iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000027669.14	ENSMUST00000155737.7	ENSMUSP00000121127.1
ENSMUSG00000027669.14	ENSMUST00000184130.6	ENSMUSP00000138886.1
ENSMUSG00000027669.14	ENSMUST00000193050.1	ENSMUSP00000141196.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.30e-38	128.8	141	176
UBD/Beta-Prp	1.40e-78	265.2	103	340

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgvl 35
           gHt+  +c++f +d+ ++++s+D t+ +WD+ tg +
   Q: 141  GHTGYLSCCRFlDDGQIITSSGDTTCALWDIETGQQ 176
           8**********988*****************99976 PP

UBD/Beta-Prp

   S: 16   vkfspdksllatgsrdgtikvwdvttgkl....lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsl 100
            +++p+++++a g+ d+   +++++t        r+l gh++  ++++f +dg  ++t+s D t  +wd++tg+++ t++gh+ +v+sl
   Q: 103  CAYAPSGNYVACGGLDNICSIYNLKTREGnvrvSRELPGHTGYLSCCRFLDDG-QIITSSGDTTCALWDIETGQQTTTFTGHSGDVMSL 190
           4678*******************99977677989999***************9.69********************************* PP
   S: 101  sfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.tgghtdsvyslsf 188
           s+sp+ +++vsG  d   ++wd++ g c +  ++gh + +n v++ p+g  +++Gs+D t+rl+dl+ ++ l      +    ++s++f
   Q: 191  SLSPDLKTFVSGACDASSKLWDIRDGMCRQ-SFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQELLLYsHDNIICGITSVAF 278
           ******************************.***********************************766654444233477899***** PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           +++g+ l++g +d    +wd  +g     l gh++ v+++ +++++  +++gs D  +riW+
   Q: 279  SKSGRLLLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
           *************************************************************8 PP

Organism

Mus musculus

Functional Description
(View)

Belongs to the WD repeat G protein beta family.

Protein Sequence
(Fasta)

MSELEQLRQE AEQLRNQIQD ARKACNDATL VQITSNMDSV GRIQMRTRRT LRGHLAKIYA 60
MHWGYDSRLL VSASQDGKLI IWDSYTTNKM HAIPLRSSWV MTCAYAPSGN YVACGGLDNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCAGCGCG CCGCGCCCGG GTCCCCGCCC CGTCCGGCGT GCAGGGCTCT GGGTGTGGTC 60
GCCGTCTTGT GTGGTGGAGC CAGCTAGCGG TTCGCGACCC GCAGCCGGGC GCCCAGCAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005834--C:heterotrimeric G-protein complex
GO:0005765--C:lysosomal membrane
GO:0043209--C:myelin sheath
GO:0003924--F:GTPase activity
GO:0032403--F:protein complex binding
GO:0004871--F:signal transducer activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0021762--P:substantia nigra development

KEGG

mmu:14696

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001727	Ailuropoda melanoleuca	96.28	0.00e+00	628.00
IUUC-Apl-003923	Anas platyrhynchos	92.59	3.00e-171	593.00
IUUC-Aca-004754	Anolis carolinensis	92.88	2.00e-172	597.00
IUUC-Bta-013200	Bos taurus	96.28	0.00e+00	629.00
IUUC-Cja-019845	Callithrix jacchus	96.28	0.00e+00	627.00
IUUC-Cfa-020395	Canis familiaris	96.28	0.00e+00	628.00
IUUC-Cpo-021376	Cavia porcellus	96.28	0.00e+00	629.00
IUUC-Csa-023295	Chlorocebus sabaeus	96.59	0.00e+00	629.00
IUUC-Cho-024766	Choloepus hoffmanni	96.00	0.00e+00	630.00
IUUC-Dno-029802	Dasypus novemcinctus	95.72	7.00e-170	589.00
IUUC-Ete-032710	Echinops telfairi	93.51	5.00e-169	586.00
IUUC-Eca-033628	Equus caballus	95.98	0.00e+00	628.00
IUUC-Eeu-034978	Erinaceus europaeus	94.51	4.00e-147	513.00
IUUC-Fal-037616	Ficedula albicollis	92.88	2.00e-172	598.00
IUUC-Gga-040249	Gallus gallus	92.88	2.00e-172	598.00
IUUC-Ggo-044954	Gorilla gorilla	96.28	0.00e+00	627.00
IUUC-Hsa-046105	Homo sapiens	96.59	0.00e+00	629.00
IUUC-Itr-048623	Ictidomys tridecemlineatus	96.58	0.00e+00	627.00
IUUC-Mcc-055787	Macaca mulatta	96.59	0.00e+00	629.00
IUUC-Mga-060050	Meleagris gallopavo	92.59	3.00e-171	593.00
IUUC-Mmr-060931	Microcebus murinus	96.59	0.00e+00	629.00
IUUC-Mdo-063055	Monodelphis domestica	92.88	2.00e-172	597.00
IUUC-Mpu-066358	Mustela putorius furo	96.28	0.00e+00	628.00
IUUC-Mlu-067328	Myotis lucifugus	95.36	1.00e-179	622.00
IUUC-Nle-069612	Nomascus leucogenys	96.59	0.00e+00	629.00
IUUC-Oan-072913	Ornithorhynchus anatinus	93.19	1.00e-173	601.00
IUUC-Ocu-074126	Oryctolagus cuniculus	96.59	0.00e+00	633.00
IUUC-Oar-089360	Ovis aries	96.59	0.00e+00	628.00
IUUC-Ptr-091437	Pan troglodytes	96.59	0.00e+00	629.00
IUUC-Pan-092195	Papio anubis	96.28	0.00e+00	627.00
IUUC-Psi-093718	Pelodiscus sinensis	92.88	2.00e-172	598.00
IUUC-Sha-106534	Sarcophilus harrisii	92.88	1.00e-172	598.00
IUUC-Tgu-117198	Taeniopygia guttata	92.88	2.00e-172	598.00
IUUC-Tsy-119354	Tarsius syrichta	94.43	2.00e-177	614.00
IUUC-Ttr-129243	Tursiops truncatus	96.59	0.00e+00	629.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence