iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013543

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

RING finger protein 11

Genbank Nucleotide ID

BC123728

Gene Name

RNF11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000012996.4	ENSBTAT00000017277.4	ENSBTAP00000017277.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.70e-09	36.8	60	100

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C iC+ df   d+ ++lpC H++h+dC+  w       +++f+CP C
   Q: 60   CVICMMDFvyGDPIRFLPCMHIYHLDCIDDW------LMRSFTCPSC 100
           ********99888******************......********** PP

Organism

Bos taurus

Functional Description
(View)

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome (By similarity).

Protein Sequence
(Fasta)

YQEQVPVPVY HPTPSQTRLA TQLTEEEQIR IAQRIGLIQH LPKGVYDPGR DGSEKKIREC 60
VICMMDFVYG DPIRFLPCMH IYHLDCIDDW LMRSFTCPSC MEPVDAALLS SYETN 115

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Nucleotide Sequence
(Fasta)

TATCAGGAAT GAATATGTCT GTGTTATGTG GTTTTCCTAT GGAAATACTT CAAGTAACAT 60
TCCATGCCAG TTTTACTGTA AACCTTGTTT TTATATCCTT TAACAGTAAG TCAGATATGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0479--Metal-binding
KW-0519--Myristate
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005769--C:early endosome
GO:0005634--C:nucleus
GO:0055037--C:recycling endosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

bta:522791

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001762	Ailuropoda melanoleuca	100.00	7.00e-61	225.00
IUUC-Apl-003879	Anas platyrhynchos	100.00	1.00e-64	237.00
IUUC-Aca-004887	Anolis carolinensis	100.00	1.00e-58	218.00
IUUC-Ame-011194	Astyanax mexicanus	92.79	4.00e-60	223.00
IUUC-Cel-018152	Caenorhabditis elegans	47.83	9.00e-22	96.30
IUUC-Cja-019172	Callithrix jacchus	100.00	9.00e-59	218.00
IUUC-Cfa-020423	Canis familiaris	100.00	7.00e-64	235.00
IUUC-Cpo-021457	Cavia porcellus	100.00	9.00e-59	218.00
IUUC-Csa-024165	Chlorocebus sabaeus	100.00	9.00e-59	218.00
IUUC-Cho-024439	Choloepus hoffmanni	99.13	1.00e-65	241.00
IUUC-Cin-025246	Ciona intestinalis	79.66	4.00e-25	105.00
IUUC-Csv-026239	Ciona savignyi	61.76	6.00e-35	139.00
IUUC-Dre-027392	Danio rerio	94.59	5.00e-61	226.00
IUUC-Dno-029468	Dasypus novemcinctus	100.00	1.00e-64	237.00
IUUC-Dor-030265	Dipodomys ordii	100.00	9.00e-59	218.00
IUUC-Dme-032121	Drosophila melanogaster	65.59	3.00e-35	140.00
IUUC-Ete-032526	Echinops telfairi	100.00	9.00e-59	218.00
IUUC-Eca-033516	Equus caballus	100.00	9.00e-59	218.00
IUUC-Eeu-035261	Erinaceus europaeus	100.00	1.00e-64	237.00
IUUC-Fca-036029	Felis catus	100.00	9.00e-59	218.00
IUUC-Fal-036620	Ficedula albicollis	99.13	1.00e-65	240.00
IUUC-Gmo-038539	Gadus morhua	94.50	2.00e-60	224.00
IUUC-Gga-040240	Gallus gallus	100.00	1.00e-58	218.00
IUUC-Gac-041863	Gasterosteus aculeatus	94.59	1.00e-60	224.00
IUUC-Ggo-045517	Gorilla gorilla	100.00	9.00e-59	218.00
IUUC-Hsa-046313	Homo sapiens	100.00	9.00e-59	218.00
IUUC-Itr-048979	Ictidomys tridecemlineatus	99.03	3.00e-58	216.00
IUUC-Lch-050201	Latimeria chalumnae	90.43	5.00e-60	222.00
IUUC-Loc-052731	Lepisosteus oculatus	97.14	4.00e-59	219.00
IUUC-Laf-053374	Loxodonta africana	100.00	3.00e-65	239.00
IUUC-Mcc-055336	Macaca mulatta	100.00	9.00e-59	218.00
IUUC-Meu-055960	Macropus eugenii	99.12	2.00e-64	236.00
IUUC-Mla-059167	Melampsora laricipopulina	45.61	2.00e-09	58.20
IUUC-Mga-059363	Meleagris gallopavo	100.00	1.00e-64	237.00
IUUC-Mmr-061651	Microcebus murinus	100.00	9.00e-59	218.00
IUUC-Mdo-062554	Monodelphis domestica	80.00	5.00e-55	206.00
IUUC-Mmu-064330	Mus musculus	99.07	3.00e-61	227.00
IUUC-Mpu-065844	Mustela putorius furo	100.00	9.00e-59	218.00
IUUC-Mlu-067557	Myotis lucifugus	100.00	9.00e-59	218.00
IUUC-Nle-069160	Nomascus leucogenys	100.00	1.00e-64	237.00
IUUC-Opr-070708	Ochotona princeps	100.00	1.00e-58	218.00
IUUC-Ont-071784	Oreochromis niloticus	96.40	1.00e-61	228.00
IUUC-Oan-073071	Ornithorhynchus anatinus	98.25	8.00e-64	234.00
IUUC-Ocu-074236	Oryctolagus cuniculus	100.00	9.00e-59	218.00
IUUC-Ola-086848	Oryzias latipes	94.78	2.00e-63	234.00
IUUC-Oga-088630	Otolemur garnettii	81.71	1.00e-36	145.00
IUUC-Oar-089615	Ovis aries	100.00	9.00e-59	218.00
IUUC-Ptr-091459	Pan troglodytes	100.00	9.00e-59	218.00
IUUC-Pan-092848	Papio anubis	100.00	9.00e-59	218.00
IUUC-Psi-092968	Pelodiscus sinensis	100.00	1.00e-58	218.00
IUUC-Pfo-096923	Poecilia formosa	95.65	9.00e-64	235.00
IUUC-Pab-098483	Pongo abelii	100.00	9.00e-59	218.00
IUUC-Pca-100978	Procavia capensis	100.00	3.00e-30	123.00
IUUC-Pva-102550	Pteropus vampyrus	100.00	9.00e-59	218.00
IUUC-Rno-105946	Rattus norvegicus	100.00	1.00e-58	218.00
IUUC-Sha-106723	Sarcophilus harrisii	99.12	7.00e-65	238.00
IUUC-Sar-113209	Sorex araneus	100.00	9.00e-59	218.00
IUUC-Sbi-114216	Sorghum bicolor	40.00	2.00e-11	62.40
IUUC-Ssc-115813	Sus scrofa	100.00	9.00e-59	218.00
IUUC-Tgu-117220	Taeniopygia guttata	100.00	3.00e-65	239.00
IUUC-Tru-118754	Takifugu rubripes	94.59	3.00e-61	227.00
IUUC-Tsy-118863	Tarsius syrichta	100.00	1.00e-64	237.00
IUUC-Tni-119702	Tetraodon nigroviridis	94.59	2.00e-61	227.00
IUUC-Tbe-127266	Tupaia belangeri	100.00	3.00e-22	95.90
IUUC-Ttr-128337	Tursiops truncatus	100.00	9.00e-59	218.00
IUUC-Vpa-130786	Vicugna pacos	100.00	1.00e-64	237.00
IUUC-Xtr-132840	Xenopus tropicalis	99.05	6.00e-60	222.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence