iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.80e-55	178.4	311	346
E3 adaptor/Cullin RING/SCF/F-box	2.50e-06	25.7	110	153
UBD/Beta-Prp	9.30e-74	246.3	268	541

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvll 36
           gH+++vtcl+f d + l+sGs D+ti++W++rt  ++
   Q: 311  GHSSGVTCLQF-DqCKLISGSMDKTIRIWNYRTSECI 346
           8**********.669*****************99886 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 103  ldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           l+ lp ei ++il++ld+++l++aa+v+++w+ela+++ +w+++
   Q: 110  LSLLPVEISFRILSFLDARSLCQAAQVSKHWKELADDDVIWHRM 153
           6779*************************************987 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
           +l+gh ++v++ ++    +++la+gs+d+ti++w++ t + ++ l+gh+++vt+++f++    l++gs D+ti++w+++t++c+++l+gh
   Q: 268  VLSGHSDGVMC-LQL--VRNILASGSYDATIRLWNLATFQQVALLEGHSSGVTCLQFDQC--KLISGSMDKTIRIWNYRTSECISILHGH 352
           57888898888.777..7******************************************..6*************************** PP
   S: 94   edsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsv 183
           +dsvl+l+f+     lvsGs+d t+++w+ + g+ +  tl+gh+g vn+v++  d  l+ sGs+D+t+++W+l+t+++l+t++  h ++v
   Q: 353  TDSVLCLTFDS--TLLVSGSADCTVKLWHFSGGKRI--TLRGHTGPVNSVRIIRDRGLVLSGSDDSTIKIWSLETNTCLHTFSA-HIGPV 437
           ***********..***********************..7*******************************************98.***** PP
   S: 184  yslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavl 273
           +sl++ +   +l s+sldgt+k wd+++++cv+tl gh + v+ ++++  + rl+sg++Dg++++W  +  ++++tl++h + v+sva+ 
   Q: 438  QSLALAD--SRLFSCSLDGTIKQWDIEKKKCVHTLFGHIEGVWEIAAD--HLRLISGAHDGVVKVW--EACECVHTLKNHSEPVTSVAL- 520
           *******..68************************************9..****************..7********************. PP
   S: 274  sfgdnvlvlgsedskvniwklkk 296
             gd ++v+gsed+k+ +w +++
   Q: 521  --GDCEVVSGSEDGKIYLWLFNN 541
           ..*****************9965 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Required for the inactivation of zip1 via ubiquitination.

Protein Sequence
(Fasta)

MTTGYESVPT SEPSDNLAPR AELWQRHLLE KKEGDQSISV SAFNISSMHN ELSGLSEKSR 60
QRVEAVWAAF SEASCSERKL ALQGILNNCS SSLLSFASST LDSLVRLDFL SLLPVEISFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGCTATTTC CTTCTTCAAT ATTGTTCATG TTATGTGATT AACCGAAAAT CATGTATTCT 60
TTCTTCTTGT AATAAATCAT CGATTTAGCT TTGTTTACGA CAACTATATA TAGGTGAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030674--F:protein binding, bridging
GO:0071276--P:cellular response to cadmium ion
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

spo:SPAC57A10.05c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	32.14	2.00e-63	235.00
IUUC-Apl-003489	Anas platyrhynchos	32.35	9.00e-64	236.00
IUUC-Aca-005318	Anolis carolinensis	32.35	2.00e-63	234.00
IUUC-Ago-007794	Ashbya gossypii	41.28	1.00e-104	371.00
IUUC-Acl-008078	Aspergillus clavatus	38.90	3.00e-112	397.00
IUUC-Afl-008744	Aspergillus flavus	40.89	1.00e-116	411.00
IUUC-Afu-008939	Aspergillus fumigatus	37.36	4.00e-108	383.00
IUUC-Ani-009383	Aspergillus nidulans	40.17	1.00e-126	444.00
IUUC-Ang-009570	Aspergillus niger	39.24	5.00e-106	376.00
IUUC-Aor-010217	Aspergillus oryzae	40.89	1.00e-116	411.00
IUUC-Ate-010336	Aspergillus terreus	40.39	1.00e-120	424.00
IUUC-Ame-010898	Astyanax mexicanus	31.87	1.00e-62	232.00
IUUC-Bgr-012225	Blumeria graminis	38.22	7.00e-113	399.00
IUUC-Bta-012391	Bos taurus	32.14	1.00e-62	232.00
IUUC-Bci-013916	Botrytis cinerea	45.56	1.00e-99	355.00
IUUC-Cja-018902	Callithrix jacchus	32.14	2.00e-63	234.00
IUUC-Cfa-020237	Canis familiaris	32.14	2.00e-63	234.00
IUUC-Cpo-022234	Cavia porcellus	32.14	7.00e-63	233.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	38.71	1.00e-45	175.00
IUUC-Csa-023532	Chlorocebus sabaeus	32.14	2.00e-63	234.00
IUUC-Cgl-026550	Colletotrichum gloeosporioides	36.53	3.00e-105	374.00
IUUC-Cne-026800	Cryptococcus neoformans	37.80	4.00e-85	307.00
IUUC-Cme-027168	Cyanidioschyzon merolae	30.28	4.00e-25	107.00
IUUC-Dre-028303	Danio rerio	32.08	3.00e-63	234.00
IUUC-Dno-029576	Dasypus novemcinctus	30.88	8.00e-59	219.00
IUUC-Dor-030196	Dipodomys ordii	32.14	3.00e-62	231.00
IUUC-Dse-031413	Dothistroma septosporum	40.05	5.00e-84	303.00
IUUC-Ete-032791	Echinops telfairi	31.99	3.00e-62	231.00
IUUC-Eca-033424	Equus caballus	32.14	1.00e-62	232.00
IUUC-Eeu-034996	Erinaceus europaeus	31.51	4.00e-61	227.00
IUUC-Fca-036422	Felis catus	32.14	2.00e-63	235.00
IUUC-Fal-037267	Ficedula albicollis	32.35	7.00e-64	236.00
IUUC-Fox-037683	Fusarium oxysporum	39.64	3.00e-107	380.00
IUUC-Fso-038092	Fusarium solani	39.39	9.00e-115	405.00
IUUC-Ggr-039842	Gaeumannomyces graminis	36.21	2.00e-96	344.00
IUUC-Gga-040667	Gallus gallus	32.35	7.00e-64	236.00
IUUC-Ggo-044422	Gorilla gorilla	32.14	2.00e-63	234.00
IUUC-Hsa-045898	Homo sapiens	32.14	2.00e-63	235.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	31.72	1.00e-62	232.00
IUUC-Kpa-049101	Komagataella pastoris	41.37	3.00e-113	400.00
IUUC-Lch-050414	Latimeria chalumnae	32.14	1.00e-63	236.00
IUUC-Loc-052348	Lepisosteus oculatus	32.29	2.00e-63	234.00
IUUC-Lma-053200	Leptosphaeria maculans	40.23	6.00e-94	336.00
IUUC-Laf-054054	Loxodonta africana	32.35	6.00e-64	236.00
IUUC-Mcc-055056	Macaca mulatta	32.14	2.00e-63	234.00
IUUC-Mor-057039	Magnaporthe oryzae	35.04	2.00e-89	321.00
IUUC-Mpo-057381	Magnaporthe poae	39.44	8.00e-115	405.00
IUUC-Mla-059099	Melampsora laricipopulina	38.20	6.00e-95	340.00
IUUC-Mga-059255	Meleagris gallopavo	32.35	9.00e-64	236.00
IUUC-Mvi-060426	Microbotryum violaceum	41.49	3.00e-53	201.00
IUUC-Mmr-061292	Microcebus murinus	32.14	2.00e-63	235.00
IUUC-Mdo-062304	Monodelphis domestica	31.72	1.00e-63	236.00
IUUC-Mmu-063610	Mus musculus	31.72	6.00e-64	236.00
IUUC-Mpu-065931	Mustela putorius furo	32.14	2.00e-63	235.00
IUUC-Mlu-066976	Myotis lucifugus	32.14	1.00e-63	235.00
IUUC-Nfi-068464	Neosartorya fischeri	39.49	2.00e-106	377.00
IUUC-Ncr-068962	Neurospora crassa	41.11	7.00e-91	326.00
IUUC-Nle-070174	Nomascus leucogenys	32.14	2.00e-63	235.00
IUUC-Ont-071997	Oreochromis niloticus	31.66	5.00e-63	233.00
IUUC-Oan-072936	Ornithorhynchus anatinus	32.14	3.00e-63	234.00
IUUC-Ocu-074742	Oryctolagus cuniculus	32.14	2.00e-63	234.00
IUUC-Ola-086653	Oryzias latipes	32.35	3.00e-62	230.00
IUUC-Olu-087837	Ostreococcus lucimarinus	36.36	2.00e-38	150.00
IUUC-Oar-090220	Ovis aries	31.88	6.00e-62	229.00
IUUC-Ptr-090492	Pan troglodytes	32.14	2.00e-63	235.00
IUUC-Pan-091770	Papio anubis	32.14	2.00e-63	234.00
IUUC-Psi-093207	Pelodiscus sinensis	32.14	6.00e-63	233.00
IUUC-Pma-094749	Petromyzon marinus	31.66	5.00e-62	229.00
IUUC-Pno-095133	Phaeosphaeria nodorum	41.55	7.00e-81	292.00
IUUC-Pfo-096493	Poecilia formosa	32.08	7.00e-61	226.00
IUUC-Pab-098141	Pongo abelii	32.14	1.00e-62	232.00
IUUC-Pca-100571	Procavia capensis	32.35	2.00e-48	184.00
IUUC-Pva-102988	Pteropus vampyrus	32.14	2.00e-63	234.00
IUUC-Pgr-103527	Puccinia graminis	39.56	5.00e-61	226.00
IUUC-Pte-104035	Pyrenophora teres	40.56	4.00e-88	317.00
IUUC-Pyt-104799	Pyrenophora triticirepentis	38.48	6.00e-88	316.00
IUUC-Rno-105706	Rattus norvegicus	31.93	3.00e-64	237.00
IUUC-Sce-106343	Saccharomyces cerevisiae	38.24	4.00e-104	370.00
IUUC-Sha-107653	Sarcophilus harrisii	31.72	1.00e-63	235.00
IUUC-Sja-107945	Schizosaccharomyces japonicus	62.11	0.00e+00	662.00
IUUC-Sar-113600	Sorex araneus	32.92	2.00e-55	208.00
IUUC-Sre-115173	Sporisorium reilianum	44.17	1.00e-55	209.00
IUUC-Ssc-115787	Sus scrofa	31.37	1.00e-59	222.00
IUUC-Tgu-117510	Taeniopygia guttata	32.35	9.00e-64	236.00
IUUC-Tru-117819	Takifugu rubripes	32.08	4.00e-64	237.00
IUUC-Tsy-118828	Tarsius syrichta	32.14	2.00e-63	234.00
IUUC-Tni-120468	Tetraodon nigroviridis	32.08	5.00e-64	236.00
IUUC-Tre-122126	Trichoderma reesei	39.46	6.00e-116	409.00
IUUC-Tvi-122482	Trichoderma virens	39.96	7.00e-119	419.00
IUUC-Tme-127212	Tuber melanosporum	39.63	2.00e-108	384.00
IUUC-Tbe-127925	Tupaia belangeri	32.14	4.00e-63	233.00
IUUC-Ttr-128899	Tursiops truncatus	32.14	2.00e-63	235.00
IUUC-Uma-129406	Ustilago maydis	42.92	2.00e-54	205.00
IUUC-Vda-129799	Verticillium dahliae	42.25	2.00e-88	317.00
IUUC-Vpa-130082	Vicugna pacos	32.36	9.00e-60	222.00
IUUC-Xtr-132213	Xenopus tropicalis	32.14	1.00e-63	236.00
IUUC-Xma-132996	Xiphophorus maculatus	33.69	1.00e-63	234.00
IUUC-Yli-134408	Yarrowia lipolytica	37.29	2.00e-100	358.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence