iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098250

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01399834

Gene Name

PRPF19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000003202.2	ENSPPYT00000003824.2	ENSPPYP00000003692.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.70e-15	56.9	3	64
E3 adaptor/Cullin RING/DCX/DWD	1.50e-29	100.9	390	423
UBD/Beta-Prp	3.90e-49	167.5	231	461

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ++C+Is+e++++P+v+p s+++y+r+ Iek++a++g+ +P+++qpl+ee+l++ ++ + +  +
   Q: 3    LICSISNEVPEHPCVSPvSNHVYERRLIEKYIAENGT-DPINNQPLSEEQLIDIKVAHPIRPK 64
           79**********************************9.***************9998877665 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH++++t++af  ++ +l++++dD ++k+WDlr+
   Q: 390  GHSGPITSIAFseNGYYLATAADDSSVKLWDLRK 423
           8**********976699**************986 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
             d++ ++tg++d+ + v+d ++++ l++l+gh+++vt+v f+p++++  ++s D+ti++w++ + +cv+++++he+ v+ ls++++gd
   Q: 231  PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD 319
           568899*********************************************************************************** PP
   S: 108  klvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkel 195
           +l+s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng +l
   Q: 320  YLLSSSDDQYWAFSDIQTGRVLTKvTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENGYYL 407
           **********************997777777789************************************9.***************** PP
   S: 196  vsgsldgtvklwdlqtgecvrtlnghtd.nvksvrfspnderlvsgssDgsiri 248
           +++++d++vklwdl++ +  +tl+  ++  vks+ f++ +++l+ g+ D +i+i
   Q: 408  ATAADDSSVKLWDLRKLKNFKTLQLDNNfEVKSLIFDQSGTYLALGGTDVQIYI 461
           ***************999999999866527********************9998 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MSLICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PINNQPLSEE QLIDIKVAHP 60
IRPKPPSATS IPAILKALQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCGTGGCGG GCCCTTTCCT GCCCGACTGC ATTCTGGGAA AGAGCAATTT CCGTTAGGTG 60
CTGAAGGCTG TGGCGCGCGG CTGTCCCCAT TCCCACGTGA AGCGCTGCGC TAGCATCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001480--Bulb-type_lectin_dom
IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50231--RICIN_B_LECTIN
PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005662--C:DNA replication factor A complex
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0000974--C:Prp19 complex
GO:0035861--C:site of double-strand break
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0034613--P:cellular protein localization
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0001833--P:inner cell mass cell proliferation
GO:0008610--P:lipid biosynthetic process
GO:0045665--P:negative regulation of neuron differentiation
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0048026--P:positive regulation of mRNA splicing, via spliceosome
GO:0010498--P:proteasomal protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0000245--P:spliceosomal complex assembly
GO:0000244--P:spliceosomal tri-snRNP complex assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	39.51	1.00e-92	335.00
IUUC-Aml-001230	Ailuropoda melanoleuca	94.46	0.00e+00	905.00
IUUC-Atr-002594	Amborella trichopoda	44.91	2.00e-116	412.00
IUUC-Apl-003686	Anas platyrhynchos	87.85	0.00e+00	729.00
IUUC-Aca-005272	Anolis carolinensis	95.88	0.00e+00	936.00
IUUC-Aly-005586	Arabidopsis lyrata	44.40	3.00e-115	408.00
IUUC-Ath-007696	Arabidopsis thaliana	44.53	5.00e-111	394.00
IUUC-Acl-008335	Aspergillus clavatus	35.79	3.00e-68	252.00
IUUC-Afl-008527	Aspergillus flavus	38.19	3.00e-73	268.00
IUUC-Afu-008957	Aspergillus fumigatus	38.32	5.00e-79	288.00
IUUC-Ani-009280	Aspergillus nidulans	38.45	6.00e-67	248.00
IUUC-Ang-009746	Aspergillus niger	36.50	3.00e-67	249.00
IUUC-Aor-009905	Aspergillus oryzae	37.97	9.00e-77	280.00
IUUC-Ate-010412	Aspergillus terreus	37.97	8.00e-66	244.00
IUUC-Ame-011561	Astyanax mexicanus	85.00	5.00e-111	393.00
IUUC-Bgr-012283	Blumeria graminis	32.85	1.00e-56	213.00
IUUC-Bta-013242	Bos taurus	98.14	0.00e+00	949.00
IUUC-Bci-013901	Botrytis cinerea	35.09	8.00e-65	241.00
IUUC-Bdi-014277	Brachypodium distachyon	43.89	7.00e-119	420.00
IUUC-Bol-016207	Brassica oleracea	45.95	2.00e-114	405.00
IUUC-Bra-017902	Brassica rapa	43.79	3.00e-112	398.00
IUUC-Cel-018271	Caenorhabditis elegans	51.98	6.00e-144	503.00
IUUC-Cja-019879	Callithrix jacchus	97.94	0.00e+00	944.00
IUUC-Cfa-020175	Canis familiaris	97.73	0.00e+00	946.00
IUUC-Cpo-022379	Cavia porcellus	97.94	0.00e+00	948.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	41.54	3.00e-97	348.00
IUUC-Csa-023500	Chlorocebus sabaeus	98.35	0.00e+00	951.00
IUUC-Cho-025065	Choloepus hoffmanni	88.10	5.00e-149	520.00
IUUC-Cin-025699	Ciona intestinalis	68.35	1.00e-175	608.00
IUUC-Csv-026128	Ciona savignyi	65.64	0.00e+00	639.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	34.32	3.00e-65	242.00
IUUC-Cne-026860	Cryptococcus neoformans	38.32	2.00e-88	319.00
IUUC-Dre-028187	Danio rerio	84.49	0.00e+00	803.00
IUUC-Dno-029453	Dasypus novemcinctus	98.14	0.00e+00	949.00
IUUC-Dor-030150	Dipodomys ordii	99.16	3.00e-128	451.00
IUUC-Dse-031220	Dothistroma septosporum	32.49	1.00e-58	220.00
IUUC-Dme-031906	Drosophila melanogaster	66.24	3.00e-179	621.00
IUUC-Ete-033035	Echinops telfairi	84.74	0.00e+00	795.00
IUUC-Eca-033478	Equus caballus	97.94	0.00e+00	947.00
IUUC-Eeu-034974	Erinaceus europaeus	97.10	2.00e-178	618.00
IUUC-Fca-036194	Felis catus	96.89	0.00e+00	936.00
IUUC-Fal-037417	Ficedula albicollis	95.46	0.00e+00	932.00
IUUC-Fox-037922	Fusarium oxysporum	34.72	4.00e-64	238.00
IUUC-Fso-038256	Fusarium solani	34.73	1.00e-65	243.00
IUUC-Gmo-038713	Gadus morhua	86.79	0.00e+00	828.00
IUUC-Ggr-039854	Gaeumannomyces graminis	33.27	1.00e-53	204.00
IUUC-Gga-041143	Gallus gallus	95.88	0.00e+00	935.00
IUUC-Gac-042129	Gasterosteus aculeatus	85.53	0.00e+00	843.00
IUUC-Gma-044273	Glycine max	46.14	2.00e-116	412.00
IUUC-Ggo-045262	Gorilla gorilla	98.35	0.00e+00	951.00
IUUC-Hsa-046036	Homo sapiens	98.35	0.00e+00	951.00
IUUC-Hvu-047442	Hordeum vulgare	42.81	2.00e-68	252.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	97.73	0.00e+00	907.00
IUUC-Lch-050105	Latimeria chalumnae	90.13	0.00e+00	882.00
IUUC-Lpe-050976	Leersia perrieri	44.72	2.00e-114	405.00
IUUC-Loc-052042	Lepisosteus oculatus	73.70	2.00e-176	611.00
IUUC-Lma-053143	Leptosphaeria maculans	34.38	1.00e-64	241.00
IUUC-Laf-053451	Loxodonta africana	94.62	0.00e+00	937.00
IUUC-Mcc-055786	Macaca mulatta	98.35	0.00e+00	951.00
IUUC-Meu-056161	Macropus eugenii	99.17	8.00e-141	493.00
IUUC-Mor-057215	Magnaporthe oryzae	34.51	1.00e-56	214.00
IUUC-Mpo-057419	Magnaporthe poae	32.24	6.00e-50	191.00
IUUC-Mtr-057756	Medicago truncatula	44.38	1.00e-111	396.00
IUUC-Mla-059085	Melampsora laricipopulina	38.16	5.00e-82	298.00
IUUC-Mga-060158	Meleagris gallopavo	91.86	0.00e+00	868.00
IUUC-Mvi-060441	Microbotryum violaceum	38.24	3.00e-73	269.00
IUUC-Mmr-061085	Microcebus murinus	98.35	0.00e+00	951.00
IUUC-Mdo-061804	Monodelphis domestica	97.94	0.00e+00	948.00
IUUC-Mmu-063608	Mus musculus	94.05	0.00e+00	932.00
IUUC-Mac-064972	Musa acuminata	44.51	6.00e-112	397.00
IUUC-Mpu-065700	Mustela putorius furo	97.73	0.00e+00	947.00
IUUC-Mlu-068223	Myotis lucifugus	94.50	0.00e+00	926.00
IUUC-Nfi-068504	Neosartorya fischeri	37.76	1.00e-78	286.00
IUUC-Ncr-068729	Neurospora crassa	36.90	1.00e-63	236.00
IUUC-Nle-069754	Nomascus leucogenys	98.35	0.00e+00	951.00
IUUC-Opr-070621	Ochotona princeps	100.00	0.00e+00	933.00
IUUC-Ont-071377	Oreochromis niloticus	85.32	0.00e+00	820.00
IUUC-Oan-073498	Ornithorhynchus anatinus	73.23	1.00e-122	432.00
IUUC-Ocu-074182	Oryctolagus cuniculus	94.27	0.00e+00	938.00
IUUC-Oba-075509	Oryza barthii	43.81	5.00e-116	411.00
IUUC-Obr-076480	Oryza brachyantha	44.83	4.00e-117	414.00
IUUC-Ogl-077052	Oryza glaberrima	43.81	5.00e-116	411.00
IUUC-Ogu-078919	Oryza glumaepatula	43.81	5.00e-116	411.00
IUUC-Oin-079357	Oryza indica	43.06	3.00e-109	388.00
IUUC-Olo-080376	Oryza longistaminata	43.57	4.00e-104	371.00
IUUC-Ome-081973	Oryza meridionalis	43.04	5.00e-104	371.00
IUUC-Oni-082849	Oryza nivara	44.02	7.00e-117	414.00
IUUC-Opu-083243	Oryza punctata	43.81	7.00e-116	410.00
IUUC-Oru-084613	Oryza rufipogon	44.11	4.00e-116	411.00
IUUC-Osa-085407	Oryza sativa	43.81	5.00e-116	411.00
IUUC-Ola-086566	Oryzias latipes	84.27	0.00e+00	812.00
IUUC-Olu-087757	Ostreococcus lucimarinus	40.52	1.00e-93	336.00
IUUC-Oga-089010	Otolemur garnettii	93.44	0.00e+00	896.00
IUUC-Oar-089638	Ovis aries	98.14	0.00e+00	949.00
IUUC-Ptr-091141	Pan troglodytes	98.35	0.00e+00	951.00
IUUC-Pan-092662	Papio anubis	98.35	0.00e+00	951.00
IUUC-Psi-093777	Pelodiscus sinensis	95.25	0.00e+00	758.00
IUUC-Pno-095115	Phaeosphaeria nodorum	35.08	4.00e-65	241.00
IUUC-Ppa-095841	Physcomitrella patens	45.73	2.00e-117	416.00
IUUC-Pfo-096390	Poecilia formosa	84.70	0.00e+00	820.00
IUUC-Pop-099854	Populus trichocarpa	45.47	6.00e-116	410.00
IUUC-Pca-100553	Procavia capensis	97.73	0.00e+00	941.00
IUUC-Ppe-101383	Prunus persica	43.95	1.00e-108	387.00
IUUC-Pva-102189	Pteropus vampyrus	97.94	0.00e+00	948.00
IUUC-Pgr-103304	Puccinia graminis	37.25	3.00e-80	292.00
IUUC-Ptt-103984	Puccinia triticina	38.16	1.00e-85	310.00
IUUC-Pte-104385	Pyrenophora teres	33.19	7.00e-69	254.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	33.62	2.00e-70	259.00
IUUC-Rno-105581	Rattus norvegicus	97.73	0.00e+00	946.00
IUUC-Sha-107071	Sarcophilus harrisii	93.69	0.00e+00	934.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	31.34	3.00e-35	142.00
IUUC-Spo-108315	Schizosaccharomyces pombe	32.40	1.00e-45	177.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	35.16	2.00e-64	239.00
IUUC-Smo-109648	Selaginella moellendorffii	45.40	1.00e-118	419.00
IUUC-Sit-109873	Setaria italica	43.81	4.00e-114	405.00
IUUC-Sly-111673	Solanum lycopersicum	45.75	7.00e-109	387.00
IUUC-Stu-112125	Solanum tuberosum	45.55	4.00e-108	384.00
IUUC-Sbi-114696	Sorghum bicolor	42.32	2.00e-102	365.00
IUUC-Sre-115134	Sporisorium reilianum	32.70	1.00e-70	260.00
IUUC-Ssc-116260	Sus scrofa	98.14	0.00e+00	949.00
IUUC-Tgu-116533	Taeniopygia guttata	95.88	0.00e+00	935.00
IUUC-Tru-117800	Takifugu rubripes	84.91	0.00e+00	845.00
IUUC-Tsy-118980	Tarsius syrichta	92.26	0.00e+00	870.00
IUUC-Tni-120334	Tetraodon nigroviridis	80.32	4.00e-158	550.00
IUUC-Tca-121807	Theobroma cacao	44.47	3.00e-116	412.00
IUUC-Tre-121920	Trichoderma reesei	33.40	4.00e-63	235.00
IUUC-Tvi-122294	Trichoderma virens	33.05	1.00e-55	210.00
IUUC-Tae-125713	Triticum aestivum	44.09	2.00e-119	422.00
IUUC-Tur-126664	Triticum urartu	39.67	2.00e-109	389.00
IUUC-Tme-127026	Tuber melanosporum	34.24	7.00e-68	251.00
IUUC-Tbe-127582	Tupaia belangeri	97.42	9.00e-178	616.00
IUUC-Ttr-128313	Tursiops truncatus	97.73	0.00e+00	939.00
IUUC-Uma-129626	Ustilago maydis	34.62	2.00e-72	266.00
IUUC-Vda-129699	Verticillium dahliae	35.36	1.00e-67	250.00
IUUC-Vpa-130593	Vicugna pacos	99.12	0.00e+00	900.00
IUUC-Vvi-131668	Vitis vinifera	44.35	3.00e-115	408.00
IUUC-Xtr-132186	Xenopus tropicalis	85.42	0.00e+00	768.00
IUUC-Xma-133212	Xiphophorus maculatus	84.49	0.00e+00	815.00
IUUC-Yli-134607	Yarrowia lipolytica	57.58	3.00e-41	160.00
IUUC-Zma-135662	Zea mays	45.12	3.00e-116	411.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence