iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069219

Ensembl Protein ID

ENSNLEP00000007890.1

UniProt Accession

G1R3W8; G1R3W8_NOMLE

Genbank Protein ID

ENSNLEP00000007890

Protein Name

Phosphoinositide phospholipase C

Genbank Nucleotide ID

ADFV01004165

Gene Name

PLCG1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000006479.2	ENSNLET00000008268.2	ENSNLEP00000007890.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-12	46.9	720	778

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekle 63
           +k  v++l+dy+aq +deLt++k  +++ +  e+q++gW++g  +  gk+ l fP+n+ve ++
   Q: 720  FKCAVKALFDYKAQREDELTFTKSAIIQNV--EKQEGGWWRG--DYGGKKQLwFPSNYVEMVN 778
           56789************************9..9*********..676666655******9986 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

VDIREIKEIR PGKTSRDFDR YQEDPAFRPD QSHCFVILYG MEFRLKTLSL QATSEDEVNM 60
WIKGLTWLME DTLQAPTPLQ IERWLRKQFY SVDRNREDRI SAKDLKNMLS QVNYRVPNMR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGATATTC GCGAAATTAA GGAGATCCGC CCGGGGAAGA CCTCACGGGA CTTTGATCGC 60
TATCAAGAGG ACCCAGCTTT CCGGCCGGAC CAGTCACATT GCTTTGTCAT TCTCTATGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0008180--C:COP9 signalosome
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005509--F:calcium ion binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0019722--P:calcium-mediated signaling
GO:0016477--P:cell migration
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0016042--P:lipid catabolic process
GO:0045766--P:positive regulation of angiogenesis
GO:0043536--P:positive regulation of blood vessel endothelial cell migration
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001452	Ailuropoda melanoleuca	96.69	0.00e+00	2108.00
IUUC-Apl-003541	Anas platyrhynchos	71.16	0.00e+00	1535.00
IUUC-Aca-005291	Anolis carolinensis	87.23	0.00e+00	1880.00
IUUC-Ame-011004	Astyanax mexicanus	71.55	0.00e+00	1525.00
IUUC-Bta-012660	Bos taurus	97.06	0.00e+00	2118.00
IUUC-Cja-019206	Callithrix jacchus	97.91	0.00e+00	2127.00
IUUC-Cfa-020257	Canis familiaris	97.06	0.00e+00	2114.00
IUUC-Cpo-022391	Cavia porcellus	90.51	0.00e+00	1942.00
IUUC-Csa-024170	Chlorocebus sabaeus	98.84	0.00e+00	1759.00
IUUC-Cin-025520	Ciona intestinalis	47.59	0.00e+00	974.00
IUUC-Dre-027944	Danio rerio	74.91	0.00e+00	1604.00
IUUC-Dno-029440	Dasypus novemcinctus	96.26	0.00e+00	2014.00
IUUC-Dor-031001	Dipodomys ordii	95.74	0.00e+00	2091.00
IUUC-Eca-033809	Equus caballus	97.35	0.00e+00	2123.00
IUUC-Fca-036510	Felis catus	96.69	0.00e+00	2105.00
IUUC-Fal-037541	Ficedula albicollis	89.37	0.00e+00	1857.00
IUUC-Gmo-038630	Gadus morhua	68.12	0.00e+00	1365.00
IUUC-Gga-040142	Gallus gallus	89.58	0.00e+00	1948.00
IUUC-Ggo-045063	Gorilla gorilla	98.96	0.00e+00	2156.00
IUUC-Hsa-046428	Homo sapiens	98.86	0.00e+00	2154.00
IUUC-Itr-048245	Ictidomys tridecemlineatus	96.69	0.00e+00	2115.00
IUUC-Lch-049766	Latimeria chalumnae	81.42	0.00e+00	1756.00
IUUC-Loc-052285	Lepisosteus oculatus	78.81	0.00e+00	1727.00
IUUC-Laf-053365	Loxodonta africana	96.78	0.00e+00	2113.00
IUUC-Mcc-054871	Macaca mulatta	98.20	0.00e+00	2134.00
IUUC-Meu-056724	Macropus eugenii	88.46	0.00e+00	1906.00
IUUC-Mga-059329	Meleagris gallopavo	88.78	0.00e+00	1930.00
IUUC-Mmr-061110	Microcebus murinus	96.59	0.00e+00	2100.00
IUUC-Mdo-062448	Monodelphis domestica	93.94	0.00e+00	2070.00
IUUC-Mmu-063565	Mus musculus	96.40	0.00e+00	2109.00
IUUC-Mpu-066683	Mustela putorius furo	96.69	0.00e+00	2111.00
IUUC-Mlu-067779	Myotis lucifugus	96.02	0.00e+00	2091.00
IUUC-Opr-070766	Ochotona princeps	92.72	0.00e+00	1133.00
IUUC-Ont-072524	Oreochromis niloticus	77.96	0.00e+00	1709.00
IUUC-Oan-073214	Ornithorhynchus anatinus	84.62	7.00e-42	162.00
IUUC-Ocu-074361	Oryctolagus cuniculus	94.53	0.00e+00	2054.00
IUUC-Ola-086820	Oryzias latipes	77.16	0.00e+00	1703.00
IUUC-Oga-088172	Otolemur garnettii	97.16	0.00e+00	2123.00
IUUC-Oar-090306	Ovis aries	94.70	0.00e+00	2056.00
IUUC-Ptr-090682	Pan troglodytes	98.96	0.00e+00	2156.00
IUUC-Pan-092835	Papio anubis	98.81	0.00e+00	1529.00
IUUC-Psi-093344	Pelodiscus sinensis	87.12	0.00e+00	1915.00
IUUC-Pfo-096984	Poecilia formosa	75.66	0.00e+00	1665.00
IUUC-Pab-097871	Pongo abelii	98.77	0.00e+00	2153.00
IUUC-Pca-100772	Procavia capensis	88.64	0.00e+00	1902.00
IUUC-Pva-102790	Pteropus vampyrus	97.06	0.00e+00	2113.00
IUUC-Rno-105974	Rattus norvegicus	96.50	0.00e+00	2110.00
IUUC-Sar-112995	Sorex araneus	94.04	0.00e+00	2039.00
IUUC-Ssc-115360	Sus scrofa	97.16	0.00e+00	2122.00
IUUC-Tgu-116585	Taeniopygia guttata	86.74	0.00e+00	1833.00
IUUC-Tru-117742	Takifugu rubripes	78.24	0.00e+00	1718.00
IUUC-Tsy-119259	Tarsius syrichta	96.43	0.00e+00	842.00
IUUC-Tni-120833	Tetraodon nigroviridis	69.22	0.00e+00	1490.00
IUUC-Tbe-127504	Tupaia belangeri	81.76	0.00e+00	1374.00
IUUC-Ttr-128650	Tursiops truncatus	96.63	0.00e+00	1176.00
IUUC-Xtr-132862	Xenopus tropicalis	79.66	0.00e+00	1703.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence