iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20676133; 19262463

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.20e-08	36.1	99	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C iC+ df   d+ ++lpC H++h+dC+  w       +++f+CP C
   Q: 99   CVICMMDFvyGDPIRFLPCMHIYHLDCIDDW------LMRSFTCPSC 139
           ********99888******************......********** PP

Organism

Homo sapiens

Functional Description
(View)

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Protein Sequence
(Fasta)

MGNCLKSPTS DDISLLHESQ SDRASFGEGT EPDQEPPPPY QEQVPVPVYH PTPSQTRLAT 60
QLTEEEQIRI AQRIGLIQHL PKGVYDPGRD GSEKKIRECV ICMMDFVYGD PIRFLPCMHI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGTGCCCG AGCCGGCCTC GTTCTGGCTG CCGCCGTCTC GCTGAGGCGG AGTAGGATGA 60
GGCCCGCGGC CGTGGCTCCG GCGTCGGCGG GGGCAGCAGC AGCTGAGGCA GCAGCTGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0479--Metal-binding
KW-0519--Myristate
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0055037--C:recycling endosome
GO:0000151--C:ubiquitin ligase complex
GO:0003677--F:DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:26994

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001762	Ailuropoda melanoleuca	99.35	8.00e-77	278.00
IUUC-Apl-003879	Anas platyrhynchos	100.00	8.00e-65	238.00
IUUC-Aca-004887	Anolis carolinensis	98.70	2.00e-73	267.00
IUUC-Ame-011194	Astyanax mexicanus	92.86	2.00e-76	277.00
IUUC-Bta-013543	Bos taurus	100.00	4.00e-66	242.00
IUUC-Bol-016328	Brassica oleracea	44.78	2.00e-12	65.10
IUUC-Cel-018152	Caenorhabditis elegans	37.01	2.00e-22	98.60
IUUC-Cja-019172	Callithrix jacchus	100.00	2.00e-74	270.00
IUUC-Cfa-020423	Canis familiaris	100.00	4.00e-64	236.00
IUUC-Cpo-021457	Cavia porcellus	100.00	2.00e-74	270.00
IUUC-Csa-024165	Chlorocebus sabaeus	100.00	2.00e-74	270.00
IUUC-Cho-024439	Choloepus hoffmanni	91.67	1.00e-73	268.00
IUUC-Cin-025246	Ciona intestinalis	79.66	4.00e-25	105.00
IUUC-Csv-026239	Ciona savignyi	61.76	5.00e-35	140.00
IUUC-Dre-027392	Danio rerio	93.51	4.00e-76	276.00
IUUC-Dno-029468	Dasypus novemcinctus	100.00	8.00e-65	238.00
IUUC-Dor-030265	Dipodomys ordii	100.00	2.00e-74	270.00
IUUC-Dme-032121	Drosophila melanogaster	53.25	2.00e-41	161.00
IUUC-Ete-032526	Echinops telfairi	100.00	2.00e-74	270.00
IUUC-Eca-033516	Equus caballus	91.95	2.00e-64	237.00
IUUC-Eeu-035261	Erinaceus europaeus	100.00	8.00e-65	238.00
IUUC-Fca-036029	Felis catus	100.00	2.00e-74	270.00
IUUC-Fal-036620	Ficedula albicollis	99.13	9.00e-66	241.00
IUUC-Gmo-038539	Gadus morhua	92.86	5.00e-76	276.00
IUUC-Gga-040240	Gallus gallus	98.05	5.00e-73	266.00
IUUC-Gac-041863	Gasterosteus aculeatus	92.86	2.00e-75	274.00
IUUC-Ggo-045517	Gorilla gorilla	100.00	2.00e-74	270.00
IUUC-Itr-048979	Ictidomys tridecemlineatus	99.35	8.00e-74	268.00
IUUC-Lch-050201	Latimeria chalumnae	90.83	2.00e-63	233.00
IUUC-Loc-052731	Lepisosteus oculatus	90.45	1.00e-72	265.00
IUUC-Laf-053374	Loxodonta africana	100.00	2.00e-65	239.00
IUUC-Mcc-055336	Macaca mulatta	100.00	2.00e-74	270.00
IUUC-Meu-055960	Macropus eugenii	99.12	2.00e-64	236.00
IUUC-Mla-059167	Melampsora laricipopulina	45.61	1.00e-09	58.50
IUUC-Mga-059363	Meleagris gallopavo	100.00	8.00e-65	238.00
IUUC-Mmr-061456	Microcebus murinus	99.35	8.00e-77	278.00
IUUC-Mdo-062780	Monodelphis domestica	98.52	3.00e-61	226.00
IUUC-Mmu-064330	Mus musculus	99.35	3.00e-77	280.00
IUUC-Mpu-065844	Mustela putorius furo	100.00	2.00e-74	270.00
IUUC-Mlu-067557	Myotis lucifugus	100.00	2.00e-74	270.00
IUUC-Nle-069160	Nomascus leucogenys	100.00	8.00e-65	238.00
IUUC-Opr-070708	Ochotona princeps	93.51	4.00e-70	256.00
IUUC-Ont-071784	Oreochromis niloticus	92.90	1.00e-75	274.00
IUUC-Oan-073071	Ornithorhynchus anatinus	91.47	6.00e-66	242.00
IUUC-Ocu-074236	Oryctolagus cuniculus	100.00	2.00e-74	270.00
IUUC-Ola-086848	Oryzias latipes	92.21	1.00e-83	301.00
IUUC-Oga-088630	Otolemur garnettii	70.78	1.00e-58	218.00
IUUC-Oar-089615	Ovis aries	100.00	2.00e-74	270.00
IUUC-Ptr-091459	Pan troglodytes	100.00	2.00e-74	270.00
IUUC-Pan-092848	Papio anubis	100.00	2.00e-74	270.00
IUUC-Psi-092968	Pelodiscus sinensis	98.70	2.00e-73	267.00
IUUC-Pfo-096923	Poecilia formosa	93.51	1.00e-84	305.00
IUUC-Pab-098483	Pongo abelii	100.00	2.00e-74	270.00
IUUC-Pca-100978	Procavia capensis	62.99	4.00e-41	160.00
IUUC-Pva-102550	Pteropus vampyrus	100.00	2.00e-74	270.00
IUUC-Ptt-103856	Puccinia triticina	45.10	2.00e-04	37.70
IUUC-Rno-105946	Rattus norvegicus	98.05	4.00e-71	259.00
IUUC-Sha-106723	Sarcophilus harrisii	99.12	5.00e-65	238.00
IUUC-Stu-112368	Solanum tuberosum	45.59	4.00e-13	67.80
IUUC-Sar-113209	Sorex araneus	100.00	2.00e-74	270.00
IUUC-Ssc-115813	Sus scrofa	100.00	2.00e-74	270.00
IUUC-Tgu-117220	Taeniopygia guttata	100.00	2.00e-65	239.00
IUUC-Tru-118754	Takifugu rubripes	93.51	6.00e-77	279.00
IUUC-Tsy-118863	Tarsius syrichta	100.00	8.00e-65	238.00
IUUC-Tni-119702	Tetraodon nigroviridis	92.86	1.00e-76	278.00
IUUC-Tbe-127266	Tupaia belangeri	100.00	6.00e-38	148.00
IUUC-Ttr-128337	Tursiops truncatus	100.00	2.00e-74	270.00
IUUC-Vpa-130786	Vicugna pacos	100.00	8.00e-65	238.00
IUUC-Xtr-132840	Xenopus tropicalis	95.45	5.00e-76	276.00
IUUC-Xma-134249	Xiphophorus maculatus	92.86	1.00e-84	304.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence