iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-005291

Ensembl Protein ID

ENSACAP00000011188.3

UniProt Accession

H9GHK8; H9GHK8_ANOCA

Protein Name

Phosphoinositide phospholipase C

Gene Name

PLCG1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000011128.3	ENSACAT00000011422.3	ENSACAP00000011188.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.60e-12	46.5	783	841

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekle 63
           +k  v++l+dy+aq +deLt++k  v++ +  e+q++gW++g  +  gk+ l fP+n+ve++ 
   Q: 783  FKCAVKALFDYKAQREDELTFTKNAVIQNV--EKQEGGWWRG--DYGGKKQLwFPSNYVEEIT 841
           56789************************9..9*********..676666655*******985 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MASLFTNGPC IQSEAEVVHL YRSLEVGTVM TLFYSKKSQR PERKTFQVKL ETRQVIWSRG 60
SEKIEGAIDI REIQEIRLGR NSRDFDRYQE DPSFRPDPAH CFVILYGMEF RLKTLSLQAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGATTCCT CGCCAGAGGT TTGCAGAGGT GCCCACTCCC CACTCCCCTC CGTTCCCCTT 60
GCTTTCCCTG CCAGTCTCTC TTCCCTTCTT CCAGCCATTG CAAACCCACA CACATCAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005509--F:calcium ion binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0019722--P:calcium-mediated signaling
GO:0016477--P:cell migration
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0009395--P:phospholipid catabolic process
GO:0045766--P:positive regulation of angiogenesis
GO:0043536--P:positive regulation of blood vessel endothelial cell migration
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:0050852--P:T cell receptor signaling pathway

KEGG

acs:100559347

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001452	Ailuropoda melanoleuca	86.30	0.00e+00	2293.00
IUUC-Apl-003541	Anas platyrhynchos	69.58	0.00e+00	1757.00
IUUC-Ame-011004	Astyanax mexicanus	68.69	0.00e+00	1808.00
IUUC-Bta-012660	Bos taurus	86.64	0.00e+00	2177.00
IUUC-Cja-019206	Callithrix jacchus	86.10	0.00e+00	2281.00
IUUC-Cfa-020257	Canis familiaris	86.72	0.00e+00	2198.00
IUUC-Cpo-022391	Cavia porcellus	81.40	0.00e+00	2120.00
IUUC-Csa-024170	Chlorocebus sabaeus	87.69	0.00e+00	1667.00
IUUC-Cin-025520	Ciona intestinalis	47.85	0.00e+00	1114.00
IUUC-Dre-027944	Danio rerio	72.19	0.00e+00	1897.00
IUUC-Dno-029440	Dasypus novemcinctus	86.03	0.00e+00	2092.00
IUUC-Dor-031001	Dipodomys ordii	85.79	0.00e+00	2281.00
IUUC-Eca-033809	Equus caballus	86.64	0.00e+00	2199.00
IUUC-Fca-036510	Felis catus	86.48	0.00e+00	2195.00
IUUC-Fal-037541	Ficedula albicollis	89.46	0.00e+00	2129.00
IUUC-Gmo-038630	Gadus morhua	65.82	0.00e+00	1442.00
IUUC-Gga-040142	Gallus gallus	89.25	0.00e+00	2310.00
IUUC-Ggo-045063	Gorilla gorilla	86.64	0.00e+00	2303.00
IUUC-Hsa-046428	Homo sapiens	86.56	0.00e+00	2301.00
IUUC-Itr-048245	Ictidomys tridecemlineatus	86.72	0.00e+00	2268.00
IUUC-Lch-049766	Latimeria chalumnae	80.48	0.00e+00	1965.00
IUUC-Loc-052285	Lepisosteus oculatus	78.48	0.00e+00	2064.00
IUUC-Laf-053365	Loxodonta africana	85.92	0.00e+00	2175.00
IUUC-Mcc-054871	Macaca mulatta	86.33	0.00e+00	2287.00
IUUC-Meu-056724	Macropus eugenii	82.96	0.00e+00	2053.00
IUUC-Mga-059329	Meleagris gallopavo	88.57	0.00e+00	2180.00
IUUC-Mmr-061110	Microcebus murinus	86.68	0.00e+00	2300.00
IUUC-Mdo-062448	Monodelphis domestica	87.34	0.00e+00	2316.00
IUUC-Mmu-063565	Mus musculus	86.02	0.00e+00	2270.00
IUUC-Mpu-066683	Mustela putorius furo	86.72	0.00e+00	2300.00
IUUC-Mlu-067779	Myotis lucifugus	86.31	0.00e+00	2185.00
IUUC-Nle-069219	Nomascus leucogenys	87.23	0.00e+00	1910.00
IUUC-Opr-070766	Ochotona princeps	83.84	0.00e+00	1331.00
IUUC-Ont-072524	Oreochromis niloticus	74.58	0.00e+00	1961.00
IUUC-Oan-073214	Ornithorhynchus anatinus	86.02	2.00e-43	167.00
IUUC-Ocu-074361	Oryctolagus cuniculus	84.54	0.00e+00	2244.00
IUUC-Ola-086820	Oryzias latipes	73.73	0.00e+00	1992.00
IUUC-Oga-088172	Otolemur garnettii	86.95	0.00e+00	2306.00
IUUC-Oar-090306	Ovis aries	84.19	0.00e+00	2110.00
IUUC-Ptr-090682	Pan troglodytes	86.64	0.00e+00	2303.00
IUUC-Pan-092835	Papio anubis	87.91	0.00e+00	1677.00
IUUC-Psi-093344	Pelodiscus sinensis	87.18	0.00e+00	2296.00
IUUC-Pfo-096984	Poecilia formosa	72.71	0.00e+00	1905.00
IUUC-Pab-097871	Pongo abelii	86.72	0.00e+00	2272.00
IUUC-Pca-100772	Procavia capensis	79.92	0.00e+00	2088.00
IUUC-Pva-102790	Pteropus vampyrus	86.89	0.00e+00	2241.00
IUUC-Rno-105974	Rattus norvegicus	86.09	0.00e+00	2290.00
IUUC-Sar-112995	Sorex araneus	84.83	0.00e+00	2220.00
IUUC-Ssc-115360	Sus scrofa	86.09	0.00e+00	2285.00
IUUC-Tgu-116585	Taeniopygia guttata	86.25	0.00e+00	2189.00
IUUC-Tru-117742	Takifugu rubripes	74.15	0.00e+00	1997.00
IUUC-Tsy-119259	Tarsius syrichta	88.12	0.00e+00	781.00
IUUC-Tni-120833	Tetraodon nigroviridis	66.61	0.00e+00	1700.00
IUUC-Tbe-127504	Tupaia belangeri	73.59	0.00e+00	1227.00
IUUC-Ttr-128650	Tursiops truncatus	86.39	0.00e+00	1144.00
IUUC-Xtr-132862	Xenopus tropicalis	78.17	0.00e+00	2008.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence