iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000109654.14	ENST00000494872.5	ENSP00000488229.1
ENSG00000109654.14	ENST00000338700.9	ENSP00000339659.5
ENSG00000109654.14	ENST00000632856.1	ENSP00000487836.1
ENSG00000109654.14	ENST00000460908.1	ENSP00000488751.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18687884; 23562820

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4.50e-08	35.2	50	91

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle++k+ p+vlpC H+f++ Clq++       s + +CP+Cr
   Q: 50   CSICLERYKN-PKVLPCLHTFCERCLQNY---IPAHSLTLSCPVCR 91
           **********.******************...44578999*****8 PP

Organism

Homo sapiens

Functional Description
(View)

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.

Protein Sequence
(Fasta)

MHRSGRYGTQ QQRAGSKTAG PPCQWSRMAS EGTNIPSPVV RQIDKQFLIC SICLERYKNP 60
KVLPCLHTFC ERCLQNYIPA HSLTLSCPVC RQTSILPEKG VAALQNNFFI TNLMDVLQRT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGGGGCGT GGTCGCCGGG CTGCCGTGCG CTCGGGATCA GTCTTTTTAT ACATATATAT 60
ATGTGTGTAT ATATATATAT ATATATATAC ACACATATAT ATATGTTATA AAATTCTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0144--Charcot-Marie-Tooth disease
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0479--Metal-binding
KW-0523--Neurodegeneration
KW-0622--Neuropathy
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR003649--Bbox_C
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00502--BBC
SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043523--P:regulation of neuron apoptotic process

KEGG

hsa:23321

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002127	Ailuropoda melanoleuca	98.57	0.00e+00	1584.00
IUUC-Apl-003865	Anas platyrhynchos	96.30	0.00e+00	1518.00
IUUC-Aca-004825	Anolis carolinensis	95.44	0.00e+00	1309.00
IUUC-Ame-011612	Astyanax mexicanus	81.12	0.00e+00	1280.00
IUUC-Bta-012548	Bos taurus	98.92	0.00e+00	1531.00
IUUC-Cja-019580	Callithrix jacchus	99.60	0.00e+00	1537.00
IUUC-Cpo-022342	Cavia porcellus	95.66	0.00e+00	1511.00
IUUC-Csa-023735	Chlorocebus sabaeus	99.47	0.00e+00	1574.00
IUUC-Cho-025025	Choloepus hoffmanni	87.85	0.00e+00	812.00
IUUC-Csv-026112	Ciona savignyi	27.85	1.00e-83	304.00
IUUC-Dre-028599	Danio rerio	79.73	0.00e+00	1211.00
IUUC-Dno-029768	Dasypus novemcinctus	99.08	0.00e+00	1569.00
IUUC-Dor-030841	Dipodomys ordii	90.99	0.00e+00	1382.00
IUUC-Eca-033960	Equus caballus	98.95	0.00e+00	1566.00
IUUC-Eeu-035207	Erinaceus europaeus	89.18	0.00e+00	1168.00
IUUC-Fca-035695	Felis catus	98.82	0.00e+00	1565.00
IUUC-Fal-037000	Ficedula albicollis	97.04	0.00e+00	1509.00
IUUC-Gmo-038767	Gadus morhua	78.63	0.00e+00	1206.00
IUUC-Gga-041007	Gallus gallus	96.64	0.00e+00	1505.00
IUUC-Gac-042586	Gasterosteus aculeatus	84.54	0.00e+00	1334.00
IUUC-Ggo-045221	Gorilla gorilla	99.87	0.00e+00	1602.00
IUUC-Lch-050198	Latimeria chalumnae	85.00	0.00e+00	1335.00
IUUC-Loc-052583	Lepisosteus oculatus	89.35	0.00e+00	1376.00
IUUC-Laf-054233	Loxodonta africana	98.95	0.00e+00	1569.00
IUUC-Mcc-055569	Macaca mulatta	99.72	0.00e+00	1479.00
IUUC-Mga-059355	Meleagris gallopavo	95.51	0.00e+00	1512.00
IUUC-Mmr-061171	Microcebus murinus	99.09	0.00e+00	1590.00
IUUC-Mdo-062885	Monodelphis domestica	97.98	0.00e+00	1517.00
IUUC-Mmu-063562	Mus musculus	98.83	0.00e+00	1581.00
IUUC-Mpu-066097	Mustela putorius furo	98.69	0.00e+00	1564.00
IUUC-Mlu-068044	Myotis lucifugus	98.95	0.00e+00	1567.00
IUUC-Nle-069532	Nomascus leucogenys	99.74	0.00e+00	1600.00
IUUC-Opr-070346	Ochotona princeps	98.25	0.00e+00	1518.00
IUUC-Ont-071572	Oreochromis niloticus	84.81	0.00e+00	1337.00
IUUC-Oan-072836	Ornithorhynchus anatinus	97.84	0.00e+00	1420.00
IUUC-Ocu-074750	Oryctolagus cuniculus	98.95	0.00e+00	1571.00
IUUC-Ola-087547	Oryzias latipes	82.24	0.00e+00	1314.00
IUUC-Oga-088484	Otolemur garnettii	99.47	0.00e+00	1575.00
IUUC-Oar-089231	Ovis aries	97.28	0.00e+00	1560.00
IUUC-Ptr-091007	Pan troglodytes	98.31	0.00e+00	1569.00
IUUC-Pan-092589	Papio anubis	99.74	0.00e+00	1600.00
IUUC-Psi-093880	Pelodiscus sinensis	97.04	0.00e+00	1507.00
IUUC-Pma-094132	Petromyzon marinus	86.57	1.00e-132	465.00
IUUC-Pfo-096688	Poecilia formosa	80.98	0.00e+00	1164.00
IUUC-Pab-098260	Pongo abelii	99.87	0.00e+00	1540.00
IUUC-Pca-100644	Procavia capensis	99.58	0.00e+00	978.00
IUUC-Pva-102141	Pteropus vampyrus	99.06	0.00e+00	1533.00
IUUC-Rno-105358	Rattus norvegicus	95.93	0.00e+00	1502.00
IUUC-Sha-106703	Sarcophilus harrisii	97.62	0.00e+00	1531.00
IUUC-Sar-113100	Sorex araneus	98.74	0.00e+00	972.00
IUUC-Ssc-116118	Sus scrofa	98.82	0.00e+00	1563.00
IUUC-Tgu-117257	Taeniopygia guttata	96.56	0.00e+00	1524.00
IUUC-Tru-118683	Takifugu rubripes	82.75	0.00e+00	1306.00
IUUC-Tni-120534	Tetraodon nigroviridis	82.49	0.00e+00	1293.00
IUUC-Tbe-127438	Tupaia belangeri	90.80	0.00e+00	934.00
IUUC-Ttr-128897	Tursiops truncatus	98.12	0.00e+00	1515.00
IUUC-Vpa-130582	Vicugna pacos	98.88	2.00e-159	556.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence