iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000110107.8	ENST00000227524.8	ENSP00000227524.4
ENSG00000110107.8	ENST00000540473.5	ENSP00000443031.1
ENSG00000110107.8	ENST00000535326.1	ENSP00000445435.1
ENSG00000110107.8	ENST00000541371.5	ENSP00000440266.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/U-box	U-box	15601865; 20595234
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	15601865; 20595234

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	4.90e-15	57.0	3	64
E3 adaptor/Cullin RING/DCX/DWD	8.20e-32	109.5	390	423
UBD/Beta-Prp	2.40e-53	182.9	231	461

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ++C+Is+e++++P+v+p s+++y+r+ Iek++a++g+ +P+++qpl+ee+l++ ++ + +  +
   Q: 3    LICSISNEVPEHPCVSPvSNHVYERRLIEKYIAENGT-DPINNQPLSEEQLIDIKVAHPIRPK 64
           79**********************************9.***************9998877665 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH++++t++af  ++ +l++++dD ++k+WDlr+
   Q: 390  GHSGPITSIAFseNGYYLATAADDSSVKLWDLRK 423
           8**********976699**************986 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklv 110
             d++ ++tg++d+ + v+d ++++ l++l+gh+++vt+v f+p++++  ++s D+ti++w++ + +cv+++++he+ v+ ls++++gd+l+
   Q: 231  PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLL 322
           568899************************************************************************************** PP
   S: 111  sGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsld 201
           s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng +l+++++d
   Q: 323  SSSDDQYWAFSDIQTGRVLTKvTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENGYYLATAADD 413
           *******************997777777789************************************9.*********************** PP
   S: 202  gtvklwdlqtgecvrtlnghtd.nvksvrfspnderlvsgssDgsiri 248
           ++vklwdl++ +  +tl+  ++  vks+ f++ +++l+ g+ D +i+i
   Q: 414  SSVKLWDLRKLKNFKTLQLDNNfEVKSLIFDQSGTYLALGGTDVQIYI 461
           *********999999999866527*******************99987 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity).

Protein Sequence
(Fasta)

MSLICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PINNQPLSEE QLIDIKVAHP 60
IRPKPPSATS IPAILKALQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAATTTCC GTTAGGTGCT GAAGGCTGTG GCGCGCGGCT GTCCCCATTC CCACGTGAAG 60
CGCTACGCTA GCATCGCTCG GCTGGCGGCT CCCAGCTCGC CGCGGAGCAG TCCCGGCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0551--Lipid droplet
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000974--C:Prp19 complex
GO:0035861--C:site of double-strand break
GO:0005819--C:spindle
GO:0071006--C:U2-type catalytic step 1 spliceosome
GO:0042802--F:identical protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0034613--P:cellular protein localization
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0001833--P:inner cell mass cell proliferation
GO:0008610--P:lipid biosynthetic process
GO:0000398--P:mRNA splicing, via spliceosome
GO:0045665--P:negative regulation of neuron differentiation
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0048026--P:positive regulation of mRNA splicing, via spliceosome
GO:0010498--P:proteasomal protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0000245--P:spliceosomal complex assembly
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006283--P:transcription-coupled nucleotide-excision repair

KEGG

hsa:27339

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	39.30	3.00e-97	350.00
IUUC-Aml-001230	Ailuropoda melanoleuca	96.19	0.00e+00	959.00
IUUC-Atr-002594	Amborella trichopoda	44.05	9.00e-119	420.00
IUUC-Apl-003686	Anas platyrhynchos	87.85	0.00e+00	732.00
IUUC-Aca-005272	Anolis carolinensis	97.42	0.00e+00	1001.00
IUUC-Aly-005586	Arabidopsis lyrata	44.10	1.00e-119	423.00
IUUC-Ath-007696	Arabidopsis thaliana	44.19	1.00e-115	410.00
IUUC-Acl-008335	Aspergillus clavatus	35.69	3.00e-68	253.00
IUUC-Afl-008527	Aspergillus flavus	38.19	2.00e-73	269.00
IUUC-Afu-008957	Aspergillus fumigatus	37.78	3.00e-79	289.00
IUUC-Ani-009280	Aspergillus nidulans	37.65	3.00e-67	249.00
IUUC-Ang-009746	Aspergillus niger	36.50	2.00e-67	249.00
IUUC-Aor-009905	Aspergillus oryzae	37.97	5.00e-77	281.00
IUUC-Ate-010412	Aspergillus terreus	37.97	7.00e-66	244.00
IUUC-Ame-011561	Astyanax mexicanus	85.00	2.00e-111	395.00
IUUC-Bgr-012283	Blumeria graminis	32.85	1.00e-56	214.00
IUUC-Bta-013242	Bos taurus	99.80	0.00e+00	1016.00
IUUC-Bci-013901	Botrytis cinerea	33.80	6.00e-65	241.00
IUUC-Bdi-014277	Brachypodium distachyon	43.76	1.00e-123	437.00
IUUC-Bol-016207	Brassica oleracea	45.54	1.00e-118	420.00
IUUC-Bra-017902	Brassica rapa	43.52	5.00e-117	414.00
IUUC-Cel-018271	Caenorhabditis elegans	51.38	7.00e-152	530.00
IUUC-Cja-019879	Callithrix jacchus	99.60	0.00e+00	1011.00
IUUC-Cfa-020175	Canis familiaris	99.40	0.00e+00	1013.00
IUUC-Cpo-022379	Cavia porcellus	99.40	0.00e+00	1013.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	40.16	3.00e-99	355.00
IUUC-Csa-023500	Chlorocebus sabaeus	100.00	0.00e+00	1018.00
IUUC-Cho-025065	Choloepus hoffmanni	88.10	8.00e-150	523.00
IUUC-Cin-025699	Ciona intestinalis	68.35	3.00e-176	611.00
IUUC-Csv-026128	Ciona savignyi	65.38	0.00e+00	682.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	33.20	2.00e-65	243.00
IUUC-Cne-026860	Cryptococcus neoformans	38.28	1.00e-93	337.00
IUUC-Dre-028187	Danio rerio	84.95	0.00e+00	863.00
IUUC-Dno-029453	Dasypus novemcinctus	99.80	0.00e+00	1016.00
IUUC-Dor-030150	Dipodomys ordii	99.16	1.00e-128	452.00
IUUC-Dse-031220	Dothistroma septosporum	32.49	1.00e-58	221.00
IUUC-Dme-031906	Drosophila melanogaster	65.74	0.00e+00	665.00
IUUC-Ete-033035	Echinops telfairi	86.90	0.00e+00	861.00
IUUC-Eca-033478	Equus caballus	99.60	0.00e+00	1014.00
IUUC-Eeu-034974	Erinaceus europaeus	99.70	0.00e+00	681.00
IUUC-Fca-036194	Felis catus	98.61	0.00e+00	1002.00
IUUC-Fal-037417	Ficedula albicollis	97.22	0.00e+00	999.00
IUUC-Fox-037922	Fusarium oxysporum	34.46	1.00e-64	241.00
IUUC-Fso-038256	Fusarium solani	34.48	3.00e-66	246.00
IUUC-Gmo-038713	Gadus morhua	86.34	0.00e+00	879.00
IUUC-Ggr-039854	Gaeumannomyces graminis	32.44	8.00e-55	208.00
IUUC-Gga-041143	Gallus gallus	97.62	0.00e+00	1001.00
IUUC-Gac-042129	Gasterosteus aculeatus	84.95	0.00e+00	893.00
IUUC-Gma-044273	Glycine max	45.77	2.00e-121	429.00
IUUC-Ggo-045262	Gorilla gorilla	100.00	0.00e+00	1018.00
IUUC-Hvu-047442	Hordeum vulgare	42.81	2.00e-68	252.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	99.40	0.00e+00	973.00
IUUC-Lch-050105	Latimeria chalumnae	90.08	0.00e+00	940.00
IUUC-Lpe-050976	Leersia perrieri	44.62	4.00e-120	425.00
IUUC-Loc-052042	Lepisosteus oculatus	74.20	0.00e+00	666.00
IUUC-Lma-053143	Leptosphaeria maculans	34.38	4.00e-64	240.00
IUUC-Laf-053451	Loxodonta africana	96.35	0.00e+00	1005.00
IUUC-Mcc-055786	Macaca mulatta	100.00	0.00e+00	1018.00
IUUC-Meu-056161	Macropus eugenii	99.17	3.00e-141	494.00
IUUC-Mor-057215	Magnaporthe oryzae	33.66	1.00e-57	217.00
IUUC-Mpo-057419	Magnaporthe poae	31.48	1.00e-51	197.00
IUUC-Mtr-057756	Medicago truncatula	43.88	5.00e-116	411.00
IUUC-Mla-059085	Melampsora laricipopulina	38.20	4.00e-86	311.00
IUUC-Mga-060158	Meleagris gallopavo	90.78	0.00e+00	887.00
IUUC-Mvi-060441	Microbotryum violaceum	38.00	3.00e-79	289.00
IUUC-Mmr-061085	Microcebus murinus	100.00	0.00e+00	1018.00
IUUC-Mdo-061804	Monodelphis domestica	99.60	0.00e+00	1015.00
IUUC-Mmu-063608	Mus musculus	95.79	0.00e+00	1000.00
IUUC-Mac-064972	Musa acuminata	44.23	7.00e-117	414.00
IUUC-Mpu-065700	Mustela putorius furo	99.40	0.00e+00	1013.00
IUUC-Mlu-068223	Myotis lucifugus	94.99	0.00e+00	991.00
IUUC-Nfi-068504	Neosartorya fischeri	37.58	5.00e-79	288.00
IUUC-Ncr-068729	Neurospora crassa	36.90	1.00e-63	237.00
IUUC-Nle-069754	Nomascus leucogenys	100.00	0.00e+00	1018.00
IUUC-Opr-070621	Ochotona princeps	95.77	0.00e+00	952.00
IUUC-Ont-071377	Oreochromis niloticus	84.95	0.00e+00	872.00
IUUC-Oan-073498	Ornithorhynchus anatinus	73.54	2.00e-123	434.00
IUUC-Ocu-074182	Oryctolagus cuniculus	96.00	0.00e+00	1004.00
IUUC-Oba-075509	Oryza barthii	43.76	1.00e-121	430.00
IUUC-Obr-076480	Oryza brachyantha	44.72	8.00e-123	434.00
IUUC-Ogl-077052	Oryza glaberrima	43.76	1.00e-121	430.00
IUUC-Ogu-078919	Oryza glumaepatula	43.76	1.00e-121	430.00
IUUC-Oin-079357	Oryza indica	43.05	6.00e-115	407.00
IUUC-Olo-080376	Oryza longistaminata	43.53	8.00e-110	390.00
IUUC-Ome-081973	Oryza meridionalis	43.03	1.00e-109	390.00
IUUC-Oni-082849	Oryza nivara	43.95	2.00e-122	432.00
IUUC-Opu-083243	Oryza punctata	43.57	4.00e-121	428.00
IUUC-Oru-084613	Oryza rufipogon	44.04	1.00e-121	430.00
IUUC-Osa-085407	Oryza sativa	43.74	3.00e-121	428.00
IUUC-Ola-086566	Oryzias latipes	84.12	0.00e+00	862.00
IUUC-Olu-087757	Ostreococcus lucimarinus	39.12	2.00e-94	339.00
IUUC-Oga-089010	Otolemur garnettii	95.27	0.00e+00	964.00
IUUC-Oar-089638	Ovis aries	99.80	0.00e+00	1016.00
IUUC-Ptr-091141	Pan troglodytes	100.00	0.00e+00	1018.00
IUUC-Pan-092662	Papio anubis	100.00	0.00e+00	1018.00
IUUC-Psi-093777	Pelodiscus sinensis	97.37	0.00e+00	824.00
IUUC-Pno-095115	Phaeosphaeria nodorum	35.08	3.00e-65	243.00
IUUC-Ppa-095841	Physcomitrella patens	44.79	1.00e-120	426.00
IUUC-Pfo-096390	Poecilia formosa	84.16	0.00e+00	870.00
IUUC-Pab-098250	Pongo abelii	98.35	0.00e+00	950.00
IUUC-Pop-099854	Populus trichocarpa	45.09	4.00e-120	425.00
IUUC-Pca-100553	Procavia capensis	99.40	0.00e+00	1008.00
IUUC-Ppe-101383	Prunus persica	44.21	2.00e-114	406.00
IUUC-Pva-102189	Pteropus vampyrus	99.60	0.00e+00	1015.00
IUUC-Pgr-103304	Puccinia graminis	37.19	3.00e-84	306.00
IUUC-Ptt-103984	Puccinia triticina	38.07	1.00e-89	324.00
IUUC-Pte-104385	Pyrenophora teres	33.12	5.00e-69	255.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	33.54	3.00e-70	259.00
IUUC-Rno-105581	Rattus norvegicus	99.40	0.00e+00	1013.00
IUUC-Sha-107071	Sarcophilus harrisii	95.44	0.00e+00	1001.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	31.34	4.00e-35	142.00
IUUC-Spo-108315	Schizosaccharomyces pombe	32.40	1.00e-45	177.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	35.16	2.00e-64	239.00
IUUC-Smo-109648	Selaginella moellendorffii	44.96	8.00e-122	430.00
IUUC-Sit-109873	Setaria italica	43.76	1.00e-119	424.00
IUUC-Sly-111673	Solanum lycopersicum	45.35	8.00e-113	400.00
IUUC-Stu-112125	Solanum tuberosum	45.16	3.00e-112	398.00
IUUC-Sbi-114696	Sorghum bicolor	42.35	4.00e-108	385.00
IUUC-Sre-115134	Sporisorium reilianum	31.65	5.00e-72	265.00
IUUC-Ssc-116260	Sus scrofa	99.60	0.00e+00	1015.00
IUUC-Tgu-116533	Taeniopygia guttata	97.62	0.00e+00	1002.00
IUUC-Tru-117800	Takifugu rubripes	84.36	0.00e+00	895.00
IUUC-Tsy-118980	Tarsius syrichta	94.08	0.00e+00	922.00
IUUC-Tni-120334	Tetraodon nigroviridis	67.92	0.00e+00	702.00
IUUC-Tca-121807	Theobroma cacao	44.12	1.00e-120	426.00
IUUC-Tre-121920	Trichoderma reesei	33.40	2.00e-63	236.00
IUUC-Tvi-122294	Trichoderma virens	33.05	2.00e-55	210.00
IUUC-Tae-125713	Triticum aestivum	44.15	1.00e-124	440.00
IUUC-Tur-126664	Triticum urartu	39.72	3.00e-114	405.00
IUUC-Tme-127026	Tuber melanosporum	34.48	1.00e-68	253.00
IUUC-Tbe-127582	Tupaia belangeri	100.00	0.00e+00	680.00
IUUC-Ttr-128313	Tursiops truncatus	99.40	0.00e+00	1005.00
IUUC-Uma-129626	Ustilago maydis	33.33	1.00e-74	273.00
IUUC-Vda-129699	Verticillium dahliae	35.36	7.00e-68	251.00
IUUC-Vpa-130593	Vicugna pacos	99.12	0.00e+00	902.00
IUUC-Vvi-131668	Vitis vinifera	44.21	8.00e-120	424.00
IUUC-Xtr-132186	Xenopus tropicalis	85.42	0.00e+00	770.00
IUUC-Xma-133212	Xiphophorus maculatus	83.96	0.00e+00	865.00
IUUC-Yli-134607	Yarrowia lipolytica	57.58	2.00e-41	160.00
IUUC-Zma-135662	Zea mays	45.00	7.00e-122	431.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence