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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046923
UUCD1 version UUC-HoS-00325
Ensembl Protein ID ENSP00000442068.1
UniProt Accession Q99618; A8K5V6; D3DUS6; CDCA3_HUMAN
Genbank Protein ID AAB51327.1; BAF84110.1; EAW88728.1; EAW88729.1; AAH02551.1; AAH36512.1
Protein Name Cell division cycle-associated protein 3; Gene-rich cluster protein C8; Trigger of mitotic entry protein 1
Genbank Nucleotide ID BG354576; AK291421; CH471116; CH471116; BC002551; BC036512
Gene Name CDCA3; C8; GRCC8; TOME1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000111665.11 ENST00000422785.7 ENSP00000415142.2
ENSG00000111665.11 ENST00000538862.6 ENSP00000442068.1
ENSG00000111665.11 ENST00000229265.10 ENSP00000229265.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 18032919; 12679038
Organism Homo sapiens
Functional Description
(View)

Functional Description


     F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).
 F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).
Protein Sequence
(Fasta)
MGSAKSVPVT PARPPPHNKH LARVADPRSP SAGILRTPIQ VESSPQPGLP AGEQLEGLKH 60
AQDSDPRSPT LGIARTPMKT SSGDPPSPLV KQLSEVFETE DSKSNLPPEP VLPPEAPLSS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046923|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCGAGAAT GGCAGTTGGA CGGAGCCTGC CTGCCGGTGC TCCGCCCCTG CCCCGCGCTT 60
GACTGACGCC AATGAGAAGC GCTCCTAAGG CAATTGATGG TTGAAAGAAC CAATCCCACT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046923|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Gene Ontology

GO:0005913--C:cell-cell adherens junction
GO:0005829--C:cytosol
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
KEGG hsa:83461
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002165 Ailuropoda melanoleuca 84.76 1.00e-104 372.00
IUUC-Aca-004249 Anolis carolinensis 38.27 2.00e-29 122.00
IUUC-Ame-010864 Astyanax mexicanus 40.83 2.00e-10 60.80
IUUC-Bta-012935 Bos taurus 80.22 2.00e-93 335.00
IUUC-Cja-019231 Callithrix jacchus 94.03 2.00e-118 418.00
IUUC-Cfa-020627 Canis familiaris 83.27 3.00e-110 390.00
IUUC-Cpo-021463 Cavia porcellus 77.70 4.00e-97 347.00
IUUC-Csa-023351 Chlorocebus sabaeus 98.51 2.00e-133 468.00
IUUC-Cho-024607 Choloepus hoffmanni 68.42 3.00e-60 224.00
IUUC-Cin-025214 Ciona intestinalis 44.83 9.00e-06 43.90
IUUC-Dre-027512 Danio rerio 46.34 6.00e-09 55.80
IUUC-Dno-029062 Dasypus novemcinctus 83.52 7.00e-104 369.00
IUUC-Dor-030348 Dipodomys ordii 68.01 2.00e-78 285.00
IUUC-Ete-033110 Echinops telfairi 66.79 2.00e-76 278.00
IUUC-Eca-033552 Equus caballus 85.82 3.00e-107 381.00
IUUC-Eeu-034959 Erinaceus europaeus 71.64 1.00e-89 322.00
IUUC-Fca-036432 Felis catus 81.04 1.00e-100 358.00
IUUC-Fal-037091 Ficedula albicollis 50.00 2.00e-10 56.60
IUUC-Gga-040304 Gallus gallus 38.32 5.00e-23 100.00
IUUC-Gac-042230 Gasterosteus aculeatus 38.27 2.00e-07 49.30
IUUC-Ggo-045609 Gorilla gorilla 99.25 1.00e-126 445.00
IUUC-Itr-047873 Ictidomys tridecemlineatus 82.46 4.00e-105 374.00
IUUC-Lch-050000 Latimeria chalumnae 54.95 2.00e-20 93.20
IUUC-Laf-054256 Loxodonta africana 84.76 5.00e-107 380.00
IUUC-Mcc-054835 Macaca mulatta 98.51 1.00e-133 468.00
IUUC-Mmr-061568 Microcebus murinus 88.81 1.00e-115 409.00
IUUC-Mdo-062917 Monodelphis domestica 58.18 9.00e-65 239.00
IUUC-Mmu-064393 Mus musculus 72.76 5.00e-95 340.00
IUUC-Mpu-066214 Mustela putorius furo 84.39 6.00e-106 376.00
IUUC-Mlu-068159 Myotis lucifugus 81.34 6.00e-99 353.00
IUUC-Nle-069228 Nomascus leucogenys 98.88 5.00e-126 443.00
IUUC-Opr-070310 Ochotona princeps 73.13 2.00e-86 311.00
IUUC-Ont-072427 Oreochromis niloticus 38.46 7.00e-09 55.10
IUUC-Oan-072771 Ornithorhynchus anatinus 68.24 1.00e-24 104.00
IUUC-Ocu-073805 Oryctolagus cuniculus 82.84 4.00e-106 377.00
IUUC-Opu-083395 Oryza punctata 29.27 3.00e-03 38.10
IUUC-Oga-088537 Otolemur garnettii 86.94 1.00e-110 392.00
IUUC-Oar-089443 Ovis aries 78.52 1.00e-94 339.00
IUUC-Ptr-091066 Pan troglodytes 99.25 6.00e-120 423.00
IUUC-Pan-092862 Papio anubis 98.51 9.00e-134 469.00
IUUC-Pfo-097097 Poecilia formosa 39.36 2.00e-08 53.50
IUUC-Pab-098378 Pongo abelii 98.51 5.00e-134 470.00
IUUC-Pca-100868 Procavia capensis 75.75 1.00e-92 332.00
IUUC-Pva-102785 Pteropus vampyrus 81.72 8.00e-86 310.00
IUUC-Rno-105147 Rattus norvegicus 67.38 7.00e-88 317.00
IUUC-Sha-106583 Sarcophilus harrisii 60.89 4.00e-70 257.00
IUUC-Sar-113398 Sorex araneus 63.78 4.00e-44 171.00
IUUC-Ssc-115765 Sus scrofa 82.46 1.00e-108 385.00
IUUC-Tsy-118800 Tarsius syrichta 69.78 8.00e-86 310.00
IUUC-Tbe-128147 Tupaia belangeri 84.33 6.00e-106 376.00
IUUC-Ttr-128517 Tursiops truncatus 85.07 8.00e-102 363.00
IUUC-Vpa-130229 Vicugna pacos 79.89 6.00e-72 263.00
Created Date 25-Jun-2017

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