iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000118939.17	ENST00000377595.7	ENSP00000366819.3
ENSG00000118939.17	ENST00000419068.1	ENSP00000398189.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/UCH	UCH	20622874
UBD/Other/Other	UBD/Other/Other	19154770; 20042598

Classification

Family	E-value	Score	Start	End
DUB/UCH	2.80e-72	245.6	3	230

Active Site

Position(s)	Description	Evidence
95	Nucleophile	{ECO:0000269\|PubMed:19154770, ECO:0000269\|PubMed:20380862, ECO:0000269\|PubMed:9790970}
169	Proton donor	ECO:0000305}

Domain Profile

DUB/UCH

   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvig 96
           +++wl+Le++P++ +++++++g++ ++q+ ++y++dpe l+++++pv+++lllF+i+ek+e +r+++   ++++++++d++++++f+kq+i+
   Q: 3    GQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEE--EEKIKSQGQDVTSSVYFMKQTIS 92
           589*************************************************************766..5589******************* PP
   S: 97   NsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvnin 187
           N+C+t++l+++++n++dk+ ++ G+tl++++e++ ++spe++a+ l+n ++++++h++ a+++++++p+ +       +k  +hf+++v+++
   Q: 93   NACGTIGLIHAIANNKDKMhFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSID-------EKVDLHFIALVHVD 177
           ********************************************************************888.......8899********** PP
   S: 188  grlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
           g+lyeldg+kpfP+++g++++++ l+d+++v+++f+er    + de+rfn++a++a+
   Q: 178  GHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMER----DPDELRFNAIALSAA 230
           **************************************....***********9875 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

Protein Sequence
(Fasta)

MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMDPE LLSMVPRPVC AVLLLFPITE 60
KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGL IHAIANNKDK MHFESGSTLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGCATGCG TAGAACGCGA GCGCTCGGCA AGGCTCGGCT CGGAAGAGTC CAAGCGTGAG 60
GGGAGAGGGC TGTGGATTCA GATACTGTTT TTCTCCCGAA ATAGGAAATT GGCTTATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0008233--F:peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0043130--F:ubiquitin binding
GO:0030163--P:protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7347

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000360	Aegilops tauschii	44.07	2.00e-53	202.00
IUUC-Aml-001344	Ailuropoda melanoleuca	100.00	2.00e-137	481.00
IUUC-Atr-002931	Amborella trichopoda	47.49	3.00e-48	184.00
IUUC-Apl-003949	Anas platyrhynchos	87.32	9.00e-105	372.00
IUUC-Aca-004924	Anolis carolinensis	82.68	3.00e-115	407.00
IUUC-Aly-005721	Arabidopsis lyrata	50.22	4.00e-60	224.00
IUUC-Ath-006827	Arabidopsis thaliana	50.88	2.00e-60	225.00
IUUC-Ago-007950	Ashbya gossypii	35.14	2.00e-27	115.00
IUUC-Acl-008305	Aspergillus clavatus	39.56	3.00e-40	158.00
IUUC-Afl-008611	Aspergillus flavus	40.25	1.00e-43	169.00
IUUC-Afu-008945	Aspergillus fumigatus	40.68	2.00e-43	169.00
IUUC-Ani-009339	Aspergillus nidulans	40.51	5.00e-44	171.00
IUUC-Ang-009691	Aspergillus niger	38.72	3.00e-43	168.00
IUUC-Aor-009961	Aspergillus oryzae	40.25	1.00e-43	169.00
IUUC-Ate-010316	Aspergillus terreus	40.85	2.00e-44	172.00
IUUC-Ame-011157	Astyanax mexicanus	73.04	2.00e-101	362.00
IUUC-Bgr-012125	Blumeria graminis	36.71	1.00e-39	156.00
IUUC-Bta-012673	Bos taurus	99.13	2.00e-136	478.00
IUUC-Bci-013734	Botrytis cinerea	37.61	2.00e-42	165.00
IUUC-Bdi-014330	Brachypodium distachyon	45.81	2.00e-56	212.00
IUUC-Bol-015214	Brassica oleracea	52.86	1.00e-63	235.00
IUUC-Bra-017491	Brassica rapa	53.30	3.00e-63	234.00
IUUC-Cel-018302	Caenorhabditis elegans	40.09	1.00e-35	142.00
IUUC-Cfa-020371	Canis familiaris	97.37	2.00e-107	381.00
IUUC-Cpo-022036	Cavia porcellus	96.52	2.00e-131	461.00
IUUC-Cre-022599	Chlamydomonas reinhardtii	44.19	3.00e-38	151.00
IUUC-Csa-023854	Chlorocebus sabaeus	99.13	1.00e-135	475.00
IUUC-Cin-025545	Ciona intestinalis	49.78	8.00e-67	246.00
IUUC-Cgl-026409	Colletotrichum gloeosporioides	34.47	3.00e-32	132.00
IUUC-Cne-026914	Cryptococcus neoformans	35.19	2.00e-30	125.00
IUUC-Cme-027216	Cyanidioschyzon merolae	37.39	3.00e-28	118.00
IUUC-Dre-028356	Danio rerio	74.35	3.00e-103	367.00
IUUC-Dse-031461	Dothistroma septosporum	40.51	4.00e-39	154.00
IUUC-Dme-032146	Drosophila melanogaster	50.67	4.00e-62	231.00
IUUC-Eca-033220	Equus caballus	99.57	2.00e-136	477.00
IUUC-Fca-036421	Felis catus	100.00	2.00e-137	481.00
IUUC-Fal-036773	Ficedula albicollis	87.10	2.00e-106	378.00
IUUC-Fox-037830	Fusarium oxysporum	36.80	3.00e-41	161.00
IUUC-Fso-038259	Fusarium solani	36.68	2.00e-39	157.00
IUUC-Gmo-039468	Gadus morhua	68.70	3.00e-84	304.00
IUUC-Ggr-039832	Gaeumannomyces graminis	37.12	2.00e-37	149.00
IUUC-Gga-041205	Gallus gallus	85.65	7.00e-112	396.00
IUUC-Gac-041629	Gasterosteus aculeatus	68.42	6.00e-88	316.00
IUUC-Gma-043057	Glycine max	49.78	9.00e-54	203.00
IUUC-Ggo-044533	Gorilla gorilla	99.57	4.00e-136	476.00
IUUC-Hvu-047176	Hordeum vulgare	41.05	7.00e-44	170.00
IUUC-Itr-047992	Ictidomys tridecemlineatus	97.47	8.00e-91	325.00
IUUC-Kpa-049123	Komagataella pastoris	37.09	7.00e-33	133.00
IUUC-Lch-049685	Latimeria chalumnae	78.51	6.00e-110	389.00
IUUC-Lpe-051377	Leersia perrieri	45.32	3.00e-47	181.00
IUUC-Loc-051988	Lepisosteus oculatus	76.52	6.00e-106	376.00
IUUC-Lma-053316	Leptosphaeria maculans	40.26	1.00e-42	166.00
IUUC-Laf-053985	Loxodonta africana	98.27	1.00e-134	471.00
IUUC-Mcc-055888	Macaca mulatta	97.83	2.00e-132	464.00
IUUC-Mor-057271	Magnaporthe oryzae	37.12	2.00e-41	162.00
IUUC-Mpo-057343	Magnaporthe poae	32.19	3.00e-22	98.20
IUUC-Mtr-057713	Medicago truncatula	48.67	1.00e-53	202.00
IUUC-Mla-058942	Melampsora laricipopulina	45.37	2.00e-47	182.00
IUUC-Mga-059702	Meleagris gallopavo	86.85	3.00e-104	370.00
IUUC-Mvi-060249	Microbotryum violaceum	44.30	5.00e-42	164.00
IUUC-Mmr-061284	Microcebus murinus	100.00	3.00e-92	331.00
IUUC-Mdo-062639	Monodelphis domestica	79.85	1.00e-122	432.00
IUUC-Mmu-063299	Mus musculus	98.26	1.00e-135	474.00
IUUC-Mac-065075	Musa acuminata	45.85	5.00e-54	204.00
IUUC-Mpu-066769	Mustela putorius furo	100.00	2.00e-137	481.00
IUUC-Mlu-066937	Myotis lucifugus	96.96	1.00e-132	465.00
IUUC-Nfi-068320	Neosartorya fischeri	40.76	2.00e-44	172.00
IUUC-Ncr-068673	Neurospora crassa	38.96	1.00e-45	176.00
IUUC-Nle-069175	Nomascus leucogenys	100.00	2.00e-124	437.00
IUUC-Opr-070652	Ochotona princeps	100.00	3.00e-64	238.00
IUUC-Ont-072170	Oreochromis niloticus	70.61	2.00e-89	321.00
IUUC-Oan-073247	Ornithorhynchus anatinus	93.81	2.00e-59	220.00
IUUC-Ocu-074422	Oryctolagus cuniculus	98.26	8.00e-136	475.00
IUUC-Oba-075098	Oryza barthii	42.04	3.00e-50	191.00
IUUC-Obr-076041	Oryza brachyantha	45.18	6.00e-55	206.00
IUUC-Ogl-076980	Oryza glaberrima	45.61	1.00e-54	206.00
IUUC-Ogu-078978	Oryza glumaepatula	38.74	9.00e-48	183.00
IUUC-Oin-079285	Oryza indica	41.59	2.00e-49	189.00
IUUC-Olo-080671	Oryza longistaminata	42.04	1.00e-49	189.00
IUUC-Ome-081428	Oryza meridionalis	41.15	2.00e-48	185.00
IUUC-Oni-082406	Oryza nivara	42.04	3.00e-50	191.00
IUUC-Opu-083305	Oryza punctata	42.04	9.00e-49	186.00
IUUC-Oru-084969	Oryza rufipogon	42.04	3.00e-50	191.00
IUUC-Osa-085830	Oryza sativa	45.61	1.00e-54	206.00
IUUC-Ola-086893	Oryzias latipes	68.42	1.00e-85	309.00
IUUC-Olu-087858	Ostreococcus lucimarinus	44.93	1.00e-52	199.00
IUUC-Oga-088055	Otolemur garnettii	99.57	4.00e-136	476.00
IUUC-Oar-090319	Ovis aries	98.70	6.00e-136	476.00
IUUC-Pan-092714	Papio anubis	98.70	9.00e-135	472.00
IUUC-Psi-094036	Pelodiscus sinensis	86.64	4.00e-106	377.00
IUUC-Pma-094412	Petromyzon marinus	64.94	4.00e-55	206.00
IUUC-Pno-094997	Phaeosphaeria nodorum	36.22	8.00e-35	140.00
IUUC-Ppa-095519	Physcomitrella patens	51.11	3.00e-64	238.00
IUUC-Pfo-096182	Poecilia formosa	67.83	2.00e-88	318.00
IUUC-Pab-098216	Pongo abelii	100.00	4.00e-83	299.00
IUUC-Pop-099282	Populus trichocarpa	49.12	8.00e-54	203.00
IUUC-Ppe-101332	Prunus persica	48.23	6.00e-56	210.00
IUUC-Pgr-103430	Puccinia graminis	47.48	7.00e-51	193.00
IUUC-Ptt-103955	Puccinia triticina	49.14	2.00e-51	195.00
IUUC-Pte-104414	Pyrenophora teres	38.89	1.00e-39	156.00
IUUC-Pyt-104753	Pyrenophora triticirepentis	34.03	8.00e-35	140.00
IUUC-Rno-105096	Rattus norvegicus	97.39	2.00e-134	471.00
IUUC-Sce-106412	Saccharomyces cerevisiae	36.08	4.00e-28	118.00
IUUC-Sha-106677	Sarcophilus harrisii	94.01	1.00e-121	428.00
IUUC-Sja-107753	Schizosaccharomyces japonicus	30.95	3.00e-26	111.00
IUUC-Spo-108322	Schizosaccharomyces pombe	31.00	4.00e-26	111.00
IUUC-Ssl-108641	Sclerotinia sclerotiorum	37.61	1.00e-38	153.00
IUUC-Smo-108914	Selaginella moellendorffii	49.14	4.00e-54	204.00
IUUC-Sit-110163	Setaria italica	47.41	1.00e-55	209.00
IUUC-Sly-111613	Solanum lycopersicum	49.78	2.00e-62	231.00
IUUC-Stu-112526	Solanum tuberosum	50.88	7.00e-58	216.00
IUUC-Sbi-114545	Sorghum bicolor	46.72	2.00e-53	202.00
IUUC-Sre-114961	Sporisorium reilianum	42.49	2.00e-40	159.00
IUUC-Ssc-115255	Sus scrofa	97.64	7.00e-123	432.00
IUUC-Tgu-117003	Taeniopygia guttata	86.09	3.00e-111	394.00
IUUC-Tru-118330	Takifugu rubripes	62.84	8.00e-69	254.00
IUUC-Tsy-119488	Tarsius syrichta	98.25	3.00e-63	234.00
IUUC-Tni-120042	Tetraodon nigroviridis	64.13	1.00e-70	261.00
IUUC-Tca-120976	Theobroma cacao	47.79	4.00e-56	211.00
IUUC-Tre-122149	Trichoderma reesei	38.70	2.00e-43	169.00
IUUC-Tvi-122450	Trichoderma virens	38.70	2.00e-43	168.00
IUUC-Tae-122693	Triticum aestivum	45.22	7.00e-54	204.00
IUUC-Tur-126250	Triticum urartu	44.07	4.00e-53	201.00
IUUC-Tme-126961	Tuber melanosporum	37.02	4.00e-36	144.00
IUUC-Uma-129382	Ustilago maydis	41.38	3.00e-43	168.00
IUUC-Vda-129678	Verticillium dahliae	32.07	6.00e-32	130.00
IUUC-Vpa-130783	Vicugna pacos	99.13	1.00e-63	236.00
IUUC-Vvi-131661	Vitis vinifera	48.03	3.00e-57	214.00
IUUC-Xtr-132428	Xenopus tropicalis	74.35	8.00e-107	379.00
IUUC-Xma-134245	Xiphophorus maculatus	67.11	3.00e-88	317.00
IUUC-Yli-134570	Yarrowia lipolytica	35.90	1.00e-36	146.00
IUUC-Zma-134740	Zea mays	45.85	4.00e-55	207.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence