iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000114354.13	ENST00000418917.6	ENSP00000397182.2
ENSG00000114354.13	ENST00000490574.5	ENSP00000419960.1
ENSG00000114354.13	ENST00000620299.4	ENSP00000479981.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/PB1	PB1	17726178; 24613659

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/PB1	1.50e-17	65.2	11	89

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 2    vrvkvsykgeirsfaldlekpgkfedLlkavrt...ltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliq 82
           +++k++++++ir++ ++ ++++++++L+ ++++    + l+n+ev++kY+DedGDl+t+++++dl++a++    ++++l+l+++
   Q: 11   LIIKAQLGEDIRRIPIH-NEDITYDELVLMMQRvfrGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQ----CSRILKLTLF 89
           579**************.***************98888********************************....9******987 PP

Organism

Homo sapiens

Functional Description
(View)

Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252).

Protein Sequence
(Fasta)

MNGQLDLSGK LIIKAQLGED IRRIPIHNED ITYDELVLMM QRVFRGKLLS NDEVTIKYKD 60
EDGDLITIFD SSDLSFAIQC SRILKLTLFV NGQPRPLESS QVKYLRRELI ELRNKVNRLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCTAAATC CCGTCATCCA GTGAGAAAGC AGGGACTCTT CGGCCTAGGC AGCCGGGACC 60
CAGCCAGCCC TGCGCCTCGC GCCGTCGCGC ATGCGTCCTG GGTATGTCCA CGCGCAATAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0890--Hereditary spastic paraplegia
KW-0488--Methylation
KW-0523--Neurodegeneration
KW-0622--Neuropathy
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome

Interpro

IPR000270--PB1_dom
IPR033512--TFG

PROSITE

PS51745--PB1

Pfam

PF00564--PB1

SMART

SM00666--PB1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0042802--F:identical protein binding
GO:0004871--F:signal transducer activity
GO:0048208--P:COPII vesicle coating
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling

KEGG

hsa:10342

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000264	Aegilops tauschii	24.32	3.10e-02	31.60
IUUC-Atr-002452	Amborella trichopoda	29.31	3.10e-02	32.70
IUUC-Apl-003220	Anas platyrhynchos	90.46	2.00e-112	398.00
IUUC-Aca-004830	Anolis carolinensis	89.47	1.00e-107	382.00
IUUC-Ame-010792	Astyanax mexicanus	82.41	8.00e-49	187.00
IUUC-Bta-012950	Bos taurus	94.26	7.00e-137	480.00
IUUC-Bdi-014647	Brachypodium distachyon	24.32	4.40e-02	31.60
IUUC-Cel-018680	Caenorhabditis elegans	32.46	4.00e-11	62.80
IUUC-Cja-019530	Callithrix jacchus	98.75	1.00e-160	559.00
IUUC-Cfa-020019	Canis familiaris	97.51	3.00e-107	382.00
IUUC-Cpo-021749	Cavia porcellus	95.51	9.00e-136	476.00
IUUC-Csa-023127	Chlorocebus sabaeus	99.58	1.00e-121	429.00
IUUC-Cho-024790	Choloepus hoffmanni	93.81	2.00e-95	342.00
IUUC-Cin-025204	Ciona intestinalis	66.38	7.00e-42	164.00
IUUC-Csv-025833	Ciona savignyi	63.16	2.00e-42	165.00
IUUC-Dre-027850	Danio rerio	79.68	4.00e-75	275.00
IUUC-Dno-029244	Dasypus novemcinctus	95.01	1.00e-138	486.00
IUUC-Dor-030191	Dipodomys ordii	97.94	9.00e-108	383.00
IUUC-Eca-033719	Equus caballus	97.93	2.00e-120	425.00
IUUC-Eeu-035270	Erinaceus europaeus	96.91	2.00e-106	379.00
IUUC-Fca-035804	Felis catus	98.56	2.00e-116	412.00
IUUC-Fal-037426	Ficedula albicollis	91.39	2.00e-108	385.00
IUUC-Gmo-038472	Gadus morhua	78.30	2.00e-91	328.00
IUUC-Gga-040715	Gallus gallus	91.87	3.00e-109	388.00
IUUC-Gac-041966	Gasterosteus aculeatus	78.95	1.00e-92	332.00
IUUC-Gma-042930	Glycine max	23.39	8.00e-03	34.70
IUUC-Hvu-047138	Hordeum vulgare	37.14	6.00e-04	39.70
IUUC-Itr-048521	Ictidomys tridecemlineatus	96.51	6.00e-137	480.00
IUUC-Lch-049822	Latimeria chalumnae	77.81	1.00e-123	436.00
IUUC-Lpe-050724	Leersia perrieri	24.36	1.60e-02	33.10
IUUC-Laf-053735	Loxodonta africana	96.62	9.00e-118	416.00
IUUC-Mcc-054955	Macaca mulatta	99.75	5.00e-150	523.00
IUUC-Mtr-058408	Medicago truncatula	33.93	5.50e-02	32.00
IUUC-Mmr-061160	Microcebus murinus	98.34	3.00e-122	431.00
IUUC-Mdo-062388	Monodelphis domestica	96.27	3.00e-119	421.00
IUUC-Mmu-063730	Mus musculus	97.58	2.00e-114	405.00
IUUC-Mac-065660	Musa acuminata	36.96	7.90e-02	30.00
IUUC-Mpu-065683	Mustela putorius furo	97.93	1.00e-120	426.00
IUUC-Mlu-067270	Myotis lucifugus	96.68	1.00e-119	423.00
IUUC-Nle-069491	Nomascus leucogenys	99.00	8.00e-149	520.00
IUUC-Opr-071160	Ochotona princeps	94.74	4.00e-111	394.00
IUUC-Ont-071943	Oreochromis niloticus	81.82	1.00e-93	336.00
IUUC-Oan-073255	Ornithorhynchus anatinus	94.74	1.00e-110	393.00
IUUC-Ocu-074001	Oryctolagus cuniculus	94.28	5.00e-137	480.00
IUUC-Obr-076745	Oryza brachyantha	30.36	1.40e-01	30.00
IUUC-Ogu-078946	Oryza glumaepatula	26.25	6.40e-02	30.40
IUUC-Oga-088931	Otolemur garnettii	97.01	6.00e-157	546.00
IUUC-Oar-089653	Ovis aries	94.76	1.00e-137	483.00
IUUC-Ptr-091043	Pan troglodytes	100.00	1.00e-150	526.00
IUUC-Pan-092436	Papio anubis	98.27	3.00e-146	511.00
IUUC-Psi-093566	Pelodiscus sinensis	91.88	2.00e-109	389.00
IUUC-Pfo-096649	Poecilia formosa	82.38	8.00e-94	337.00
IUUC-Pab-098182	Pongo abelii	99.25	2.00e-149	522.00
IUUC-Pva-102449	Pteropus vampyrus	95.40	5.00e-61	228.00
IUUC-Rno-105324	Rattus norvegicus	98.04	1.00e-112	400.00
IUUC-Sha-106837	Sarcophilus harrisii	97.05	3.00e-118	418.00
IUUC-Sit-110216	Setaria italica	33.93	1.40e-01	30.80
IUUC-Sar-112937	Sorex araneus	79.10	4.00e-72	265.00
IUUC-Sbi-114334	Sorghum bicolor	25.00	6.20e-02	31.20
IUUC-Ssc-115848	Sus scrofa	93.24	2.00e-108	385.00
IUUC-Tgu-117454	Taeniopygia guttata	90.91	3.00e-108	385.00
IUUC-Tru-117548	Takifugu rubripes	85.71	4.00e-90	325.00
IUUC-Tsy-119108	Tarsius syrichta	86.28	5.00e-157	547.00
IUUC-Tni-120677	Tetraodon nigroviridis	81.90	9.00e-93	333.00
IUUC-Tca-121767	Theobroma cacao	32.14	4.50e-02	32.30
IUUC-Tae-123421	Triticum aestivum	24.32	4.20e-02	31.60
IUUC-Tur-126762	Triticum urartu	33.33	1.40e+00	26.90
IUUC-Tbe-127251	Tupaia belangeri	97.94	2.00e-107	382.00
IUUC-Ttr-129157	Tursiops truncatus	91.77	5.00e-147	514.00
IUUC-Vpa-130130	Vicugna pacos	81.30	1.00e-114	406.00
IUUC-Xtr-132566	Xenopus tropicalis	88.73	4.00e-102	364.00
IUUC-Xma-134169	Xiphophorus maculatus	83.33	1.00e-97	350.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence