iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000116514.16	ENST00000373456.11	ENSP00000362555.7
ENSG00000116514.16	ENST00000356990.9	ENSP00000349482.5
ENSG00000116514.16	ENST00000235150.4	ENSP00000235150.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RBR	RBR	16709802; 23269922

Classification

Family	E-value	Score	Start	End
E3 activity/RBR	2.70e-53	181.4	119	318

Active Site

Position(s)	Description	Evidence
302	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++Cl++l++e+++ ll+C h+ C++Cl++yl+l+i+e++ + iscp  ec+e+l++++i+ ll+++ l+++ye+++l++++++d++++w
   Q: 119  CPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESR-VPISCP--ECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRW 205
           ****************************************.9*****..89*************************************** PP
   S: 91   cpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeek......eeaeskelleanskkCpkCkvyie 172
           cpapdC ++v++  +a  +kl++e+e+c++efC++Ck++wH++++C+++++++a+t + +       ++ +++  ++++k+Cp+C++yi+
   Q: 206  CPAPDCGYAVIAYGCAscPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRtkhtsgLSYGQESGPADDIKPCPRCSAYII 295
           *************999899************************************99988888888888899999*************** PP
   S: 173  k..negCnhmtCakCkaefCwlC 193
           k  +++CnhmtCa C++efCwlC
   Q: 296  KmnDGSCNHMTCAVCGCEFCWLC 318
           997889***************** PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.

Protein Sequence
(Fasta)

MGSEKDSESP RSTSLHAAAP DPKCRSGGRR RRLTLHSVFS ASARGRRARA KPQAEPPPPA 60
AQPPPAPAPA AAQGPPPEAL PAEPAAEAEA EAAAAAAEPG FDDEEAAEGG GPGAEEVECP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTCCG AGAAGGACTC CGAGTCGCCG CGCTCCACAT CGCTACATGC GGCCGCACCC 60
GACCCTAAGT GCCGCAGCGG CGGCCGGCGC CGGCGCCTCA CCTTGCACAG CGTCTTCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0391--Immunity
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00184--RING

Gene Ontology

GO:0044194--C:cytolytic granule
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002250--P:adaptive immune response
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:127544

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002183	Ailuropoda melanoleuca	94.92	0.00e+00	1070.00
IUUC-Apl-003468	Anas platyrhynchos	89.89	0.00e+00	852.00
IUUC-Aca-004324	Anolis carolinensis	87.60	0.00e+00	964.00
IUUC-Ame-011813	Astyanax mexicanus	65.97	0.00e+00	684.00
IUUC-Bta-013135	Bos taurus	95.64	0.00e+00	1117.00
IUUC-Cja-019264	Callithrix jacchus	87.86	0.00e+00	987.00
IUUC-Cpo-022502	Cavia porcellus	95.61	0.00e+00	964.00
IUUC-Cho-025032	Choloepus hoffmanni	75.73	0.00e+00	741.00
IUUC-Dre-028769	Danio rerio	67.96	0.00e+00	735.00
IUUC-Dor-030551	Dipodomys ordii	96.98	5.00e-119	421.00
IUUC-Ete-033008	Echinops telfairi	83.30	0.00e+00	803.00
IUUC-Eca-033267	Equus caballus	97.13	0.00e+00	929.00
IUUC-Fca-035520	Felis catus	96.37	0.00e+00	923.00
IUUC-Fal-037090	Ficedula albicollis	89.48	0.00e+00	761.00
IUUC-Gga-041229	Gallus gallus	87.37	0.00e+00	742.00
IUUC-Gac-041619	Gasterosteus aculeatus	67.64	0.00e+00	726.00
IUUC-Itr-048425	Ictidomys tridecemlineatus	96.14	0.00e+00	970.00
IUUC-Lch-049552	Latimeria chalumnae	83.11	0.00e+00	912.00
IUUC-Loc-051738	Lepisosteus oculatus	69.35	0.00e+00	769.00
IUUC-Laf-054252	Loxodonta africana	93.81	0.00e+00	933.00
IUUC-Meu-055920	Macropus eugenii	92.77	0.00e+00	947.00
IUUC-Mga-059587	Meleagris gallopavo	87.22	0.00e+00	796.00
IUUC-Mdo-061985	Monodelphis domestica	93.09	0.00e+00	1085.00
IUUC-Mmu-064262	Mus musculus	95.62	0.00e+00	1097.00
IUUC-Mpu-066101	Mustela putorius furo	96.38	0.00e+00	1117.00
IUUC-Mlu-067347	Myotis lucifugus	96.92	0.00e+00	930.00
IUUC-Ont-071298	Oreochromis niloticus	66.95	0.00e+00	744.00
IUUC-Oan-073219	Ornithorhynchus anatinus	89.08	0.00e+00	860.00
IUUC-Ocu-073792	Oryctolagus cuniculus	95.36	0.00e+00	892.00
IUUC-Ola-086499	Oryzias latipes	68.52	0.00e+00	751.00
IUUC-Oga-088812	Otolemur garnettii	98.64	0.00e+00	1081.00
IUUC-Oar-090353	Ovis aries	94.46	0.00e+00	981.00
IUUC-Psi-092988	Pelodiscus sinensis	90.08	0.00e+00	844.00
IUUC-Pfo-096268	Poecilia formosa	66.17	0.00e+00	743.00
IUUC-Pca-100597	Procavia capensis	96.92	0.00e+00	915.00
IUUC-Pva-102542	Pteropus vampyrus	85.04	0.00e+00	873.00
IUUC-Sha-106512	Sarcophilus harrisii	92.19	0.00e+00	1058.00
IUUC-Sar-113233	Sorex araneus	95.40	0.00e+00	889.00
IUUC-Ssc-115781	Sus scrofa	96.10	0.00e+00	1156.00
IUUC-Tgu-117384	Taeniopygia guttata	95.68	0.00e+00	773.00
IUUC-Tru-117919	Takifugu rubripes	67.71	0.00e+00	728.00
IUUC-Tsy-119275	Tarsius syrichta	93.80	0.00e+00	917.00
IUUC-Tbe-127335	Tupaia belangeri	99.73	0.00e+00	669.00
IUUC-Ttr-128554	Tursiops truncatus	95.78	0.00e+00	909.00
IUUC-Vpa-130407	Vicugna pacos	89.49	0.00e+00	917.00
IUUC-Xtr-132325	Xenopus tropicalis	84.98	0.00e+00	725.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence