iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046537

UUCD1 version

UUC-HoS-01083

Ensembl Protein ID

ENSP00000342812.3

UniProt Accession

O00507; O14601; USP9Y_HUMAN

Genbank Protein ID

AAC51833.1; CAA73940.1; CAA73941.1; ENSP00000342812

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase FAF-Y; Deubiquitinating enzyme FAF-Y; Fat facets protein-related, Y-linked; Ubiquitin thioesterase FAF-Y; Ubiquitin-specific protease 9, Y chromosome; Ubiquitin-specific-processing protease FAF-Y

Genbank Nucleotide ID

AF000986; Y13618; Y13619; AC002531

Gene Name

USP9Y; DFFRY

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000114374.12	ENST00000338981.7	ENSP00000342812.3
ENSG00000114374.12	ENST00000453031.1	ENSP00000406876.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	microRNA	TRANSFAC	TargetScan
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
InWeb_IM
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	12895410

Classification

Family	E-value	Score	Start	End
DUB/USP	1.10e-81	276.4	1559	1958

Active Site

Position(s)	Description	Evidence
1568	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
1881	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle................kkkeklneenp...............................k 43
           +GlkN g+tCYmNSv+Q+L++ip++r+ +l                 k         +                               k
   Q: 1559 VGLKNAGATCYMNSVIQQLYMIPSIRNSILAiegtgsdlhddmfgdeK---------QdsesnvdprddvfgyphqfedkpalsktedrK 1639
           6******************************99888886666555431.........233334445677777777777777777776667 PP
   S: 44   epkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeek 133
           e +  +l++lq +f +l  s+ +++ pr ++k+++ + e ++  eq+Da Ef++ l+d+l+e+l                          
   Q: 1640 EYNIGVLRHLQVIFGHLAASQLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEAL-------------------------- 1703
           7777************************************************************.......................... PP
   S: 134  kkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklkl 223
           k   ++ ++s++++g++ +q +c+ c ++++ ee+f++l++++++++     +l d+Le++ k + leg+n+y+cekc+kk++++k+l +
   Q: 1704 KALGHPAILSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQ-----NLLDSLEQYIKGDLLEGANAYHCEKCDKKVDTVKRLLI 1788
           67999******************************************.....9************************************* PP
   S: 224  kklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................peekqke.....kkkYeLiavvvH 286
           kklP+vL ++LkRf ++ e+++ +k+n+++efp+eLd+ p+++                       +     +      +kY+L++v+vH
   Q: 1789 KKLPRVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMGPYTVAgvanlerdnvnsenelieqkeqS-----DnetagGTKYRLVGVLVH 1873
           ********************************************88888888777777777654442.....1446669*********** PP
   S: 287  sGslssGHYvayvknekgk......WllfdDskVtevkeeevleetg...........................staYvlfYkrr 338
           sG++s+GHY++y+ +++gk      W++fdD  Vte+k+++ +e+++                           ++aY+lfY+++
   Q: 1874 SGQASGGHYYSYIIQRNGKddqtdhWYKFDDGDVTECKMDDDEEMKNqcfggeymgevfdhmmkrmsyrrqkrwWNAYILFYEQM 1958
           ***************7777778888*******************9999**********************************985 PP

Organism

Homo sapiens

Functional Description
(View)

May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).

Protein Sequence
(Fasta)

MTAITHGSPV GGNDSQGQVL DGQSQHLFQQ NQTSSPDSSN ENSVATPPPE EQGQGDAPPQ 60
HEDEEPAFPH TELANLDDMI NRPRWVVPVL PKGELEVLLE AAIDLSVKGL DVKSEACQRF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAATAATTG AACTTTGTTT ATTTCTCCAT ATTTTTGCAG TGGTAATTCC ATTATAAAAC 60
CTAATGAAAC AATGTTTTTA TAGATGGTGT GGAAAGACTT TTCTGGGCTC AGAGGTGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070410--F:co-SMAD binding
GO:0008234--F:cysteine-type peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030509--P:BMP signaling pathway
GO:0016477--P:cell migration
GO:0016579--P:protein deubiquitination
GO:0007283--P:spermatogenesis
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:8287

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence