iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000003261.7	ENSRNOT00000080651.1	ENSRNOP00000072190.1
ENSRNOG00000003261.7	ENSRNOT00000048980.5	ENSRNOP00000043441.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-84	284.6	1557	1956

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle................kkkeklneenp............................. 42
           +GlkN g+tCYmNSv+Q+L++ip++r+ +l                 k         +                             
   Q: 1557 VGLKNAGATCYMNSVIQQLYMIPSIRNGILAiegtgsdvdddmsgdeK---------Qdnesnvdprddvfgypqqfedkpplskte 1634
           6******************************98888877766654431.........033333455677777777777777777777 PP
   S: 43   ..kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedksels 127
             ke +  +l++lq +f +l  s+ +++ pr ++k+++ + e ++  eq+Da Ef++ l+d+l+e+l                    
   Q: 1635 drKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEAL-------------------- 1701
           7677777************************************************************.................... PP
   S: 128  deaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkk 214
                 k   ++ ++s++++g++ +q +c+ c ++++ ee+f++l++++++++     +l d+Le+++k + leg+n+y+cekc+kk
   Q: 1702 ------KALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQ-----NLLDSLEQYVKGDLLEGANAYHCEKCNKK 1777
           ......67999******************************************.....9**************************** PP
   S: 215  qeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................peekqkekkkYe 279
           ++++k+l +kklP+vL ++LkRf ++ e+++ +k+n+++efp+eLd++p+++                       +e++++ ++kY+
   Q: 1778 VDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAgvaklegdnvnpesqliqqneqSESEKAGSTKYR 1864
           *****************************************************99999999999888888776654444444***** PP
   S: 280  LiavvvHsGslssGHYvayvkn......ekgkWllfdDskVtevkeeevleetg...........................staYvl 333
           L++v+vHsG++s+GHY++y+ +      ek++W++fdD  Vte+k+++ +e+++                           ++aY+l
   Q: 1865 LVGVLVHSGQASGGHYYSYIIQrnggdgEKNRWYKFDDGDVTECKMDDDEEMKNqcfggeymgevfdhmmkrmsyrrqkrwWNAYIL 1951
           **********************6666655666*******************9999******************************** PP
   S: 334  fYkrr 338
           fY+r+
   Q: 1952 FYERM 1956
           ***96 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MTATTRGSPV GGNDNQGQAP DGQSQPPLQQ NQTSSPDSSN ENSPATPPDE QGQGDAPPQI 60
EDEEPAFPHT DLAKLDDMIN RPRWVVPVLP KGELEVLLEA AIDLSKKGLD VKSEACQRFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCGGCGCT GAGACTAGTG GGAGTCTGCG CTGCTGCCGC TGCTGCCGCT GCTGTCGCTG 60
TCGCTGCTGC CGCTGCCGCC GCCGACACTG CCACTGGCCG TGCGGGTTTT CTTTTTCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030426--C:growth cone
GO:0016020--C:membrane
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0048675--P:axon extension
GO:0030509--P:BMP signaling pathway
GO:0016477--P:cell migration
GO:0001764--P:neuron migration
GO:0016579--P:protein deubiquitination
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001640	Ailuropoda melanoleuca	98.55	0.00e+00	5001.00
IUUC-Apl-003592	Anas platyrhynchos	94.87	0.00e+00	4828.00
IUUC-Aca-004939	Anolis carolinensis	94.64	0.00e+00	4789.00
IUUC-Ame-011772	Astyanax mexicanus	87.75	0.00e+00	4533.00
IUUC-Bta-012775	Bos taurus	98.16	0.00e+00	4961.00
IUUC-Cja-019464	Callithrix jacchus	98.20	0.00e+00	4889.00
IUUC-Cfa-020569	Canis familiaris	98.27	0.00e+00	3223.00
IUUC-Csa-023405	Chlorocebus sabaeus	98.67	0.00e+00	4952.00
IUUC-Cho-024524	Choloepus hoffmanni	93.22	0.00e+00	797.00
IUUC-Cin-025551	Ciona intestinalis	63.75	4.00e-143	501.00
IUUC-Csv-025956	Ciona savignyi	53.78	0.00e+00	2502.00
IUUC-Dre-028329	Danio rerio	88.12	0.00e+00	4564.00
IUUC-Dno-028936	Dasypus novemcinctus	98.43	0.00e+00	5001.00
IUUC-Dor-030352	Dipodomys ordii	93.89	0.00e+00	2245.00
IUUC-Dme-032160	Drosophila melanogaster	47.88	0.00e+00	2168.00
IUUC-Ete-032287	Echinops telfairi	96.51	0.00e+00	2764.00
IUUC-Eca-033352	Equus caballus	97.28	0.00e+00	4984.00
IUUC-Eeu-034907	Erinaceus europaeus	86.61	0.00e+00	1837.00
IUUC-Fca-035458	Felis catus	97.86	0.00e+00	5022.00
IUUC-Fal-036924	Ficedula albicollis	94.70	0.00e+00	4732.00
IUUC-Gmo-039578	Gadus morhua	89.57	0.00e+00	4468.00
IUUC-Gga-040978	Gallus gallus	94.95	0.00e+00	4833.00
IUUC-Gac-041970	Gasterosteus aculeatus	90.30	0.00e+00	4564.00
IUUC-Ggo-045575	Gorilla gorilla	97.98	0.00e+00	4972.00
IUUC-Hsa-046295	Homo sapiens	98.05	0.00e+00	4978.00
IUUC-Itr-048768	Ictidomys tridecemlineatus	98.90	0.00e+00	5013.00
IUUC-Lch-050493	Latimeria chalumnae	92.15	0.00e+00	4630.00
IUUC-Loc-052667	Lepisosteus oculatus	89.61	0.00e+00	4670.00
IUUC-Laf-054094	Loxodonta africana	97.86	0.00e+00	4991.00
IUUC-Mcc-054861	Macaca mulatta	97.52	0.00e+00	4934.00
IUUC-Meu-056849	Macropus eugenii	82.72	0.00e+00	1411.00
IUUC-Mga-060159	Meleagris gallopavo	94.76	0.00e+00	4825.00
IUUC-Mmr-060732	Microcebus murinus	98.52	0.00e+00	5007.00
IUUC-Mdo-062274	Monodelphis domestica	95.06	0.00e+00	4898.00
IUUC-Mmu-064056	Mus musculus	99.65	0.00e+00	5052.00
IUUC-Mpu-066669	Mustela putorius furo	98.59	0.00e+00	5008.00
IUUC-Mlu-067516	Myotis lucifugus	97.69	0.00e+00	4960.00
IUUC-Nle-069664	Nomascus leucogenys	98.74	0.00e+00	3665.00
IUUC-Opr-070185	Ochotona princeps	87.76	0.00e+00	797.00
IUUC-Ont-072119	Oreochromis niloticus	89.50	0.00e+00	4576.00
IUUC-Oan-073154	Ornithorhynchus anatinus	94.64	0.00e+00	4875.00
IUUC-Ocu-074485	Oryctolagus cuniculus	98.37	0.00e+00	5048.00
IUUC-Ola-086350	Oryzias latipes	89.95	0.00e+00	4495.00
IUUC-Oga-088328	Otolemur garnettii	97.55	0.00e+00	5045.00
IUUC-Oar-090098	Ovis aries	97.47	0.00e+00	4984.00
IUUC-Pan-091741	Papio anubis	98.58	0.00e+00	3792.00
IUUC-Psi-093040	Pelodiscus sinensis	94.80	0.00e+00	4816.00
IUUC-Pfo-096871	Poecilia formosa	88.79	0.00e+00	4560.00
IUUC-Pab-098374	Pongo abelii	98.63	0.00e+00	4948.00
IUUC-Pca-100801	Procavia capensis	89.08	0.00e+00	2417.00
IUUC-Pva-102992	Pteropus vampyrus	92.42	0.00e+00	2416.00
IUUC-Sha-106648	Sarcophilus harrisii	92.41	0.00e+00	4717.00
IUUC-Smo-108879	Selaginella moellendorffii	28.10	0.00e+00	810.00
IUUC-Sar-113729	Sorex araneus	94.27	0.00e+00	3143.00
IUUC-Ssc-116261	Sus scrofa	92.03	0.00e+00	4778.00
IUUC-Tgu-117126	Taeniopygia guttata	94.91	0.00e+00	4831.00
IUUC-Tru-117676	Takifugu rubripes	89.93	0.00e+00	4566.00
IUUC-Tsy-119209	Tarsius syrichta	86.69	0.00e+00	2676.00
IUUC-Tni-120207	Tetraodon nigroviridis	85.29	0.00e+00	2040.00
IUUC-Tbe-128033	Tupaia belangeri	98.80	0.00e+00	1058.00
IUUC-Ttr-128742	Tursiops truncatus	96.63	0.00e+00	4919.00
IUUC-Vpa-130581	Vicugna pacos	94.68	0.00e+00	4778.00
IUUC-Xtr-132145	Xenopus tropicalis	92.49	0.00e+00	4747.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence