iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046295

UUCD1 version

UUC-HoS-01137

Ensembl Protein ID

ENSP00000316357.6

UniProt Accession

Q93008; O75550; Q8WWT3; Q8WX12; USP9X_HUMAN

Genbank Protein ID

CAA66942.1; CAD13527.2; CAD13527.2; CAD18900.2; CAD18900.2; AAC25395.1

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Deubiquitinating enzyme FAF-X; Fat facets in mammals; Fat facets protein-related, X-linked; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X

Genbank Nucleotide ID

X98296; AL391259; AL109797; AL109797; AL391259; AF070645

Gene Name

USP9X; DFFRX; FAM; USP9

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000124486.12	ENST00000378308.6	ENSP00000367558.2
ENSG00000124486.12	ENST00000324545.8	ENSP00000316357.6
ENSG00000124486.12	ENST00000462850.1	ENSP00000420570.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	20023629; 18410486

Classification

Family	E-value	Score	Start	End
DUB/USP	3.70e-84	284.5	1557	1956

Active Site

Position(s)	Description	Evidence
1566	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
1879	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle................kkkeklneenp...............................k 43
           +GlkN g+tCYmNSv+Q+L++ip++r+ +l                 k         +                               k
   Q: 1557 VGLKNAGATCYMNSVIQQLYMIPSIRNGILAiegtgsdvdddmsgdeK---------QdnesnvdprddvfgypqqfedkpalsktedrK 1637
           6******************************88888877666654331.........033334456677777777777777777777667 PP
   S: 44   epkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeek 133
           e +  +l++lq +f +l  s+ +++ pr ++k+++ + e ++  eq+Da Ef++ l+d+l+e+l                          
   Q: 1638 EYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEAL-------------------------- 1701
           7777************************************************************.......................... PP
   S: 134  kkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklkl 223
           k   ++ ++s++++g++ +q +c+ c ++++ ee+f++l++++++++     +l d+Le+++k + leg+n+y+cekc+kk++++k+l +
   Q: 1702 KALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQ-----NLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLI 1786
           67999******************************************.....9************************************* PP
   S: 224  kklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................peekqke.....kkkYeLiavvvH 286
           kklP+vL ++LkRf ++ e+++ +k+n+++efp+eLd++p+++                       +     e     ++kY+L++v+vH
   Q: 1787 KKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAgvaklegdnvnpesqliqqseqS-----EsetagSTKYRLVGVLVH 1871
           ********************************************89989888888888887665543.....144555************ PP
   S: 287  sGslssGHYvayvknekgk......WllfdDskVtevkeeevleetg...........................staYvlfYkrr 338
           sG++s+GHY++y+ +++g+      W++fdD  Vte+k+++ +e+++                           ++aY+lfY+r+
   Q: 1872 SGQASGGHYYSYIIQRNGGdgernrWYKFDDGDVTECKMDDDEEMKNqcfggeymgevfdhmmkrmsyrrqkrwWNAYILFYERM 1956
           ***************5444555556*******************9999***********************************96 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Involved in axonal growth and neuronal cell migration.

Protein Sequence
(Fasta)

MTATTRGSPV GGNDNQGQAP DGQSQPPLQQ NQTSSPDSSN ENSPATPPDE QGQGDAPPQL 60
EDEEPAFPHT DLAKLDDMIN RPRWVVPVLP KGELEVLLEA AIDLSKKGLD VKSEACQRFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCCGCCT TAGCGCCCGG TGCTTGGGTC GGCGCCGGGA GCGAGGAGCG AGCTACTTCA 60
AAGCCACCAG GCCTGGAGCG GGGACAGAGG CGGCGACTAG GGGAAGGTGA AGCCGTCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0378--Hydrolase
KW-0991--Mental retardation
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030426--C:growth cone
GO:0016020--C:membrane
GO:0070410--F:co-SMAD binding
GO:0004197--F:cysteine-type endopeptidase activity
GO:0008234--F:cysteine-type peptidase activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0048675--P:axon extension
GO:0030509--P:BMP signaling pathway
GO:0051301--P:cell division
GO:0044267--P:cellular protein metabolic process
GO:0007059--P:chromosome segregation
GO:0007292--P:female gamete generation
GO:0007067--P:mitotic nuclear division
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001764--P:neuron migration
GO:0016579--P:protein deubiquitination
GO:0016567--P:protein ubiquitination
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:8239

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001640	Ailuropoda melanoleuca	98.09	0.00e+00	5024.00
IUUC-Apl-003592	Anas platyrhynchos	94.17	0.00e+00	4843.00
IUUC-Aca-004939	Anolis carolinensis	93.85	0.00e+00	4808.00
IUUC-Ame-011772	Astyanax mexicanus	88.55	0.00e+00	4559.00
IUUC-Bta-012775	Bos taurus	97.86	0.00e+00	4984.00
IUUC-Cja-019464	Callithrix jacchus	98.29	0.00e+00	4930.00
IUUC-Cfa-020569	Canis familiaris	98.57	0.00e+00	3236.00
IUUC-Csa-023405	Chlorocebus sabaeus	98.91	0.00e+00	4992.00
IUUC-Cho-024524	Choloepus hoffmanni	94.16	0.00e+00	803.00
IUUC-Cin-025551	Ciona intestinalis	63.50	2.00e-142	498.00
IUUC-Csv-025956	Ciona savignyi	53.70	0.00e+00	2497.00
IUUC-Dre-028329	Danio rerio	88.67	0.00e+00	4592.00
IUUC-Dno-028936	Dasypus novemcinctus	98.02	0.00e+00	5022.00
IUUC-Dor-030352	Dipodomys ordii	93.81	0.00e+00	2244.00
IUUC-Dme-032160	Drosophila melanogaster	47.93	0.00e+00	2178.00
IUUC-Ete-032287	Echinops telfairi	96.58	0.00e+00	2773.00
IUUC-Eca-033352	Equus caballus	98.25	0.00e+00	5048.00
IUUC-Eeu-034907	Erinaceus europaeus	86.89	0.00e+00	1846.00
IUUC-Fca-035458	Felis catus	98.60	0.00e+00	5055.00
IUUC-Fal-036924	Ficedula albicollis	93.98	0.00e+00	4749.00
IUUC-Gmo-039578	Gadus morhua	89.43	0.00e+00	4484.00
IUUC-Gga-040978	Gallus gallus	94.32	0.00e+00	4848.00
IUUC-Gac-041970	Gasterosteus aculeatus	89.77	0.00e+00	4576.00
IUUC-Ggo-045575	Gorilla gorilla	99.88	0.00e+00	5062.00
IUUC-Itr-048768	Ictidomys tridecemlineatus	98.40	0.00e+00	5030.00
IUUC-Lch-050493	Latimeria chalumnae	91.85	0.00e+00	4648.00
IUUC-Loc-052667	Lepisosteus oculatus	90.22	0.00e+00	4702.00
IUUC-Laf-054094	Loxodonta africana	98.99	0.00e+00	5058.00
IUUC-Mcc-054861	Macaca mulatta	97.77	0.00e+00	4974.00
IUUC-Meu-056849	Macropus eugenii	83.79	0.00e+00	1439.00
IUUC-Mga-060159	Meleagris gallopavo	94.13	0.00e+00	4844.00
IUUC-Mmr-060732	Microcebus murinus	97.94	0.00e+00	5027.00
IUUC-Mdo-062274	Monodelphis domestica	94.63	0.00e+00	4917.00
IUUC-Mmu-064056	Mus musculus	97.51	0.00e+00	5000.00
IUUC-Mpu-066669	Mustela putorius furo	98.13	0.00e+00	5029.00
IUUC-Mlu-067516	Myotis lucifugus	97.20	0.00e+00	4979.00
IUUC-Nle-069664	Nomascus leucogenys	99.84	0.00e+00	3700.00
IUUC-Opr-070185	Ochotona princeps	88.68	0.00e+00	804.00
IUUC-Ont-072119	Oreochromis niloticus	90.28	0.00e+00	4612.00
IUUC-Oan-073154	Ornithorhynchus anatinus	94.12	0.00e+00	4892.00
IUUC-Ocu-074485	Oryctolagus cuniculus	99.26	0.00e+00	5106.00
IUUC-Ola-086350	Oryzias latipes	89.46	0.00e+00	4507.00
IUUC-Oga-088328	Otolemur garnettii	98.68	0.00e+00	5112.00
IUUC-Oar-090098	Ovis aries	98.72	0.00e+00	5049.00
IUUC-Pan-091741	Papio anubis	99.95	0.00e+00	3835.00
IUUC-Psi-093040	Pelodiscus sinensis	94.17	0.00e+00	4833.00
IUUC-Pfo-096871	Poecilia formosa	89.16	0.00e+00	4578.00
IUUC-Pab-098374	Pongo abelii	98.95	0.00e+00	4991.00
IUUC-Pca-100801	Procavia capensis	89.64	0.00e+00	2432.00
IUUC-Pva-102992	Pteropus vampyrus	92.91	0.00e+00	2431.00
IUUC-Rno-105377	Rattus norvegicus	97.70	0.00e+00	5009.00
IUUC-Sha-106648	Sarcophilus harrisii	91.99	0.00e+00	4736.00
IUUC-Smo-108879	Selaginella moellendorffii	28.05	0.00e+00	811.00
IUUC-Sar-113729	Sorex araneus	94.76	0.00e+00	3172.00
IUUC-Ssc-116261	Sus scrofa	93.08	0.00e+00	4841.00
IUUC-Tgu-117126	Taeniopygia guttata	94.20	0.00e+00	4844.00
IUUC-Tru-117676	Takifugu rubripes	89.44	0.00e+00	4582.00
IUUC-Tsy-119209	Tarsius syrichta	86.94	0.00e+00	2685.00
IUUC-Tni-120207	Tetraodon nigroviridis	85.38	0.00e+00	2044.00
IUUC-Tbe-128033	Tupaia belangeri	98.11	0.00e+00	1051.00
IUUC-Ttr-128742	Tursiops truncatus	96.69	0.00e+00	4944.00
IUUC-Vpa-130581	Vicugna pacos	94.67	0.00e+00	4806.00
IUUC-Xtr-132145	Xenopus tropicalis	91.92	0.00e+00	4761.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence