iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000114626.17	ENST00000483857.5	ENSP00000420748.1
ENSG00000114626.17	ENST00000232744.12	ENSP00000232744.8
ENSG00000114626.17	ENST00000497162.1	ENSP00000418439.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other	BTB_Other	18429817; 18459963

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.60e-30	105.4	115	180

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd..vqpevfrallkFlYtgklde 67
           +Dv++vv g+ f++h++vL a+S +F ++++++++    k+ v+++   + p +f all++lYtg+ld+
   Q: 115  SDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKG---KSVVVLRHplINPVAFGALLQYLYTGRLDI 180
           6*****************************999985...4699999889******************96 PP

Organism

Homo sapiens

Functional Description
(View)

May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes.

Protein Sequence
(Fasta)

MDTSDLFASC RKGDVGRVRY LLEQRDVEVN VRDKWDSTPL YYACLCGHEE LVLYLLANGA 60
RCEANTFDGE RCLYGALSDP IRRALRDYKQ VTASCRRRDY YDDFLQRLLE QGIHSDVVFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGGCGGGG CGGGGCTGAG CGTGTTTACA TCCGCCGGGT GCGCGGCTTC GCCGCCCGAG 60
GTCGTTCGGC TCGGGTACCA TCCTCCGCGC CATGGACACC AGCGACCTGT TCGCCAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0251--Elongation factor
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB

Pfam

PF12796--Ank_2
PF00651--BTB

SMART

SM00248--ANK
SM00225--BTB

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:0019005--C:SCF ubiquitin ligase complex
GO:0003746--F:translation elongation factor activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

hsa:80325

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000443	Aegilops tauschii	24.07	2.00e-18	87.00
IUUC-Aml-001651	Ailuropoda melanoleuca	96.03	0.00e+00	891.00
IUUC-Atr-002929	Amborella trichopoda	24.92	1.00e-24	107.00
IUUC-Apl-003737	Anas platyrhynchos	76.74	0.00e+00	677.00
IUUC-Aca-005362	Anolis carolinensis	76.15	0.00e+00	705.00
IUUC-Aly-005560	Arabidopsis lyrata	30.42	1.00e-50	194.00
IUUC-Ath-007684	Arabidopsis thaliana	30.62	5.00e-51	195.00
IUUC-Acl-008196	Aspergillus clavatus	37.63	2.00e-23	103.00
IUUC-Afl-008477	Aspergillus flavus	29.34	1.00e-36	148.00
IUUC-Afu-009053	Aspergillus fumigatus	39.44	3.00e-23	103.00
IUUC-Ang-009825	Aspergillus niger	40.57	3.00e-24	107.00
IUUC-Aor-010132	Aspergillus oryzae	29.34	1.00e-36	148.00
IUUC-Ate-010330	Aspergillus terreus	27.54	8.00e-33	135.00
IUUC-Ame-010691	Astyanax mexicanus	65.32	5.00e-163	567.00
IUUC-Bgr-012002	Blumeria graminis	26.87	7.00e-31	129.00
IUUC-Bta-012987	Bos taurus	82.85	0.00e+00	734.00
IUUC-Bci-013710	Botrytis cinerea	34.68	4.00e-24	106.00
IUUC-Bdi-014977	Brachypodium distachyon	49.43	1.00e-17	85.10
IUUC-Bol-016212	Brassica oleracea	31.87	5.00e-51	195.00
IUUC-Bra-016855	Brassica rapa	31.51	6.00e-49	188.00
IUUC-Cja-019303	Callithrix jacchus	96.65	0.00e+00	916.00
IUUC-Cfa-020840	Canis familiaris	95.61	0.00e+00	909.00
IUUC-Cpo-021992	Cavia porcellus	93.31	0.00e+00	868.00
IUUC-Csa-023233	Chlorocebus sabaeus	98.54	0.00e+00	907.00
IUUC-Cin-025170	Ciona intestinalis	44.63	1.00e-94	339.00
IUUC-Csv-026159	Ciona savignyi	45.74	2.00e-114	406.00
IUUC-Cgl-026440	Colletotrichum gloeosporioides	27.59	2.00e-34	140.00
IUUC-Cme-027271	Cyanidioschyzon merolae	29.89	8.00e-24	105.00
IUUC-Dre-027436	Danio rerio	69.25	0.00e+00	687.00
IUUC-Dno-029837	Dasypus novemcinctus	93.10	0.00e+00	714.00
IUUC-Dse-031307	Dothistroma septosporum	25.20	2.00e-22	100.00
IUUC-Ete-032833	Echinops telfairi	88.28	0.00e+00	835.00
IUUC-Eca-034247	Equus caballus	95.82	0.00e+00	905.00
IUUC-Fca-035764	Felis catus	95.22	0.00e+00	870.00
IUUC-Fal-036709	Ficedula albicollis	76.63	0.00e+00	706.00
IUUC-Fox-037679	Fusarium oxysporum	26.09	1.00e-29	124.00
IUUC-Fso-038182	Fusarium solani	28.02	3.00e-32	133.00
IUUC-Gmo-038709	Gadus morhua	61.47	2.00e-171	595.00
IUUC-Ggr-039933	Gaeumannomyces graminis	25.69	3.00e-23	103.00
IUUC-Gga-040642	Gallus gallus	76.78	0.00e+00	718.00
IUUC-Gac-041542	Gasterosteus aculeatus	63.56	0.00e+00	631.00
IUUC-Gma-044195	Glycine max	30.97	4.00e-48	186.00
IUUC-Ggo-045298	Gorilla gorilla	98.91	0.00e+00	900.00
IUUC-Hvu-047766	Hordeum vulgare	24.04	3.00e-14	73.20
IUUC-Itr-048809	Ictidomys tridecemlineatus	86.13	0.00e+00	672.00
IUUC-Kpa-049236	Komagataella pastoris	25.31	2.00e-25	110.00
IUUC-Lch-050088	Latimeria chalumnae	70.80	0.00e+00	627.00
IUUC-Lpe-051044	Leersia perrieri	23.78	1.00e-19	91.70
IUUC-Loc-052787	Lepisosteus oculatus	70.56	0.00e+00	699.00
IUUC-Lma-053329	Leptosphaeria maculans	36.65	7.00e-23	102.00
IUUC-Laf-054099	Loxodonta africana	93.10	0.00e+00	844.00
IUUC-Mcc-055242	Macaca mulatta	97.02	0.00e+00	874.00
IUUC-Meu-056512	Macropus eugenii	78.66	0.00e+00	686.00
IUUC-Mor-057053	Magnaporthe oryzae	34.21	1.00e-18	88.20
IUUC-Mpo-057397	Magnaporthe poae	33.87	8.00e-19	89.00
IUUC-Mtr-058594	Medicago truncatula	28.88	1.00e-44	174.00
IUUC-Mga-059397	Meleagris gallopavo	76.52	0.00e+00	685.00
IUUC-Mmr-061427	Microcebus murinus	78.35	1.00e-105	376.00
IUUC-Mdo-061956	Monodelphis domestica	78.12	0.00e+00	676.00
IUUC-Mmu-063506	Mus musculus	94.14	0.00e+00	872.00
IUUC-Mac-065218	Musa acuminata	28.23	3.00e-42	166.00
IUUC-Mpu-066102	Mustela putorius furo	95.61	0.00e+00	904.00
IUUC-Mlu-067293	Myotis lucifugus	84.94	0.00e+00	769.00
IUUC-Nfi-068356	Neosartorya fischeri	30.88	6.00e-37	149.00
IUUC-Ncr-068884	Neurospora crassa	32.97	9.00e-19	89.00
IUUC-Nle-069809	Nomascus leucogenys	99.16	0.00e+00	938.00
IUUC-Opr-070691	Ochotona princeps	94.56	0.00e+00	832.00
IUUC-Ont-072314	Oreochromis niloticus	65.27	0.00e+00	649.00
IUUC-Oan-073035	Ornithorhynchus anatinus	74.29	1.00e-168	585.00
IUUC-Ocu-073868	Oryctolagus cuniculus	94.57	0.00e+00	804.00
IUUC-Oba-075254	Oryza barthii	23.97	7.00e-21	95.50
IUUC-Obr-076877	Oryza brachyantha	24.84	1.00e-22	101.00
IUUC-Ogu-078108	Oryza glumaepatula	23.97	5.00e-21	96.30
IUUC-Olo-081059	Oryza longistaminata	23.97	4.00e-21	95.90
IUUC-Oni-082081	Oryza nivara	23.97	2.00e-20	94.40
IUUC-Opu-083551	Oryza punctata	23.20	5.00e-19	89.40
IUUC-Oru-085228	Oryza rufipogon	23.97	1.00e-20	95.10
IUUC-Osa-085844	Oryza sativa	23.97	1.00e-20	95.10
IUUC-Ola-086680	Oryzias latipes	65.06	0.00e+00	646.00
IUUC-Oga-088474	Otolemur garnettii	94.98	0.00e+00	888.00
IUUC-Oar-090327	Ovis aries	82.21	6.00e-147	513.00
IUUC-Ptr-090511	Pan troglodytes	98.69	5.00e-168	583.00
IUUC-Pan-092758	Papio anubis	98.33	0.00e+00	907.00
IUUC-Psi-093772	Pelodiscus sinensis	74.35	2.00e-153	535.00
IUUC-Pma-094548	Petromyzon marinus	64.52	1.00e-155	543.00
IUUC-Pno-094959	Phaeosphaeria nodorum	30.49	2.00e-17	84.70
IUUC-Ppa-095931	Physcomitrella patens	34.16	1.00e-33	138.00
IUUC-Pfo-096211	Poecilia formosa	65.14	0.00e+00	651.00
IUUC-Pab-098352	Pongo abelii	90.17	0.00e+00	828.00
IUUC-Pop-099552	Populus trichocarpa	30.62	2.00e-46	180.00
IUUC-Pca-100943	Procavia capensis	89.29	1.00e-108	387.00
IUUC-Ppe-101944	Prunus persica	30.02	8.00e-47	181.00
IUUC-Pva-102566	Pteropus vampyrus	86.61	0.00e+00	781.00
IUUC-Pte-104208	Pyrenophora teres	34.60	1.00e-25	111.00
IUUC-Pyt-104617	Pyrenophora triticirepentis	34.08	8.00e-26	112.00
IUUC-Rno-104967	Rattus norvegicus	94.56	0.00e+00	877.00
IUUC-Sce-106261	Saccharomyces cerevisiae	27.78	6.00e-30	125.00
IUUC-Sha-107095	Sarcophilus harrisii	81.63	0.00e+00	736.00
IUUC-Sja-107811	Schizosaccharomyces japonicus	28.09	1.00e-37	151.00
IUUC-Spo-108277	Schizosaccharomyces pombe	29.72	2.00e-40	160.00
IUUC-Ssl-108583	Sclerotinia sclerotiorum	28.89	6.00e-30	125.00
IUUC-Smo-108744	Selaginella moellendorffii	29.34	7.00e-30	125.00
IUUC-Sit-110191	Setaria italica	28.67	1.00e-36	148.00
IUUC-Sly-110836	Solanum lycopersicum	28.82	6.00e-44	172.00
IUUC-Stu-112766	Solanum tuberosum	28.60	5.00e-43	169.00
IUUC-Sbi-114848	Sorghum bicolor	28.67	2.00e-37	150.00
IUUC-Ssc-115778	Sus scrofa	86.67	0.00e+00	778.00
IUUC-Tgu-117174	Taeniopygia guttata	76.78	0.00e+00	712.00
IUUC-Tru-117645	Takifugu rubripes	60.79	1.00e-171	595.00
IUUC-Tsy-119394	Tarsius syrichta	93.71	2.00e-158	551.00
IUUC-Tni-120500	Tetraodon nigroviridis	58.80	3.00e-163	568.00
IUUC-Tca-121738	Theobroma cacao	31.58	1.00e-45	177.00
IUUC-Tre-121929	Trichoderma reesei	27.92	4.00e-28	119.00
IUUC-Tvi-122627	Trichoderma virens	26.91	6.00e-33	135.00
IUUC-Tae-125436	Triticum aestivum	26.37	2.00e-35	143.00
IUUC-Tme-126911	Tuber melanosporum	25.65	5.00e-21	95.90
IUUC-Ttr-128844	Tursiops truncatus	84.10	0.00e+00	701.00
IUUC-Vda-129922	Verticillium dahliae	27.01	2.00e-31	130.00
IUUC-Vvi-131681	Vitis vinifera	27.06	8.00e-43	168.00
IUUC-Xtr-132110	Xenopus tropicalis	71.27	0.00e+00	681.00
IUUC-Xma-132990	Xiphophorus maculatus	65.90	0.00e+00	659.00
IUUC-Yli-134395	Yarrowia lipolytica	28.70	3.00e-31	129.00
IUUC-Zma-135189	Zea mays	28.30	6.00e-35	142.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence