iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000012823.6	ENSGALT00000085886.1	ENSGALP00000062956.1
ENSGALG00000012823.6	ENSGALT00000020916.5	ENSGALP00000020886.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.60e-09	37.0	942	986

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C+vC++gge    l++CekC ++fH  C+ +s   ++p+ e wiC+ Cr
   Q: 942  DWCAVCQNGGE----LLCCEKCPKVFHLSCHVPS-LMSFPSGE-WICTFCR 986
           79*********....*******************.*******8.******8 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MRGVAAGAGA LWGRGPCEGG GWFVRGLAGK ARAARSQGAW PGRGVSRRER GTGRGGACCE 60
GRGAGGRWPC GAAGQPPPGA GTQTARAARG RAGVGAGRRA NGGGQRGRPA SFRRSGGRHR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGGGGCG TGGCCGCTGG AGCGGGGGCG CTGTGGGGGC GGGGCCCGTG TGAGGGTGGG 60
GGCTGGTTCG TGCGAGGGCT GGCTGGGAAA GCTCGCGCCG CACGTAGCCA GGGGGCGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR019786--Zinc_finger_PHD-type_CS
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box

PRINTS

PR00503--BROMODOMAIN

SMART

SM00502--BBC
SM00336--BBOX
SM00297--BROMO
SM00249--PHD
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005719--C:nuclear euchromatin
GO:0005654--C:nucleoplasm
GO:0005726--C:perichromatin fibrils
GO:0003682--F:chromatin binding
GO:0034056--F:estrogen response element binding
GO:0016922--F:ligand-dependent nuclear receptor binding
GO:0004672--F:protein kinase activity
GO:0043565--F:sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0055074--P:calcium ion homeostasis
GO:0071391--P:cellular response to estrogen stimulus
GO:0008285--P:negative regulation of cell proliferation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0046777--P:protein autophosphorylation
GO:0030163--P:protein catabolic process
GO:0042981--P:regulation of apoptotic process
GO:0031647--P:regulation of protein stability
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0070562--P:regulation of vitamin D receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001838	Ailuropoda melanoleuca	78.25	0.00e+00	1382.00
IUUC-Apl-003697	Anas platyrhynchos	93.09	0.00e+00	1545.00
IUUC-Ame-011506	Astyanax mexicanus	51.66	9.00e-121	427.00
IUUC-Bta-013282	Bos taurus	78.21	0.00e+00	1406.00
IUUC-Bra-017954	Brassica rapa	44.83	9.00e-12	65.90
IUUC-Cel-018225	Caenorhabditis elegans	23.33	7.00e-19	89.40
IUUC-Cja-018920	Callithrix jacchus	76.57	0.00e+00	1417.00
IUUC-Cfa-020984	Canis familiaris	78.44	0.00e+00	1415.00
IUUC-Cpo-022035	Cavia porcellus	79.10	0.00e+00	1375.00
IUUC-Csa-024208	Chlorocebus sabaeus	78.44	0.00e+00	1433.00
IUUC-Cho-024413	Choloepus hoffmanni	76.14	2.00e-124	439.00
IUUC-Dno-029145	Dasypus novemcinctus	80.19	0.00e+00	1381.00
IUUC-Dor-030396	Dipodomys ordii	75.69	0.00e+00	1001.00
IUUC-Ete-032414	Echinops telfairi	72.83	0.00e+00	778.00
IUUC-Eca-033489	Equus caballus	80.49	0.00e+00	1334.00
IUUC-Eeu-034654	Erinaceus europaeus	74.73	2.00e-173	602.00
IUUC-Fca-035844	Felis catus	77.05	0.00e+00	1215.00
IUUC-Fal-036735	Ficedula albicollis	89.82	0.00e+00	1533.00
IUUC-Ggo-044542	Gorilla gorilla	78.44	0.00e+00	1431.00
IUUC-Hsa-046785	Homo sapiens	78.32	0.00e+00	1428.00
IUUC-Itr-048262	Ictidomys tridecemlineatus	78.10	0.00e+00	1378.00
IUUC-Laf-054279	Loxodonta africana	77.38	0.00e+00	1399.00
IUUC-Mcc-055668	Macaca mulatta	78.44	0.00e+00	1433.00
IUUC-Meu-056195	Macropus eugenii	67.87	0.00e+00	709.00
IUUC-Mga-059272	Meleagris gallopavo	97.62	0.00e+00	1612.00
IUUC-Mmr-060936	Microcebus murinus	77.76	0.00e+00	1415.00
IUUC-Mdo-062848	Monodelphis domestica	78.50	0.00e+00	1442.00
IUUC-Mmu-063598	Mus musculus	77.52	0.00e+00	1384.00
IUUC-Mpu-066272	Mustela putorius furo	79.79	0.00e+00	1318.00
IUUC-Mlu-067958	Myotis lucifugus	78.29	0.00e+00	1325.00
IUUC-Nle-069375	Nomascus leucogenys	78.44	0.00e+00	1433.00
IUUC-Opr-070836	Ochotona princeps	66.67	2.00e-150	526.00
IUUC-Oan-073393	Ornithorhynchus anatinus	75.92	0.00e+00	920.00
IUUC-Ocu-074873	Oryctolagus cuniculus	77.40	0.00e+00	1336.00
IUUC-Oga-088692	Otolemur garnettii	77.56	0.00e+00	1382.00
IUUC-Oar-090160	Ovis aries	80.06	0.00e+00	1325.00
IUUC-Ptr-090756	Pan troglodytes	78.32	0.00e+00	1428.00
IUUC-Pan-091719	Papio anubis	78.34	0.00e+00	1428.00
IUUC-Psi-093433	Pelodiscus sinensis	85.04	0.00e+00	1439.00
IUUC-Pab-098599	Pongo abelii	77.27	0.00e+00	1401.00
IUUC-Pca-100540	Procavia capensis	75.08	0.00e+00	818.00
IUUC-Pva-102478	Pteropus vampyrus	72.49	0.00e+00	1259.00
IUUC-Sha-106740	Sarcophilus harrisii	75.61	0.00e+00	1268.00
IUUC-Sar-113615	Sorex araneus	77.55	0.00e+00	1139.00
IUUC-Tgu-117368	Taeniopygia guttata	87.15	0.00e+00	1646.00
IUUC-Tsy-118904	Tarsius syrichta	78.32	0.00e+00	1337.00
IUUC-Tbe-127354	Tupaia belangeri	64.34	2.00e-157	549.00
IUUC-Ttr-128983	Tursiops truncatus	75.99	0.00e+00	961.00
IUUC-Vpa-130420	Vicugna pacos	77.47	0.00e+00	1294.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence