iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046785

UUCD1 version

UUC-HoS-00017

Ensembl Protein ID

ENSP00000340507.4

UniProt Accession

O15164; A4D1R7; A4D1R8; O95854; TIF1A_HUMAN

Genbank Protein ID

AAB63585.1; AAD17258.1; BAG52105.1; EAL24046.1; EAL24047.1; EAW83884.1; EAW83885.1; AAH28689.2

Protein Name

Transcription intermediary factor 1-alpha; E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alpha; Tripartite motif-containing protein 24

Genbank Nucleotide ID

AF009353; AF119042; AK075306; AC008265; CH236950; CH471070; CH471070; BC028689

Gene Name

TRIM24; RNF82; TIF1; TIF1A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000122779.17	ENST00000343526.8	ENSP00000340507.4
ENSG00000122779.17	ENST00000415680.6	ENSP00000390829.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19584248

Classification

Family	E-value	Score	Start	End
E3 activity/RING/PHD	4.20e-09	38.1	827	871
E3 activity/RING/RING	4.70e-05	25.5	56	130

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C+vC++gge    l++CekC ++fH  C+ ++  +++p+ e wiC+ Cr
   Q: 827  DWCAVCQNGGE----LLCCEKCPKVFHLSCHVPT-LTNFPSGE-WICTFCR 871
           79*********....*******************.*******8.******8 PP

E3 activity/RING/RING

   S: 1    CaiCledf.kdgplvlpCgHvfhadCl...qkw...................pglknssskefr.......CPlC 45
           Ca+C++ + ++ p++lpC H f++ Cl   q++                   pg++ s s  f        CP+C
   Q: 56   CAVCHQNIqSRAPKLLPCLHSFCQRCLpapQRYlmlpapmlgsaetpppvpaPGSPVSGSSPFAtqvgvirCPVC 130
           ****99887777*********************99999999999999888886666555555535555555**** PP

Organism

Homo sapiens

Functional Description
(View)

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).

Protein Sequence
(Fasta)

MEVAVEKAVA AAAAASAAAS GGPSAAPSGE NEAESRQGPD SERGGEAARL NLLDTCAVCH 60
QNIQSRAPKL LPCLHSFCQR CLPAPQRYLM LPAPMLGSAE TPPPVPAPGS PVSGSSPFAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACAGATACC CTCCTTCCGG CCGCGCCACT CGGGAGGCGG ATCCCGTGGG CCTGAGGAGG 60
CTTCCCCCGC CCGGTTTGCT TTCCCTCCCT CGCTGGCGCT GCCGCGAGTC CACCGAGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR019786--Zinc_finger_PHD-type_CS
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box

PRINTS

PR00503--BROMODOMAIN

SMART

SM00502--BBC
SM00336--BBOX
SM00297--BROMO
SM00249--PHD
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005719--C:nuclear euchromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005726--C:perichromatin fibrils
GO:0003682--F:chromatin binding
GO:0034056--F:estrogen response element binding
GO:0070577--F:lysine-acetylated histone binding
GO:0002039--F:p53 binding
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0043565--F:sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0055074--P:calcium ion homeostasis
GO:0071391--P:cellular response to estrogen stimulus
GO:0008285--P:negative regulation of cell proliferation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0046777--P:protein autophosphorylation
GO:0030163--P:protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0031647--P:regulation of protein stability
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0070562--P:regulation of vitamin D receptor signaling pathway
GO:0006366--P:transcription from RNA polymerase II promoter

KEGG

hsa:8805

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001838	Ailuropoda melanoleuca	97.21	0.00e+00	1697.00
IUUC-Apl-003697	Anas platyrhynchos	80.90	0.00e+00	1298.00
IUUC-Bta-013282	Bos taurus	96.39	0.00e+00	1736.00
IUUC-Cja-018920	Callithrix jacchus	98.43	0.00e+00	1782.00
IUUC-Cfa-020984	Canis familiaris	97.85	0.00e+00	1752.00
IUUC-Cpo-022035	Cavia porcellus	95.80	0.00e+00	1607.00
IUUC-Csa-024208	Chlorocebus sabaeus	99.71	0.00e+00	1805.00
IUUC-Cho-024413	Choloepus hoffmanni	65.18	1.00e-161	563.00
IUUC-Dno-029145	Dasypus novemcinctus	97.52	0.00e+00	1630.00
IUUC-Dor-030396	Dipodomys ordii	93.53	0.00e+00	1218.00
IUUC-Ete-032414	Echinops telfairi	87.30	0.00e+00	917.00
IUUC-Eca-033489	Equus caballus	97.95	0.00e+00	1606.00
IUUC-Eeu-034654	Erinaceus europaeus	93.83	0.00e+00	762.00
IUUC-Fca-035844	Felis catus	93.77	0.00e+00	1474.00
IUUC-Fal-036735	Ficedula albicollis	80.43	0.00e+00	1313.00
IUUC-Gga-041124	Gallus gallus	79.02	0.00e+00	1372.00
IUUC-Ggo-044542	Gorilla gorilla	99.90	0.00e+00	1802.00
IUUC-Itr-048262	Ictidomys tridecemlineatus	97.29	0.00e+00	1697.00
IUUC-Laf-054279	Loxodonta africana	94.09	0.00e+00	1679.00
IUUC-Mcc-055668	Macaca mulatta	99.71	0.00e+00	1806.00
IUUC-Meu-056195	Macropus eugenii	77.78	0.00e+00	796.00
IUUC-Mga-059272	Meleagris gallopavo	80.36	0.00e+00	1286.00
IUUC-Mmr-060936	Microcebus murinus	95.90	0.00e+00	1752.00
IUUC-Mdo-062848	Monodelphis domestica	88.96	0.00e+00	1592.00
IUUC-Mmu-063598	Mus musculus	92.32	0.00e+00	1693.00
IUUC-Mpu-066272	Mustela putorius furo	97.81	0.00e+00	1618.00
IUUC-Mlu-067958	Myotis lucifugus	94.95	0.00e+00	1586.00
IUUC-Nle-069375	Nomascus leucogenys	99.81	0.00e+00	1806.00
IUUC-Opr-070836	Ochotona princeps	82.74	0.00e+00	668.00
IUUC-Oan-073393	Ornithorhynchus anatinus	80.39	0.00e+00	1013.00
IUUC-Ocu-074873	Oryctolagus cuniculus	94.97	0.00e+00	1562.00
IUUC-Oga-088692	Otolemur garnettii	95.62	0.00e+00	1737.00
IUUC-Oar-090160	Ovis aries	96.99	0.00e+00	1592.00
IUUC-Ptr-090756	Pan troglodytes	100.00	0.00e+00	1801.00
IUUC-Pan-091719	Papio anubis	99.62	0.00e+00	1801.00
IUUC-Psi-093433	Pelodiscus sinensis	81.47	0.00e+00	1348.00
IUUC-Pab-098599	Pongo abelii	98.48	0.00e+00	1775.00
IUUC-Pca-100540	Procavia capensis	88.27	0.00e+00	971.00
IUUC-Pva-102478	Pteropus vampyrus	90.29	0.00e+00	1568.00
IUUC-Rno-105478	Rattus norvegicus	78.00	0.00e+00	651.00
IUUC-Sha-106740	Sarcophilus harrisii	85.19	0.00e+00	1374.00
IUUC-Sar-113615	Sorex araneus	94.64	0.00e+00	1399.00
IUUC-Tgu-117368	Taeniopygia guttata	77.57	0.00e+00	1389.00
IUUC-Tsy-118904	Tarsius syrichta	98.49	0.00e+00	1639.00
IUUC-Tbe-127354	Tupaia belangeri	83.15	0.00e+00	717.00
IUUC-Ttr-128983	Tursiops truncatus	92.84	0.00e+00	1189.00
IUUC-Vpa-130420	Vicugna pacos	95.37	0.00e+00	1573.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence