iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000122550.17	ENST00000339077.9	ENSP00000343273.4
ENSG00000122550.17	ENST00000322275.9	ENSP00000323270.5
ENSG00000122550.17	ENST00000410047.1	ENSP00000386999.1
ENSG00000122550.17	ENST00000414163.1	ENSP00000404181.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	19520207

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	3.80e-18	67.3	44	110
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	3.70e-14	51.6	144	174

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dvil v++++++ah++vLaa+S++F+ +f++++ esk + +ve+kd +p+  ++l++F Yt +++ n
   Q: 44   CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESK-SFEVELKDAEPDIIEQLVEFAYTARISVN 110
           9*************************************.*************************9876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           +Nclgi  +A+++dcp+Lk  a+dfi++hF+
   Q: 144  SNCLGISVLAECLDCPELKATADDFIHQHFT 174
           8*****************************7 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.

Protein Sequence
(Fasta)

MAASGVEKSS KKKTEKKLAA REEAKLLAGF MGVMNNMRKQ KTLCDVILMV QERKIPAHRV 60
VLAAASHFFN LMFTTNMLES KSFEVELKDA EPDIIEQLVE FAYTARISVN SNNVQSLLDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGTGCGCAG GCTCCTGGGC AGGGCTCGGG TTCTGCCCGG GGACGCAGCC CAGTTGGTAG 60
CGTCGCTCCC TGAGCGTTTC TAAGGGGGCC GCCCGGCCTT GTCTTTCGGC AGTGGCCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0682--Retinitis pigmentosa
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030599--KLHL7
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0042802--F:identical protein binding
GO:0042803--F:protein homodimerization activity
GO:0016567--P:protein ubiquitination

KEGG

hsa:55975

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001981	Ailuropoda melanoleuca	99.83	0.00e+00	1175.00
IUUC-Apl-003183	Anas platyrhynchos	98.56	0.00e+00	1160.00
IUUC-Aca-004273	Anolis carolinensis	98.20	0.00e+00	1161.00
IUUC-Ame-011343	Astyanax mexicanus	83.36	0.00e+00	969.00
IUUC-Bta-012785	Bos taurus	99.66	0.00e+00	1172.00
IUUC-Cja-019038	Callithrix jacchus	99.83	0.00e+00	1199.00
IUUC-Cfa-020774	Canis familiaris	99.82	0.00e+00	1147.00
IUUC-Cpo-021716	Cavia porcellus	99.66	0.00e+00	1169.00
IUUC-Csa-023029	Chlorocebus sabaeus	100.00	0.00e+00	1177.00
IUUC-Cho-024947	Choloepus hoffmanni	76.96	0.00e+00	849.00
IUUC-Dre-028014	Danio rerio	83.40	0.00e+00	878.00
IUUC-Dno-029946	Dasypus novemcinctus	99.66	0.00e+00	1174.00
IUUC-Dor-030916	Dipodomys ordii	83.20	7.00e-177	613.00
IUUC-Dse-031294	Dothistroma septosporum	32.95	3.00e-06	44.30
IUUC-Ete-032454	Echinops telfairi	94.01	0.00e+00	638.00
IUUC-Eca-034041	Equus caballus	99.49	0.00e+00	1173.00
IUUC-Eeu-034627	Erinaceus europaeus	98.98	0.00e+00	972.00
IUUC-Fca-035854	Felis catus	99.83	0.00e+00	1175.00
IUUC-Fal-036883	Ficedula albicollis	98.12	0.00e+00	1160.00
IUUC-Gmo-038902	Gadus morhua	78.74	0.00e+00	898.00
IUUC-Gga-040866	Gallus gallus	98.29	0.00e+00	1167.00
IUUC-Gac-041428	Gasterosteus aculeatus	78.14	0.00e+00	940.00
IUUC-Ggo-044846	Gorilla gorilla	93.86	0.00e+00	1082.00
IUUC-Itr-048807	Ictidomys tridecemlineatus	99.62	6.00e-141	493.00
IUUC-Lch-049815	Latimeria chalumnae	89.84	0.00e+00	1055.00
IUUC-Loc-052232	Lepisosteus oculatus	84.76	0.00e+00	914.00
IUUC-Laf-053520	Loxodonta africana	99.49	0.00e+00	1171.00
IUUC-Mcc-055237	Macaca mulatta	99.83	0.00e+00	1177.00
IUUC-Meu-056095	Macropus eugenii	92.90	1.00e-175	608.00
IUUC-Mga-059927	Meleagris gallopavo	98.29	0.00e+00	1167.00
IUUC-Mvi-060550	Microbotryum violaceum	39.02	9.20e-01	29.60
IUUC-Mmr-060974	Microcebus murinus	98.57	0.00e+00	1155.00
IUUC-Mdo-062729	Monodelphis domestica	92.01	0.00e+00	1117.00
IUUC-Mmu-063841	Mus musculus	97.78	0.00e+00	1156.00
IUUC-Mpu-066524	Mustela putorius furo	97.01	0.00e+00	1165.00
IUUC-Mlu-067215	Myotis lucifugus	99.82	0.00e+00	1174.00
IUUC-Ncr-068856	Neurospora crassa	28.71	3.00e-04	39.30
IUUC-Nle-069341	Nomascus leucogenys	100.00	0.00e+00	1177.00
IUUC-Opr-070269	Ochotona princeps	99.49	0.00e+00	1172.00
IUUC-Ont-071551	Oreochromis niloticus	79.79	0.00e+00	944.00
IUUC-Oan-072718	Ornithorhynchus anatinus	99.27	0.00e+00	1150.00
IUUC-Ocu-074287	Oryctolagus cuniculus	100.00	0.00e+00	1177.00
IUUC-Ola-086718	Oryzias latipes	78.37	0.00e+00	955.00
IUUC-Oga-088757	Otolemur garnettii	99.49	0.00e+00	1174.00
IUUC-Oar-090309	Ovis aries	99.66	0.00e+00	1172.00
IUUC-Ptr-090509	Pan troglodytes	100.00	0.00e+00	1177.00
IUUC-Pan-092929	Papio anubis	100.00	0.00e+00	1177.00
IUUC-Psi-092941	Pelodiscus sinensis	98.74	0.00e+00	1162.00
IUUC-Pfo-097421	Poecilia formosa	79.39	0.00e+00	931.00
IUUC-Pab-097792	Pongo abelii	100.00	0.00e+00	1177.00
IUUC-Pca-101033	Procavia capensis	90.04	0.00e+00	856.00
IUUC-Pva-102364	Pteropus vampyrus	89.42	0.00e+00	1030.00
IUUC-Rno-105596	Rattus norvegicus	97.95	0.00e+00	1158.00
IUUC-Sha-106815	Sarcophilus harrisii	99.26	0.00e+00	1127.00
IUUC-Smo-109320	Selaginella moellendorffii	26.72	1.00e-15	79.00
IUUC-Sar-113305	Sorex araneus	99.15	0.00e+00	1170.00
IUUC-Ssc-115871	Sus scrofa	95.86	2.00e-168	584.00
IUUC-Tgu-116940	Taeniopygia guttata	97.78	0.00e+00	1156.00
IUUC-Tru-118682	Takifugu rubripes	78.69	0.00e+00	958.00
IUUC-Tsy-118787	Tarsius syrichta	99.21	0.00e+00	803.00
IUUC-Tni-120224	Tetraodon nigroviridis	79.26	0.00e+00	961.00
IUUC-Tbe-127633	Tupaia belangeri	57.05	7.00e-88	317.00
IUUC-Ttr-128500	Tursiops truncatus	98.39	0.00e+00	1157.00
IUUC-Vpa-130512	Vicugna pacos	97.26	0.00e+00	1118.00
IUUC-Xtr-131983	Xenopus tropicalis	96.95	0.00e+00	1146.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence