-105	375.00
IUUC-Aly-005467	Arabidopsis lyrata	29.74	2.00e-33	136.00
IUUC-Ath-007043	Arabidopsis thaliana	29.38	1.00e-33	137.00
IUUC-Ago-007833	Ashbya gossypii	26.97	1.00e-14	74.30
IUUC-Acl-008074	Aspergillus clavatus	25.25	6.00e-27	115.00
IUUC-Afl-008656	Aspergillus flavus	29.37	2.00e-23	103.00
IUUC-Afu-008808	Aspergillus fumigatus	25.25	1.00e-20	94.70
IUUC-Ani-009154	Aspergillus nidulans	26.59	1.00e-26	114.00
IUUC-Ang-009803	Aspergillus niger	26.23	2.00e-21	97.10
IUUC-Aor-009984	Aspergillus oryzae	29.37	2.00e-23	103.00
IUUC-Ate-010567	Aspergillus terreus	26.50	3.00e-04	39.30
IUUC-Ame-010950	Astyanax mexicanus	61.22	2.00e-106	379.00
IUUC-Bgr-011992	Blumeria graminis	25.75	3.00e-24	106.00
IUUC-Bta-012658	Bos taurus	93.87	2.00e-180	624.00
IUUC-Bci-013586	Botrytis cinerea	27.47	7.00e-23	101.00
IUUC-Bdi-014625	Brachypodium distachyon	30.33	7.00e-37	147.00
IUUC-Bol-015713	Brassica oleracea	30.05	4.00e-26	112.00
IUUC-Bra-017037	Brassica rapa	31.37	3.00e-29	122.00
IUUC-Cel-018483	Caenorhabditis elegans	36.72	5.00e-55	207.00
IUUC-Cja-019601	Callithrix jacchus	95.82	0.00e+00	664.00
IUUC-Cfa-020854	Canis familiaris	92.20	2.00e-175	608.00
IUUC-Cpo-021920	Cavia porcellus	92.48	0.00e+00	637.00
IUUC-Cre-022816	Chlamydomonas reinhardtii	30.17	5.00e-18	86.70
IUUC-Csa-023545	Chlorocebus sabaeus	97.49	0.00e+00	643.00
IUUC-Cin-025523	Ciona intestinalis	37.78	8.00e-62	230.00
IUUC-Csv-026141	Ciona savignyi	33.80	5.00e-56	211.00
IUUC-Cgl-026641	Colletotrichum gloeosporioides	29.61	5.00e-19	88.60
IUUC-Cne-026949	Cryptococcus neoformans	25.81	4.00e-06	46.20
IUUC-Cme-027334	Cyanidioschyzon merolae	28.33	3.00e-31	129.00
IUUC-Dre-027602	Danio rerio	60.17	9.00e-113	399.00
IUUC-Dno-029980	Dasypus novemcinctus	92.20	2.00e-177	614.00
IUUC-Dor-030627	Dipodomys ordii	92.76	2.00e-177	614.00
IUUC-Dse-031219	Dothistroma septosporum	24.57	7.00e-26	112.00
IUUC-Dme-031953	Drosophila melanogaster	28.08	5.00e-20	91.70
IUUC-Ete-032811	Echinops telfairi	84.40	7.00e-171	593.00
IUUC-Eca-033635	Equus caballus	94.15	0.00e+00	654.00
IUUC-Eeu-034584	Erinaceus europaeus	91.09	0.00e+00	657.00
IUUC-Fca-035710	Felis catus	93.59	1.00e-180	625.00
IUUC-Fal-037416	Ficedula albicollis	74.21	1.00e-126	446.00
IUUC-Fox-037908	Fusarium oxysporum	27.39	1.00e-25	110.00
IUUC-Fso-038283	Fusarium solani	26.82	4.00e-27	115.00
IUUC-Gmo-039567	Gadus morhua	52.34	1.00e-21	97.40
IUUC-Ggr-040097	Gaeumannomyces graminis	27.97	7.00e-18	85.10
IUUC-Gga-040757	Gallus gallus	76.04	2.00e-151	528.00
IUUC-Gac-042008	Gasterosteus aculeatus	51.77	1.00e-72	266.00
IUUC-Gma-044278	Glycine max	32.62	9.00e-41	160.00
IUUC-Ggo-044888	Gorilla gorilla	99.72	0.00e+00	689.00
IUUC-Hvu-047274	Hordeum vulgare	42.06	1.00e-18	85.90
IUUC-Itr-048925	Ictidomys tridecemlineatus	91.92	4.00e-175	607.00
IUUC-Kpa-049394	Komagataella pastoris	23.76	8.00e-18	84.70
IUUC-Lch-050347	Latimeria chalumnae	68.42	9.00e-137	479.00
IUUC-Lpe-051711	Leersia perrieri	29.84	3.00e-36	145.00
IUUC-Loc-052943	Lepisosteus oculatus	65.93	1.00e-103	369.00
IUUC-Lma-053231	Leptosphaeria maculans	26.74	1.00e-20	96.30
IUUC-Laf-053506	Loxodonta africana	93.87	5.00e-179	620.00
IUUC-Mcc-055863	Macaca mulatta	97.77	0.00e+00	652.00
IUUC-Meu-056343	Macropus eugenii	85.36	8.00e-168	582.00
IUUC-Mor-057266	Magnaporthe oryzae	29.66	4.00e-19	89.40
IUUC-Mtr-058337	Medicago truncatula	29.16	4.00e-31	129.00
IUUC-Mla-058905	Melampsora laricipopulina	28.39	6.00e-37	148.00
IUUC-Mga-059695	Meleagris gallopavo	73.77	4.00e-130	457.00
IUUC-Mvi-060538	Microbotryum violaceum	26.15	4.00e-31	129.00
IUUC-Mmr-061680	Microcebus murinus	93.31	0.00e+00	645.00
IUUC-Mdo-063013	Monodelphis domestica	85.79	4.00e-170	590.00
IUUC-Mmu-063239	Mus musculus	89.42	0.00e+00	654.00
IUUC-Mac-064765	Musa acuminata	31.01	2.00e-39	156.00
IUUC-Mpu-066866	Mustela putorius furo	93.31	3.00e-162	564.00
IUUC-Mlu-067535	Myotis lucifugus	94.15	0.00e+00	651.00
IUUC-Nfi-068561	Neosartorya fischeri	26.67	5.00e-21	95.90
IUUC-Ncr-068700	Neurospora crassa	30.31	2.00e-21	97.10
IUUC-Nle-069709	Nomascus leucogenys	98.61	0.00e+00	656.00
IUUC-Opr-070983	Ochotona princeps	91.09	0.00e+00	631.00
IUUC-Ont-071734	Oreochromis niloticus	55.15	7.00e-91	327.00
IUUC-Oan-072762	Ornithorhynchus anatinus	65.55	3.00e-51	195.00
IUUC-Ocu-074733	Oryctolagus cuniculus	93.04	0.00e+00	646.00
IUUC-Oba-075943	Oryza barthii	29.24	8.00e-35	141.00
IUUC-Obr-076017	Oryza brachyantha	29.50	1.00e-35	144.00
IUUC-Ogl-077702	Oryza glaberrima	29.24	8.00e-35	141.00
IUUC-Ogu-078692	Oryza glumaepatula	29.09	1.00e-34	140.00
IUUC-Oin-079133	Oryza indica	29.24	9.00e-35	141.00
IUUC-Oni-082667	Oryza nivara	29.24	9.00e-35	141.00
IUUC-Opu-083858	Oryza punctata	29.24	1.00e-35	144.00
IUUC-Oru-084886	Oryza rufipogon	29.24	8.00e-35	141.00
IUUC-Osa-085512	Oryza sativa	29.24	8.00e-35	141.00
IUUC-Ola-087150	Oryzias latipes	50.97	2.00e-91	329.00
IUUC-Olu-087595	Ostreococcus lucimarinus	25.89	1.00e-24	107.00
IUUC-Oga-088647	Otolemur garnettii	93.59	0.00e+00	636.00
IUUC-Oar-089308	Ovis aries	92.76	4.00e-176	610.00
IUUC-Ptr-090543	Pan troglodytes	99.44	0.00e+00	687.00
IUUC-Pan-091907	Papio anubis	97.49	0.00e+00	647.00
IUUC-Psi-093888	Pelodiscus sinensis	79.11	4.00e-156	544.00
IUUC-Pno-094821	Phaeosphaeria nodorum	25.42	5.00e-21	95.90
IUUC-Ppa-095287	Physcomitrella patens	31.73	5.00e-43	168.00
IUUC-Pfo-097238	Poecilia formosa	53.28	8.00e-97	347.00
IUUC-Pab-097938	Pongo abelii	98.61	0.00e+00	682.00
IUUC-Pop-098827	Populus trichocarpa	30.57	1.00e-36	147.00
IUUC-Pca-100488	Procavia capensis	91.56	1.00e-110	392.00
IUUC-Ppe-101914	Prunus persica	31.95	3.00e-40	159.00
IUUC-Pva-102469	Pteropus vampyrus	89.97	4.00e-167	580.00
IUUC-Pgr-103388	Puccinia graminis	25.51	1.00e-28	120.00
IUUC-Ptt-103988	Puccinia triticina	25.38	2.00e-24	106.00
IUUC-Pte-104186	Pyrenophora teres	26.18	2.00e-22	100.00
IUUC-Pyt-104605	Pyrenophora triticirepentis	26.18	2.00e-21	97.40
IUUC-Rno-105071	Rattus norvegicus	88.58	0.00e+00	652.00
IUUC-Sce-106238	Saccharomyces cerevisiae	24.14	2.00e-15	77.00
IUUC-Sha-107200	Sarcophilus harrisii	84.57	1.00e-148	519.00
IUUC-Sja-108008	Schizosaccharomyces japonicus	22.67	5.00e-17	81.60
IUUC-Spo-108077	Schizosaccharomyces pombe	20.73	4.00e-05	42.40
IUUC-Ssl-108559	Sclerotinia sclerotiorum	27.56	1.00e-22	101.00
IUUC-Smo-109083	Selaginella moellendorffii	33.78	4.00e-43	168.00
IUUC-Sit-110306	Setaria italica	31.27	2.00e-37	150.00
IUUC-Sly-111409	Solanum lycopersicum	32.46	6.00e-40	158.00
IUUC-Stu-112852	Solanum tuberosum	32.20	2.00e-39	156.00
IUUC-Sar-112967	Sorex araneus	89.01	5.00e-91	326.00
IUUC-Sbi-114722	Sorghum bicolor	29.50	3.00e-35	142.00
IUUC-Sre-115089	Sporisorium reilianum	29.12	3.00e-27	116.00
IUUC-Ssc-115367	Sus scrofa	93.31	0.00e+00	659.00
IUUC-Tgu-117176	Taeniopygia guttata	71.87	9.00e-141	493.00
IUUC-Tru-118162	Takifugu rubripes	52.62	2.00e-94	339.00
IUUC-Tsy-119231	Tarsius syrichta	94.99	0.00e+00	658.00
IUUC-Tni-119962	Tetraodon nigroviridis	55.15	4.00e-92	331.00
IUUC-Tca-121100	Theobroma cacao	30.63	2.00e-37	150.00
IUUC-Tre-122015	Trichoderma reesei	30.58	8.00e-28	118.00
IUUC-Tvi-122573	Trichoderma virens	26.65	1.00e-29	124.00
IUUC-Tae-123664	Triticum aestivum	28.39	8.00e-34	137.00
IUUC-Tur-126843	Triticum urartu	28.39	8.00e-34	137.00
IUUC-Tme-127060	Tuber melanosporum	27.30	3.00e-35	142.00
IUUC-Ttr-128998	Tursiops truncatus	90.25	0.00e+00	635.00
IUUC-Uma-129524	Ustilago maydis	30.82	1.00e-30	127.00
IUUC-Vvi-130933	Vitis vinifera	31.54	2.00e-36	146.00
IUUC-Xtr-132968	Xenopus tropicalis	64.90	9.00e-127	446.00
IUUC-Xma-133355	Xiphophorus maculatus	52.32	3.00e-98	351.00
IUUC-Yli-134388	Yarrowia lipolytica	27.27	1.00e-28	120.00
IUUC-Zma-135423	Zea mays	29.50	3.00e-35	142.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence