iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000114650.18	ENST00000320017.10	ENSP00000324296.6
ENSG00000114650.18	ENST00000441517.6	ENSP00000416847.3
ENSG00000114650.18	ENST00000265565.9	ENSP00000265565.5
ENSG00000114650.18	ENST00000416208.5	ENSP00000409183.1
ENSG00000114650.18	ENST00000448217.2	ENSP00000415195.1
ENSG00000114650.18	ENST00000545718.2	ENSP00000438956.2
ENSG00000114650.18	ENST00000428413.5	ENSP00000401819.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-14	55.0	1117	1150

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tl.lvsGsdDgtikvWDlrtg 33
           gH++ +t +   d t+ l+sG+ Dg i +WD+ tg
   Q: 1117 GHSGAITTVYI-DqTMvLASGGQDGAICLWDVLTG 1150
           8********88.446648*************9887 PP

Organism

Homo sapiens

Functional Description
(View)

Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).

Protein Sequence
(Fasta)

MTLTERLREK ISRAFYNHGL LCASYPIPII LFTGFCILAC CYPLLKLPLP GTGPVEFTTP 60
VKDYSPPPVD SDRKQGEPTE QPEWYVGAPV AYVQQIFVKS SVFPWHKNLL AVDVFRSPLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGTCCGGT GGGAACTGGG TTTTAGGAGG AGGTATCTGA AGAATGTGTA GTGGGTCGGG 60
GGCTGGTGCG GTCAGAAGGG CCACCTCTAA TTTCTGCCTT GCATTGGTGA CTAGATCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0153--Cholesterol metabolism
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0753--Steroid metabolism
KW-1207--Sterol metabolism
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0853--WD repeat

Interpro

IPR030225--SCAP
IPR000731--SSD
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50156--SSD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12349--Sterol-sensing
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0012507--C:ER to Golgi transport vesicle membrane
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0043234--C:protein complex
GO:0015485--F:cholesterol binding
GO:0051082--F:unfolded protein binding
GO:0007568--P:aging
GO:0008203--P:cholesterol metabolic process
GO:0045541--P:negative regulation of cholesterol biosynthetic process
GO:0045716--P:positive regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0042304--P:regulation of fatty acid biosynthetic process
GO:0001666--P:response to hypoxia
GO:0032868--P:response to insulin
GO:0032933--P:SREBP signaling pathway

KEGG

hsa:22937

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001802	Ailuropoda melanoleuca	94.43	0.00e+00	1092.00
IUUC-Apl-003294	Anas platyrhynchos	76.42	0.00e+00	1726.00
IUUC-Aca-004424	Anolis carolinensis	69.92	0.00e+00	1521.00
IUUC-Bta-013478	Bos taurus	92.58	0.00e+00	2100.00
IUUC-Cel-018160	Caenorhabditis elegans	29.78	3.00e-64	240.00
IUUC-Cja-019123	Callithrix jacchus	95.54	0.00e+00	2179.00
IUUC-Cfa-021082	Canis familiaris	91.16	0.00e+00	2043.00
IUUC-Cpo-022477	Cavia porcellus	84.71	0.00e+00	1901.00
IUUC-Csa-023176	Chlorocebus sabaeus	95.07	0.00e+00	2162.00
IUUC-Cin-025490	Ciona intestinalis	38.35	1.00e-91	331.00
IUUC-Csv-026115	Ciona savignyi	37.35	1.00e-133	471.00
IUUC-Dre-028008	Danio rerio	68.27	0.00e+00	1524.00
IUUC-Dno-028887	Dasypus novemcinctus	91.46	0.00e+00	1216.00
IUUC-Dor-030467	Dipodomys ordii	92.90	0.00e+00	878.00
IUUC-Dme-032087	Drosophila melanogaster	32.88	1.00e-109	391.00
IUUC-Ete-032372	Echinops telfairi	77.55	0.00e+00	1731.00
IUUC-Eca-033896	Equus caballus	93.44	0.00e+00	2180.00
IUUC-Eeu-035099	Erinaceus europaeus	85.44	0.00e+00	1222.00
IUUC-Fca-035616	Felis catus	87.27	0.00e+00	1948.00
IUUC-Fal-037231	Ficedula albicollis	74.11	0.00e+00	1650.00
IUUC-Gmo-039439	Gadus morhua	74.28	0.00e+00	679.00
IUUC-Gac-041516	Gasterosteus aculeatus	67.46	0.00e+00	1518.00
IUUC-Itr-048879	Ictidomys tridecemlineatus	93.12	0.00e+00	2164.00
IUUC-Lch-049689	Latimeria chalumnae	70.37	0.00e+00	1646.00
IUUC-Loc-052417	Lepisosteus oculatus	52.77	5.00e-135	474.00
IUUC-Laf-053795	Loxodonta africana	90.68	0.00e+00	2100.00
IUUC-Mcc-055502	Macaca mulatta	98.12	0.00e+00	2283.00
IUUC-Mga-059805	Meleagris gallopavo	77.35	0.00e+00	1741.00
IUUC-Mmr-060997	Microcebus murinus	94.14	0.00e+00	2215.00
IUUC-Mdo-062940	Monodelphis domestica	81.08	0.00e+00	1830.00
IUUC-Mmu-063255	Mus musculus	91.95	0.00e+00	2125.00
IUUC-Mpu-066158	Mustela putorius furo	92.18	0.00e+00	2099.00
IUUC-Mlu-067201	Myotis lucifugus	88.49	0.00e+00	2051.00
IUUC-Nle-069145	Nomascus leucogenys	98.75	0.00e+00	1438.00
IUUC-Opr-070797	Ochotona princeps	88.12	0.00e+00	1971.00
IUUC-Ont-071553	Oreochromis niloticus	67.00	0.00e+00	1512.00
IUUC-Ocu-074598	Oryctolagus cuniculus	93.59	0.00e+00	2103.00
IUUC-Ola-086650	Oryzias latipes	84.23	1.00e-112	398.00
IUUC-Oar-089287	Ovis aries	85.99	0.00e+00	1115.00
IUUC-Pan-092004	Papio anubis	98.11	0.00e+00	2259.00
IUUC-Psi-093028	Pelodiscus sinensis	71.79	0.00e+00	1516.00
IUUC-Pma-094145	Petromyzon marinus	51.86	0.00e+00	1135.00
IUUC-Pfo-096320	Poecilia formosa	67.30	0.00e+00	1515.00
IUUC-Pab-097862	Pongo abelii	99.06	0.00e+00	2345.00
IUUC-Pca-100862	Procavia capensis	78.91	0.00e+00	1663.00
IUUC-Pva-103050	Pteropus vampyrus	92.71	0.00e+00	1340.00
IUUC-Rno-105852	Rattus norvegicus	92.49	0.00e+00	2150.00
IUUC-Sha-107312	Sarcophilus harrisii	81.64	0.00e+00	1846.00
IUUC-Sar-113311	Sorex araneus	89.26	0.00e+00	850.00
IUUC-Ssc-116356	Sus scrofa	92.66	0.00e+00	2151.00
IUUC-Tgu-116896	Taeniopygia guttata	61.83	6.00e-150	525.00
IUUC-Tru-118197	Takifugu rubripes	68.09	0.00e+00	1516.00
IUUC-Tni-119823	Tetraodon nigroviridis	65.24	0.00e+00	1486.00
IUUC-Ttr-129164	Tursiops truncatus	93.05	0.00e+00	2115.00
IUUC-Xtr-132819	Xenopus tropicalis	68.76	0.00e+00	1625.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence