iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000114648.11	ENST00000433449.5	ENSP00000407114.1
ENSG00000114648.11	ENST00000232766.5	ENSP00000232766.5
ENSG00000114648.11	ENST00000442272.1	ENSP00000392507.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.10e-20	73.0	38	103
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.50e-10	39.5	137	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+l++g+ +f+ah+ivLaas ++F+a+f++++ e k ++++++++++p++++al++F Y g l +
   Q: 38   CDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECK-QDEIVMQGMDPSALEALINFAYNGNLAI 103
           9*************************************.************************9865 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           + Nclg+++fA+++ c  L+daa++fi++hF
   Q: 137  PKNCLGVRQFAETMMCAVLYDAANSFIHQHF 167
           68***************************** PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MVEDGAEELE DLVHFSVSEL PSRGYGVMEE IRRQGKLCDV TLKIGDHKFS AHRIVLAASI 60
PYFHAMFTND MMECKQDEIV MQGMDPSALE ALINFAYNGN LAIDQQNVQS LLMGASFLQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGTCTAGC CGGCCGGCGA GGCCTGCGCA GTTGCAGCGG CCGGGGAAGA TGGTGGAGGA 60
CGGCGCGGAG GAGCTGGAGG ATCTGGTGCA CTTCTCCGTG TCTGAGTTGC CTAGTCGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination

KEGG

hsa:23276

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001536	Ailuropoda melanoleuca	97.56	0.00e+00	1164.00
IUUC-Apl-003270	Anas platyrhynchos	89.08	0.00e+00	986.00
IUUC-Aca-005395	Anolis carolinensis	90.27	0.00e+00	1078.00
IUUC-Bta-013481	Bos taurus	95.85	0.00e+00	1149.00
IUUC-Cel-018622	Caenorhabditis elegans	44.48	2.00e-140	492.00
IUUC-Cja-019847	Callithrix jacchus	99.30	0.00e+00	1189.00
IUUC-Cfa-020341	Canis familiaris	96.86	0.00e+00	1155.00
IUUC-Cpo-021613	Cavia porcellus	95.90	0.00e+00	1070.00
IUUC-Csa-023611	Chlorocebus sabaeus	99.48	0.00e+00	1187.00
IUUC-Cho-024605	Choloepus hoffmanni	81.27	2.00e-136	479.00
IUUC-Cin-025289	Ciona intestinalis	54.23	0.00e+00	639.00
IUUC-Dre-028248	Danio rerio	83.54	0.00e+00	1016.00
IUUC-Dno-029609	Dasypus novemcinctus	95.99	0.00e+00	1149.00
IUUC-Dor-030541	Dipodomys ordii	97.66	1.00e-151	529.00
IUUC-Dme-032107	Drosophila melanogaster	54.77	0.00e+00	652.00
IUUC-Eca-033507	Equus caballus	97.56	0.00e+00	1083.00
IUUC-Eeu-034750	Erinaceus europaeus	88.51	0.00e+00	966.00
IUUC-Fca-035731	Felis catus	97.39	0.00e+00	1165.00
IUUC-Fal-036959	Ficedula albicollis	89.89	0.00e+00	1041.00
IUUC-Gga-040166	Gallus gallus	91.71	0.00e+00	1090.00
IUUC-Ggo-044853	Gorilla gorilla	99.65	0.00e+00	1189.00
IUUC-Itr-048529	Ictidomys tridecemlineatus	96.46	0.00e+00	1056.00
IUUC-Lch-050195	Latimeria chalumnae	77.99	0.00e+00	905.00
IUUC-Loc-051787	Lepisosteus oculatus	86.22	0.00e+00	989.00
IUUC-Laf-053489	Loxodonta africana	96.69	0.00e+00	1162.00
IUUC-Mcc-055250	Macaca mulatta	98.62	0.00e+00	1181.00
IUUC-Meu-056871	Macropus eugenii	87.88	0.00e+00	1025.00
IUUC-Mga-059425	Meleagris gallopavo	91.71	0.00e+00	1085.00
IUUC-Mmr-061394	Microcebus murinus	97.24	0.00e+00	1167.00
IUUC-Mdo-062285	Monodelphis domestica	94.30	0.00e+00	1110.00
IUUC-Mmu-063975	Mus musculus	97.58	0.00e+00	1169.00
IUUC-Mpu-066369	Mustela putorius furo	97.91	0.00e+00	1166.00
IUUC-Mlu-067832	Myotis lucifugus	93.64	0.00e+00	1050.00
IUUC-Nle-069338	Nomascus leucogenys	92.01	0.00e+00	1068.00
IUUC-Opr-071035	Ochotona princeps	84.75	0.00e+00	921.00
IUUC-Ont-071440	Oreochromis niloticus	82.30	0.00e+00	967.00
IUUC-Ola-087275	Oryzias latipes	80.94	0.00e+00	955.00
IUUC-Oga-087921	Otolemur garnettii	98.26	0.00e+00	1173.00
IUUC-Oar-089968	Ovis aries	88.95	0.00e+00	1023.00
IUUC-Ptr-091272	Pan troglodytes	99.65	0.00e+00	1189.00
IUUC-Pan-092629	Papio anubis	99.65	0.00e+00	1191.00
IUUC-Psi-093456	Pelodiscus sinensis	93.06	0.00e+00	983.00
IUUC-Pma-094509	Petromyzon marinus	69.03	0.00e+00	792.00
IUUC-Pfo-096450	Poecilia formosa	79.12	0.00e+00	960.00
IUUC-Pab-097917	Pongo abelii	99.48	0.00e+00	1187.00
IUUC-Pop-099153	Populus trichocarpa	32.76	6.00e-35	142.00
IUUC-Pca-100330	Procavia capensis	97.32	2.00e-174	605.00
IUUC-Pva-103189	Pteropus vampyrus	97.91	0.00e+00	1169.00
IUUC-Pyt-104758	Pyrenophora triticirepentis	33.75	9.00e-07	47.00
IUUC-Sha-107283	Sarcophilus harrisii	94.11	0.00e+00	1073.00
IUUC-Sar-112989	Sorex araneus	95.86	0.00e+00	1061.00
IUUC-Tgu-117146	Taeniopygia guttata	81.06	0.00e+00	905.00
IUUC-Tru-118132	Takifugu rubripes	81.85	0.00e+00	947.00
IUUC-Tsy-119058	Tarsius syrichta	81.27	8.00e-138	483.00
IUUC-Tni-120892	Tetraodon nigroviridis	79.47	0.00e+00	951.00
IUUC-Tbe-127347	Tupaia belangeri	95.12	0.00e+00	1132.00
IUUC-Ttr-128343	Tursiops truncatus	74.58	0.00e+00	770.00
IUUC-Vpa-130796	Vicugna pacos	84.49	0.00e+00	972.00
IUUC-Xtr-132077	Xenopus tropicalis	82.48	0.00e+00	940.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence