iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000109790.16	ENST00000504108.5	ENSP00000423897.1
ENSG00000109790.16	ENST00000381930.7	ENSP00000371355.3
ENSG00000109790.16	ENST00000261426.9	ENSP00000261426.5
ENSG00000109790.16	ENST00000514399.1	ENSP00000426949.1
ENSG00000109790.16	ENST00000515612.1	ENSP00000425512.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.60e-19	69.7	220	287
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	7.80e-09	34.7	319	349

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dvilv g+++++ah++vL++ S++F a+f+++ +e + ++++++++v+p ++  l+++ Ytg+l+++e
   Q: 220  CDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAR-QEEIKMEGVEPNSLWSLIQYAYTGRLELKE 287
           9************************************9.**************************9986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++Nclgi++fAd+ +c+dL+++a++++  hF
   Q: 319  PSNCLGIRSFADAQGCTDLHKVAHNYTMEHF 349
           89************************98777 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MNVIYFPLHI FVVYSRAYTS LVLVGCTNLC AVLFARCLDD HLVSLRMSGS RKEFDVKQIL 60
KIRWRWFGHQ ASSPNSTVDS QQGEFWNRGQ TGANGGRKFL DPCSLQLPLA SIGYRRSSQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCCGCCTG GCCGCCCCGG CCCGCCGTGA CCCACGGCCG CCTCCGGAGC CCGACGCGGT 60
AAGTGCGACT TCCTTCTCGG CATCGGGGAG GGGGCCGCCT CGGGCAGGGC CCGCTTCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0016567--P:protein ubiquitination

KEGG

hsa:51088

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000220	Aegilops tauschii	33.19	1.00e-37	152.00
IUUC-Aml-001239	Ailuropoda melanoleuca	98.76	0.00e+00	1169.00
IUUC-Apl-003930	Anas platyrhynchos	89.71	0.00e+00	1226.00
IUUC-Aca-004826	Anolis carolinensis	87.38	0.00e+00	1320.00
IUUC-Ame-011037	Astyanax mexicanus	80.81	0.00e+00	839.00
IUUC-Bta-013448	Bos taurus	97.71	0.00e+00	1458.00
IUUC-Cja-019953	Callithrix jacchus	98.52	0.00e+00	1475.00
IUUC-Cfa-020335	Canis familiaris	98.76	0.00e+00	1446.00
IUUC-Cpo-021385	Cavia porcellus	98.62	0.00e+00	1441.00
IUUC-Csa-023109	Chlorocebus sabaeus	98.85	0.00e+00	1392.00
IUUC-Cho-024402	Choloepus hoffmanni	98.73	0.00e+00	1405.00
IUUC-Csv-026377	Ciona savignyi	65.81	0.00e+00	751.00
IUUC-Dre-028618	Danio rerio	82.37	0.00e+00	967.00
IUUC-Dme-032222	Drosophila melanogaster	58.11	0.00e+00	660.00
IUUC-Eca-034002	Equus caballus	99.03	0.00e+00	1446.00
IUUC-Fca-035953	Felis catus	91.50	0.00e+00	1345.00
IUUC-Fal-037331	Ficedula albicollis	92.85	0.00e+00	1165.00
IUUC-Gmo-039309	Gadus morhua	75.94	0.00e+00	881.00
IUUC-Gga-041137	Gallus gallus	95.86	0.00e+00	1130.00
IUUC-Gac-042162	Gasterosteus aculeatus	77.56	0.00e+00	865.00
IUUC-Ggo-044697	Gorilla gorilla	97.63	0.00e+00	1493.00
IUUC-Lch-050568	Latimeria chalumnae	85.60	0.00e+00	1273.00
IUUC-Loc-052139	Lepisosteus oculatus	78.65	0.00e+00	1137.00
IUUC-Laf-054213	Loxodonta africana	98.42	0.00e+00	1387.00
IUUC-Mcc-054988	Macaca mulatta	98.92	0.00e+00	1485.00
IUUC-Mga-059394	Meleagris gallopavo	84.48	0.00e+00	1258.00
IUUC-Mmr-061186	Microcebus murinus	98.40	0.00e+00	1029.00
IUUC-Mdo-062687	Monodelphis domestica	96.99	0.00e+00	1362.00
IUUC-Mmu-063695	Mus musculus	96.70	0.00e+00	1361.00
IUUC-Mpu-065886	Mustela putorius furo	93.70	0.00e+00	1373.00
IUUC-Mlu-067820	Myotis lucifugus	97.44	0.00e+00	1466.00
IUUC-Nle-069647	Nomascus leucogenys	99.06	0.00e+00	1489.00
IUUC-Opr-070814	Ochotona princeps	96.90	0.00e+00	1449.00
IUUC-Ont-071631	Oreochromis niloticus	77.17	0.00e+00	877.00
IUUC-Oan-073455	Ornithorhynchus anatinus	91.04	0.00e+00	1157.00
IUUC-Oga-088236	Otolemur garnettii	97.58	0.00e+00	1459.00
IUUC-Oar-089243	Ovis aries	97.71	0.00e+00	1466.00
IUUC-Ptr-090722	Pan troglodytes	98.92	0.00e+00	1486.00
IUUC-Pan-092727	Papio anubis	98.57	0.00e+00	1389.00
IUUC-Psi-093068	Pelodiscus sinensis	90.53	0.00e+00	1300.00
IUUC-Pma-094371	Petromyzon marinus	78.99	0.00e+00	947.00
IUUC-Ppa-095209	Physcomitrella patens	30.04	1.00e-20	94.00
IUUC-Pfo-096355	Poecilia formosa	77.96	0.00e+00	875.00
IUUC-Pab-097795	Pongo abelii	99.02	0.00e+00	1049.00
IUUC-Pva-103111	Pteropus vampyrus	97.32	0.00e+00	1460.00
IUUC-Rno-105085	Rattus norvegicus	97.13	0.00e+00	1358.00
IUUC-Sha-107240	Sarcophilus harrisii	96.13	0.00e+00	1348.00
IUUC-Sit-109883	Setaria italica	25.00	4.00e-17	83.60
IUUC-Sar-113739	Sorex araneus	96.71	0.00e+00	1188.00
IUUC-Ssc-115542	Sus scrofa	98.97	0.00e+00	953.00
IUUC-Tgu-116703	Taeniopygia guttata	91.63	0.00e+00	1315.00
IUUC-Tru-117551	Takifugu rubripes	67.75	0.00e+00	907.00
IUUC-Tsy-118944	Tarsius syrichta	92.95	0.00e+00	1384.00
IUUC-Tni-120665	Tetraodon nigroviridis	77.36	0.00e+00	869.00
IUUC-Ttr-128501	Tursiops truncatus	97.83	0.00e+00	1463.00
IUUC-Vpa-130295	Vicugna pacos	89.74	0.00e+00	1319.00
IUUC-Xtr-132607	Xenopus tropicalis	82.00	0.00e+00	1189.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence