iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059329

Ensembl Protein ID

ENSMGAP00000003099.2

UniProt Accession

G1MWG7; G1MWG7_MELGA

Protein Name

Phosphoinositide phospholipase C

Gene Name

PLCG1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000003334.2	ENSMGAT00000003793.2	ENSMGAP00000003099.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.70e-12	46.9	724	782

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekle 63
           +k  v++l+dy+aq +deLt++k  +++ +  e+q++gW++g  +  gk+ l fP+n+ve+++
   Q: 724  FKCAVKALFDYKAQREDELTFTKNAIIQNV--EKQEGGWWRG--DYGGKKQLwFPSNYVEEIS 782
           56789************************9..9*********..676666655*******996 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

SVDIREIKEI RPGKNSRDFD RYQEDPCFRP DQSHCFVVLY GTEFRLKTLS LQATSEDEVN 60
MWIKGLNWLV ADTLRAATPL QIERWLRKQF YTLDRNREDR ISAKDLKNML SQVNYRVPNM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGTGGATA TTCGTGAAAT CAAAGAGATT CGTCCTGGAA AGAATTCACG TGATTTTGAC 60
CGATACCAGG AGGATCCGTG CTTCCGACCA GACCAGTCCC ATTGCTTCGT GGTCCTGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005509--F:calcium ion binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0019722--P:calcium-mediated signaling
GO:0016477--P:cell migration
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0009395--P:phospholipid catabolic process
GO:0045766--P:positive regulation of angiogenesis
GO:0043536--P:positive regulation of blood vessel endothelial cell migration
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001452	Ailuropoda melanoleuca	88.73	0.00e+00	2229.00
IUUC-Aca-005291	Anolis carolinensis	88.57	0.00e+00	2199.00
IUUC-Afu-009104	Aspergillus fumigatus	37.50	2.00e-10	62.00
IUUC-Ame-011004	Astyanax mexicanus	68.40	0.00e+00	1682.00
IUUC-Bta-012660	Bos taurus	88.48	0.00e+00	2222.00
IUUC-Cja-019206	Callithrix jacchus	88.06	0.00e+00	2206.00
IUUC-Cfa-020257	Canis familiaris	88.64	0.00e+00	2224.00
IUUC-Cpo-022391	Cavia porcellus	84.76	0.00e+00	2074.00
IUUC-Csa-024170	Chlorocebus sabaeus	89.77	0.00e+00	1623.00
IUUC-Dre-027944	Danio rerio	72.05	0.00e+00	1779.00
IUUC-Dno-029440	Dasypus novemcinctus	87.57	0.00e+00	2120.00
IUUC-Dor-031001	Dipodomys ordii	87.44	0.00e+00	2201.00
IUUC-Eca-033809	Equus caballus	88.56	0.00e+00	2227.00
IUUC-Fca-036510	Felis catus	88.32	0.00e+00	2217.00
IUUC-Fal-037541	Ficedula albicollis	95.88	0.00e+00	2272.00
IUUC-Gmo-038630	Gadus morhua	78.49	0.00e+00	1372.00
IUUC-Gga-040142	Gallus gallus	98.12	0.00e+00	2417.00
IUUC-Ggo-045063	Gorilla gorilla	88.24	0.00e+00	2223.00
IUUC-Hsa-046428	Homo sapiens	88.16	0.00e+00	2219.00
IUUC-Itr-048245	Ictidomys tridecemlineatus	87.99	0.00e+00	2219.00
IUUC-Lch-049766	Latimeria chalumnae	80.74	0.00e+00	1977.00
IUUC-Loc-052285	Lepisosteus oculatus	77.60	0.00e+00	1935.00
IUUC-Laf-053365	Loxodonta africana	87.59	0.00e+00	2196.00
IUUC-Mcc-054871	Macaca mulatta	88.32	0.00e+00	2221.00
IUUC-Meu-056724	Macropus eugenii	83.92	0.00e+00	2052.00
IUUC-Mmr-061110	Microcebus murinus	88.08	0.00e+00	2212.00
IUUC-Mdo-062448	Monodelphis domestica	88.81	0.00e+00	2241.00
IUUC-Mmu-063565	Mus musculus	88.24	0.00e+00	2219.00
IUUC-Mpu-066683	Mustela putorius furo	88.33	0.00e+00	2222.00
IUUC-Mlu-067779	Myotis lucifugus	88.14	0.00e+00	2220.00
IUUC-Nfi-068248	Neosartorya fischeri	37.50	2.00e-10	62.00
IUUC-Nle-069219	Nomascus leucogenys	89.07	0.00e+00	1957.00
IUUC-Opr-070766	Ochotona princeps	84.26	0.00e+00	1311.00
IUUC-Ont-072524	Oreochromis niloticus	74.35	0.00e+00	1865.00
IUUC-Oan-073214	Ornithorhynchus anatinus	90.32	8.00e-45	172.00
IUUC-Ocu-074361	Oryctolagus cuniculus	86.57	0.00e+00	2170.00
IUUC-Ola-086820	Oryzias latipes	73.43	0.00e+00	1881.00
IUUC-Oga-088172	Otolemur garnettii	88.73	0.00e+00	2235.00
IUUC-Oar-090306	Ovis aries	85.63	0.00e+00	2143.00
IUUC-Ptr-090682	Pan troglodytes	88.24	0.00e+00	2222.00
IUUC-Pan-092835	Papio anubis	88.90	0.00e+00	1666.00
IUUC-Psi-093344	Pelodiscus sinensis	89.46	0.00e+00	2238.00
IUUC-Pfo-096984	Poecilia formosa	72.35	0.00e+00	1815.00
IUUC-Pab-097871	Pongo abelii	88.00	0.00e+00	2219.00
IUUC-Pop-099175	Populus trichocarpa	25.89	1.40e-02	33.50
IUUC-Pca-100772	Procavia capensis	81.71	0.00e+00	2015.00
IUUC-Pva-102790	Pteropus vampyrus	88.47	0.00e+00	2175.00
IUUC-Rno-105974	Rattus norvegicus	88.32	0.00e+00	2228.00
IUUC-Sar-112995	Sorex araneus	86.37	0.00e+00	2167.00
IUUC-Ssc-115360	Sus scrofa	87.99	0.00e+00	2220.00
IUUC-Tgu-116585	Taeniopygia guttata	93.71	0.00e+00	2247.00
IUUC-Tru-117742	Takifugu rubripes	74.19	0.00e+00	1891.00
IUUC-Tsy-119259	Tarsius syrichta	90.02	0.00e+00	793.00
IUUC-Tbe-127504	Tupaia belangeri	75.86	0.00e+00	1270.00
IUUC-Ttr-128650	Tursiops truncatus	89.46	0.00e+00	1096.00
IUUC-Xtr-132862	Xenopus tropicalis	77.90	0.00e+00	1893.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence