iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000113575.9	ENST00000481195.5	ENSP00000418447.1
ENSG00000113575.9	ENST00000523082.1	ENSP00000428816.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	20092282

Organism

Homo sapiens

Functional Description
(View)

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.

Protein Sequence
(Fasta)

MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTCCCCT CCGCTCCCCG CCGCCTCCTG ACGCCGGGCG TGACGTCACC ACGCCCGGCG 60
GCCGCCATTA CAGAGAGCCG AGCTCTGGAG CCTCAGCGAG CGGAGGAGGA GGCGCAGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0464--Manganese
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR004843--Calcineurin-like_PHP_ApaH
IPR029052--Metallo-depent_PP-like
IPR006186--Ser/Thr-sp_prot-phosphatase

PROSITE

PS00125--SER_THR_PHOSPHATASE

Pfam

PF00149--Metallophos

PRINTS

PR00114--STPHPHTASE

SMART

SM00156--PP2Ac

Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0015630--C:microtubule cytoskeleton
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000159--C:protein phosphatase type 2A complex
GO:0000922--C:spindle pole
GO:0046872--F:metal ion binding
GO:0004721--F:phosphoprotein phosphatase activity
GO:0006915--P:apoptotic process
GO:0006672--P:ceramide metabolic process
GO:0000188--P:inactivation of MAPK activity
GO:0051321--P:meiotic cell cycle
GO:0007498--P:mesoderm development
GO:0007084--P:mitotic nuclear envelope reassembly
GO:0030308--P:negative regulation of cell growth
GO:0010719--P:negative regulation of epithelial to mesenchymal transition
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0000184--P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0006470--P:protein dephosphorylation
GO:0030155--P:regulation of cell adhesion
GO:0045595--P:regulation of cell differentiation
GO:0006275--P:regulation of DNA replication
GO:0040008--P:regulation of growth
GO:0006355--P:regulation of transcription, DNA-templated
GO:0030111--P:regulation of Wnt signaling pathway
GO:0010033--P:response to organic substance
GO:0008380--P:RNA splicing
GO:0019932--P:second-messenger-mediated signaling

KEGG

hsa:5515

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000073	Aegilops tauschii	81.40	1.00e-153	535.00
IUUC-Aml-001862	Ailuropoda melanoleuca	100.00	0.00e+00	649.00
IUUC-Atr-002565	Amborella trichopoda	82.39	5.00e-155	540.00
IUUC-Apl-004163	Anas platyrhynchos	97.42	0.00e+00	633.00
IUUC-Aca-005038	Anolis carolinensis	99.03	0.00e+00	645.00
IUUC-Aly-005921	Arabidopsis lyrata	80.20	1.00e-153	535.00
IUUC-Ath-007164	Arabidopsis thaliana	80.20	2.00e-153	534.00
IUUC-Ame-010907	Astyanax mexicanus	99.03	0.00e+00	645.00
IUUC-Bgr-012186	Blumeria graminis	84.04	6.00e-159	553.00
IUUC-Bta-013583	Bos taurus	100.00	0.00e+00	649.00
IUUC-Bci-013884	Botrytis cinerea	85.02	8.00e-161	559.00
IUUC-Bdi-014993	Brachypodium distachyon	81.40	1.00e-153	535.00
IUUC-Bra-017702	Brassica rapa	80.20	2.00e-154	537.00
IUUC-Cja-019549	Callithrix jacchus	100.00	0.00e+00	649.00
IUUC-Cfa-020295	Canis familiaris	100.00	0.00e+00	649.00
IUUC-Cpo-022311	Cavia porcellus	100.00	0.00e+00	649.00
IUUC-Cre-022625	Chlamydomonas reinhardtii	78.43	8.00e-148	516.00
IUUC-Csa-023283	Chlorocebus sabaeus	100.00	0.00e+00	649.00
IUUC-Cin-025581	Ciona intestinalis	93.07	2.00e-173	601.00
IUUC-Csv-026026	Ciona savignyi	91.91	8.00e-152	529.00
IUUC-Cgl-026758	Colletotrichum gloeosporioides	84.69	1.00e-160	559.00
IUUC-Cne-026997	Cryptococcus neoformans	85.38	2.00e-160	558.00
IUUC-Cme-027101	Cyanidioschyzon merolae	82.52	5.00e-158	550.00
IUUC-Dre-027487	Danio rerio	97.41	0.00e+00	640.00
IUUC-Dno-028872	Dasypus novemcinctus	100.00	0.00e+00	649.00
IUUC-Ete-032859	Echinops telfairi	100.00	0.00e+00	649.00
IUUC-Fca-036395	Felis catus	100.00	0.00e+00	649.00
IUUC-Fal-036826	Ficedula albicollis	100.00	1.00e-166	578.00
IUUC-Fox-037783	Fusarium oxysporum	84.36	5.00e-161	560.00
IUUC-Fso-038215	Fusarium solani	84.69	4.00e-161	560.00
IUUC-Gmo-038520	Gadus morhua	96.43	9.00e-180	622.00
IUUC-Ggr-039745	Gaeumannomyces graminis	84.69	2.00e-160	558.00
IUUC-Gga-040663	Gallus gallus	99.03	0.00e+00	645.00
IUUC-Gac-042221	Gasterosteus aculeatus	96.44	0.00e+00	632.00
IUUC-Gma-042753	Glycine max	81.73	2.00e-154	538.00
IUUC-Ggo-044960	Gorilla gorilla	100.00	0.00e+00	649.00
IUUC-Itr-048646	Ictidomys tridecemlineatus	100.00	0.00e+00	649.00
IUUC-Kpa-049311	Komagataella pastoris	76.49	1.00e-143	502.00
IUUC-Lch-050295	Latimeria chalumnae	99.03	0.00e+00	646.00
IUUC-Lpe-051261	Leersia perrieri	81.40	8.00e-155	539.00
IUUC-Loc-052336	Lepisosteus oculatus	99.35	0.00e+00	647.00
IUUC-Lma-053211	Leptosphaeria maculans	84.69	3.00e-161	560.00
IUUC-Laf-053835	Loxodonta africana	100.00	0.00e+00	649.00
IUUC-Mcc-055756	Macaca mulatta	100.00	0.00e+00	649.00
IUUC-Meu-056068	Macropus eugenii	75.40	3.00e-130	457.00
IUUC-Mor-057272	Magnaporthe oryzae	84.69	9.00e-161	559.00
IUUC-Mpo-057478	Magnaporthe poae	84.69	1.00e-160	558.00
IUUC-Mtr-057736	Medicago truncatula	80.40	3.00e-152	530.00
IUUC-Mla-059001	Melampsora laricipopulina	85.15	2.00e-161	561.00
IUUC-Mga-059904	Meleagris gallopavo	97.24	3.00e-170	590.00
IUUC-Mvi-060467	Microbotryum violaceum	85.86	5.00e-162	563.00
IUUC-Mmr-060867	Microcebus murinus	100.00	0.00e+00	649.00
IUUC-Mdo-062353	Monodelphis domestica	100.00	0.00e+00	649.00
IUUC-Mmu-064204	Mus musculus	99.68	0.00e+00	648.00
IUUC-Mac-064924	Musa acuminata	82.72	7.00e-156	543.00
IUUC-Mpu-066183	Mustela putorius furo	100.00	0.00e+00	649.00
IUUC-Mlu-067115	Myotis lucifugus	99.68	0.00e+00	647.00
IUUC-Ncr-068958	Neurospora crassa	85.02	4.00e-161	560.00
IUUC-Nle-069365	Nomascus leucogenys	100.00	0.00e+00	649.00
IUUC-Opr-071012	Ochotona princeps	100.00	0.00e+00	649.00
IUUC-Ont-071469	Oreochromis niloticus	97.09	0.00e+00	635.00
IUUC-Oan-072869	Ornithorhynchus anatinus	95.55	1.00e-167	582.00
IUUC-Ocu-074394	Oryctolagus cuniculus	100.00	0.00e+00	649.00
IUUC-Oba-075432	Oryza barthii	81.06	7.00e-154	536.00
IUUC-Ogl-077436	Oryza glaberrima	82.39	9.00e-155	539.00
IUUC-Ogu-078351	Oryza glumaepatula	81.06	7.00e-154	536.00
IUUC-Oin-080218	Oryza indica	82.39	1.00e-154	538.00
IUUC-Olo-080223	Oryza longistaminata	82.39	9.00e-155	539.00
IUUC-Ome-081581	Oryza meridionalis	82.39	1.00e-154	538.00
IUUC-Oni-082094	Oryza nivara	82.39	1.00e-154	538.00
IUUC-Opu-083544	Oryza punctata	82.06	1.00e-154	538.00
IUUC-Oru-084975	Oryza rufipogon	82.39	1.00e-154	538.00
IUUC-Osa-085945	Oryza sativa	82.39	1.00e-154	538.00
IUUC-Ola-087141	Oryzias latipes	96.76	0.00e+00	634.00
IUUC-Oga-087919	Otolemur garnettii	100.00	0.00e+00	649.00
IUUC-Oar-089240	Ovis aries	100.00	1.00e-166	578.00
IUUC-Ptr-091367	Pan troglodytes	99.35	0.00e+00	643.00
IUUC-Pan-091956	Papio anubis	100.00	0.00e+00	649.00
IUUC-Psi-094099	Pelodiscus sinensis	98.05	0.00e+00	631.00
IUUC-Pma-094369	Petromyzon marinus	90.70	5.00e-89	319.00
IUUC-Pno-094872	Phaeosphaeria nodorum	78.00	6.00e-138	483.00
IUUC-Ppa-095520	Physcomitrella patens	84.05	1.00e-158	552.00
IUUC-Pfo-097359	Poecilia formosa	97.41	0.00e+00	636.00
IUUC-Pop-099210	Populus trichocarpa	81.73	1.00e-154	538.00
IUUC-Pca-100122	Procavia capensis	86.73	6.00e-155	540.00
IUUC-Ppe-101822	Prunus persica	81.40	2.00e-153	535.00
IUUC-Pva-102237	Pteropus vampyrus	89.64	2.00e-163	567.00
IUUC-Pgr-103259	Puccinia graminis	84.49	3.00e-160	557.00
IUUC-Pte-104116	Pyrenophora teres	84.69	5.00e-161	560.00
IUUC-Pyt-104768	Pyrenophora triticirepentis	84.69	5.00e-161	560.00
IUUC-Rno-104853	Rattus norvegicus	99.68	0.00e+00	648.00
IUUC-Sce-106338	Saccharomyces cerevisiae	76.16	1.00e-144	506.00
IUUC-Sha-107562	Sarcophilus harrisii	100.00	0.00e+00	650.00
IUUC-Sja-107705	Schizosaccharomyces japonicus	81.40	5.00e-154	536.00
IUUC-Spo-108240	Schizosaccharomyces pombe	80.07	3.00e-152	531.00
IUUC-Smo-109421	Selaginella moellendorffii	84.44	1.00e-158	552.00
IUUC-Sit-110313	Setaria italica	81.73	1.00e-154	538.00
IUUC-Sly-111492	Solanum lycopersicum	82.06	9.00e-155	539.00
IUUC-Stu-112108	Solanum tuberosum	82.06	9.00e-155	539.00
IUUC-Sar-113253	Sorex araneus	95.11	3.00e-174	604.00
IUUC-Sbi-114125	Sorghum bicolor	81.40	8.00e-154	536.00
IUUC-Sre-115054	Sporisorium reilianum	86.38	2.00e-161	561.00
IUUC-Tgu-117419	Taeniopygia guttata	99.03	0.00e+00	645.00
IUUC-Tru-117531	Takifugu rubripes	96.76	0.00e+00	633.00
IUUC-Tsy-119543	Tarsius syrichta	100.00	0.00e+00	649.00
IUUC-Tni-120904	Tetraodon nigroviridis	96.44	0.00e+00	630.00
IUUC-Tca-120941	Theobroma cacao	82.45	9.00e-155	539.00
IUUC-Tre-121939	Trichoderma reesei	83.06	3.00e-158	550.00
IUUC-Tvi-122516	Trichoderma virens	83.06	1.00e-158	552.00
IUUC-Tae-124897	Triticum aestivum	81.40	1.00e-153	535.00
IUUC-Tbe-127639	Tupaia belangeri	100.00	0.00e+00	649.00
IUUC-Ttr-128718	Tursiops truncatus	99.68	0.00e+00	649.00
IUUC-Uma-129470	Ustilago maydis	86.38	2.00e-161	561.00
IUUC-Vvi-131390	Vitis vinifera	81.73	3.00e-154	537.00
IUUC-Xtr-132784	Xenopus tropicalis	99.03	0.00e+00	645.00
IUUC-Xma-133450	Xiphophorus maculatus	96.44	0.00e+00	630.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence