iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000123977.9	ENST00000373666.6	ENSP00000362770.2
ENSG00000123977.9	ENST00000309931.2	ENSP00000311899.2
ENSG00000123977.9	ENST00000454999.5	ENSP00000403670.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-60	200.1	132	171
UBD/Beta-Prp	9.90e-124	414.0	47	269

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH + v+++af  +  + +++Gs D+t+k+W++ tg++ +
   Q: 132  GHRNVVYAIAFnnPYgDKIATGSFDKTCKLWSVETGKCYH 171
           8**********8755788*******************976 PP

UBD/Beta-Prp

   S: 18   fspdksllatgsrdgtikvwdvttgkl...........lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvl 98
            +++ + l+t+sr++ +k+   + + +           ++ l+ h  + t v ++++g+ ++tgs Drt k+wd  +g+ + tl+gh + v+
   Q: 47   EIQKAEPLLTASRTEQVKLLIQRLQEKlgqnsnhtfylFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVY 138
           46677778888888888887777666646666666666666677777799999999999999999999999999999999999999999999 PP
   S: 99   slsfsp.sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfd 189
           +++f+  +gdk+++Gs d+t ++w +etg+c++ t++gh++ + c++++p++ l+++Gs D+t +lWd+++g+ ++tl+g h   + slsf+
   Q: 139  AIAFNNpYGDKIATGSFDKTCKLWSVETGKCYH-TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRG-HSAEIISLSFN 228
           999988899999999999999999999999999.9999999999999999999999999999999999999999999998.99999999999 PP
   S: 190  sngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrf 230
            +g ++++gs d tv +wd  tg+ v++l+gh + ++s  f
   Q: 229  TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASF 269
           99999999999999999999999999999999988888776 PP

Organism

Homo sapiens

Functional Description
(View)

May play a role in axonemal outer row dynein assembly.

Protein Sequence
(Fasta)

MKLKSLLLRY YPPGIMLEYE KHGELKTKSI DLLDLGPSTD VSALVEEIQK AEPLLTASRT 60
EQVKLLIQRL QEKLGQNSNH TFYLFKVLKA HILPLTNVAL NKSGSCFITG SYDRTCKLWD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCTTTCTG GTGTAGGTTC CGACGCACCT GCCTTCCATT CCCGCCTATC CATTTAGGCT 60
GCGACCTCTG GTAGTTCTCC ACTTTCTCTA ATTCTGAGTT ACTTCATCCT TAAGAAGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0969--Cilium
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005929--C:cilium
GO:0005737--C:cytoplasm
GO:0007368--P:determination of left/right symmetry
GO:0007507--P:heart development

KEGG

hsa:164781

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002244	Ailuropoda melanoleuca	92.77	0.00e+00	763.00
IUUC-Apl-003764	Anas platyrhynchos	77.80	0.00e+00	653.00
IUUC-Aca-005354	Anolis carolinensis	81.20	0.00e+00	716.00
IUUC-Afl-008745	Aspergillus flavus	34.85	3.00e-60	226.00
IUUC-Afu-008962	Aspergillus fumigatus	38.05	2.00e-61	230.00
IUUC-Aor-010048	Aspergillus oryzae	38.96	3.00e-62	232.00
IUUC-Ame-010648	Astyanax mexicanus	67.87	2.00e-172	598.00
IUUC-Bta-013294	Bos taurus	91.81	0.00e+00	786.00
IUUC-Bci-013681	Botrytis cinerea	36.09	8.00e-59	223.00
IUUC-Cja-018728	Callithrix jacchus	94.22	0.00e+00	817.00
IUUC-Cfa-021122	Canis familiaris	92.53	0.00e+00	808.00
IUUC-Cpo-021472	Cavia porcellus	86.57	0.00e+00	728.00
IUUC-Cre-022946	Chlamydomonas reinhardtii	42.04	8.00e-63	234.00
IUUC-Csa-023349	Chlorocebus sabaeus	97.83	0.00e+00	839.00
IUUC-Cho-024337	Choloepus hoffmanni	72.31	2.00e-158	551.00
IUUC-Cin-025447	Ciona intestinalis	67.71	0.00e+00	626.00
IUUC-Csv-026024	Ciona savignyi	67.47	7.00e-180	623.00
IUUC-Cgl-026771	Colletotrichum gloeosporioides	31.34	7.00e-50	193.00
IUUC-Dre-028787	Danio rerio	70.96	0.00e+00	645.00
IUUC-Dno-029788	Dasypus novemcinctus	84.82	0.00e+00	720.00
IUUC-Dor-030679	Dipodomys ordii	88.34	2.00e-84	306.00
IUUC-Dme-031913	Drosophila melanogaster	37.69	9.00e-89	320.00
IUUC-Ete-032844	Echinops telfairi	88.38	6.00e-104	370.00
IUUC-Eca-034088	Equus caballus	92.05	0.00e+00	796.00
IUUC-Eeu-034898	Erinaceus europaeus	79.01	3.00e-148	518.00
IUUC-Fca-036058	Felis catus	83.05	0.00e+00	670.00
IUUC-Fal-036638	Ficedula albicollis	78.64	2.00e-158	551.00
IUUC-Fox-037826	Fusarium oxysporum	36.57	3.00e-47	185.00
IUUC-Fso-038216	Fusarium solani	35.35	1.00e-54	208.00
IUUC-Gmo-039010	Gadus morhua	68.28	9.00e-151	526.00
IUUC-Ggr-039928	Gaeumannomyces graminis	37.58	1.00e-61	231.00
IUUC-Gga-040984	Gallus gallus	79.71	0.00e+00	697.00
IUUC-Gac-042552	Gasterosteus aculeatus	71.74	0.00e+00	640.00
IUUC-Ggo-044596	Gorilla gorilla	86.83	0.00e+00	708.00
IUUC-Itr-048672	Ictidomys tridecemlineatus	91.79	3.00e-146	510.00
IUUC-Lch-049902	Latimeria chalumnae	82.41	0.00e+00	727.00
IUUC-Loc-051919	Lepisosteus oculatus	82.17	0.00e+00	730.00
IUUC-Laf-053877	Loxodonta africana	89.88	0.00e+00	779.00
IUUC-Mcc-055010	Macaca mulatta	97.83	0.00e+00	839.00
IUUC-Meu-055980	Macropus eugenii	71.28	2.00e-157	548.00
IUUC-Mga-059883	Meleagris gallopavo	73.52	3.00e-180	624.00
IUUC-Mmr-061645	Microcebus murinus	93.61	0.00e+00	794.00
IUUC-Mdo-062166	Monodelphis domestica	88.81	0.00e+00	746.00
IUUC-Mmu-063653	Mus musculus	89.88	0.00e+00	782.00
IUUC-Mpu-066807	Mustela putorius furo	92.38	0.00e+00	790.00
IUUC-Mlu-067792	Myotis lucifugus	91.06	0.00e+00	784.00
IUUC-Nfi-068459	Neosartorya fischeri	34.35	2.00e-58	222.00
IUUC-Nle-069067	Nomascus leucogenys	96.87	0.00e+00	826.00
IUUC-Opr-070841	Ochotona princeps	76.73	6.00e-176	610.00
IUUC-Ont-072191	Oreochromis niloticus	72.95	0.00e+00	653.00
IUUC-Oan-073649	Ornithorhynchus anatinus	83.87	3.00e-105	374.00
IUUC-Ocu-074966	Oryctolagus cuniculus	78.28	0.00e+00	636.00
IUUC-Ola-087021	Oryzias latipes	60.38	5.00e-155	540.00
IUUC-Oga-088193	Otolemur garnettii	92.81	0.00e+00	795.00
IUUC-Oar-089207	Ovis aries	93.01	0.00e+00	805.00
IUUC-Ptr-091298	Pan troglodytes	99.52	0.00e+00	854.00
IUUC-Pan-092620	Papio anubis	97.67	0.00e+00	691.00
IUUC-Psi-093232	Pelodiscus sinensis	83.13	0.00e+00	726.00
IUUC-Ppa-095852	Physcomitrella patens	34.63	1.00e-52	201.00
IUUC-Pfo-096971	Poecilia formosa	71.26	0.00e+00	638.00
IUUC-Pab-098360	Pongo abelii	98.79	0.00e+00	845.00
IUUC-Pca-100384	Procavia capensis	86.27	0.00e+00	752.00
IUUC-Pva-102206	Pteropus vampyrus	90.10	0.00e+00	761.00
IUUC-Pyt-104470	Pyrenophora triticirepentis	36.70	2.00e-64	241.00
IUUC-Rno-105944	Rattus norvegicus	89.88	0.00e+00	781.00
IUUC-Sha-106970	Sarcophilus harrisii	88.81	0.00e+00	747.00
IUUC-Ssl-108470	Sclerotinia sclerotiorum	42.42	2.00e-77	284.00
IUUC-Smo-109147	Selaginella moellendorffii	34.97	2.00e-51	196.00
IUUC-Ssc-115618	Sus scrofa	90.14	0.00e+00	767.00
IUUC-Tgu-117237	Taeniopygia guttata	77.70	0.00e+00	660.00
IUUC-Tsy-119604	Tarsius syrichta	92.47	2.00e-76	279.00
IUUC-Tbe-127358	Tupaia belangeri	76.14	0.00e+00	631.00
IUUC-Ttr-129197	Tursiops truncatus	90.60	0.00e+00	780.00
IUUC-Vpa-130692	Vicugna pacos	85.54	0.00e+00	722.00
IUUC-Xtr-132612	Xenopus tropicalis	79.62	0.00e+00	708.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence