iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	21757720

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.00089	21.0	273	317

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 96   egpdaglldrlpeeilveilklldkeellraarvcrrwq.elasqk 140
           egp++g +d+lp+e+++ il++l+ ++l+r+a++c+ ++ ++++ +
   Q: 273  EGPNNGYFDKLPYELIQLILNHLTLPDLCRLAQTCKLLSqHCCD-P 317
           9***********************************99966665.4 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSPVFPMLTV LTMFYYICLR RRARTATRGE MMNTHRAIES NSQTSPLNAE VVQYAKEVVD 60
FSSHYGSENS MSYTMWNLAG VPNVFPSSGD FTQTAVFRTY GTWWDQCPSA SLPFKRTPPN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCTCCCCG GCTCCGCCCC GCCTCCCCGG GCCCGCCGCT CCTCGCGGCC TCCGCGTCTT 60
CCTTCCGGGT CGCGCTAGGC CGGGCTTGCG GCGGTTGTGC CGCATCTAGA GAGTCGGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0433--Leucine-rich repeat
KW-0488--Methylation
KW-0496--Mitochondrion
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp

PROSITE

PS50181--FBOX

Pfam

PF00646--F-box

SMART

SM00367--LRR_CC

Gene Ontology

GO:0005829--C:cytosol
GO:0005758--C:mitochondrial intermembrane space
GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:26235

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001706	Ailuropoda melanoleuca	95.33	0.00e+00	1212.00
IUUC-Apl-004115	Anas platyrhynchos	86.63	0.00e+00	1100.00
IUUC-Aca-004482	Anolis carolinensis	81.96	0.00e+00	1020.00
IUUC-Ame-010656	Astyanax mexicanus	65.22	0.00e+00	806.00
IUUC-Bta-013498	Bos taurus	77.33	0.00e+00	943.00
IUUC-Cja-019838	Callithrix jacchus	97.58	0.00e+00	1239.00
IUUC-Cfa-020456	Canis familiaris	95.33	0.00e+00	1215.00
IUUC-Csa-024014	Chlorocebus sabaeus	97.58	0.00e+00	1237.00
IUUC-Cho-024333	Choloepus hoffmanni	96.05	8.00e-141	494.00
IUUC-Cin-025800	Ciona intestinalis	41.38	5.00e-118	418.00
IUUC-Csv-026119	Ciona savignyi	39.52	8.00e-117	414.00
IUUC-Dre-027364	Danio rerio	68.06	0.00e+00	872.00
IUUC-Dno-029258	Dasypus novemcinctus	93.08	0.00e+00	1160.00
IUUC-Dor-030963	Dipodomys ordii	81.48	0.00e+00	957.00
IUUC-Dme-031781	Drosophila melanogaster	32.60	6.00e-72	265.00
IUUC-Ete-032619	Echinops telfairi	86.53	0.00e+00	757.00
IUUC-Eca-033869	Equus caballus	94.52	0.00e+00	1211.00
IUUC-Eeu-034752	Erinaceus europaeus	85.01	0.00e+00	647.00
IUUC-Fca-036554	Felis catus	95.65	0.00e+00	1215.00
IUUC-Fal-036695	Ficedula albicollis	86.47	0.00e+00	1088.00
IUUC-Gmo-039192	Gadus morhua	67.46	0.00e+00	830.00
IUUC-Gga-040713	Gallus gallus	86.47	0.00e+00	1094.00
IUUC-Gac-041952	Gasterosteus aculeatus	69.39	0.00e+00	838.00
IUUC-Ggo-044425	Gorilla gorilla	98.39	0.00e+00	1267.00
IUUC-Itr-047877	Ictidomys tridecemlineatus	94.82	0.00e+00	695.00
IUUC-Lch-049424	Latimeria chalumnae	76.80	0.00e+00	986.00
IUUC-Loc-052577	Lepisosteus oculatus	73.23	0.00e+00	902.00
IUUC-Laf-054305	Loxodonta africana	95.18	0.00e+00	1171.00
IUUC-Mcc-055258	Macaca mulatta	89.37	0.00e+00	1107.00
IUUC-Meu-056888	Macropus eugenii	89.78	0.00e+00	833.00
IUUC-Mga-059700	Meleagris gallopavo	86.31	0.00e+00	1103.00
IUUC-Mmr-061712	Microcebus murinus	93.24	0.00e+00	1161.00
IUUC-Mdo-062098	Monodelphis domestica	89.21	0.00e+00	1137.00
IUUC-Mmu-063505	Mus musculus	93.40	0.00e+00	1194.00
IUUC-Mpu-066263	Mustela putorius furo	95.17	0.00e+00	1212.00
IUUC-Mlu-067327	Myotis lucifugus	93.89	0.00e+00	1152.00
IUUC-Nle-069478	Nomascus leucogenys	98.25	0.00e+00	1148.00
IUUC-Opr-070497	Ochotona princeps	94.71	1.00e-90	327.00
IUUC-Ont-071391	Oreochromis niloticus	68.51	0.00e+00	830.00
IUUC-Oan-073721	Ornithorhynchus anatinus	81.10	0.00e+00	1002.00
IUUC-Ocu-073821	Oryctolagus cuniculus	93.88	0.00e+00	1192.00
IUUC-Ola-087182	Oryzias latipes	68.64	0.00e+00	850.00
IUUC-Oga-088018	Otolemur garnettii	93.57	0.00e+00	1187.00
IUUC-Oar-090339	Ovis aries	92.91	0.00e+00	1160.00
IUUC-Ptr-090776	Pan troglodytes	98.55	0.00e+00	1269.00
IUUC-Pan-092203	Papio anubis	97.91	0.00e+00	1241.00
IUUC-Psi-093022	Pelodiscus sinensis	85.99	0.00e+00	1090.00
IUUC-Pfo-097500	Poecilia formosa	67.42	0.00e+00	845.00
IUUC-Pab-097943	Pongo abelii	97.91	0.00e+00	1240.00
IUUC-Pca-100898	Procavia capensis	93.24	0.00e+00	1142.00
IUUC-Pva-102663	Pteropus vampyrus	94.52	0.00e+00	1212.00
IUUC-Rno-105570	Rattus norvegicus	92.91	0.00e+00	1186.00
IUUC-Sha-106688	Sarcophilus harrisii	89.21	0.00e+00	1139.00
IUUC-Sar-113608	Sorex araneus	93.58	0.00e+00	695.00
IUUC-Ssc-115444	Sus scrofa	93.88	0.00e+00	1204.00
IUUC-Tgu-117129	Taeniopygia guttata	90.45	0.00e+00	626.00
IUUC-Tru-118101	Takifugu rubripes	68.39	0.00e+00	808.00
IUUC-Tsy-119589	Tarsius syrichta	94.85	0.00e+00	1204.00
IUUC-Tni-120420	Tetraodon nigroviridis	68.06	0.00e+00	830.00
IUUC-Tbe-128069	Tupaia belangeri	93.66	8.00e-142	497.00
IUUC-Ttr-128566	Tursiops truncatus	84.22	0.00e+00	1047.00
IUUC-Vpa-130059	Vicugna pacos	93.40	0.00e+00	1194.00
IUUC-Xtr-132488	Xenopus tropicalis	69.82	0.00e+00	818.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence