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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046416
UUCD1 version UUC-HoS-00036
Ensembl Protein ID ENSP00000433102.1
UniProt Accession O75382; B7Z5E6; F5H2Q8; Q4V9L4; Q9C038; Q9C039; TRIM3_HUMAN
Genbank Protein ID AAC24809.1; AAG53474.1; AAG53475.1; AAG53476.1; BAF84085.1; BAH12882.1; EAW68709.1; AAH96827.1
Protein Name Tripartite motif-containing protein 3; Brain-expressed RING finger protein; RING finger protein 22; RING finger protein 97
Genbank Nucleotide ID AF045239; AF220020; AF220021; AF220022; AK291396; AK298843; AC084337; BC096827
Gene Name TRIM3; BERP; RNF22; RNF97
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000110171.18 ENST00000525074.5 ENSP00000433102.1
ENSG00000110171.18 ENST00000536344.5 ENSP00000445460.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18248090
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.80e-07 33.2 22 63
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+++++ p+vlpC H+f++ Clq++      +s + +CP+Cr
   Q: 22   CSICLDRYQC-PKVLPCLHTFCERCLQNY---IPAQSLTLSCPVCR 63
           **********.******************...5569999******8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probably involved in vesicular trafficking via its association with the CART complex (PubMed:15772161). The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity).
 Probably involved in vesicular trafficking via its association with the CART complex (PubMed:15772161). The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity).
Protein Sequence
(Fasta)
MAKREDSPGP EVQPMDKQFL VCSICLDRYQ CPKVLPCLHT FCERCLQNYI PAQSLTLSCP 60
VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPDGAHDPE DPHPLSVVAG RPLSCPNHEG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046416|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCTTCTCCCA GAGTTCTGGG TACTGCCCTT CTGCCGCCCA GAGATCGTGC TGAGGTACAG 60
ACGGTTTCTA CGTCTTCCTG GTCAGCCGAT AGACTAGCAT ATTCCATAGG AGCACTCCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046416|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR003649--Bbox_C
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR015943--WD40/YVTN_repeat-like_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00502--BBC
SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0005769--C:early endosome
GO:0005794--C:Golgi apparatus
GO:0008022--F:protein C-terminus binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007399--P:nervous system development
GO:0015031--P:protein transport
KEGG hsa:10612
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001769 Ailuropoda melanoleuca 98.92 0.00e+00 1494.00
IUUC-Bta-013091 Bos taurus 99.19 0.00e+00 1523.00
IUUC-Cja-019116 Callithrix jacchus 99.46 0.00e+00 1525.00
IUUC-Cfa-020946 Canis familiaris 99.06 0.00e+00 1519.00
IUUC-Cpo-021747 Cavia porcellus 99.46 0.00e+00 1526.00
IUUC-Csa-023901 Chlorocebus sabaeus 99.33 0.00e+00 1522.00
IUUC-Dre-028509 Danio rerio 73.64 0.00e+00 1158.00
IUUC-Dno-029414 Dasypus novemcinctus 99.06 0.00e+00 1520.00
IUUC-Ete-032776 Echinops telfairi 97.98 0.00e+00 1496.00
IUUC-Eca-034308 Equus caballus 99.19 0.00e+00 1519.00
IUUC-Eeu-034845 Erinaceus europaeus 91.26 0.00e+00 1374.00
IUUC-Fca-035594 Felis catus 99.19 0.00e+00 1523.00
IUUC-Gga-040515 Gallus gallus 79.09 0.00e+00 1229.00
IUUC-Gac-042506 Gasterosteus aculeatus 74.56 0.00e+00 1134.00
IUUC-Gma-044219 Glycine max 38.75 5.00e-08 53.90
IUUC-Ggo-045603 Gorilla gorilla 99.60 0.00e+00 1526.00
IUUC-Itr-048448 Ictidomys tridecemlineatus 99.06 0.00e+00 1519.00
IUUC-Lch-050005 Latimeria chalumnae 69.15 0.00e+00 1102.00
IUUC-Lpe-050809 Leersia perrieri 38.46 1.00e-07 52.40
IUUC-Loc-052433 Lepisosteus oculatus 74.77 0.00e+00 1186.00
IUUC-Laf-053930 Loxodonta africana 98.52 0.00e+00 1511.00
IUUC-Mcc-055778 Macaca mulatta 99.33 0.00e+00 1521.00
IUUC-Meu-056100 Macropus eugenii 91.86 0.00e+00 1321.00
IUUC-Mmr-060733 Microcebus murinus 99.46 0.00e+00 1524.00
IUUC-Mdo-062705 Monodelphis domestica 91.26 0.00e+00 1408.00
IUUC-Mmu-063965 Mus musculus 98.66 0.00e+00 1511.00
IUUC-Mac-065515 Musa acuminata 35.00 3.00e-07 51.60
IUUC-Mpu-066757 Mustela putorius furo 99.33 0.00e+00 1524.00
IUUC-Mlu-067822 Myotis lucifugus 87.63 0.00e+00 1155.00
IUUC-Nle-069595 Nomascus leucogenys 99.01 0.00e+00 1431.00
IUUC-Ont-071250 Oreochromis niloticus 76.00 0.00e+00 1159.00
IUUC-Ocu-074675 Oryctolagus cuniculus 99.60 0.00e+00 1522.00
IUUC-Ogl-077726 Oryza glaberrima 38.46 1.00e-07 52.80
IUUC-Ogu-078410 Oryza glumaepatula 38.46 1.00e-07 52.80
IUUC-Oni-083081 Oryza nivara 38.46 1.00e-07 52.80
IUUC-Oru-084365 Oryza rufipogon 38.46 2.00e-07 51.60
IUUC-Osa-085953 Oryza sativa 38.46 1.00e-07 52.80
IUUC-Ola-087179 Oryzias latipes 75.20 0.00e+00 1147.00
IUUC-Oga-089121 Otolemur garnettii 99.73 0.00e+00 1529.00
IUUC-Oar-089931 Ovis aries 95.97 0.00e+00 1446.00
IUUC-Ptr-090907 Pan troglodytes 100.00 0.00e+00 1530.00
IUUC-Pan-092076 Papio anubis 99.33 0.00e+00 1521.00
IUUC-Pfo-097324 Poecilia formosa 72.51 0.00e+00 1130.00
IUUC-Pab-097602 Pongo abelii 95.16 0.00e+00 1437.00
IUUC-Pva-103232 Pteropus vampyrus 99.06 0.00e+00 1493.00
IUUC-Rno-104998 Rattus norvegicus 98.79 0.00e+00 1513.00
IUUC-Sha-107604 Sarcophilus harrisii 91.53 0.00e+00 1411.00
IUUC-Sly-111723 Solanum lycopersicum 34.25 1.00e-05 45.80
IUUC-Stu-112510 Solanum tuberosum 37.50 2.00e-09 55.80
IUUC-Sar-113243 Sorex araneus 98.23 0.00e+00 899.00
IUUC-Sbi-114481 Sorghum bicolor 33.77 1.00e-05 45.40
IUUC-Ssc-115253 Sus scrofa 91.39 0.00e+00 1383.00
IUUC-Tru-118267 Takifugu rubripes 74.50 0.00e+00 1166.00
IUUC-Tsy-119487 Tarsius syrichta 99.61 0.00e+00 1043.00
IUUC-Tni-120733 Tetraodon nigroviridis 74.57 0.00e+00 1152.00
Created Date 25-Jun-2017

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