iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000122735.15	ENST00000437363.5	ENSP00000395396.1
ENSG00000122735.15	ENST00000242317.8	ENSP00000242317.4
ENSG00000122735.15	ENST00000470169.5	ENSP00000434296.1
ENSG00000122735.15	ENST00000442556.1	ENSP00000408129.1
ENSG00000122735.15	ENST00000614641.4	ENSP00000480538.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	microRNA	TRANSFAC
RepTar	miRcode	RAID2
Disease-associated Variation
ClinVar	GWASdb	OMIM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-09	39.4	435	469

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.....sdtl...lvsGsdDgtikvWDl 30
           H+d+v+ +++     +      + s s Dg i  W l
   Q: 435  HSDPVWQVKWqkddmD--QnlnFFSVSSDGRIVSWTL 469
           ***********85541..24469*********99976 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MIPASAKAPH KQPHKQSISI GRGTRKRDED SGTEVGEGTD EWAQSKATVR PPDQLELTDA 60
ELKEEFTRIL TANNPHAPQN IVRYSFKEGT YKPIGFVNQL AVHYTQVGNL IPKDSDEGRR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGACCGCG GACAGGCGGC AGGATCCGCG CCCAGCAAGG ACTTCAGGCA CGTAGGCCTA 60
AGATGATGGG GGCTCTTCCC AACCAGTGCG CACAGGCAGC TCCAGCGCGA CCCCACTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0007368--P:determination of left/right symmetry
GO:0003351--P:epithelial cilium movement
GO:0007507--P:heart development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001508	Ailuropoda melanoleuca	86.54	0.00e+00	1100.00
IUUC-Apl-003576	Anas platyrhynchos	71.36	0.00e+00	932.00
IUUC-Aca-004263	Anolis carolinensis	71.90	0.00e+00	991.00
IUUC-Bta-012580	Bos taurus	86.28	0.00e+00	1209.00
IUUC-Cja-018885	Callithrix jacchus	93.05	0.00e+00	1281.00
IUUC-Cfa-021154	Canis familiaris	86.55	0.00e+00	1134.00
IUUC-Cpo-022365	Cavia porcellus	88.70	0.00e+00	1212.00
IUUC-Cre-022804	Chlamydomonas reinhardtii	44.09	1.00e-151	530.00
IUUC-Csa-023890	Chlorocebus sabaeus	94.78	0.00e+00	1280.00
IUUC-Cin-025296	Ciona intestinalis	67.25	0.00e+00	713.00
IUUC-Csv-026179	Ciona savignyi	60.12	0.00e+00	811.00
IUUC-Dre-027574	Danio rerio	58.64	0.00e+00	772.00
IUUC-Dno-029648	Dasypus novemcinctus	88.19	0.00e+00	982.00
IUUC-Dor-030738	Dipodomys ordii	84.26	0.00e+00	1164.00
IUUC-Dme-032178	Drosophila melanogaster	48.25	4.00e-143	501.00
IUUC-Ete-033096	Echinops telfairi	78.84	0.00e+00	1134.00
IUUC-Eca-033256	Equus caballus	86.63	0.00e+00	1174.00
IUUC-Fca-036388	Felis catus	85.69	0.00e+00	1131.00
IUUC-Fal-036675	Ficedula albicollis	71.60	0.00e+00	693.00
IUUC-Gmo-039187	Gadus morhua	62.67	0.00e+00	780.00
IUUC-Gga-041235	Gallus gallus	80.00	0.00e+00	718.00
IUUC-Gac-042452	Gasterosteus aculeatus	56.82	0.00e+00	769.00
IUUC-Ggo-045038	Gorilla gorilla	98.58	0.00e+00	1367.00
IUUC-Loc-052443	Lepisosteus oculatus	67.62	0.00e+00	892.00
IUUC-Laf-053468	Loxodonta africana	89.34	0.00e+00	1226.00
IUUC-Mcc-055368	Macaca mulatta	94.74	0.00e+00	1306.00
IUUC-Meu-055996	Macropus eugenii	72.16	0.00e+00	745.00
IUUC-Mmr-061626	Microcebus murinus	87.94	0.00e+00	1221.00
IUUC-Mdo-062267	Monodelphis domestica	75.89	0.00e+00	1046.00
IUUC-Mmu-064412	Mus musculus	85.65	0.00e+00	1211.00
IUUC-Mpu-066739	Mustela putorius furo	86.43	0.00e+00	1129.00
IUUC-Mlu-068200	Myotis lucifugus	83.55	0.00e+00	1164.00
IUUC-Nle-069649	Nomascus leucogenys	93.32	0.00e+00	1281.00
IUUC-Opr-071052	Ochotona princeps	83.33	0.00e+00	1134.00
IUUC-Ont-071236	Oreochromis niloticus	63.70	0.00e+00	843.00
IUUC-Oan-072791	Ornithorhynchus anatinus	65.62	0.00e+00	857.00
IUUC-Ocu-074950	Oryctolagus cuniculus	88.64	0.00e+00	1221.00
IUUC-Oga-088139	Otolemur garnettii	87.89	0.00e+00	1215.00
IUUC-Oar-089578	Ovis aries	86.54	0.00e+00	1213.00
IUUC-Ptr-091329	Pan troglodytes	98.29	0.00e+00	1348.00
IUUC-Pan-092773	Papio anubis	95.01	0.00e+00	1281.00
IUUC-Psi-093756	Pelodiscus sinensis	68.09	0.00e+00	930.00
IUUC-Pma-094402	Petromyzon marinus	63.06	0.00e+00	700.00
IUUC-Pfo-097027	Poecilia formosa	58.22	0.00e+00	749.00
IUUC-Pab-098475	Pongo abelii	92.75	0.00e+00	1258.00
IUUC-Pca-100350	Procavia capensis	76.32	0.00e+00	1075.00
IUUC-Pva-103001	Pteropus vampyrus	87.38	0.00e+00	1169.00
IUUC-Rno-105185	Rattus norvegicus	84.04	0.00e+00	1189.00
IUUC-Sha-106892	Sarcophilus harrisii	76.16	0.00e+00	1060.00
IUUC-Tgu-116586	Taeniopygia guttata	65.66	0.00e+00	772.00
IUUC-Tru-118061	Takifugu rubripes	57.29	0.00e+00	702.00
IUUC-Tbe-127275	Tupaia belangeri	79.29	0.00e+00	1119.00
IUUC-Ttr-128540	Tursiops truncatus	84.62	0.00e+00	1104.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence