iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036194

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02054534

Gene Name

PRPF19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000013668.3	ENSFCAT00000013672.3	ENSFCAP00000012676.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	9.70e-13	48.0	5	62
E3 adaptor/Cullin RING/DCX/DWD	4.00e-32	108.9	388	421
UBD/Beta-Prp	1.10e-53	182.3	230	459

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 10   IslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           +s+e++++P+v+p s+++y+r+ Iek++a++g+ +P+++qpl+ee+l++ ++ + +  +
   Q: 5    VSNEVPEHPCVSPvSNHVYERRLIEKYIAENGT-DPINNQPLSEEQLIDIKVAHPIRPK 62
           89******************************9.***************9998877665 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH++++t++af  ++ +l++++dD ++k+WDlr+
   Q: 388  GHSGPITSIAFseNGYYLATAADDSSVKLWDLRK 421
           8**********976699**************986 PP

UBD/Beta-Prp

   S: 20   pdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdk 108
            d++ ++tg++d+ + v+d ++++ l++l+gh+++vt+v f+p++++  ++s D+ti++w++ + +cv+++++he+ v+ ls++++gd+
   Q: 230  ADTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQELVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDY 318
           58899************************************************************************************ PP
   S: 109  lvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelv 196
           l+s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng +l+
   Q: 319  LLSSSDDQYWAFSDIQTGRVLTKvTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENGYYLA 406
           *********************997777777789************************************9.****************** PP
   S: 197  sgsldgtvklwdlqtgecvrtlnghtd.nvksvrfspnderlvsgssDgsiri 248
           ++++d++vklwdl++ +  +tl+  ++  vks+ f++ +++l+ g+ D +i+i
   Q: 407  TAADDSSVKLWDLRKLKNFKTLQLDNNfEVKSLIFDQSGTYLALGGTDVQIYI 459
           **************999999999866527*******************99987 PP

Organism

Felis catus

Protein Sequence
(Fasta)

LFSTVSNEVP EHPCVSPVSN HVYERRLIEK YIAENGTDPI NNQPLSEEQL IDIKVAHPIR 60
PKPPSATSIP AILKALQDEW DAVMLHSFTL RQQLQTTRQE LSHALYQHDA ACRVIARLTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCACCCCCA CCCCCATTCC CAGCACCATC CTTCCTTTAG ATGTTTACAC GAGATGTTTA 60
CTGGGTGCCT GCTGGGCATC TGCATTGTAC TGGAAGTCAG AGACCAGCCA TAATCCCTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50231--RICIN_B_LECTIN
PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005662--C:DNA replication factor A complex
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0000974--C:Prp19 complex
GO:0035861--C:site of double-strand break
GO:0071006--C:U2-type catalytic step 1 spliceosome
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0034613--P:cellular protein localization
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0001833--P:inner cell mass cell proliferation
GO:0008610--P:lipid biosynthetic process
GO:0045665--P:negative regulation of neuron differentiation
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0048026--P:positive regulation of mRNA splicing, via spliceosome
GO:0010498--P:proteasomal protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0000245--P:spliceosomal complex assembly
GO:0000244--P:spliceosomal tri-snRNP complex assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	39.30	3.00e-97	350.00
IUUC-Aml-001230	Ailuropoda melanoleuca	95.98	0.00e+00	952.00
IUUC-Atr-002594	Amborella trichopoda	43.75	8.00e-118	417.00
IUUC-Apl-003686	Anas platyrhynchos	88.08	0.00e+00	734.00
IUUC-Aca-005272	Anolis carolinensis	96.41	0.00e+00	989.00
IUUC-Aly-005586	Arabidopsis lyrata	43.50	8.00e-118	417.00
IUUC-Ath-007696	Arabidopsis thaliana	43.77	4.00e-114	404.00
IUUC-Acl-008335	Aspergillus clavatus	36.21	6.00e-68	251.00
IUUC-Afl-008527	Aspergillus flavus	37.97	4.00e-72	265.00
IUUC-Afu-008957	Aspergillus fumigatus	37.78	2.00e-78	286.00
IUUC-Ani-009280	Aspergillus nidulans	37.05	1.00e-65	243.00
IUUC-Ang-009746	Aspergillus niger	35.86	3.00e-65	242.00
IUUC-Aor-009905	Aspergillus oryzae	37.76	1.00e-75	276.00
IUUC-Ate-010412	Aspergillus terreus	37.34	2.00e-64	239.00
IUUC-Ame-011561	Astyanax mexicanus	84.45	1.00e-108	385.00
IUUC-Bgr-012283	Blumeria graminis	33.12	2.00e-56	213.00
IUUC-Bta-013242	Bos taurus	98.80	0.00e+00	1004.00
IUUC-Bci-013901	Botrytis cinerea	33.40	2.00e-63	236.00
IUUC-Bdi-014277	Brachypodium distachyon	43.71	1.00e-121	429.00
IUUC-Bol-016207	Brassica oleracea	45.14	3.00e-117	415.00
IUUC-Bra-017902	Brassica rapa	42.91	5.00e-115	407.00
IUUC-Cel-018271	Caenorhabditis elegans	51.20	4.00e-149	521.00
IUUC-Cja-019879	Callithrix jacchus	98.21	0.00e+00	996.00
IUUC-Cfa-020175	Canis familiaris	99.20	0.00e+00	1007.00
IUUC-Cpo-022379	Cavia porcellus	98.41	0.00e+00	1003.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	39.57	1.00e-97	350.00
IUUC-Csa-023500	Chlorocebus sabaeus	98.61	0.00e+00	1003.00
IUUC-Cho-025065	Choloepus hoffmanni	85.76	3.00e-145	507.00
IUUC-Cin-025699	Ciona intestinalis	68.12	2.00e-175	608.00
IUUC-Csv-026128	Ciona savignyi	65.56	0.00e+00	679.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	33.01	8.00e-64	237.00
IUUC-Cne-026860	Cryptococcus neoformans	38.09	6.00e-93	334.00
IUUC-Dre-028187	Danio rerio	84.29	0.00e+00	853.00
IUUC-Dno-029453	Dasypus novemcinctus	98.41	0.00e+00	1001.00
IUUC-Dor-030150	Dipodomys ordii	98.74	3.00e-128	451.00
IUUC-Dse-031220	Dothistroma septosporum	32.08	7.00e-57	214.00
IUUC-Dme-031906	Drosophila melanogaster	65.61	0.00e+00	656.00
IUUC-Ete-033035	Echinops telfairi	85.66	0.00e+00	847.00
IUUC-Eca-033478	Equus caballus	98.61	0.00e+00	1001.00
IUUC-Eeu-034974	Erinaceus europaeus	99.70	0.00e+00	682.00
IUUC-Fal-037417	Ficedula albicollis	96.81	0.00e+00	990.00
IUUC-Fox-037922	Fusarium oxysporum	34.34	8.00e-63	234.00
IUUC-Fso-038256	Fusarium solani	34.07	6.00e-64	238.00
IUUC-Gmo-038713	Gadus morhua	85.29	0.00e+00	867.00
IUUC-Ggr-039854	Gaeumannomyces graminis	32.30	2.00e-52	200.00
IUUC-Gga-041143	Gallus gallus	96.81	0.00e+00	990.00
IUUC-Gac-042129	Gasterosteus aculeatus	84.49	0.00e+00	882.00
IUUC-Gma-044273	Glycine max	45.28	2.00e-120	426.00
IUUC-Ggo-045262	Gorilla gorilla	98.61	0.00e+00	1003.00
IUUC-Hsa-046036	Homo sapiens	98.61	0.00e+00	1003.00
IUUC-Hvu-047442	Hordeum vulgare	42.72	2.00e-66	245.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	98.01	0.00e+00	959.00
IUUC-Lch-050105	Latimeria chalumnae	89.24	0.00e+00	929.00
IUUC-Lpe-050976	Leersia perrieri	43.71	2.00e-117	416.00
IUUC-Loc-052042	Lepisosteus oculatus	74.41	0.00e+00	668.00
IUUC-Lma-053143	Leptosphaeria maculans	33.89	3.00e-62	233.00
IUUC-Laf-053451	Loxodonta africana	95.38	0.00e+00	992.00
IUUC-Mcc-055786	Macaca mulatta	98.61	0.00e+00	1003.00
IUUC-Meu-056161	Macropus eugenii	98.34	2.00e-140	492.00
IUUC-Mor-057215	Magnaporthe oryzae	33.07	2.00e-55	210.00
IUUC-Mpo-057419	Magnaporthe poae	31.33	7.00e-49	187.00
IUUC-Mtr-057756	Medicago truncatula	44.05	2.00e-116	412.00
IUUC-Mla-059085	Melampsora laricipopulina	38.62	2.00e-86	312.00
IUUC-Mga-060158	Meleagris gallopavo	90.38	0.00e+00	886.00
IUUC-Mvi-060441	Microbotryum violaceum	37.36	6.00e-77	281.00
IUUC-Mmr-061085	Microcebus murinus	98.61	0.00e+00	1003.00
IUUC-Mdo-061804	Monodelphis domestica	98.21	0.00e+00	1000.00
IUUC-Mmu-063608	Mus musculus	94.82	0.00e+00	988.00
IUUC-Mac-064972	Musa acuminata	44.02	3.00e-115	408.00
IUUC-Mpu-065700	Mustela putorius furo	99.20	0.00e+00	1007.00
IUUC-Mlu-068223	Myotis lucifugus	94.39	0.00e+00	981.00
IUUC-Nfi-068504	Neosartorya fischeri	37.58	4.00e-78	285.00
IUUC-Ncr-068729	Neurospora crassa	36.69	5.00e-62	231.00
IUUC-Nle-069754	Nomascus leucogenys	98.61	0.00e+00	1003.00
IUUC-Opr-070621	Ochotona princeps	95.17	0.00e+00	948.00
IUUC-Ont-071377	Oreochromis niloticus	84.69	0.00e+00	862.00
IUUC-Oan-073498	Ornithorhynchus anatinus	73.09	4.00e-123	434.00
IUUC-Ocu-074182	Oryctolagus cuniculus	94.65	0.00e+00	990.00
IUUC-Oba-075509	Oryza barthii	42.99	2.00e-119	422.00
IUUC-Obr-076480	Oryza brachyantha	43.91	1.00e-120	426.00
IUUC-Ogl-077052	Oryza glaberrima	42.99	2.00e-119	422.00
IUUC-Ogu-078919	Oryza glumaepatula	42.99	2.00e-119	422.00
IUUC-Oin-079357	Oryza indica	42.28	2.00e-112	399.00
IUUC-Olo-080376	Oryza longistaminata	43.39	6.00e-110	390.00
IUUC-Ome-081973	Oryza meridionalis	42.83	3.00e-109	388.00
IUUC-Oni-082849	Oryza nivara	43.19	4.00e-120	424.00
IUUC-Opu-083243	Oryza punctata	42.80	1.00e-118	420.00
IUUC-Oru-084613	Oryza rufipogon	43.33	7.00e-120	424.00
IUUC-Osa-085407	Oryza sativa	42.97	7.00e-119	420.00
IUUC-Ola-086566	Oryzias latipes	83.66	0.00e+00	852.00
IUUC-Olu-087757	Ostreococcus lucimarinus	38.92	8.00e-94	337.00
IUUC-Oga-089010	Otolemur garnettii	95.46	0.00e+00	966.00
IUUC-Oar-089638	Ovis aries	98.80	0.00e+00	1004.00
IUUC-Ptr-091141	Pan troglodytes	98.61	0.00e+00	1003.00
IUUC-Pan-092662	Papio anubis	98.61	0.00e+00	1003.00
IUUC-Psi-093777	Pelodiscus sinensis	97.37	0.00e+00	823.00
IUUC-Pno-095115	Phaeosphaeria nodorum	34.39	1.00e-63	236.00
IUUC-Ppa-095841	Physcomitrella patens	44.59	6.00e-120	424.00
IUUC-Pfo-096390	Poecilia formosa	83.70	0.00e+00	860.00
IUUC-Pab-098250	Pongo abelii	96.89	0.00e+00	936.00
IUUC-Pop-099854	Populus trichocarpa	44.04	4.00e-119	421.00
IUUC-Pca-100553	Procavia capensis	98.01	0.00e+00	993.00
IUUC-Ppe-101383	Prunus persica	43.33	3.00e-112	399.00
IUUC-Pva-102189	Pteropus vampyrus	98.61	0.00e+00	1003.00
IUUC-Pgr-103304	Puccinia graminis	36.93	8.00e-84	304.00
IUUC-Ptt-103984	Puccinia triticina	37.69	3.00e-89	322.00
IUUC-Pte-104385	Pyrenophora teres	32.70	2.00e-67	249.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	32.91	2.00e-68	252.00
IUUC-Rno-105581	Rattus norvegicus	98.41	0.00e+00	1002.00
IUUC-Sha-107071	Sarcophilus harrisii	94.08	0.00e+00	986.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	30.93	2.00e-34	140.00
IUUC-Spo-108315	Schizosaccharomyces pombe	32.17	7.00e-45	174.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	34.51	1.00e-62	233.00
IUUC-Smo-109648	Selaginella moellendorffii	44.57	8.00e-121	427.00
IUUC-Sit-109873	Setaria italica	43.33	2.00e-117	416.00
IUUC-Sly-111673	Solanum lycopersicum	45.24	2.00e-112	399.00
IUUC-Stu-112125	Solanum tuberosum	45.05	1.00e-111	397.00
IUUC-Sbi-114696	Sorghum bicolor	42.21	9.00e-107	380.00
IUUC-Sre-115134	Sporisorium reilianum	31.47	4.00e-71	262.00
IUUC-Ssc-116260	Sus scrofa	98.61	0.00e+00	1003.00
IUUC-Tgu-116533	Taeniopygia guttata	96.81	0.00e+00	991.00
IUUC-Tru-117800	Takifugu rubripes	83.50	0.00e+00	882.00
IUUC-Tsy-118980	Tarsius syrichta	94.08	0.00e+00	922.00
IUUC-Tni-120334	Tetraodon nigroviridis	67.20	0.00e+00	691.00
IUUC-Tca-121807	Theobroma cacao	43.22	3.00e-118	419.00
IUUC-Tre-121920	Trichoderma reesei	33.55	1.00e-62	233.00
IUUC-Tvi-122294	Trichoderma virens	32.84	4.00e-54	205.00
IUUC-Tae-125713	Triticum aestivum	44.10	2.00e-122	432.00
IUUC-Tur-126664	Triticum urartu	40.35	2.00e-114	406.00
IUUC-Tme-127026	Tuber melanosporum	34.48	6.00e-68	251.00
IUUC-Tbe-127582	Tupaia belangeri	99.39	0.00e+00	678.00
IUUC-Ttr-128313	Tursiops truncatus	98.41	0.00e+00	993.00
IUUC-Uma-129626	Ustilago maydis	33.15	2.00e-73	269.00
IUUC-Vda-129699	Verticillium dahliae	35.15	2.00e-66	246.00
IUUC-Vpa-130593	Vicugna pacos	98.90	0.00e+00	901.00
IUUC-Vvi-131668	Vitis vinifera	43.52	7.00e-118	417.00
IUUC-Xtr-132186	Xenopus tropicalis	85.35	0.00e+00	764.00
IUUC-Xma-133212	Xiphophorus maculatus	83.50	0.00e+00	855.00
IUUC-Yli-134607	Yarrowia lipolytica	54.55	4.00e-39	152.00
IUUC-Zma-135662	Zea mays	44.49	3.00e-120	425.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence