iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-017769

Ensembl Protein ID

Bra004123.1-P

UniProt Accession

M4CIT9; M4CIT9_BRARP

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra004123	Bra004123.1	Bra004123.1-P

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.60e-77	261.0	2	320

Active Site

Position(s)	Description	Evidence
82	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
157	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCaty 102
           +w+++esdPg+ft+l+++  vk++ qveelysLd ++l+ + +pv+gl++lFk++   +  r          +  +d ++++ffa+qvi+N+Cat+
   Q: 2    SWCTIESDPGVFTELIQQMQVKGV-QVEELYSLDLDSLNNL-KPVYGLIFLFKWQAGVKDDR---------PT-IQDPVSNLFFANQVINNACATQ 85
           7***********************.****************.**************999998.........22.368999**************** PP
   S: 103  AllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkp 198
           A+ls lln  ++  d+G++ls lke+tk + ++ k+la++n+++++ +hns+ar+e++  +e++ ++   ++++++hf+syv+++g lyeldglk+
   Q: 86   AILSILLNSPQV--DIGPELSTLKEFTKNFPSDLKGLAINNSEAIRTAHNSFARPEPFVPEEQKTAT---KDDDVYHFISYVPVDGVLYELDGLKE 176
           ********9998..********************************************988777555...59************************ PP
   S: 199  fPldlgkkkete...elkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid................keLlkLlkdieseeek 275
            P+ lg++  ++   e+ + ++ v+   eri+ +++ eirfnlla+ ++r+ i+t+ l+ l+ +                 eL  L  ++ s +e 
   Q: 177  GPISLGPCPGDQsgiEWLQLVQPVI--QERIERYSQSEIRFNLLAVIKNRKDIYTAELKELQRQkeqmllelagaeksraGELEVLIGEVRSGIEA 270
           ********55542337888888888..******************************987777779*************99*************** PP
   S: 276  ieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveet 325
            + ++  e+ek  k+k ++ rR++ny  f++ f+k la++++l+ l e+ 
   Q: 271  VSDKIVMEEEKFMKWKTENVRRKHNYIPFLFNFLKLLAEKKQLKPLIEKA 320
           *********************************************99984 PP

Organism

Brassica rapa

Protein Sequence
(Fasta)

MSWCTIESDP GVFTELIQQM QVKGVQVEEL YSLDLDSLNN LKPVYGLIFL FKWQAGVKDD 60
RPTIQDPVSN LFFANQVINN ACATQAILSI LLNSPQVDIG PELSTLKEFT KNFPSDLKGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTTGGT GCACGATCGA GTCGGATCCT GGTACGTATG GTCTCCTCCT CATCTTCTCT 60
TGCGATGGAT AAATAATGGT GTTGGGTTAC AAGATCTCAC TAACTTGAAT TTTAAATCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0010016--P:shoot system morphogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	74.39	9.00e-141	492.00
IUUC-Aml-001866	Ailuropoda melanoleuca	49.69	8.00e-87	313.00
IUUC-Atr-002966	Amborella trichopoda	72.84	3.00e-135	474.00
IUUC-Apl-003306	Anas platyrhynchos	45.43	4.00e-80	291.00
IUUC-Aca-004763	Anolis carolinensis	49.06	3.00e-85	308.00
IUUC-Aly-005581	Arabidopsis lyrata	89.70	3.00e-158	550.00
IUUC-Ath-007283	Arabidopsis thaliana	89.09	3.00e-161	560.00
IUUC-Ago-007999	Ashbya gossypii	42.71	8.00e-31	127.00
IUUC-Acl-008231	Aspergillus clavatus	52.74	3.00e-64	238.00
IUUC-Afl-008557	Aspergillus flavus	44.16	2.00e-63	235.00
IUUC-Afu-008988	Aspergillus fumigatus	53.36	2.00e-62	232.00
IUUC-Ani-009420	Aspergillus nidulans	47.56	1.00e-65	242.00
IUUC-Ang-009859	Aspergillus niger	43.65	5.00e-61	227.00
IUUC-Aor-010145	Aspergillus oryzae	44.16	2.00e-63	235.00
IUUC-Ate-010347	Aspergillus terreus	47.67	3.00e-61	228.00
IUUC-Ame-010791	Astyanax mexicanus	50.00	5.00e-89	320.00
IUUC-Bgr-012298	Blumeria graminis	42.72	2.00e-60	225.00
IUUC-Bta-013251	Bos taurus	49.38	2.00e-86	311.00
IUUC-Bci-013786	Botrytis cinerea	41.84	5.00e-63	234.00
IUUC-Bdi-014132	Brachypodium distachyon	75.15	4.00e-136	476.00
IUUC-Bol-015611	Brassica oleracea	99.09	0.00e+00	636.00
IUUC-Cel-018604	Caenorhabditis elegans	40.73	1.00e-65	242.00
IUUC-Cja-019768	Callithrix jacchus	45.40	2.00e-81	295.00
IUUC-Cfa-020207	Canis familiaris	49.69	8.00e-87	313.00
IUUC-Cpo-021925	Cavia porcellus	47.19	4.00e-80	290.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	50.46	4.00e-85	307.00
IUUC-Csa-023958	Chlorocebus sabaeus	49.06	5.00e-86	310.00
IUUC-Cho-024928	Choloepus hoffmanni	55.41	3.00e-17	82.00
IUUC-Cin-025771	Ciona intestinalis	43.43	5.00e-71	260.00
IUUC-Csv-026149	Ciona savignyi	44.41	6.00e-75	273.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	36.94	1.00e-49	189.00
IUUC-Cne-026955	Cryptococcus neoformans	34.57	5.00e-49	187.00
IUUC-Cme-027104	Cyanidioschyzon merolae	31.55	1.00e-46	179.00
IUUC-Dre-027409	Danio rerio	49.39	4.00e-87	314.00
IUUC-Dno-028921	Dasypus novemcinctus	49.69	9.00e-87	313.00
IUUC-Dor-030891	Dipodomys ordii	39.30	2.00e-40	160.00
IUUC-Dse-031170	Dothistroma septosporum	41.52	8.00e-61	226.00
IUUC-Dme-031677	Drosophila melanogaster	48.02	1.00e-80	292.00
IUUC-Ete-032646	Echinops telfairi	45.25	8.00e-44	171.00
IUUC-Eca-033776	Equus caballus	48.50	3.00e-78	284.00
IUUC-Eeu-035305	Erinaceus europaeus	45.60	2.00e-39	155.00
IUUC-Fca-035846	Felis catus	45.82	2.00e-82	298.00
IUUC-Fal-037597	Ficedula albicollis	46.77	2.00e-73	268.00
IUUC-Fox-037670	Fusarium oxysporum	42.58	5.00e-52	197.00
IUUC-Fso-038243	Fusarium solani	42.86	3.00e-52	198.00
IUUC-Gmo-038499	Gadus morhua	45.91	9.00e-79	286.00
IUUC-Ggr-039975	Gaeumannomyces graminis	45.27	1.00e-53	202.00
IUUC-Gga-040904	Gallus gallus	49.69	1.00e-89	323.00
IUUC-Gac-042058	Gasterosteus aculeatus	49.37	2.00e-86	312.00
IUUC-Gma-043763	Glycine max	80.18	6.00e-149	519.00
IUUC-Ggo-044699	Gorilla gorilla	46.47	3.00e-75	275.00
IUUC-Hsa-046227	Homo sapiens	49.69	4.00e-87	314.00
IUUC-Hvu-047359	Hordeum vulgare	74.31	3.00e-139	487.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	45.58	6.00e-82	297.00
IUUC-Lch-049829	Latimeria chalumnae	50.00	1.00e-86	312.00
IUUC-Lpe-050899	Leersia perrieri	74.84	3.00e-130	457.00
IUUC-Loc-052264	Lepisosteus oculatus	49.22	4.00e-84	304.00
IUUC-Lma-053110	Leptosphaeria maculans	51.75	8.00e-56	210.00
IUUC-Laf-053639	Loxodonta africana	49.69	8.00e-87	313.00
IUUC-Mcc-055506	Macaca mulatta	49.06	7.00e-86	310.00
IUUC-Meu-056267	Macropus eugenii	42.48	8.00e-50	191.00
IUUC-Mor-057001	Magnaporthe oryzae	46.37	1.00e-57	216.00
IUUC-Mpo-057608	Magnaporthe poae	45.60	2.00e-37	148.00
IUUC-Mtr-057731	Medicago truncatula	76.95	2.00e-145	508.00
IUUC-Mla-059016	Melampsora laricipopulina	46.50	9.00e-45	172.00
IUUC-Mga-060178	Meleagris gallopavo	48.53	7.00e-81	293.00
IUUC-Mvi-060353	Microbotryum violaceum	38.04	3.00e-55	208.00
IUUC-Mmr-060738	Microcebus murinus	49.38	1.00e-86	312.00
IUUC-Mdo-062266	Monodelphis domestica	53.85	7.00e-62	229.00
IUUC-Mmu-063619	Mus musculus	50.00	4.00e-87	314.00
IUUC-Mac-065301	Musa acuminata	78.95	3.00e-151	527.00
IUUC-Mpu-066058	Mustela putorius furo	49.69	6.00e-87	313.00
IUUC-Mlu-067292	Myotis lucifugus	50.31	2.00e-86	311.00
IUUC-Nfi-068275	Neosartorya fischeri	41.98	2.00e-63	235.00
IUUC-Ncr-068713	Neurospora crassa	39.21	4.00e-59	221.00
IUUC-Nle-069013	Nomascus leucogenys	49.06	3.00e-86	311.00
IUUC-Opr-070628	Ochotona princeps	43.93	5.00e-76	277.00
IUUC-Ont-072688	Oreochromis niloticus	48.28	1.00e-84	305.00
IUUC-Oan-073004	Ornithorhynchus anatinus	53.64	4.00e-66	243.00
IUUC-Ocu-074303	Oryctolagus cuniculus	49.69	2.00e-86	313.00
IUUC-Oba-075002	Oryza barthii	72.64	4.00e-137	480.00
IUUC-Obr-076392	Oryza brachyantha	73.27	1.00e-133	468.00
IUUC-Ogl-077271	Oryza glaberrima	72.64	4.00e-137	480.00
IUUC-Ogu-078493	Oryza glumaepatula	72.95	4.00e-138	483.00
IUUC-Oin-080084	Oryza indica	72.95	4.00e-138	483.00
IUUC-Olo-080803	Oryza longistaminata	72.64	9.00e-138	482.00
IUUC-Ome-081146	Oryza meridionalis	72.04	1.00e-136	478.00
IUUC-Oni-082146	Oryza nivara	72.95	4.00e-138	483.00
IUUC-Opu-083633	Oryza punctata	73.58	2.00e-132	464.00
IUUC-Oru-084789	Oryza rufipogon	72.95	4.00e-138	483.00
IUUC-Osa-086196	Oryza sativa	72.95	4.00e-138	483.00
IUUC-Ola-087126	Oryzias latipes	49.37	1.00e-84	305.00
IUUC-Olu-087665	Ostreococcus lucimarinus	46.33	1.00e-73	269.00
IUUC-Oga-089140	Otolemur garnettii	45.53	7.00e-82	296.00
IUUC-Oar-090296	Ovis aries	49.84	4.00e-86	310.00
IUUC-Ptr-090566	Pan troglodytes	49.69	4.00e-87	314.00
IUUC-Pan-092052	Papio anubis	49.06	6.00e-86	310.00
IUUC-Psi-093723	Pelodiscus sinensis	47.83	4.00e-77	281.00
IUUC-Pma-094568	Petromyzon marinus	42.52	2.00e-62	231.00
IUUC-Pno-095120	Phaeosphaeria nodorum	50.00	9.00e-56	209.00
IUUC-Ppa-095761	Physcomitrella patens	69.97	9.00e-133	466.00
IUUC-Pfo-096210	Poecilia formosa	48.74	1.00e-85	308.00
IUUC-Pab-098463	Pongo abelii	49.69	3.00e-87	314.00
IUUC-Pop-099109	Populus trichocarpa	73.27	2.00e-140	491.00
IUUC-Pca-100108	Procavia capensis	53.53	2.00e-71	262.00
IUUC-Ppe-101176	Prunus persica	77.81	5.00e-144	503.00
IUUC-Pva-102629	Pteropus vampyrus	53.97	3.00e-73	268.00
IUUC-Pgr-103419	Puccinia graminis	44.49	2.00e-55	209.00
IUUC-Pte-104207	Pyrenophora teres	52.73	2.00e-39	154.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	40.73	2.00e-60	225.00
IUUC-Rno-105579	Rattus norvegicus	42.86	1.00e-73	269.00
IUUC-Sha-106894	Sarcophilus harrisii	48.24	2.00e-73	268.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	41.39	4.00e-66	244.00
IUUC-Spo-108371	Schizosaccharomyces pombe	44.68	9.00e-73	266.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	40.85	2.00e-50	192.00
IUUC-Smo-109396	Selaginella moellendorffii	72.09	1.00e-130	458.00
IUUC-Sit-110630	Setaria italica	73.03	1.00e-135	475.00
IUUC-Sly-110972	Solanum lycopersicum	79.49	1.00e-146	511.00
IUUC-Stu-112185	Solanum tuberosum	80.66	9.00e-159	552.00
IUUC-Sar-113294	Sorex araneus	55.74	1.00e-56	213.00
IUUC-Sbi-113951	Sorghum bicolor	72.42	2.00e-132	464.00
IUUC-Ssc-115501	Sus scrofa	48.23	2.00e-80	291.00
IUUC-Tgu-117152	Taeniopygia guttata	46.77	2.00e-73	268.00
IUUC-Tru-118388	Takifugu rubripes	48.74	7.00e-86	310.00
IUUC-Tsy-119109	Tarsius syrichta	49.69	4.00e-87	314.00
IUUC-Tni-120048	Tetraodon nigroviridis	48.74	3.00e-86	311.00
IUUC-Tca-121750	Theobroma cacao	77.91	3.00e-153	533.00
IUUC-Tre-122130	Trichoderma reesei	40.89	5.00e-58	217.00
IUUC-Tvi-122284	Trichoderma virens	46.54	5.00e-54	204.00
IUUC-Tae-124082	Triticum aestivum	74.92	4.00e-141	493.00
IUUC-Tur-126366	Triticum urartu	63.26	7.00e-103	367.00
IUUC-Tme-127187	Tuber melanosporum	44.66	2.00e-69	255.00
IUUC-Tbe-127619	Tupaia belangeri	42.86	1.00e-59	222.00
IUUC-Ttr-128867	Tursiops truncatus	47.37	2.00e-60	225.00
IUUC-Vda-129912	Verticillium dahliae	39.07	1.00e-56	212.00
IUUC-Vpa-130552	Vicugna pacos	54.11	6.00e-62	230.00
IUUC-Vvi-130881	Vitis vinifera	78.14	1.00e-146	511.00
IUUC-Xtr-131934	Xenopus tropicalis	50.31	5.00e-91	327.00
IUUC-Xma-133312	Xiphophorus maculatus	48.74	9.00e-86	309.00
IUUC-Yli-134487	Yarrowia lipolytica	41.28	2.00e-51	195.00
IUUC-Zma-135639	Zea mays	62.57	1.00e-122	432.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence