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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046428
Ensembl Protein ID ENSP00000244007.3
UniProt Accession P19174; B7ZLY7; B9EGH4; E1P5W4; Q2V575; PLCG1_HUMAN
Genbank Protein ID AAA36452.1; ABB84466.1; CAA18537.1; EAW75991.1; EAW75992.1; AAI36467.1; AAI44137.1
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; Phospholipase C-gamma-1
Genbank Nucleotide ID M34667; DQ297143; AL022394; CH471077; CH471077; BC136466; BC144136
Gene Name PLCG1; PLC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000124181.14 ENST00000244007.7 ENSP00000244007.3
ENSG00000124181.14 ENST00000373271.5 ENSP00000362368.1
ENSG00000124181.14 ENST00000612731.2 ENSP00000485760.1
ENSG00000124181.14 ENST00000599785.5 ENSP00000468958.1
ENSG00000124181.14 ENST00000608885.5 ENSP00000476432.1
ENSG00000124181.14 ENST00000609257.5 ENSP00000476757.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDPhosphoBasemUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 7.60e-11 43.5 792 849
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekl 62
           +k  v++l+dy+aq +deLt+ k  +++ +  e+q++gW++g  +  gk+ l fP+n+ve++
   Q: 792  FKCAVKALFDYKAQREDELTFIKSAIIQNV--EKQEGGWWRG--DYGGKKQLwFPSNYVEEM 849
           56789************************9..9*********..676666655******985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
 Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Protein Sequence
(Fasta)
MAGAASPCAN GCGPGAPSDA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT FQVKLETRQI 60
TWSRGADKIE GAIDIREIKE IRPGKTSRDF DRYQEDPAFR PDQSHCFVIL YGMEFRLKTL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046428|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGGCGCGC GGAGGACCCG CCGCCGCCGG TGTGAGGCGG CCCGTCCTGG CTCCCTTGTC 60
CGGGAAGCCC GCCCAGGTAA CTGAGTTTGG CCGGGCATTC CCGGAGGACG CGCCATCCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046428|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer
KW-0832--Ubl conjugation
Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain
PROSITE

PS50004--C2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3
Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0042995--C:cell projection
GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005509--F:calcium ion binding
GO:0005168--F:neurotrophin TRKA receptor binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004629--F:phospholipase C activity
GO:0019901--F:protein kinase binding
GO:0005057--F:signal transducer activity, downstream of receptor
GO:0000186--P:activation of MAPKK activity
GO:0007411--P:axon guidance
GO:0019722--P:calcium-mediated signaling
GO:0016477--P:cell migration
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0001701--P:in utero embryonic development
GO:0043647--P:inositol phosphate metabolic process
GO:0050900--P:leukocyte migration
GO:0009395--P:phospholipid catabolic process
GO:0045766--P:positive regulation of angiogenesis
GO:0043536--P:positive regulation of blood vessel endothelial cell migration
GO:0010634--P:positive regulation of epithelial cell migration
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:0007165--P:signal transduction
GO:0050852--P:T cell receptor signaling pathway
GO:0016032--P:viral process
KEGG hsa:5335
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001452 Ailuropoda melanoleuca 97.22 0.00e+00 2577.00
IUUC-Apl-003541 Anas platyrhynchos 70.41 0.00e+00 1759.00
IUUC-Aca-005291 Anolis carolinensis 86.56 0.00e+00 2253.00
IUUC-Ame-011004 Astyanax mexicanus 68.97 0.00e+00 1798.00
IUUC-Bta-012660 Bos taurus 97.05 0.00e+00 2441.00
IUUC-Cja-019206 Callithrix jacchus 98.68 0.00e+00 2603.00
IUUC-Cfa-020257 Canis familiaris 97.70 0.00e+00 2442.00
IUUC-Cpo-022391 Cavia porcellus 91.80 0.00e+00 2403.00
IUUC-Csa-024170 Chlorocebus sabaeus 99.57 0.00e+00 1928.00
IUUC-Cin-025520 Ciona intestinalis 47.70 0.00e+00 1102.00
IUUC-Dre-027944 Danio rerio 72.28 0.00e+00 1883.00
IUUC-Dno-029440 Dasypus novemcinctus 96.69 0.00e+00 2340.00
IUUC-Dor-031001 Dipodomys ordii 96.59 0.00e+00 2565.00
IUUC-Eca-033809 Equus caballus 98.11 0.00e+00 2460.00
IUUC-Fca-036510 Felis catus 97.05 0.00e+00 2435.00
IUUC-Fal-037541 Ficedula albicollis 88.02 0.00e+00 2106.00
IUUC-Gmo-038630 Gadus morhua 66.35 0.00e+00 1461.00
IUUC-Gga-040142 Gallus gallus 88.64 0.00e+00 2303.00
IUUC-Ggo-045063 Gorilla gorilla 99.92 0.00e+00 2671.00
IUUC-Itr-048245 Ictidomys tridecemlineatus 97.30 0.00e+00 2509.00
IUUC-Lch-049766 Latimeria chalumnae 80.08 0.00e+00 1965.00
IUUC-Loc-052285 Lepisosteus oculatus 76.98 0.00e+00 2041.00
IUUC-Laf-053365 Loxodonta africana 96.40 0.00e+00 2412.00
IUUC-Mcc-054871 Macaca mulatta 98.91 0.00e+00 2598.00
IUUC-Meu-056724 Macropus eugenii 89.26 0.00e+00 2193.00
IUUC-Mga-059329 Meleagris gallopavo 87.51 0.00e+00 2173.00
IUUC-Mmr-061110 Microcebus murinus 97.52 0.00e+00 2583.00
IUUC-Mdo-062448 Monodelphis domestica 93.73 0.00e+00 2505.00
IUUC-Mmu-063565 Mus musculus 96.86 0.00e+00 2562.00
IUUC-Mpu-066683 Mustela putorius furo 97.52 0.00e+00 2587.00
IUUC-Mlu-067779 Myotis lucifugus 96.64 0.00e+00 2415.00
IUUC-Nle-069219 Nomascus leucogenys 98.86 0.00e+00 2152.00
IUUC-Opr-070766 Ochotona princeps 93.10 0.00e+00 1439.00
IUUC-Ont-072524 Oreochromis niloticus 73.56 0.00e+00 1954.00
IUUC-Oan-073214 Ornithorhynchus anatinus 91.30 3.00e-46 177.00
IUUC-Ocu-074361 Oryctolagus cuniculus 95.05 0.00e+00 2507.00
IUUC-Ola-086820 Oryzias latipes 72.73 0.00e+00 1967.00
IUUC-Oga-088172 Otolemur garnettii 98.14 0.00e+00 2602.00
IUUC-Oar-090306 Ovis aries 94.10 0.00e+00 2355.00
IUUC-Ptr-090682 Pan troglodytes 99.85 0.00e+00 2670.00
IUUC-Pan-092835 Papio anubis 99.56 0.00e+00 1884.00
IUUC-Psi-093344 Pelodiscus sinensis 86.55 0.00e+00 2285.00
IUUC-Pfo-096984 Poecilia formosa 71.88 0.00e+00 1911.00
IUUC-Pab-097871 Pongo abelii 99.60 0.00e+00 2593.00
IUUC-Pca-100772 Procavia capensis 90.55 0.00e+00 2367.00
IUUC-Pva-102790 Pteropus vampyrus 97.85 0.00e+00 2541.00
IUUC-Rno-105974 Rattus norvegicus 96.90 0.00e+00 2571.00
IUUC-Sar-112995 Sorex araneus 94.86 0.00e+00 2446.00
IUUC-Ssc-115360 Sus scrofa 97.51 0.00e+00 2573.00
IUUC-Tgu-116585 Taeniopygia guttata 85.85 0.00e+00 2199.00
IUUC-Tru-117742 Takifugu rubripes 73.76 0.00e+00 1981.00
IUUC-Tsy-119259 Tarsius syrichta 97.86 0.00e+00 860.00
IUUC-Tni-120833 Tetraodon nigroviridis 67.68 0.00e+00 1704.00
IUUC-Tbe-127504 Tupaia belangeri 82.68 0.00e+00 1398.00
IUUC-Ttr-128650 Tursiops truncatus 97.45 0.00e+00 1335.00
IUUC-Xtr-132862 Xenopus tropicalis 77.86 0.00e+00 2001.00
Created Date 25-Jun-2017

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