iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	94.34	0.00e+00	1419.00	IUUC-Hsa-046631

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (By similarity).

Protein Sequence
(Fasta)

MSARTPLPTV NERDTENHTS VDGYTETHIP PAKSSSRQNL PRCRNSITSA TDEQPHIGNY 60
RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 120

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Nucleotide Sequence
(Fasta)

TCCCCGGCGC GGCCTGCTCG CGCGCGCCCG CCCTCGCCGA AGCCCTCCGC GGCCCGCGAC 60
CCGCCGGACC CCCCGCTCGA CCCCGCTGCC CGCGCAAGAT GTCGGCGCGG ACGCCATTGC 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0446--Lipid-binding
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0879--Wnt signaling pathway

Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR033624--MARK/par1
IPR033627--MARK1
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA

PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF02149--KA1
PF00069--Pkinase
PF00627--UBA

SMART

SM00220--S_TKc
SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0070300--F:phosphatidic acid binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0001786--F:phosphatidylserine binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0050321--F:tau-protein kinase activity
GO:0030010--P:establishment of cell polarity
GO:0035556--P:intracellular signal transduction
GO:0000226--P:microtubule cytoskeleton organization
GO:0001764--P:neuron migration
GO:0006468--P:protein phosphorylation
GO:0016055--P:Wnt signaling pathway

KEGG

mmu:226778

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001559	Ailuropoda melanoleuca	94.74	0.00e+00	1420.00
IUUC-Aca-004735	Anolis carolinensis	66.47	0.00e+00	1026.00
IUUC-Ame-011737	Astyanax mexicanus	70.95	0.00e+00	1034.00
IUUC-Bta-013462	Bos taurus	94.09	0.00e+00	1380.00
IUUC-Cja-019358	Callithrix jacchus	94.09	0.00e+00	1481.00
IUUC-Cfa-020498	Canis familiaris	93.57	0.00e+00	1370.00
IUUC-Cpo-022467	Cavia porcellus	91.28	0.00e+00	1399.00
IUUC-Csa-023035	Chlorocebus sabaeus	94.21	0.00e+00	1491.00
IUUC-Dre-028387	Danio rerio	67.40	0.00e+00	994.00
IUUC-Dno-029052	Dasypus novemcinctus	67.92	0.00e+00	1009.00
IUUC-Dor-031094	Dipodomys ordii	86.29	0.00e+00	1246.00
IUUC-Ete-032429	Echinops telfairi	83.27	0.00e+00	1233.00
IUUC-Eca-033265	Equus caballus	94.47	0.00e+00	1360.00
IUUC-Fca-035360	Felis catus	89.23	0.00e+00	1302.00
IUUC-Fal-036617	Ficedula albicollis	89.34	0.00e+00	1186.00
IUUC-Gga-040502	Gallus gallus	71.66	0.00e+00	1067.00
IUUC-Gac-041559	Gasterosteus aculeatus	77.04	0.00e+00	1130.00
IUUC-Hsa-046631	Homo sapiens	94.34	0.00e+00	1492.00
IUUC-Laf-054266	Loxodonta africana	92.02	0.00e+00	1393.00
IUUC-Mcc-054650	Macaca mulatta	94.34	0.00e+00	1487.00
IUUC-Mdo-061932	Monodelphis domestica	86.86	0.00e+00	1324.00
IUUC-Mpu-065989	Mustela putorius furo	93.58	0.00e+00	1150.00
IUUC-Mlu-067700	Myotis lucifugus	92.28	0.00e+00	1308.00
IUUC-Nle-069385	Nomascus leucogenys	93.31	0.00e+00	1467.00
IUUC-Ont-071262	Oreochromis niloticus	79.45	0.00e+00	1181.00
IUUC-Oan-073352	Ornithorhynchus anatinus	89.69	0.00e+00	1373.00
IUUC-Ocu-073777	Oryctolagus cuniculus	94.59	0.00e+00	1428.00
IUUC-Oar-089313	Ovis aries	90.77	0.00e+00	1355.00
IUUC-Ptr-091421	Pan troglodytes	94.09	0.00e+00	1485.00
IUUC-Pan-092891	Papio anubis	69.82	0.00e+00	1056.00
IUUC-Psi-093307	Pelodiscus sinensis	89.46	0.00e+00	1321.00
IUUC-Pma-094666	Petromyzon marinus	68.00	0.00e+00	1033.00
IUUC-Pab-098232	Pongo abelii	94.59	0.00e+00	1495.00
IUUC-Pca-100975	Procavia capensis	81.85	0.00e+00	820.00
IUUC-Pva-102596	Pteropus vampyrus	87.50	0.00e+00	1347.00
IUUC-Rno-105027	Rattus norvegicus	97.23	0.00e+00	1440.00
IUUC-Sha-106668	Sarcophilus harrisii	88.30	0.00e+00	1310.00
IUUC-Ssc-115321	Sus scrofa	69.47	0.00e+00	958.00
IUUC-Tgu-116652	Taeniopygia guttata	89.18	0.00e+00	1386.00
IUUC-Tru-118387	Takifugu rubripes	59.93	0.00e+00	897.00
IUUC-Tsy-119138	Tarsius syrichta	81.69	0.00e+00	914.00
IUUC-Tni-120412	Tetraodon nigroviridis	78.28	0.00e+00	1156.00
IUUC-Tbe-127841	Tupaia belangeri	94.36	0.00e+00	1193.00
IUUC-Ttr-128406	Tursiops truncatus	93.86	0.00e+00	1409.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence