iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.40e-83	280.4	442	918

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtCY+NSvLQ+L++ +++r+++l+     l e+    ++++l+++lq lf+ l +s++ a+sp+++l+a +   + fs   qq
   Q: 442  GLINLGNTCYVNSVLQALFMASDFRHCVLR-----LTEN----NSQPLMTKLQWLFAFLEHSQRPAISPENFLSASW--TPWFSPGTQQ 519
           9*****************************.....4433....3579***************************998..677******* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           D++E+l++lld+l+ee      k+ ++ +++ k+++  + +e+ +++n + ++++F+g++ ++i cl+c nvssree f+dlsl++p  
   Q: 520  DCSEYLKYLLDRLHEEE-----KTGMRICQKLKQSSLPSPQEELPSSNATSVEKMFGGKIVTRICCLHCLNVSSREEAFTDLSLAFPPP 603
           *****************.....678888888888888889999********************************************88 PP
   S: 180  eetkke................................................................................... 185
           e + ++                                                                                   
   Q: 604  ERSRHRrlgsvmlptedvrvqeltlaprapgaqrqrkrcitgdaprtgldsegvdtigtggrsgqekvereqagkekevaedreeegtr 692
           87766689********************************************************************************* PP
   S: 186  ...........................................................slqdcLesftkeeelegenkyycekckkkq 215
                                                                      s+ d+ + f ++e+l+ en+yyce+c ++q
   Q: 693  eeekeegeekdkekekkedekekeaengkekegdslgpgthreaatppreqtcgpegsrSVLDLVNYFLSPERLTAENRYYCESCASLQ 781
           ***************************************************************************************** PP
   S: 216  eaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn.. 301
           +aek ++l++ P++Lil L Rfsf+ ++++r+ki + v++pl L l     +        + Y+L++vvvHsG s++sGHY++y+++  
   Q: 782  DAEKVVELSQGPRYLILTLLRFSFDLRTMRRRKILDDVTIPLLLRLPLAGGQ-------GQAYDLCSVVVHSGvSSESGHYYCYAREga 863
           *****************************************99999844444.......89**************************99 PP
   S: 302  ..............ekgkWllfdDskVtevkeeevleetg....staYvlfYkrr 338
                          +++W+lf+D++V+ ++ e+v + t+    +taYvlfY++r
   Q: 864  arpapvlgsterpePENQWYLFNDTRVSYSSFESVSNVTSffpkDTAYVLFYRQR 918
           999999999998888999*******************999************985 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MDKILEAVVT SSYPASVKQG LVRRVLEAAR QPLEREQCLA LLALGARLYV GGTEELPRRV 60
GCQLLHVAGR HHPDVFAEFF SARRVLRLLQ GGAGPPGARA LACVQLGLQL LPDGPAADEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCACTGCCCA GGTCCATCTA GGGTTGTGCG GAGCGGGGTG GGTGGAGTTG GACATCACAA 60
AGTAGCAGCA GCATCCCTGC GGTCTGGGAC CCCTCGGTAG GGGAGCGGAG GACCCGCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:244144

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001744	Ailuropoda melanoleuca	82.06	0.00e+00	1303.00
IUUC-Apl-004121	Anas platyrhynchos	60.82	0.00e+00	1105.00
IUUC-Aca-005070	Anolis carolinensis	65.51	4.00e-167	581.00
IUUC-Bta-012545	Bos taurus	92.02	0.00e+00	1160.00
IUUC-Cja-019731	Callithrix jacchus	92.57	0.00e+00	1169.00
IUUC-Cfa-020095	Canis familiaris	87.00	0.00e+00	1494.00
IUUC-Cpo-021961	Cavia porcellus	89.20	0.00e+00	1169.00
IUUC-Csa-023167	Chlorocebus sabaeus	91.04	0.00e+00	1163.00
IUUC-Dno-029186	Dasypus novemcinctus	81.60	0.00e+00	832.00
IUUC-Dor-030538	Dipodomys ordii	97.74	0.00e+00	978.00
IUUC-Dme-031871	Drosophila melanogaster	32.41	8.00e-46	179.00
IUUC-Ete-032512	Echinops telfairi	88.54	4.00e-105	375.00
IUUC-Eca-033279	Equus caballus	95.93	0.00e+00	912.00
IUUC-Eeu-035120	Erinaceus europaeus	71.49	0.00e+00	830.00
IUUC-Fca-035969	Felis catus	84.52	0.00e+00	1226.00
IUUC-Fal-037625	Ficedula albicollis	71.34	0.00e+00	909.00
IUUC-Gga-040767	Gallus gallus	69.01	0.00e+00	914.00
IUUC-Ggo-045323	Gorilla gorilla	90.27	0.00e+00	934.00
IUUC-Hsa-046124	Homo sapiens	92.22	0.00e+00	1156.00
IUUC-Itr-048704	Ictidomys tridecemlineatus	86.76	0.00e+00	1563.00
IUUC-Lch-049513	Latimeria chalumnae	55.61	0.00e+00	1003.00
IUUC-Laf-053999	Loxodonta africana	87.89	0.00e+00	1131.00
IUUC-Mcc-055266	Macaca mulatta	91.08	0.00e+00	1141.00
IUUC-Meu-056906	Macropus eugenii	76.64	0.00e+00	1001.00
IUUC-Mga-059595	Meleagris gallopavo	71.78	0.00e+00	889.00
IUUC-Mmr-061720	Microcebus murinus	90.12	0.00e+00	722.00
IUUC-Mdo-062167	Monodelphis domestica	75.76	0.00e+00	1005.00
IUUC-Mpu-066195	Mustela putorius furo	91.65	0.00e+00	1150.00
IUUC-Mlu-067583	Myotis lucifugus	78.13	0.00e+00	1067.00
IUUC-Opr-070454	Ochotona princeps	91.33	1.00e-160	560.00
IUUC-Ocu-074121	Oryctolagus cuniculus	85.60	0.00e+00	958.00
IUUC-Oga-088593	Otolemur garnettii	92.25	0.00e+00	1147.00
IUUC-Oar-090140	Ovis aries	91.72	0.00e+00	1145.00
IUUC-Pan-092168	Papio anubis	91.34	0.00e+00	1165.00
IUUC-Psi-093707	Pelodiscus sinensis	67.56	0.00e+00	913.00
IUUC-Pab-097614	Pongo abelii	91.52	0.00e+00	1153.00
IUUC-Pca-100683	Procavia capensis	87.03	0.00e+00	1125.00
IUUC-Pva-103146	Pteropus vampyrus	78.86	0.00e+00	1334.00
IUUC-Rno-105061	Rattus norvegicus	96.33	0.00e+00	1739.00
IUUC-Sha-106686	Sarcophilus harrisii	74.02	0.00e+00	971.00
IUUC-Tgu-117024	Taeniopygia guttata	63.78	0.00e+00	1155.00
IUUC-Tsy-119505	Tarsius syrichta	77.86	6.00e-171	594.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence