iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046380

Ensembl Protein ID

ENSP00000423972.1

UniProt Accession

O96028; A2A2T2; A2A2T3; A2A2T4; A7MCZ1; D3DVQ2; O96031; Q4VBY8; Q672J1; Q6IS00; Q86V01; Q9BZB4; Q9UI92; Q9UPR2; NSD2_HUMAN

Genbank Protein ID

Protein Name

Histone-lysine N-methyltransferase NSD2; Multiple myeloma SET domain-containing protein; Nuclear SET domain-containing protein 2; Protein trithorax-5; Wolf-Hirschhorn syndrome candidate 1 protein

Genbank Nucleotide ID

AF071593; AF071594; AF083386; AF083387; AF083388; AF083389; AF083390; AF083391; AF178206; AF178199; AF178198; AF178202; AF178204; AF178205; AF178203; AF178201; AF178200; AF178219; AF178198; AF178199; AF178200; AF178202; AF178204; AF178207; AF178216; AF178215; AF178214; AF178213; AF178212; AF178211; AF178210; AF178209; AF178208; AF178218; AF178217; AF178205; AF178203; AF178201; AF330040; AY694128; AJ007042; AB029013; AK289697; AC105448; AL132868; AL132868; CH471131; CH471131; CH471131; CH471131; CH471131; BC052254; BC070176; BC094825; BC141815; BC152

Gene Name

WHSC1; NSD2; KIAA1090; MMSET; TRX5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000109685.17	ENST00000508803.5	ENSP00000423972.1
ENSG00000109685.17	ENST00000514045.5	ENSP00000421681.1
ENSG00000109685.17	ENST00000353275.9	ENSP00000329167.5
ENSG00000109685.17	ENST00000512700.1	ENSP00000427516.1
ENSG00000109685.17	ENST00000511904.1	ENSP00000424482.1
ENSG00000109685.17	ENST00000514329.5	ENSP00000425094.1
ENSG00000109685.17	ENST00000382888.3	ENSP00000372344.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.50e-15	58.0	833	873

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl+++    +p+ + w+C++Cr
   Q: 833  WCFVCSKGGS----LLCCESCPAAFHPDCLNIE----MPDGS-WFCNDCR 873
           8*********....*******************....9***8.******8 PP

Organism

Homo sapiens

Functional Description
(View)

Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.

Protein Sequence
(Fasta)

MEFSIKQSPL SVQSVVKCIK MKQAPEILGS ANGKTPSCEV NRECSVFLSK AQLSSSLQEG 60
VMQKFNGHDA LPFIPADKLK DLTSRVFNGE PGAHDAKLRF ESQEMKGIGT PPNTTPIKNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCTGCGCCC GCCGCCGCCG CCGCCCCCTC CCCGCCTGGG CCCTACCGCC GCACGGCCCC 60
GGCCCCCTCC CAGCCTGCCG CTCCGGAGAG CCGCCCGCCG AGGATGCGAC GCACCGCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00184--RING
SM00317--SET

Gene Ontology

GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0042799--F:histone methyltransferase activity (H4-K20 specific)
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0009653--P:anatomical structure morphogenesis
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0010452--P:histone H3-K36 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:7468

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002181	Ailuropoda melanoleuca	92.26	0.00e+00	2429.00
IUUC-Apl-003677	Anas platyrhynchos	80.95	0.00e+00	2148.00
IUUC-Aca-004278	Anolis carolinensis	75.42	0.00e+00	1407.00
IUUC-Ame-011932	Astyanax mexicanus	70.79	0.00e+00	1027.00
IUUC-Bta-012522	Bos taurus	86.11	0.00e+00	2258.00
IUUC-Cja-018908	Callithrix jacchus	98.13	0.00e+00	2504.00
IUUC-Cfa-020894	Canis familiaris	91.62	0.00e+00	2472.00
IUUC-Cpo-021982	Cavia porcellus	89.47	0.00e+00	2379.00
IUUC-Csa-023807	Chlorocebus sabaeus	98.58	0.00e+00	2538.00
IUUC-Cho-024405	Choloepus hoffmanni	74.01	0.00e+00	733.00
IUUC-Csv-026298	Ciona savignyi	39.29	1.00e-57	217.00
IUUC-Dre-027492	Danio rerio	71.61	0.00e+00	1066.00
IUUC-Dno-030020	Dasypus novemcinctus	87.48	0.00e+00	2078.00
IUUC-Dor-031103	Dipodomys ordii	84.76	0.00e+00	2157.00
IUUC-Ete-032488	Echinops telfairi	81.89	0.00e+00	2142.00
IUUC-Eca-034066	Equus caballus	93.35	0.00e+00	2499.00
IUUC-Eeu-035199	Erinaceus europaeus	71.16	0.00e+00	761.00
IUUC-Fca-035434	Felis catus	87.06	0.00e+00	1989.00
IUUC-Fal-037113	Ficedula albicollis	78.95	0.00e+00	2157.00
IUUC-Gmo-039686	Gadus morhua	70.62	0.00e+00	1017.00
IUUC-Gga-040273	Gallus gallus	79.18	0.00e+00	2126.00
IUUC-Gac-042123	Gasterosteus aculeatus	51.05	0.00e+00	1258.00
IUUC-Ggo-044643	Gorilla gorilla	99.63	0.00e+00	2593.00
IUUC-Itr-048658	Ictidomys tridecemlineatus	93.13	0.00e+00	1446.00
IUUC-Lch-050217	Latimeria chalumnae	67.09	0.00e+00	1751.00
IUUC-Lpe-051201	Leersia perrieri	28.48	1.00e-10	61.60
IUUC-Loc-052766	Lepisosteus oculatus	59.06	0.00e+00	1287.00
IUUC-Laf-053780	Loxodonta africana	89.77	0.00e+00	2432.00
IUUC-Mcc-054928	Macaca mulatta	98.73	0.00e+00	2573.00
IUUC-Meu-056184	Macropus eugenii	75.36	0.00e+00	790.00
IUUC-Mga-059576	Meleagris gallopavo	79.91	0.00e+00	2131.00
IUUC-Mmr-061045	Microcebus murinus	93.05	0.00e+00	2479.00
IUUC-Mdo-062576	Monodelphis domestica	83.20	0.00e+00	2220.00
IUUC-Mmu-063640	Mus musculus	91.26	0.00e+00	2383.00
IUUC-Mac-065303	Musa acuminata	29.22	3.00e-11	63.90
IUUC-Mpu-066512	Mustela putorius furo	92.49	0.00e+00	2431.00
IUUC-Mlu-067280	Myotis lucifugus	80.46	0.00e+00	1103.00
IUUC-Nle-069896	Nomascus leucogenys	99.69	0.00e+00	2464.00
IUUC-Ont-072197	Oreochromis niloticus	73.44	0.00e+00	1039.00
IUUC-Oan-072724	Ornithorhynchus anatinus	78.99	0.00e+00	1368.00
IUUC-Ocu-074758	Oryctolagus cuniculus	89.71	0.00e+00	2311.00
IUUC-Olo-080702	Oryza longistaminata	41.47	4.00e-45	177.00
IUUC-Opu-083371	Oryza punctata	41.88	1.00e-46	182.00
IUUC-Oga-088702	Otolemur garnettii	92.51	0.00e+00	2142.00
IUUC-Oar-089736	Ovis aries	81.28	0.00e+00	1993.00
IUUC-Ptr-091055	Pan troglodytes	99.85	0.00e+00	2568.00
IUUC-Pan-092752	Papio anubis	99.74	0.00e+00	1476.00
IUUC-Psi-093620	Pelodiscus sinensis	80.58	0.00e+00	2160.00
IUUC-Pfo-097464	Poecilia formosa	50.94	0.00e+00	1222.00
IUUC-Pab-098051	Pongo abelii	99.63	0.00e+00	2594.00
IUUC-Pop-099927	Populus trichocarpa	28.96	7.00e-12	66.20
IUUC-Pca-100273	Procavia capensis	89.46	0.00e+00	2368.00
IUUC-Pva-102473	Pteropus vampyrus	79.55	0.00e+00	1969.00
IUUC-Rno-105056	Rattus norvegicus	90.75	0.00e+00	2384.00
IUUC-Sha-107494	Sarcophilus harrisii	84.05	0.00e+00	2207.00
IUUC-Sar-113310	Sorex araneus	91.39	0.00e+00	1894.00
IUUC-Sbi-114581	Sorghum bicolor	35.19	7.00e-10	58.20
IUUC-Ssc-116344	Sus scrofa	85.84	0.00e+00	2265.00
IUUC-Tgu-116786	Taeniopygia guttata	80.63	0.00e+00	2157.00
IUUC-Tru-117638	Takifugu rubripes	50.98	0.00e+00	1242.00
IUUC-Tsy-118937	Tarsius syrichta	97.19	0.00e+00	1565.00
IUUC-Tni-120452	Tetraodon nigroviridis	53.92	0.00e+00	1179.00
IUUC-Tae-125237	Triticum aestivum	31.51	2.00e-07	50.10
IUUC-Tbe-127291	Tupaia belangeri	88.51	0.00e+00	1532.00
IUUC-Ttr-129017	Tursiops truncatus	83.90	0.00e+00	1790.00
IUUC-Xtr-132673	Xenopus tropicalis	67.47	0.00e+00	1783.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence