iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063825

UUCD1 version

UUC-MuM-00478

Ensembl Protein ID

ENSMUSP00000138333.1

UniProt Accession

O88738; E9PYU6; Q69ZM5; Q8BNX0; Q8BR72; Q8BRV7; Q8C737; BIRC6_MOUSE

Genbank Protein ID

CAA76720.1; BAC30874.1; BAC32373.1; BAC35061.1; BAC37801.1; BAD32421.1

Protein Name

Baculoviral IAP repeat-containing protein 6; BIR repeat-containing ubiquitin-conjugating enzyme; RING-type E3 ubiquitin transferase BIRC6; Ubiquitin-conjugating BIR domain enzyme apollon

Genbank Nucleotide ID

Y17267; AC098726; AK045446; AK052612; AK079995; AK173143

Gene Name

Birc6; Kiaa1289

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000024073.14	ENSMUST00000180037.7	ENSMUSP00000136329.1
ENSMUSG00000024073.14	ENSMUST00000182944.7	ENSMUSP00000138732.1
ENSMUSG00000024073.14	ENSMUST00000182597.7	ENSMUSP00000138333.1
ENSMUSG00000024073.14	ENSMUST00000182133.7	ENSMUSP00000138693.1
ENSMUSG00000024073.14	ENSMUST00000183224.7	ENSMUSP00000138270.1
ENSMUSG00000024073.14	ENSMUST00000177957.7	ENSMUSP00000137114.1
ENSMUSG00000024073.14	ENSMUST00000182323.1	ENSMUSP00000138672.1
ENSMUSG00000024073.14	ENSMUST00000182845.7	ENSMUSP00000138717.1
ENSMUSG00000024073.14	ENSMUST00000182278.2	ENSMUSP00000138343.1
ENSMUSG00000024073.14	ENSMUST00000182817.1	ENSMUSP00000138349.1
ENSMUSG00000024073.14	ENSMUST00000183249.1	ENSMUSP00000138521.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.70e-34	117.8	4602	4758

Active Site

Position(s)	Description	Evidence
4691	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdpp....egisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk.....ifhPnvyen 78
           Rl++e+ +l+++ p    +++++++++e  l+ ++vli+Gp+dtpY++g+F+++++fp+dYP++PP v+++t+     +f+Pn+y++
   Q: 4602 RLAQEAVTLSTSLPlsssSSVFVRCDEE-RLDIMKVLITGPADTPYANGCFEFDVYFPQDYPSSPPLVNLETTgghsvRFNPNLYND 4687
           8999999999998877768899999999.6********************************************************* PP
   S: 79   GkvClsilk.....eeekWsp.alsvesvllsiqsll..aepnpesplneeaa...ellkknreeykkkvre 139
           GkvClsil+     +eekW+p ++s+ +vl+s+qsl+  aep++++p +e+++   + ++++re y+ ++r+
   Q: 4688 GKVCLSILNtwhgrPEEKWNPqTSSFLQVLVSVQSLIlvAEPYFNEPGYERSRgtpSGTQSSRE-YDGNIRQ 4758
           ********7788889******8899***********999***********99866555666655.9998875 PP

Organism

Mus musculus

Functional Description
(View)

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development.

Protein Sequence
(Fasta)

MVTGCGAAPP GTVTERLPSV IVLSAGRKMA AAAAEASGPS CSSAAAAAGA GAAGVSEWLV 60
LRDGCMRCDA DGLHSLSYHP ALNAILAVTS RGTIKVIDGT SGATLQASAL SAKPGGQVKC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCATGCTCCA CCCCCTGGGC TCCGGCCCCT CCTTTGGTGC GGCCCTCTCT CCCCTCCCCC 60
GCCAGCCTGC GAGCTCGCTT GGCCTGGCCG GCCTGGCGGG CGACGTTCCC TGTGCGTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0646--Protease inhibitor
KW-1185--Reference proteome
KW-0789--Thiol protease inhibitor
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR001370--BIR_rpt
IPR022103--BIRC6
IPR008979--Galactose-bd-like
IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50143--BIR_REPEAT_2
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00653--BIR
PF12356--BIRC6
PF00179--UQ_con

SMART

SM00238--BIR

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0000922--C:spindle pole
GO:0005802--C:trans-Golgi network
GO:0004869--F:cysteine-type endopeptidase inhibitor activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0051301--P:cell division
GO:0060711--P:labyrinthine layer development
GO:0007067--P:mitotic nuclear division
GO:0043066--P:negative regulation of apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0001890--P:placenta development
GO:0008284--P:positive regulation of cell proliferation
GO:0016567--P:protein ubiquitination
GO:0042127--P:regulation of cell proliferation
GO:0032465--P:regulation of cytokinesis
GO:0009966--P:regulation of signal transduction
GO:0060712--P:spongiotrophoblast layer development

KEGG

mmu:12211

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001583	Ailuropoda melanoleuca	94.68	0.00e+00	8523.00
IUUC-Atr-003108	Amborella trichopoda	42.31	9.00e-45	174.00
IUUC-Apl-004144	Anas platyrhynchos	90.24	0.00e+00	5513.00
IUUC-Aca-005257	Anolis carolinensis	88.27	0.00e+00	7924.00
IUUC-Ath-007217	Arabidopsis thaliana	37.40	1.00e-43	171.00
IUUC-Ame-011337	Astyanax mexicanus	77.17	0.00e+00	6618.00
IUUC-Bta-012501	Bos taurus	94.00	0.00e+00	8344.00
IUUC-Bdi-014931	Brachypodium distachyon	38.06	5.00e-46	179.00
IUUC-Bol-015976	Brassica oleracea	45.76	2.00e-45	176.00
IUUC-Bra-017967	Brassica rapa	45.76	9.00e-46	177.00
IUUC-Cel-018661	Caenorhabditis elegans	37.01	5.00e-81	295.00
IUUC-Cja-018746	Callithrix jacchus	94.96	0.00e+00	8446.00
IUUC-Cfa-020170	Canis familiaris	94.91	0.00e+00	8357.00
IUUC-Cpo-022138	Cavia porcellus	95.12	0.00e+00	5726.00
IUUC-Cre-022768	Chlamydomonas reinhardtii	45.25	7.00e-45	173.00
IUUC-Csa-023927	Chlorocebus sabaeus	95.12	0.00e+00	8456.00
IUUC-Cho-024890	Choloepus hoffmanni	92.69	0.00e+00	1915.00
IUUC-Cne-026995	Cryptococcus neoformans	42.21	6.00e-37	149.00
IUUC-Dre-027941	Danio rerio	78.92	0.00e+00	6944.00
IUUC-Dno-028913	Dasypus novemcinctus	93.16	0.00e+00	8314.00
IUUC-Dor-030715	Dipodomys ordii	93.57	0.00e+00	1919.00
IUUC-Dse-031232	Dothistroma septosporum	43.96	1.00e-37	152.00
IUUC-Dme-031592	Drosophila melanogaster	52.26	0.00e+00	666.00
IUUC-Ete-032587	Echinops telfairi	76.18	0.00e+00	2017.00
IUUC-Eca-033819	Equus caballus	95.05	0.00e+00	8453.00
IUUC-Eeu-034863	Erinaceus europaeus	85.83	0.00e+00	2517.00
IUUC-Fca-035505	Felis catus	92.19	0.00e+00	8158.00
IUUC-Fal-037318	Ficedula albicollis	90.46	0.00e+00	8096.00
IUUC-Gmo-039521	Gadus morhua	80.07	0.00e+00	1657.00
IUUC-Ggr-040040	Gaeumannomyces graminis	47.06	2.00e-33	138.00
IUUC-Gga-040728	Gallus gallus	90.14	0.00e+00	7997.00
IUUC-Gac-042251	Gasterosteus aculeatus	82.95	0.00e+00	1759.00
IUUC-Ggo-045562	Gorilla gorilla	93.76	0.00e+00	1565.00
IUUC-Hsa-046339	Homo sapiens	95.11	0.00e+00	8372.00
IUUC-Hvu-047441	Hordeum vulgare	46.70	8.00e-47	181.00
IUUC-Itr-048099	Ictidomys tridecemlineatus	96.23	0.00e+00	2679.00
IUUC-Lch-050164	Latimeria chalumnae	84.11	0.00e+00	7375.00
IUUC-Lpe-051294	Leersia perrieri	39.85	7.00e-47	181.00
IUUC-Loc-052800	Lepisosteus oculatus	83.86	0.00e+00	7401.00
IUUC-Laf-054034	Loxodonta africana	93.49	0.00e+00	8370.00
IUUC-Mcc-055267	Macaca mulatta	95.26	0.00e+00	8461.00
IUUC-Meu-056461	Macropus eugenii	89.73	0.00e+00	1192.00
IUUC-Mpo-057396	Magnaporthe poae	49.03	2.00e-34	141.00
IUUC-Mtr-057797	Medicago truncatula	39.11	9.00e-47	181.00
IUUC-Mga-059594	Meleagris gallopavo	89.85	0.00e+00	7575.00
IUUC-Mmr-061179	Microcebus murinus	95.46	0.00e+00	8461.00
IUUC-Mdo-062990	Monodelphis domestica	91.66	0.00e+00	8059.00
IUUC-Mac-064881	Musa acuminata	42.86	2.00e-41	163.00
IUUC-Mpu-065908	Mustela putorius furo	95.17	0.00e+00	5465.00
IUUC-Mlu-067106	Myotis lucifugus	93.85	0.00e+00	8366.00
IUUC-Nle-069347	Nomascus leucogenys	95.22	0.00e+00	8438.00
IUUC-Opr-070799	Ochotona princeps	85.68	0.00e+00	2500.00
IUUC-Ont-072046	Oreochromis niloticus	78.46	0.00e+00	6710.00
IUUC-Oan-073415	Ornithorhynchus anatinus	90.62	0.00e+00	3302.00
IUUC-Ocu-074556	Oryctolagus cuniculus	94.98	0.00e+00	8415.00
IUUC-Oba-075870	Oryza barthii	38.93	4.00e-47	182.00
IUUC-Obr-076463	Oryza brachyantha	38.43	2.00e-46	179.00
IUUC-Ogl-077040	Oryza glaberrima	39.10	2.00e-39	157.00
IUUC-Ogu-077966	Oryza glumaepatula	38.93	4.00e-47	182.00
IUUC-Oin-079561	Oryza indica	39.10	2.00e-39	156.00
IUUC-Olo-080416	Oryza longistaminata	39.47	5.00e-40	160.00
IUUC-Ome-081384	Oryza meridionalis	39.10	3.00e-39	156.00
IUUC-Oni-082326	Oryza nivara	39.08	6.00e-47	181.00
IUUC-Opu-083659	Oryza punctata	38.35	1.00e-45	177.00
IUUC-Oru-085077	Oryza rufipogon	38.93	4.00e-47	182.00
IUUC-Osa-086014	Oryza sativa	38.93	4.00e-47	182.00
IUUC-Ola-087459	Oryzias latipes	81.86	0.00e+00	2846.00
IUUC-Oga-088251	Otolemur garnettii	92.64	0.00e+00	8036.00
IUUC-Oar-090367	Ovis aries	94.44	0.00e+00	8395.00
IUUC-Ptr-091512	Pan troglodytes	95.13	0.00e+00	8418.00
IUUC-Pan-092222	Papio anubis	93.99	0.00e+00	8391.00
IUUC-Pma-094574	Petromyzon marinus	60.98	0.00e+00	2973.00
IUUC-Ppa-095592	Physcomitrella patens	40.15	3.00e-49	190.00
IUUC-Pfo-097086	Poecilia formosa	77.05	0.00e+00	6747.00
IUUC-Pab-098390	Pongo abelii	93.62	0.00e+00	8215.00
IUUC-Pop-099284	Populus trichocarpa	37.35	1.00e-41	164.00
IUUC-Pca-101036	Procavia capensis	86.72	0.00e+00	4028.00
IUUC-Pva-103053	Pteropus vampyrus	89.68	0.00e+00	3491.00
IUUC-Pte-104333	Pyrenophora teres	40.80	2.00e-43	171.00
IUUC-Pyt-104498	Pyrenophora triticirepentis	38.96	8.00e-44	172.00
IUUC-Rno-106049	Rattus norvegicus	97.47	0.00e+00	7026.00
IUUC-Sha-107483	Sarcophilus harrisii	88.58	0.00e+00	7583.00
IUUC-Smo-108915	Selaginella moellendorffii	42.59	6.00e-44	171.00
IUUC-Sly-110929	Solanum lycopersicum	38.15	6.00e-46	179.00
IUUC-Stu-112554	Solanum tuberosum	38.55	3.00e-46	180.00
IUUC-Sar-112965	Sorex araneus	83.87	0.00e+00	1754.00
IUUC-Sbi-113880	Sorghum bicolor	34.23	5.00e-44	172.00
IUUC-Ssc-115927	Sus scrofa	95.25	0.00e+00	5857.00
IUUC-Tgu-117132	Taeniopygia guttata	89.95	0.00e+00	7969.00
IUUC-Tru-118115	Takifugu rubripes	75.06	0.00e+00	6599.00
IUUC-Tsy-118899	Tarsius syrichta	91.74	0.00e+00	4914.00
IUUC-Tni-120891	Tetraodon nigroviridis	74.01	0.00e+00	6571.00
IUUC-Tae-125407	Triticum aestivum	47.25	5.00e-47	182.00
IUUC-Tur-126479	Triticum urartu	45.86	4.00e-43	169.00
IUUC-Tme-126930	Tuber melanosporum	43.05	5.00e-48	186.00
IUUC-Tbe-127630	Tupaia belangeri	91.17	0.00e+00	1501.00
IUUC-Ttr-128629	Tursiops truncatus	92.77	0.00e+00	8236.00
IUUC-Vpa-130310	Vicugna pacos	93.91	0.00e+00	8123.00
IUUC-Xtr-131861	Xenopus tropicalis	82.47	0.00e+00	7151.00
IUUC-Xma-133613	Xiphophorus maculatus	77.19	0.00e+00	6716.00
IUUC-Zma-135768	Zea mays	35.03	1.00e-44	176.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence