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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046435
Ensembl Protein ID ENSP00000240123.7
UniProt Accession O60504; Q5BJE4; Q6NX54; Q96FY4; Q9UQE4; VINEX_HUMAN
Genbank Protein ID AAD32304.1; AAC09244.1; EAW63675.1; AAH67260.2; AAH91514.1; AAH10146.1
Protein Name Vinexin; SH3-containing adapter molecule 1; Sorbin and SH3 domain-containing protein 3
Genbank Nucleotide ID AF064807; AF037261; AC037459; BC067260; BC091514; BC010146
Gene Name SORBS3; SCAM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000120896.13 ENST00000240123.11 ENSP00000240123.7
ENSG00000120896.13 ENST00000517500.5 ENSP00000429723.1
ENSG00000120896.13 ENST00000520563.3 ENSP00000428102.1
ENSG00000120896.13 ENST00000523348.1 ENSP00000428678.1
ENSG00000120896.13 ENST00000517962.1 ENSP00000428327.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosSNPPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.70e-39 134.6 618 671
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +++y+y +qn+deL+l++Gd v+v+  ++ d gW +gv+  ++k G fP n+v+ +
   Q: 618  RAMYQYRPQNEDELELREGDRVDVM--QQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
           699*********************9..88999*********************875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with DLG5 through its third SH3 domain (By similarity). Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with INPPL1/SHIP2, SAFB2, SOCS7 and SRCIN1. Interacts with FASLG. Interacts with MAPK1/ERK2 (By similarity).
 Interacts with DLG5 through its third SH3 domain (By similarity). Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with INPPL1/SHIP2, SAFB2, SOCS7 and SRCIN1. Interacts with FASLG. Interacts with MAPK1/ERK2 (By similarity).
Protein Sequence
(Fasta)
MQGPPRSLRA GLSLDDFIPG HLQSHIGSSS RGTRVPVIRN GGSNTLNFQF HDPAPRTVCN 60
GGYTPRRDAS QHPDPAWYQT WPGPGSKPSA STKIPASQHT QNWSATWTKD SKRRDKRWVK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046435|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCAGAAAA GATGGCAGAG GGAGGGTGAA CCCAGGGCCC ATCTGTGGGT ATGGGCTCCA 60
ATTTCCTAAA TTGTTTGTGG TTATAACCAT GGCTTCCACC TTGTCTGGCA CCGGGTCCAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046435|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
Interpro

IPR001452--SH3_domain
IPR003127--SoHo_dom
IPR028510--Vinexin
PROSITE

PS50002--SH3
PS50831--SOHO
Pfam

PF00018--SH3_1
PF14604--SH3_9
PF02208--Sorb
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
SM00459--Sorb
Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0005634--C:nucleus
GO:0005200--F:structural constituent of cytoskeleton
GO:0017166--F:vinculin binding
GO:0007015--P:actin filament organization
GO:0007155--P:cell adhesion
GO:0031589--P:cell-substrate adhesion
GO:0006936--P:muscle contraction
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051495--P:positive regulation of cytoskeleton organization
GO:0043410--P:positive regulation of MAPK cascade
GO:0051496--P:positive regulation of stress fiber assembly
KEGG hsa:10174
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001334 Ailuropoda melanoleuca 81.02 0.00e+00 1011.00
IUUC-Aca-004742 Anolis carolinensis 66.19 1.00e-98 352.00
IUUC-Ame-011484 Astyanax mexicanus 66.43 2.00e-54 207.00
IUUC-Bta-013006 Bos taurus 81.07 0.00e+00 991.00
IUUC-Cja-018889 Callithrix jacchus 91.21 0.00e+00 1157.00
IUUC-Cfa-020116 Canis familiaris 72.84 0.00e+00 916.00
IUUC-Cpo-022410 Cavia porcellus 75.66 0.00e+00 922.00
IUUC-Csa-023880 Chlorocebus sabaeus 95.08 0.00e+00 1157.00
IUUC-Dor-031099 Dipodomys ordii 80.30 0.00e+00 1018.00
IUUC-Ete-033119 Echinops telfairi 80.08 4.00e-100 358.00
IUUC-Eca-033308 Equus caballus 80.64 0.00e+00 1046.00
IUUC-Eeu-034908 Erinaceus europaeus 73.24 0.00e+00 656.00
IUUC-Fca-035613 Felis catus 77.63 0.00e+00 964.00
IUUC-Ggo-045404 Gorilla gorilla 93.86 0.00e+00 1213.00
IUUC-Itr-048874 Ictidomys tridecemlineatus 80.43 0.00e+00 1018.00
IUUC-Lch-049463 Latimeria chalumnae 59.72 3.00e-94 338.00
IUUC-Loc-052576 Lepisosteus oculatus 42.45 3.00e-71 263.00
IUUC-Laf-053952 Loxodonta africana 80.32 0.00e+00 1022.00
IUUC-Mcc-055482 Macaca mulatta 95.53 0.00e+00 1176.00
IUUC-Meu-056517 Macropus eugenii 59.72 3.00e-179 622.00
IUUC-Mvi-060304 Microbotryum violaceum 36.05 1.00e-19 91.70
IUUC-Mmr-061231 Microcebus murinus 86.31 0.00e+00 1086.00
IUUC-Mdo-061965 Monodelphis domestica 60.17 0.00e+00 665.00
IUUC-Mmu-063208 Mus musculus 79.36 0.00e+00 1038.00
IUUC-Mpu-066398 Mustela putorius furo 82.21 0.00e+00 1056.00
IUUC-Mlu-067369 Myotis lucifugus 70.48 0.00e+00 863.00
IUUC-Nle-069995 Nomascus leucogenys 96.13 0.00e+00 1195.00
IUUC-Opr-070845 Ochotona princeps 81.44 7.00e-91 328.00
IUUC-Ont-071643 Oreochromis niloticus 44.01 1.00e-79 290.00
IUUC-Oan-072838 Ornithorhynchus anatinus 62.91 0.00e+00 696.00
IUUC-Ocu-074532 Oryctolagus cuniculus 79.45 0.00e+00 947.00
IUUC-Ola-086962 Oryzias latipes 39.80 1.00e-61 231.00
IUUC-Oga-089133 Otolemur garnettii 79.94 0.00e+00 1020.00
IUUC-Oar-089690 Ovis aries 79.42 0.00e+00 1026.00
IUUC-Ptr-091678 Pan troglodytes 98.66 0.00e+00 1256.00
IUUC-Pan-091746 Papio anubis 93.84 0.00e+00 1166.00
IUUC-Pab-098678 Pongo abelii 97.17 0.00e+00 1194.00
IUUC-Pca-100286 Procavia capensis 79.02 0.00e+00 1017.00
IUUC-Pva-102673 Pteropus vampyrus 82.78 0.00e+00 795.00
IUUC-Rno-105212 Rattus norvegicus 80.38 0.00e+00 1068.00
IUUC-Sha-107072 Sarcophilus harrisii 61.92 0.00e+00 735.00
IUUC-Ssc-116138 Sus scrofa 82.11 0.00e+00 1041.00
IUUC-Tsy-118791 Tarsius syrichta 88.27 1.00e-150 527.00
IUUC-Tur-126269 Triticum urartu 31.58 2.00e-02 33.10
IUUC-Tbe-127945 Tupaia belangeri 88.80 2.00e-110 392.00
Created Date 25-Jun-2017

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