iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000119682.16	ENST00000356357.8	ENSP00000348714.4
ENSG00000119682.16	ENST00000555330.5	ENSP00000450557.1
ENSG00000119682.16	ENST00000481010.6	ENSP00000450912.1
ENSG00000119682.16	ENST00000490805.2	ENSP00000451710.1
ENSG00000119682.16	ENST00000553411.5	ENSP00000451375.1
ENSG00000119682.16	ENST00000553279.5	ENSP00000452456.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	23479728

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	1.30e-101	342.0	485	822

Active Site

Position(s)	Description	Evidence
790	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104, ECO:0000269\|PubMed:23479728}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg.......r 86
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++++lf ++s+n+++ ++pnp++  +   +lk++ef+Grl+gk+l+++       +
   Q: 485  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFtRFSDNNQALVHPNPNRPAH--LRLKMYEFAGRLVGKCLYESslggaykQ 574
           7999**************************************888999***********975..9******************99999999* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++ +  k++eL++gG+++pVtn+Nk  Y +l+
   Q: 575  LVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLL 663
           **********************************99****99...9****9****9999999****************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsseerkafLqFv 268
           ++yrl +++ke+ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v++++++ee +++LqF+
   Q: 664  AQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAvVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFT 755
           ********************************************************555788999*************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 756  TGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGcEGFGM 822
           ***************99555555.**************************************9***97 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.

Protein Sequence
(Fasta)

MFYVIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC 60
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAGCCCGGA AGCGGAAACT CCTTGGGGAA AGGGCAATCC CCCGAGCCGG TTCCCAGGCC 60
GGGTGGAGAC CAACTCTGGG GTCTGTTGGT GGGAGAGTGG GGAGCCCGTC TTCTGCTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:9870

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	97.93	0.00e+00	1648.00
IUUC-Apl-004071	Anas platyrhynchos	90.89	0.00e+00	1472.00
IUUC-Aca-005218	Anolis carolinensis	91.26	0.00e+00	1501.00
IUUC-Ame-011871	Astyanax mexicanus	79.95	0.00e+00	1389.00
IUUC-Bta-012978	Bos taurus	97.21	0.00e+00	1640.00
IUUC-Cja-019081	Callithrix jacchus	99.64	0.00e+00	1673.00
IUUC-Cfa-020736	Canis familiaris	95.37	0.00e+00	1548.00
IUUC-Cpo-021581	Cavia porcellus	97.45	0.00e+00	1639.00
IUUC-Csa-024189	Chlorocebus sabaeus	99.16	0.00e+00	949.00
IUUC-Cho-024751	Choloepus hoffmanni	96.60	0.00e+00	1558.00
IUUC-Cin-025773	Ciona intestinalis	42.64	5.00e-149	521.00
IUUC-Csv-026090	Ciona savignyi	40.57	3.00e-173	602.00
IUUC-Dre-027788	Danio rerio	80.44	0.00e+00	1393.00
IUUC-Dno-030022	Dasypus novemcinctus	97.81	0.00e+00	1644.00
IUUC-Dme-031577	Drosophila melanogaster	47.37	0.00e+00	729.00
IUUC-Ete-032402	Echinops telfairi	95.24	0.00e+00	1559.00
IUUC-Eca-033908	Equus caballus	98.91	0.00e+00	1661.00
IUUC-Eeu-034869	Erinaceus europaeus	98.49	0.00e+00	928.00
IUUC-Fca-036023	Felis catus	97.93	0.00e+00	1646.00
IUUC-Fal-037477	Ficedula albicollis	91.62	0.00e+00	1532.00
IUUC-Gmo-039197	Gadus morhua	80.44	0.00e+00	1368.00
IUUC-Gga-040704	Gallus gallus	91.37	0.00e+00	1522.00
IUUC-Gac-041511	Gasterosteus aculeatus	79.10	0.00e+00	1373.00
IUUC-Ggo-044527	Gorilla gorilla	96.48	0.00e+00	1600.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	97.93	0.00e+00	1650.00
IUUC-Lch-049772	Latimeria chalumnae	76.91	0.00e+00	1246.00
IUUC-Loc-052541	Lepisosteus oculatus	81.70	0.00e+00	1400.00
IUUC-Laf-053852	Loxodonta africana	97.69	0.00e+00	1639.00
IUUC-Mcc-054759	Macaca mulatta	100.00	0.00e+00	863.00
IUUC-Meu-056247	Macropus eugenii	78.19	0.00e+00	845.00
IUUC-Mga-060161	Meleagris gallopavo	90.53	0.00e+00	1503.00
IUUC-Mmr-061447	Microcebus murinus	98.30	0.00e+00	1650.00
IUUC-Mdo-062110	Monodelphis domestica	94.78	0.00e+00	1543.00
IUUC-Mmu-064349	Mus musculus	97.21	0.00e+00	1642.00
IUUC-Mpu-065824	Mustela putorius furo	97.93	0.00e+00	1637.00
IUUC-Mlu-067729	Myotis lucifugus	97.81	0.00e+00	1614.00
IUUC-Nle-069721	Nomascus leucogenys	99.27	0.00e+00	1654.00
IUUC-Opr-070189	Ochotona princeps	97.67	0.00e+00	1632.00
IUUC-Ont-072122	Oreochromis niloticus	80.92	0.00e+00	1370.00
IUUC-Oan-072700	Ornithorhynchus anatinus	84.43	0.00e+00	1233.00
IUUC-Ocu-074057	Oryctolagus cuniculus	97.93	0.00e+00	1645.00
IUUC-Ola-087492	Oryzias latipes	79.25	0.00e+00	1372.00
IUUC-Oga-088084	Otolemur garnettii	98.42	0.00e+00	1648.00
IUUC-Oar-090354	Ovis aries	97.54	0.00e+00	1621.00
IUUC-Ptr-091456	Pan troglodytes	99.76	0.00e+00	1674.00
IUUC-Pan-092596	Papio anubis	98.54	0.00e+00	1644.00
IUUC-Psi-092942	Pelodiscus sinensis	92.59	0.00e+00	1533.00
IUUC-Pma-094662	Petromyzon marinus	60.95	0.00e+00	755.00
IUUC-Pfo-096838	Poecilia formosa	80.68	0.00e+00	1353.00
IUUC-Pab-097849	Pongo abelii	99.51	0.00e+00	1671.00
IUUC-Pca-100498	Procavia capensis	95.79	0.00e+00	941.00
IUUC-Pva-102599	Pteropus vampyrus	97.93	0.00e+00	1627.00
IUUC-Rno-105776	Rattus norvegicus	97.69	0.00e+00	1634.00
IUUC-Sha-106699	Sarcophilus harrisii	94.65	0.00e+00	1545.00
IUUC-Sar-113621	Sorex araneus	96.06	0.00e+00	1591.00
IUUC-Ssc-115742	Sus scrofa	97.93	0.00e+00	1649.00
IUUC-Tgu-116490	Taeniopygia guttata	91.13	0.00e+00	1530.00
IUUC-Tru-117679	Takifugu rubripes	79.95	0.00e+00	1360.00
IUUC-Tsy-119607	Tarsius syrichta	94.06	0.00e+00	1144.00
IUUC-Tni-120376	Tetraodon nigroviridis	76.66	0.00e+00	1282.00
IUUC-Tbe-127348	Tupaia belangeri	67.89	0.00e+00	652.00
IUUC-Ttr-128786	Tursiops truncatus	94.29	0.00e+00	1576.00
IUUC-Vpa-130180	Vicugna pacos	97.29	0.00e+00	1309.00
IUUC-Xtr-132631	Xenopus tropicalis	68.12	0.00e+00	1147.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence