iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046108

Ensembl Protein ID

ENSP00000376077.2

UniProt Accession

P63165; A8MUS8; B2R4I5; P55856; Q6FGG0; Q6NZ62; Q93068; SUMO1_HUMAN

Genbank Protein ID

CAA67898.1; AAB40388.1; AAC50733.1; AAC50996.1; AAB40390.1; AAB39999.1; BAB93477.1; AAP35278.1; CAG46944.1; CAG46953.1; BAG34782.1; AAY24035.1; EAW70304.1; EAW70307.1; AAH06462.1; AAH53528.1; AAH66306.1

Protein Name

Small ubiquitin-related modifier 1; GAP-modifying protein 1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Ubiquitin-like protein UBL1

Genbank Nucleotide ID

X99586; U61397; U38784; U67122; U72722; U83117; AB062294; BT006632; CR542147; CR542156; AK311840; AC079354; CH471063; CH471063; BC006462; BC053528; BC066306

Gene Name

SUMO1; SMT3C; SMT3H3; UBL1; OK/SW-cl.43

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000116030.16	ENST00000392246.6	ENSP00000376077.2
ENSG00000116030.16	ENST00000409368.5	ENSP00000387204.1
ENSG00000116030.16	ENST00000392244.7	ENSP00000376075.3
ENSG00000116030.16	ENST00000409712.5	ENSP00000386296.1
ENSG00000116030.16	ENST00000409181.1	ENSP00000386753.1
ENSG00000116030.16	ENST00000409627.6	ENSP00000386500.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/SUMO	SUMO	9856335; 17303403

Classification

Family	E-value	Score	Start	End
ULD/UBL/SUMO	1.10e-30	107.8	20	97
ULD/UDP/UBQ/UBQ_Other	2.00e-06	29.2	28	95

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/SUMO

   S: 7    apvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
           ++++lkv gqd+se++fk+k++++lkkl+e+ Y++r+++ +ns+rf+f+gq+i++++tp+el++e+ed+ie++++++GG
   Q: 20   EYIKLKVIGQDSSEIHFKVKMTTHLKKLKES-YCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGG 97
           69*****************************.**********************************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 7    sldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekks 74
             d+se  +kv+ ++  ++LKe   +++g+p+++ r +++G+ + d++t +++g+ ++++i +++++ 
   Q: 28   GQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQT 95
           445557778899999*************************************************9875 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).

Protein Sequence
(Fasta)

MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN 60
SLRFLFEGQR IADNHTPKEL GMEEEDVIEV YQEQTGGHST V 101

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCGCGAAG CGGAAGTGAC GCGAGGCGTA GCGGAAGTTA CTGCAGCCGC GGTGTTGTGC 60
TGTGGGGAAG GGAGAAGGAT TTGTAAACCC CGGAGCGAGG TTCTGCTTAC CCGAGGCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF11976--Rad60-SLD

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0001650--C:fibrillar center
GO:0000792--C:heterochromatin
GO:0016604--C:nuclear body
GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0016607--C:nuclear speck
GO:0097165--C:nuclear stress granule
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0016605--C:PML body
GO:0031510--C:SUMO activating enzyme complex
GO:0045202--C:synapse
GO:0001741--C:XY body
GO:0019899--F:enzyme binding
GO:0035259--F:glucocorticoid receptor binding
GO:0044325--F:ion channel binding
GO:0015459--F:potassium channel regulator activity
GO:0030674--F:protein binding, bridging
GO:0008022--F:protein C-terminus binding
GO:0031386--F:protein tag
GO:0003723--F:RNA binding
GO:0044388--F:small protein activating enzyme binding
GO:0001222--F:transcription corepressor binding
GO:0008134--F:transcription factor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0071276--P:cellular response to cadmium ion
GO:0034605--P:cellular response to heat
GO:0006281--P:DNA repair
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0070911--P:global genome nucleotide-excision repair
GO:0045759--P:negative regulation of action potential
GO:1902260--P:negative regulation of delayed rectifier potassium channel activity
GO:0043392--P:negative regulation of DNA binding
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0060021--P:palate development
GO:0030578--P:PML body organization
GO:1901896--P:positive regulation of calcium-transporting ATPase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031334--P:positive regulation of protein complex assembly
GO:0090204--P:protein localization to nuclear pore
GO:0050821--P:protein stabilization
GO:0016925--P:protein sumoylation
GO:0086004--P:regulation of cardiac muscle cell contraction
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway
GO:0032880--P:regulation of protein localization
GO:0016032--P:viral process

KEGG

hsa:7341

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001056	Aegilops tauschii	41.44	5.00e-17	79.30
IUUC-Aml-001606	Ailuropoda melanoleuca	98.98	4.00e-54	202.00
IUUC-Apl-003638	Anas platyrhynchos	97.96	5.00e-53	198.00
IUUC-Aca-004710	Anolis carolinensis	96.04	5.00e-54	201.00
IUUC-Ago-007749	Ashbya gossypii	48.98	1.00e-18	84.30
IUUC-Ame-011662	Astyanax mexicanus	85.71	8.00e-45	171.00
IUUC-Bta-013491	Bos taurus	100.00	3.00e-56	209.00
IUUC-Cel-018251	Caenorhabditis elegans	65.82	2.00e-28	116.00
IUUC-Cja-019109	Callithrix jacchus	97.03	2.00e-54	203.00
IUUC-Cfa-020657	Canis familiaris	99.01	5.00e-56	208.00
IUUC-Cpo-022508	Cavia porcellus	100.00	9.00e-54	201.00
IUUC-Cre-022970	Chlamydomonas reinhardtii	46.00	1.00e-20	90.50
IUUC-Csa-023026	Chlorocebus sabaeus	99.01	7.00e-46	174.00
IUUC-Cho-024767	Choloepus hoffmanni	100.00	5.00e-39	152.00
IUUC-Cne-027072	Cryptococcus neoformans	48.48	2.00e-14	70.10
IUUC-Dre-028383	Danio rerio	86.60	5.00e-44	168.00
IUUC-Dno-029820	Dasypus novemcinctus	100.00	3.00e-56	209.00
IUUC-Ete-032782	Echinops telfairi	75.26	6.00e-35	138.00
IUUC-Eca-033958	Equus caballus	99.01	5.00e-56	208.00
IUUC-Eeu-034822	Erinaceus europaeus	100.00	4.00e-55	205.00
IUUC-Fca-035601	Felis catus	98.98	5.00e-54	201.00
IUUC-Fal-036740	Ficedula albicollis	97.96	7.00e-53	198.00
IUUC-Gmo-038847	Gadus morhua	91.18	3.00e-33	132.00
IUUC-Gga-040129	Gallus gallus	98.02	4.00e-55	205.00
IUUC-Gac-042112	Gasterosteus aculeatus	87.63	1.00e-46	177.00
IUUC-Ggo-045413	Gorilla gorilla	100.00	3.00e-56	209.00
IUUC-Itr-047968	Ictidomys tridecemlineatus	100.00	1.00e-55	206.00
IUUC-Kpa-049243	Komagataella pastoris	46.81	4.00e-13	65.90
IUUC-Lch-049881	Latimeria chalumnae	84.54	2.00e-39	152.00
IUUC-Loc-052189	Lepisosteus oculatus	90.62	6.00e-48	181.00
IUUC-Laf-053478	Loxodonta africana	98.98	1.00e-53	200.00
IUUC-Mcc-055059	Macaca mulatta	65.54	3.00e-47	180.00
IUUC-Meu-056112	Macropus eugenii	97.03	2.00e-54	204.00
IUUC-Mla-059030	Melampsora laricipopulina	40.51	2.00e-07	48.10
IUUC-Mga-060035	Meleagris gallopavo	97.96	3.00e-53	199.00
IUUC-Mmr-060903	Microcebus murinus	100.00	3.00e-56	209.00
IUUC-Mdo-062633	Monodelphis domestica	97.03	1.00e-54	204.00
IUUC-Mmu-063272	Mus musculus	100.00	3.00e-56	209.00
IUUC-Mpu-066505	Mustela putorius furo	97.96	2.00e-53	200.00
IUUC-Mlu-067991	Myotis lucifugus	97.03	9.00e-50	187.00
IUUC-Nle-069344	Nomascus leucogenys	100.00	6.00e-40	154.00
IUUC-Opr-070351	Ochotona princeps	49.50	5.00e-18	83.60
IUUC-Ont-071436	Oreochromis niloticus	87.63	1.00e-46	177.00
IUUC-Oan-072986	Ornithorhynchus anatinus	96.30	1.00e-25	107.00
IUUC-Ocu-073781	Oryctolagus cuniculus	97.03	7.00e-54	201.00
IUUC-Ola-086373	Oryzias latipes	86.60	3.00e-45	172.00
IUUC-Olu-087670	Ostreococcus lucimarinus	44.29	2.00e-16	77.00
IUUC-Oga-088024	Otolemur garnettii	89.11	3.00e-50	189.00
IUUC-Oar-089991	Ovis aries	98.02	2.00e-54	202.00
IUUC-Ptr-090688	Pan troglodytes	98.02	6.00e-55	204.00
IUUC-Pan-092204	Papio anubis	100.00	3.00e-56	209.00
IUUC-Psi-093396	Pelodiscus sinensis	97.96	4.00e-53	198.00
IUUC-Pfo-096306	Poecilia formosa	86.00	5.00e-46	176.00
IUUC-Pab-098393	Pongo abelii	100.00	3.00e-56	211.00
IUUC-Pca-100237	Procavia capensis	99.01	5.00e-54	202.00
IUUC-Pva-102353	Pteropus vampyrus	100.00	3.00e-43	166.00
IUUC-Pgr-103683	Puccinia graminis	40.74	5.00e-15	72.80
IUUC-Rno-105286	Rattus norvegicus	100.00	3.00e-56	209.00
IUUC-Sce-106231	Saccharomyces cerevisiae	47.42	4.00e-19	85.90
IUUC-Sha-106712	Sarcophilus harrisii	98.61	8.00e-39	150.00
IUUC-Sja-107710	Schizosaccharomyces japonicus	51.04	3.00e-22	96.70
IUUC-Spo-108261	Schizosaccharomyces pombe	52.08	3.00e-22	96.70
IUUC-Sit-110664	Setaria italica	30.86	1.00e-07	48.90
IUUC-Sar-113550	Sorex araneus	98.97	5.00e-53	198.00
IUUC-Sre-115172	Sporisorium reilianum	53.16	8.00e-20	87.80
IUUC-Ssc-115837	Sus scrofa	96.04	1.00e-54	204.00
IUUC-Tgu-117064	Taeniopygia guttata	97.94	1.00e-52	197.00
IUUC-Tru-117752	Takifugu rubripes	87.63	7.00e-47	178.00
IUUC-Tsy-119358	Tarsius syrichta	100.00	2.00e-40	157.00
IUUC-Tni-120621	Tetraodon nigroviridis	87.63	3.00e-46	176.00
IUUC-Tme-126902	Tuber melanosporum	45.68	1.00e-17	81.30
IUUC-Tbe-127355	Tupaia belangeri	75.26	6.00e-35	138.00
IUUC-Ttr-128166	Tursiops truncatus	98.02	5.00e-55	206.00
IUUC-Uma-129444	Ustilago maydis	53.16	3.00e-20	89.70
IUUC-Vpa-130172	Vicugna pacos	100.00	4.00e-56	209.00
IUUC-Xtr-132473	Xenopus tropicalis	93.14	1.00e-51	194.00
IUUC-Xma-133814	Xiphophorus maculatus	86.00	9.00e-47	177.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence