iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000008471.7	ENSRNOT00000090599.1	ENSRNOP00000074306.1
ENSRNOG00000008471.7	ENSRNOT00000011324.7	ENSRNOP00000011324.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-29	101.1	1541	1575
UBD/Beta-Prp	2.90e-41	142.0	1406	1611

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           H+d+v++laf ++ ++l+s+++ g ikvW+++ ++
   Q: 1541 HKDWVCALAFvPGrPMLLSACRAGFIKVWNVDNFT 1575
           ***********999****************98765 PP

UBD/Beta-Prp

   S: 49   sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp..sg.dklvsGshdrtirvwdletgqclee. 131
           s+ e +++++ +sp+g +++ +++ +++++w+l+ ++++ +l+gh   v++l++ +  ++ d +v+Gs+d +++++  + g c+   
   Q: 1406 SQGEHQINQMALSPSG-TMLYVASGNAVRIWELNRFQPIGKLTGHIGPVMCLTVTQtsNQhDLVVTGSKDHYVKMF--QLGDCVTGt 1489
           667888*********9.9999*********************************9998445***************..567777667 PP
   S: 132  ......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtg 212
                 ++ +h + + c+++++  ++l+sGs D+ ++ Wdl +++l+++   +h+d v  l+f + ++ l+s+ + g +k+w++ + 
   Q: 1490 igpthnFEPPHYDGIECLAIQG--DILFSGSRDNGIKKWDLDQQELIQQIPNAHKDWVCALAFVPGRPMLLSACRAGFIKVWNVDNF 1574
           899899999************9..9*************************999********************************** PP
   S: 213  ecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
           + + + +gh+++++ + +   ++++ ++ssD  +++W++
   Q: 1575 TPIGEIKGHDSPINAICTN--SKHIFTASSDCRVKLWNY 1611
           **************77777..****************96 PP

Organism

Rattus norvegicus

Functional Description
(View)

Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.

Protein Sequence
(Fasta)

MAGQGDCCVK VAVRIRPQLS KEKIEGCHIC TSVTPGEPQV LLGKDKAFTY DFVFDLDTWQ 60
EQIYSTCVSK LIEGCFEGYN ATVLAYGQTG AGKTYTMGTG FDTVTSEEEQ GIIPRAIAHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGTGGCGG TCCGGGTGGG AGGTGTGTGC GCGCGCGTGT GCCGCGCTGT AGGGAGCTGC 60
GGGTCTCACT GCCCGCTGTC AACGAGCTCA ACACCTCCGC GCGATGGCTG GAGAAGAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0505--Motor protein
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR019821--Kinesin_motor_CS
IPR001752--Kinesin_motor_dom
IPR027417--P-loop_NTPase
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00411--KINESIN_MOTOR_1
PS50067--KINESIN_MOTOR_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00225--Kinesin
PF00400--WD40

PRINTS

PR00380--KINESINHEAVY

SMART

SM00129--KISc
SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0031410--C:cytoplasmic vesicle
GO:0030425--C:dendrite
GO:0030426--C:growth cone
GO:0005871--C:kinesin complex
GO:0005874--C:microtubule
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003777--F:microtubule motor activity
GO:0007018--P:microtubule-based movement

KEGG

rno:289397

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001279	Ailuropoda melanoleuca	93.89	0.00e+00	2787.00
IUUC-Apl-003204	Anas platyrhynchos	87.42	0.00e+00	867.00
IUUC-Aca-004506	Anolis carolinensis	82.45	0.00e+00	1642.00
IUUC-Ame-011515	Astyanax mexicanus	75.67	0.00e+00	1469.00
IUUC-Bta-013185	Bos taurus	74.51	0.00e+00	2159.00
IUUC-Cel-018402	Caenorhabditis elegans	52.76	1.00e-152	534.00
IUUC-Cja-018844	Callithrix jacchus	91.30	0.00e+00	2789.00
IUUC-Cfa-021187	Canis familiaris	95.06	0.00e+00	2855.00
IUUC-Cpo-022444	Cavia porcellus	94.27	0.00e+00	2824.00
IUUC-Csa-023852	Chlorocebus sabaeus	95.36	0.00e+00	2875.00
IUUC-Csv-026158	Ciona savignyi	59.18	8.00e-179	621.00
IUUC-Dre-027839	Danio rerio	74.70	0.00e+00	1436.00
IUUC-Dno-030058	Dasypus novemcinctus	91.68	0.00e+00	2758.00
IUUC-Dor-030673	Dipodomys ordii	91.76	0.00e+00	2692.00
IUUC-Ete-032705	Echinops telfairi	83.21	0.00e+00	896.00
IUUC-Eca-033885	Equus caballus	93.60	0.00e+00	2774.00
IUUC-Eeu-035338	Erinaceus europaeus	80.47	0.00e+00	2173.00
IUUC-Fca-035388	Felis catus	94.82	0.00e+00	2665.00
IUUC-Fal-037044	Ficedula albicollis	86.36	0.00e+00	2685.00
IUUC-Gmo-039034	Gadus morhua	68.20	0.00e+00	1266.00
IUUC-Gac-041328	Gasterosteus aculeatus	72.73	0.00e+00	2272.00
IUUC-Ggo-045392	Gorilla gorilla	94.84	0.00e+00	2860.00
IUUC-Hsa-046713	Homo sapiens	95.42	0.00e+00	2879.00
IUUC-Itr-049068	Ictidomys tridecemlineatus	96.91	0.00e+00	1682.00
IUUC-Loc-052703	Lepisosteus oculatus	79.89	0.00e+00	2506.00
IUUC-Laf-054193	Loxodonta africana	84.76	0.00e+00	2472.00
IUUC-Mcc-055484	Macaca mulatta	93.70	0.00e+00	2828.00
IUUC-Meu-056278	Macropus eugenii	85.52	0.00e+00	1197.00
IUUC-Mga-059816	Meleagris gallopavo	83.82	0.00e+00	2573.00
IUUC-Mmr-061071	Microcebus murinus	91.88	0.00e+00	2757.00
IUUC-Mdo-062845	Monodelphis domestica	90.24	0.00e+00	2795.00
IUUC-Mmu-063967	Mus musculus	97.44	0.00e+00	2919.00
IUUC-Mpu-066448	Mustela putorius furo	93.90	0.00e+00	2856.00
IUUC-Nle-070037	Nomascus leucogenys	93.57	0.00e+00	2212.00
IUUC-Opr-070325	Ochotona princeps	89.70	0.00e+00	2623.00
IUUC-Ont-071851	Oreochromis niloticus	73.01	0.00e+00	2304.00
IUUC-Oan-073615	Ornithorhynchus anatinus	87.78	0.00e+00	2524.00
IUUC-Ocu-073855	Oryctolagus cuniculus	94.09	0.00e+00	2812.00
IUUC-Ola-086703	Oryzias latipes	73.97	0.00e+00	1475.00
IUUC-Oga-088171	Otolemur garnettii	93.20	0.00e+00	2781.00
IUUC-Oar-089693	Ovis aries	77.35	0.00e+00	1223.00
IUUC-Ptr-090535	Pan troglodytes	95.05	0.00e+00	1805.00
IUUC-Pan-091917	Papio anubis	95.00	0.00e+00	2643.00
IUUC-Psi-093752	Pelodiscus sinensis	78.06	0.00e+00	1402.00
IUUC-Pfo-096827	Poecilia formosa	69.81	0.00e+00	1351.00
IUUC-Pab-098441	Pongo abelii	95.67	0.00e+00	2892.00
IUUC-Pca-100781	Procavia capensis	95.81	0.00e+00	904.00
IUUC-Pva-103099	Pteropus vampyrus	90.64	0.00e+00	1351.00
IUUC-Sha-107097	Sarcophilus harrisii	89.46	0.00e+00	2646.00
IUUC-Ssc-115638	Sus scrofa	93.07	0.00e+00	2439.00
IUUC-Tgu-116504	Taeniopygia guttata	85.78	0.00e+00	1691.00
IUUC-Tru-118242	Takifugu rubripes	72.82	0.00e+00	2293.00
IUUC-Ttr-128824	Tursiops truncatus	89.69	0.00e+00	2254.00
IUUC-Xtr-131798	Xenopus tropicalis	64.71	0.00e+00	1889.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence