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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045738
UUCD1 version UUC-HoS-00342
Ensembl Protein ID ENSP00000348632.5
UniProt Accession Q9BYM8; O95623; Q86SL2; Q96BS3; Q9BYM9; HOIL1_HUMAN
Genbank Protein ID AAD00162.1; BAC75409.1; CAC17516.1; CAC28312.2; AAH15219.2
Protein Name RanBP-type and C3HC4-type zinc finger-containing protein 1; HBV-associated factor 4; Heme-oxidized IRP2 ubiquitin ligase 1; Hepatitis B virus X-associated protein 4; RING finger protein 54; RING-type E3 ubiquitin transferase HOIL-1; Ubiquitin-conjugating enzyme 7-interacting protein 3
Genbank Nucleotide ID U67322; AB107766; AL121747; AL121747; BC000983
Gene Name RBCK1; C20orf18; RNF54; UBCE7IP3; XAP3; XAP4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000125826.19 ENST00000382214.7 ENSP00000371649.3
ENSG00000125826.19 ENST00000356286.9 ENSP00000348632.5
ENSG00000125826.19 ENST00000415942.5 ENSP00000405288.1
ENSG00000125826.19 ENST00000475269.5 ENSP00000417173.1
ENSG00000125826.19 ENST00000441733.5 ENSP00000387799.1
ENSG00000125826.19 ENST00000353660.7 ENSP00000254960.5
ENSG00000125826.19 ENST00000382181.2 ENSP00000371616.2
ENSG00000125826.19 ENST00000400247.3 ENSP00000383106.3
ENSG00000125826.19 ENST00000414880.1 ENSP00000393841.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RBR RBR 21455180; 18711448; 16643902; 16275334; 25118570
UBD/ZnF/NZF NZF 22139374
Classification
Family E-value Score Start End
UBD/ZnF/NZF 9.30e-11 42.7 195 221
E3 activity/RBR 3.80e-41 141.8 282 475
ULD/UDP/UBQ/UBQ_Other 2.40e-06 29.0 60 122
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/NZF
   S: 3    aqWaCsaCTflNePeavkCemCsrpRg 29
            +W+C+ CTf+N+P +++CemC+r R+
   Q: 195  VGWQCPGCTFINKPTRPGCEMCCRARP 221
           68************************8 PP
   

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscp....aaecpekleeseikellveeelykryekllleevveada 86
           C+vC++ l++ e++vl eC htfC+eCl+ +    i+++q++e+scp    +++c+ kl e+eik+ l+++e y+r+ +l ++ + +++a
   Q: 282  CPVCYSVLAPGEAVVLRECLHTFCRECLQGT----IRNSQEAEVSCPfidnTYSCSGKLLEREIKA-LLTPEDYQRFLDLGISIAENRSA 366
           *****************************98....9***********999999*************.699******************** PP
   S: 87   alkwcpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeek......eeaeskelleanskkCpkCkvy 170
             ++c++pdC+ ++++e+  + +e++c+ c +++C+ Ck++ He+++Cke++e+la +++++      +e+ + +l++ ++++Cp+C+++
   Q: 367  FSYHCKTPDCKGWCFFED--DVNEFTCPVCFHVNCLLCKAI-HEQMNCKEYQEDLALRAQNDvaarqtTEMLKVMLQQGEAMRCPQCQIV 453
           ******************..699999*************99.*****************99999**9999******************** PP
   S: 171  ieknegCnhmtCakCkaefCwl 192
           ++k++gC+ + C+ C++e Cw+
   Q: 454  VQKKDGCDWIRCTVCHTEICWV 475
           *********************7 PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 4    tvksldgseltlk..vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdg 64
            v++++  + t++  v p++tVa LK++++   g+pp  q++++ G+ L +d  tL ++g++++
   Q: 60   SVEDAQMHTVTIWltVRPDMTVASLKDMVFLDYGFPPVLQQWVI-GQRLaRDQETLHSHGVRQN 122
           5666665577777889****************************.55555**********9875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.
 E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.
Protein Sequence
(Fasta)
MDEKTKKAEE MALSLTRAVA GGDEQVAMKC AIWLAEQRVP LSVQLKPEVS PTQDIRLWVS 60
VEDAQMHTVT IWLTVRPDMT VASLKDMVFL DYGFPPVLQQ WVIGQRLARD QETLHSHGVR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045738|E3,RBR;UBD,NZF;ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCGGAGGAG GTGAGGGATG AGATTCTGCA AGTGGAGCCC GCAGGATCTG CTGATCGATG 60
GGACGAGGAA CGGGAGAAAA ATTAAAGCGG CGCATGAGGC AGACGAATGC AAACTTCACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045738|E3,RBR;UBD,NZF;ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0945--Host-virus interaction
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR002867--IBR_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR027370--Znf-RING_LisH
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50053--UBIQUITIN_2
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF01485--IBR
PF13445--zf-RING_UBOX
SMART

SM00184--RING
SM00547--ZnF_RBZ
Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0060546--P:negative regulation of necroptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0042346--P:positive regulation of NF-kappaB import into nucleus
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination
GO:0000209--P:protein polyubiquitination
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0016032--P:viral process
KEGG hsa:10616
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001540 Ailuropoda melanoleuca 92.55 0.00e+00 861.00
IUUC-Apl-003627 Anas platyrhynchos 61.54 1.00e-18 84.00
IUUC-Aca-004507 Anolis carolinensis 64.10 2.00e-153 535.00
IUUC-Ame-011008 Astyanax mexicanus 52.76 5.00e-143 501.00
IUUC-Bta-013247 Bos taurus 94.71 0.00e+00 910.00
IUUC-Bci-013637 Botrytis cinerea 25.85 1.00e-12 68.90
IUUC-Cja-018880 Callithrix jacchus 98.24 0.00e+00 943.00
IUUC-Cfa-020477 Canis familiaris 94.71 0.00e+00 912.00
IUUC-Cpo-021558 Cavia porcellus 90.39 0.00e+00 861.00
IUUC-Csa-024129 Chlorocebus sabaeus 98.82 0.00e+00 903.00
IUUC-Cin-025630 Ciona intestinalis 39.67 5.00e-81 295.00
IUUC-Csv-026069 Ciona savignyi 51.20 3.00e-72 264.00
IUUC-Dre-027591 Danio rerio 52.72 8.00e-142 497.00
IUUC-Dno-029015 Dasypus novemcinctus 92.35 0.00e+00 872.00
IUUC-Dor-030313 Dipodomys ordii 82.67 0.00e+00 740.00
IUUC-Ete-032908 Echinops telfairi 81.20 0.00e+00 761.00
IUUC-Eca-034295 Equus caballus 77.34 0.00e+00 724.00
IUUC-Eeu-034454 Erinaceus europaeus 86.44 9.00e-116 410.00
IUUC-Fca-036380 Felis catus 95.29 0.00e+00 915.00
IUUC-Fal-037440 Ficedula albicollis 56.90 3.00e-15 72.80
IUUC-Gmo-038561 Gadus morhua 53.62 5.00e-119 421.00
IUUC-Gac-041319 Gasterosteus aculeatus 52.54 2.00e-137 482.00
IUUC-Ggo-044456 Gorilla gorilla 68.65 1.00e-158 553.00
IUUC-Itr-049042 Ictidomys tridecemlineatus 92.94 0.00e+00 868.00
IUUC-Lch-050269 Latimeria chalumnae 44.74 5.00e-114 405.00
IUUC-Loc-052776 Lepisosteus oculatus 49.00 3.00e-136 479.00
IUUC-Laf-054269 Loxodonta africana 91.76 0.00e+00 884.00
IUUC-Mcc-055669 Macaca mulatta 99.61 0.00e+00 917.00
IUUC-Mga-059615 Meleagris gallopavo 54.69 2.00e-17 80.50
IUUC-Mmr-061562 Microcebus murinus 93.82 0.00e+00 780.00
IUUC-Mdo-062263 Monodelphis domestica 78.10 0.00e+00 751.00
IUUC-Mmu-064325 Mus musculus 91.18 0.00e+00 847.00
IUUC-Mpu-066385 Mustela putorius furo 94.71 0.00e+00 909.00
IUUC-Mlu-067000 Myotis lucifugus 91.37 0.00e+00 863.00
IUUC-Nle-069812 Nomascus leucogenys 99.22 0.00e+00 911.00
IUUC-Opr-070575 Ochotona princeps 93.63 1.00e-106 380.00
IUUC-Ont-072405 Oreochromis niloticus 52.30 2.00e-138 485.00
IUUC-Ocu-074358 Oryctolagus cuniculus 80.80 0.00e+00 770.00
IUUC-Ola-086403 Oryzias latipes 53.22 1.00e-140 493.00
IUUC-Oga-087986 Otolemur garnettii 93.73 0.00e+00 856.00
IUUC-Oar-089600 Ovis aries 92.35 0.00e+00 901.00
IUUC-Ptr-091224 Pan troglodytes 99.80 0.00e+00 902.00
IUUC-Pan-092739 Papio anubis 99.80 0.00e+00 920.00
IUUC-Pma-094407 Petromyzon marinus 43.66 2.00e-112 399.00
IUUC-Pfo-097161 Poecilia formosa 53.10 7.00e-134 470.00
IUUC-Pab-098627 Pongo abelii 99.80 0.00e+00 897.00
IUUC-Pca-100641 Procavia capensis 92.24 0.00e+00 823.00
IUUC-Pva-102670 Pteropus vampyrus 91.96 0.00e+00 868.00
IUUC-Pte-104234 Pyrenophora teres 25.41 4.00e-12 66.20
IUUC-Rno-105504 Rattus norvegicus 90.98 0.00e+00 844.00
IUUC-Sha-107342 Sarcophilus harrisii 78.10 0.00e+00 768.00
IUUC-Sar-113425 Sorex araneus 88.13 3.00e-113 401.00
IUUC-Ssc-115904 Sus scrofa 93.64 9.00e-90 322.00
IUUC-Tru-118096 Takifugu rubripes 51.73 1.00e-138 486.00
IUUC-Tni-119873 Tetraodon nigroviridis 49.90 1.00e-138 486.00
IUUC-Tbe-127578 Tupaia belangeri 91.02 0.00e+00 694.00
IUUC-Ttr-129107 Tursiops truncatus 94.51 0.00e+00 858.00
IUUC-Vpa-130353 Vicugna pacos 95.55 5.00e-125 441.00
IUUC-Xtr-132168 Xenopus tropicalis 42.21 6.00e-94 338.00
Created Date 25-Jun-2017

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