iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000110497.14	ENST00000314845.7	ENSP00000318313.3
ENSG00000110497.14	ENST00000533727.5	ENSP00000433372.1
ENSG00000110497.14	ENST00000534300.5	ENSP00000431926.1
ENSG00000110497.14	ENST00000458649.6	ENSP00000415327.2
ENSG00000110497.14	ENST00000526545.5	ENSP00000434895.1
ENSG00000110497.14	ENST00000528950.1	ENSP00000433945.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	20562859

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-07	32.5	93	126

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd..tllvsGsdDgtikvWDlr 31
           gH    +c+ f ++  +l++sG+ Dg +++WDl+
   Q: 93   GHRRTPWCVTFhPTisGLIASGCLDGEVRIWDLH 126
           6777779*****76779***************97 PP

Organism

Homo sapiens

Functional Description
(View)

Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).

Protein Sequence
(Fasta)

MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP DSPRSTFLLA 60
FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC VTFHPTISGL IASGCLDGEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCTGTTTT TCGGCGCTCG GCTGTGGTTC CTTGAACGAT TGCTTGGGCG TTCCTCCTTT 60
GATGTCTGGG GCGTTCTTGT ATTCGGTGAT CTTTTGCGCC GTCTTCTTGC TTGATGTCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0488--Methylation
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0005776--C:autophagosome
GO:0005930--C:axoneme
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0048471--C:perinuclear region of cytoplasm
GO:0045335--C:phagocytic vesicle
GO:0031625--F:ubiquitin protein ligase binding
GO:0030154--P:cell differentiation
GO:0009267--P:cellular response to starvation
GO:0016236--P:macroautophagy
GO:0010667--P:negative regulation of cardiac muscle cell apoptotic process
GO:0008285--P:negative regulation of cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0021915--P:neural tube development
GO:0098779--P:positive regulation of macromitophagy in response to mitochondrial depolarization
GO:1903599--P:positive regulation of mitophagy
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000785--P:regulation of autophagosome assembly

KEGG

hsa:55626

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001917	Ailuropoda melanoleuca	97.81	0.00e+00	1813.00
IUUC-Atr-002557	Amborella trichopoda	37.74	3.00e-30	127.00
IUUC-Apl-004186	Anas platyrhynchos	81.80	0.00e+00	1944.00
IUUC-Aca-004419	Anolis carolinensis	77.59	0.00e+00	1837.00
IUUC-Aly-006308	Arabidopsis lyrata	37.85	1.00e-28	122.00
IUUC-Ath-007656	Arabidopsis thaliana	36.92	3.00e-28	120.00
IUUC-Ame-011354	Astyanax mexicanus	59.17	0.00e+00	1312.00
IUUC-Bta-012455	Bos taurus	94.46	0.00e+00	2237.00
IUUC-Bdi-014580	Brachypodium distachyon	42.33	4.00e-30	126.00
IUUC-Bol-016094	Brassica oleracea	40.22	1.00e-28	122.00
IUUC-Bra-017308	Brassica rapa	40.76	1.00e-29	125.00
IUUC-Cja-019073	Callithrix jacchus	98.82	3.00e-169	588.00
IUUC-Cfa-020994	Canis familiaris	95.01	0.00e+00	1528.00
IUUC-Cpo-022101	Cavia porcellus	94.85	0.00e+00	2208.00
IUUC-Csa-023273	Chlorocebus sabaeus	98.12	0.00e+00	1635.00
IUUC-Cin-025567	Ciona intestinalis	54.64	6.00e-56	212.00
IUUC-Csv-026005	Ciona savignyi	51.26	5.00e-56	210.00
IUUC-Dre-028282	Danio rerio	58.72	0.00e+00	1298.00
IUUC-Dno-029948	Dasypus novemcinctus	96.23	0.00e+00	2226.00
IUUC-Dor-030568	Dipodomys ordii	96.78	0.00e+00	1258.00
IUUC-Ete-032864	Echinops telfairi	94.31	0.00e+00	1182.00
IUUC-Eca-034392	Equus caballus	96.87	0.00e+00	1641.00
IUUC-Eeu-034440	Erinaceus europaeus	87.98	0.00e+00	1248.00
IUUC-Fca-035359	Felis catus	94.18	0.00e+00	2186.00
IUUC-Fal-037483	Ficedula albicollis	82.17	0.00e+00	1983.00
IUUC-Gmo-039343	Gadus morhua	75.72	0.00e+00	780.00
IUUC-Gga-040787	Gallus gallus	82.79	0.00e+00	1246.00
IUUC-Gac-041321	Gasterosteus aculeatus	62.43	0.00e+00	1369.00
IUUC-Gma-044022	Glycine max	36.63	4.00e-29	123.00
IUUC-Ggo-044775	Gorilla gorilla	99.66	0.00e+00	1112.00
IUUC-Hvu-047536	Hordeum vulgare	41.57	1.00e-29	124.00
IUUC-Itr-048376	Ictidomys tridecemlineatus	98.27	0.00e+00	1266.00
IUUC-Lch-050255	Latimeria chalumnae	70.32	0.00e+00	1425.00
IUUC-Lpe-050684	Leersia perrieri	41.76	2.00e-30	128.00
IUUC-Loc-052881	Lepisosteus oculatus	67.86	0.00e+00	1506.00
IUUC-Laf-053342	Loxodonta africana	73.27	0.00e+00	988.00
IUUC-Mcc-055848	Macaca mulatta	96.69	0.00e+00	2292.00
IUUC-Meu-056320	Macropus eugenii	85.44	0.00e+00	1102.00
IUUC-Mtr-058484	Medicago truncatula	38.54	2.00e-29	124.00
IUUC-Mga-059401	Meleagris gallopavo	85.62	0.00e+00	1681.00
IUUC-Mmr-061037	Microcebus murinus	96.47	0.00e+00	2220.00
IUUC-Mdo-062484	Monodelphis domestica	75.32	0.00e+00	1698.00
IUUC-Mmu-064090	Mus musculus	95.69	0.00e+00	2229.00
IUUC-Mac-065675	Musa acuminata	34.89	2.00e-29	124.00
IUUC-Mpu-066165	Mustela putorius furo	95.62	0.00e+00	1541.00
IUUC-Mlu-068038	Myotis lucifugus	95.23	0.00e+00	2306.00
IUUC-Nle-069361	Nomascus leucogenys	99.26	0.00e+00	1981.00
IUUC-Opr-070360	Ochotona princeps	93.45	0.00e+00	875.00
IUUC-Ont-071277	Oreochromis niloticus	63.67	0.00e+00	1372.00
IUUC-Oan-073623	Ornithorhynchus anatinus	83.19	0.00e+00	1038.00
IUUC-Ocu-074600	Oryctolagus cuniculus	97.57	0.00e+00	1420.00
IUUC-Oba-075024	Oryza barthii	38.19	6.00e-32	133.00
IUUC-Obr-076172	Oryza brachyantha	34.71	1.00e-32	135.00
IUUC-Ogl-077411	Oryza glaberrima	34.30	8.00e-32	132.00
IUUC-Ogu-078025	Oryza glumaepatula	38.19	8.00e-32	132.00
IUUC-Oni-082463	Oryza nivara	38.19	5.00e-32	133.00
IUUC-Opu-084041	Oryza punctata	38.19	1.00e-31	131.00
IUUC-Oru-085075	Oryza rufipogon	38.19	2.00e-31	131.00
IUUC-Osa-085781	Oryza sativa	38.19	7.00e-32	132.00
IUUC-Ola-086729	Oryzias latipes	63.72	0.00e+00	1400.00
IUUC-Olu-087735	Ostreococcus lucimarinus	40.32	8.00e-24	105.00
IUUC-Oga-089113	Otolemur garnettii	95.54	0.00e+00	2169.00
IUUC-Oar-090171	Ovis aries	95.71	0.00e+00	2082.00
IUUC-Ptr-090970	Pan troglodytes	99.92	0.00e+00	2343.00
IUUC-Pan-092778	Papio anubis	98.22	0.00e+00	1662.00
IUUC-Psi-093571	Pelodiscus sinensis	81.73	0.00e+00	1971.00
IUUC-Pma-094563	Petromyzon marinus	74.58	2.00e-106	378.00
IUUC-Ppa-095832	Physcomitrella patens	36.70	1.00e-30	128.00
IUUC-Pfo-097365	Poecilia formosa	61.26	0.00e+00	1282.00
IUUC-Pab-098647	Pongo abelii	99.31	0.00e+00	1278.00
IUUC-Pop-099742	Populus trichocarpa	40.32	1.00e-29	125.00
IUUC-Pca-101035	Procavia capensis	92.78	0.00e+00	1194.00
IUUC-Ppe-101783	Prunus persica	42.22	3.00e-29	124.00
IUUC-Pva-103187	Pteropus vampyrus	99.01	0.00e+00	942.00
IUUC-Rno-105701	Rattus norvegicus	95.69	0.00e+00	2211.00
IUUC-Sha-107612	Sarcophilus harrisii	85.68	0.00e+00	2007.00
IUUC-Smo-109107	Selaginella moellendorffii	39.66	6.00e-27	116.00
IUUC-Sit-110786	Setaria italica	38.12	2.00e-32	134.00
IUUC-Sly-110859	Solanum lycopersicum	38.10	7.00e-32	132.00
IUUC-Stu-112031	Solanum tuberosum	38.57	7.00e-32	132.00
IUUC-Sar-113242	Sorex araneus	95.86	0.00e+00	1090.00
IUUC-Ssc-116094	Sus scrofa	96.62	0.00e+00	2274.00
IUUC-Tru-118308	Takifugu rubripes	62.19	0.00e+00	1331.00
IUUC-Tsy-119552	Tarsius syrichta	94.86	0.00e+00	1247.00
IUUC-Tca-121616	Theobroma cacao	38.10	1.00e-30	128.00
IUUC-Tae-124768	Triticum aestivum	42.17	5.00e-30	126.00
IUUC-Tur-126480	Triticum urartu	42.17	2.00e-30	127.00
IUUC-Tbe-127902	Tupaia belangeri	95.65	0.00e+00	983.00
IUUC-Ttr-129278	Tursiops truncatus	94.72	0.00e+00	1207.00
IUUC-Vpa-130741	Vicugna pacos	90.17	0.00e+00	838.00
IUUC-Vvi-131437	Vitis vinifera	40.30	2.00e-29	124.00
IUUC-Xtr-132247	Xenopus tropicalis	65.12	0.00e+00	1325.00
IUUC-Xma-134277	Xiphophorus maculatus	61.63	0.00e+00	1393.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence